Extracts of Phellinus linteus grown on germinated brown rice suppress liver damage induced by carbon tetrachloride in rats

From the paper

Abstract

Extracts of Phellinus linteus (EPB), grown on germinated brown rice, protected rats from liver injury induced by carbon tetrachloride (CCl₄). Peroxidation products in the liver were decreased to 10% by EPB. Catalase and superoxide dismutase activities were significantly decreased to 55% and 39% by CCl₄ administration, but EPB blocked this effect, resulting in enzyme activities at control levels. Expression of cytochrome P450 2E1 (CYP2E1) protein was significantly decreased to 88% in CCl₄-treated rats but remained at control levels when EPB was also administered. EPB did not affect the altered fatty acid composition induced by CCl₄. The hepatoprotective effect of EPB may be mediated by EPB's prevention of CCl₄-induced CYP2E1 degradation.