A novel oligosaccharide isolated from Hericium erinaceus and its protection against LPS‐induced Caco‐2 cells via the TLR4/NF‐κB pathway

From the paper

Abstract

A novel oligosaccharide showed that protection against LPS‐induced Caco‐2 cells was purified from the mycelium of Hericium erinaceus (HE). WEP‐1 is mainly composed of neutral monosaccharides with molecular weight of 4,010 Da and of mannose, glucose, and galactose in a molar ratio of 1.2:16.9:1. The structure of WEP‐1 includes α‐D‐Glc (1 → 3) and β‐D‐Gal (1 → 3) as the backbone with β‐D‐Glc (1 → 3) as branches attached to the C‐4 position and β‐D‐Man as a terminal residue. The oligosaccharide reduced acetic acid‐induced colonic mucosa injury in rats. It also showed significant protection against LPS‐induced Caco‐2 cells via the TLR4/NF‐κB pathway.

PRACTICAL APPLICATIONS: In the study, the oligosaccharide from HE has the potential to be developed into functional foods or medicines for the treatment of intestinal diseases. The protection against LPS‐induced Caco‐2 cells via the TLR4/NF‐κB pathway may be a key target for the pharmacological activity of HE.