MYCELIUM EXTRACTS OF PHELLIUNUS LINTEUS COMPOSITION HAVING STABILITY IN WATER ABSORPTION AND RAPID DISSOLUTION, AND PREPARING METHOD THEREOF

From the paper

Abstract

A composition of the mycelium extract of Phellinus linteus having stability in water absorption and being rapidly dissolved, and a preparing method thereof are provided to inhibit hardness of Phellinus linteus mycelium extract during storage by water absorption, delay of disintegration time and lowering of drug bioavailability. The composition for improving stability in water absorption and rapidly dissolving the mycelium extract of Phellinus linteus comprises 40-99.5 wt.% of the mycelium extract of Phellinus linteus and 0.5-60 wt.% of pregelatinized starch as an excipient, and is formulated as capsule. The Phellinus linteus mycelium extract composition is prepared by mixing the Phellinus linteus mycelium extract with pregelatinized starch to obtain tablets, pulverizing the tablet with dry granulation method to prepare granules, and directly filing the capsules with the granules without drying them.