Mesima, Sanghwang · 2009 · Research Article
High relevanceAntitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model.
Phellinus linteus
Key points
- The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model
- When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer
- The highest dose was highly effective, reducing tumor formation by 26% compared with the control group
- The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner
- Lysosomal enzyme activity of macrophages was increased by 2-fold (100 µg/ml) compared with the control group
- Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action
Metadata-grounded summary
Citation abstract
The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly effective, reducing tumor formation by 26% compared with the control group. The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner. Lysosomal enzyme activity of macrophages was increased by 2-fold (100 µg/ml) compared with the control group. Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action.
Citation
Yang BK, Hwang SL, Yun IJ, Do EJ, Lee WH, Jung YM, et al. (2009). Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model. Mycobiology https://doi.org/10.4489/MYCO.2009.37.2.128 PMID: 23983521
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