Niu-Chang-Chih · 2009 · Patent
Medium relevanceCyclohexenones from Antrodia Camphorata for use in the treatment of hepatitis B (HBV)
Antrodia camphorata
OncologyLiver support
Key points
- A compound of formula (1) as defined therein, obtained from Antrodia camphorate may used to inhibit hepatitis B (HBV), in particular 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone
- The said compound shows cytotoxicity to the HBV-secreting human hepatoma cell line HepG2 2.2.15, decreased synthesis of HBV particles and further inhibited synthesis of HbsAg and HbeAg
- A pharmaceutical composition comprising the aforementioned compound may also be prepared
From the paper
Abstract
A compound of formula (1) as defined therein, obtained from Antrodia camphorate may used to inhibit hepatitis B (HBV), in particular 4-hydroxy-2,3-dimethoxy-6-methyl-5(3,7,11-trimethyl-dodeca-2,6,10-trienyl)-cyclohex-2-enone. The said compound shows cytotoxicity to the HBV-secreting human hepatoma cell line HepG2 2.2.15, decreased synthesis of HBV particles and further inhibited synthesis of HbsAg and HbeAg. A pharmaceutical composition comprising the aforementioned compound may also be prepared.
Citation
LIU SHENG-YUN, KUO MAO-TIEN, WEN WU-CHE (2009). Cyclohexenones from Antrodia Camphorata for use in the treatment of hepatitis B (HBV).
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