Mesima, Sanghwang · 2012 · Brief Report
Medium relevanceNeuraminidase Inhibitors from the Culture Broth of Phellinus linteus.
Phellinus linteus
Key points
- During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity
- Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth
- According to (1)H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC(50) values of 13.1 and 0.03 µM, respectively
Metadata-grounded summary
Citation abstract
During the search for neuraminidase inhibitors from medicinal fungi, we found that the culture broth of Phellinus linteus exhibited potent inhibitory activity. Solvent partition, Sephadex LH-20 column chromatography, and high-performance liquid chromatography (HPLC) were performed for purification of two active substances from the culture broth. According to (1)H NMR measurements and comparison of HPLC retention times with those of authentic compounds, their chemical structures were identified as hispidin and hypholomine B. Compounds (hispidin) 1 and 2 (hypholomine B) inhibited neuraminidase, with IC(50) values of 13.1 and 0.03 µM, respectively.
Citation
Yeom JH, Lee IK, Ki DW, Lee MS, Seok SJ, Yun BS (2012). Neuraminidase Inhibitors from the Culture Broth of Phellinus linteus. Mycobiology https://doi.org/10.5941/MYCO.2012.40.2.142 PMID: 22870059
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