Anti-inflammatory and immunomodulatory effects in vitro of polysaccharide- and polyphenol-rich extracts of white button and Turkey Tail mushrooms

From the paper

Abstract

The health-promoting properties of mushrooms are associated with bioactive natural compounds such as polysaccharides and polyphenols. Anti-inflammatory and immunomodulatory properties of edible white button mushroom (WBM) and medicinal Turkey Tail mushroom (TT) were investigated. The results showed that polysaccharide-rich water extract of WBM and TT exhibit an anti-inflammatory effect in lipopolysaccharide-activated mouse liver cells by attenuating the interleukin (IL)6 and IL1β at mRNA and polysaccharide-rich water extract of WBM by attenuating IL6 and IL1β at protein levels. Also, polysaccharide-rich water and polyphenol-rich ethanolic extracts of WBM stimulated IgA secretion in the human plasma cells (H929 cells) in vitro which was partly mediated by the Signal Transducer and Activator of Transcription 3 (STAT3) pathway. These results suggest that WBM possesses potential anti-inflammatory and immune-enhancing properties and could be further assessed for use as a dietary supplement against inflammation and boosting immunity simultaneously.