Snow Fungus, Silver Ear · 2007 · Research Article
High relevanceThe Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells.
Tremella fuciformis
Key points
- We examined the neuroprotective and neurotrophic effects of Tremella fuciformis
- The neurotrophic effects of the hot water extract of T. fuciformis was evaluated by microscopically monitoring its potency to induce neurite outgrowth in PC12h cells
- The hot water extract of T. fuciformis promoted neurite outgrowth in PC12h cells in this study, superior to other natural substances which was reported previously
- When cells were treated with the hot water extract of T. fuciformis prior to β-amyloid peptide treatment (active domain of A peptide 25~35 treated), toxicity was significantly diminished (p<0.01)
- These results suggest that T. fuciformis might potentially be used as a precautionary agent in neurodegenerative disease, such as Alzheimer's disease, etc
Metadata-grounded summary
Citation abstract
We examined the neuroprotective and neurotrophic effects of Tremella fuciformis. The neurotrophic effects of the hot water extract of T. fuciformis was evaluated by microscopically monitoring its potency to induce neurite outgrowth in PC12h cells. The hot water extract of T. fuciformis promoted neurite outgrowth in PC12h cells in this study, superior to other natural substances which was reported previously. When cells were treated with the hot water extract of T. fuciformis prior to β-amyloid peptide treatment (active domain of A peptide 25~35 treated), toxicity was significantly diminished (p<0.01). These results suggest that T. fuciformis might potentially be used as a precautionary agent in neurodegenerative disease, such as Alzheimer's disease, etc.
Citation
Park KJ, Lee SY, Kim HS, Yamazaki M, Chiba K, Ha HC (2007). The Neuroprotective and Neurotrophic Effects of Tremella fuciformis in PC12h Cells. Mycobiology https://doi.org/10.4489/MYCO.2007.35.1.011 PMID: 24015061
Open citation