Cultivated Cordyceps militaris exerts anti-allergic effects in a cockroach-induced allergic dermatitis mouse model by suppressing inflammation and enhancing epidermal homeostasis

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Abstract

The study evaluated the anti-allergic effects of ethanol extract derived from laboratory-cultivated Cordyceps militaris (ECM) using the HaCaT cells and cockroach allergen Per a 2-induced allergic dermatitis mouse model. The results indicated that oral administration of ECM significantly reduced serum IgE levels, decreased secretion of Th2-type and proinflammatory cytokines in splenocytes, improved scratch bouts, mitigated epidermal infiltration, and reduced mRNA expression of Thymic Stromal Lymphopoietin (TSLP) and IL-33 in skin lesions in the allergen-sensitized mice. The RNA sequencing analysis of skin lesions revealed the aryl hydrocarbon receptor repressor (AHRR) gene downregulated, enhancing epidermal homeostasis and mediating skin barrier function. Our findings provide evidence for the application of oral ECM in atopic dermatitis and various allergic dermatitis.