Zhu Ling, Umbrella Polypore · 1992 · English Abstract
Low relevance[A study on the role of immunosuppression in the pathogenesis of brucellosis].
Polyporus umbellatus
Key points
- An immunosuppressive effect was seen in murine brucellosis as detected by using plaque forming cell (PFC) and 3H-labelled lymphocyte blastogenesis transformation (LBT) assays
- The immunosuppression PFC could last until 11 months after infection, while that of LBT was only seen at 3 months after infection
- This immunosuppression could be relieved by using immunomodulators such as levamisole, bestatin, IL-2 and polyporus umbellatus
- IL-2 and polyporus umbellatus could reverse the suppression to normal levels
- Thus, this study provided evidence that immunosuppression is a component of pathogenesis of brucellosis
Metadata-grounded summary
Citation abstract
An immunosuppressive effect was seen in murine brucellosis as detected by using plaque forming cell (PFC) and 3H-labelled lymphocyte blastogenesis transformation (LBT) assays. The immunosuppression PFC could last until 11 months after infection, while that of LBT was only seen at 3 months after infection. This immunosuppression could be relieved by using immunomodulators such as levamisole, bestatin, IL-2 and polyporus umbellatus. IL-2 and polyporus umbellatus could reverse the suppression to normal levels. Thus, this study provided evidence that immunosuppression is a component of pathogenesis of brucellosis.
Citation
Zhang J (1992). [A study on the role of immunosuppression in the pathogenesis of brucellosis]. Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae PMID: 1394733
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