Grifola frondosa beta-dextran freeze-dried powder for injection

From the paper

Abstract

The invention relates to a freeze-dried powder for injection which is prepared by Beta-glucan that is extracted and separated by using Grifola frondosa mycelium and has the structure shown in the attached figure I and a preparation method thereof, which pertains to the technical field of medical preparations. The figure shows that monosaccharide of the polysaccharide are composed of glucose, the glucose residue of a main chain is connected by a Beta-1, 6-glycosidic bond, the glucose residue of a branched chain is connected by a Beta-1, 3-glycosidic bond, the length of the branched chain is 2 glucose residues, and the degree of branch is about one half. The range of the molecular weight of the Beta-glucan is 50,000 to 250,000 Daltons, and the distribution width of the molecular weight is less than 3.0. The glucan is a single component with a certain range of the molecular weight, and the molecules of the component have the same repeated unit structures regardless of the size of the molecular weight. The tests prove that the freeze-dried powder for injection provided by the invention is characterized by immune regulation, anti-radiation and tumor inhibition.