Maitake, Hen of the Woods · 2018 · Review
High relevanceGrifola frondosa polysaccharide: a review of antitumor and other biological activity studies in China.
Grifola frondosa
Key points
- Grifola frondosa, a species of Basidiomycotina, is an edible medicinal mushroom with a large fruiting body characterized by overlapping caps
- The β-glucan is the major biologically active component in G. frondosa polysaccharide (GFP) or D-fraction, which has been studied extensively for nearly 30 years
- GFP was approved as an adjunctive therapeutic drug in China for treating cancers in 2010
- In this article, based on the search results of Chinese VIP, CNKI, and Wanfang databases, 105 independent animal studies were summarized
- The chemical structure, the antitumor, immunomodulatory, anti-diabetic, anti-hyperlipidemia, and antiviral activities and molecular mechanisms of GFP are reviewed and discussed
Metadata-grounded summary
Citation abstract
Grifola frondosa, a species of Basidiomycotina, is an edible medicinal mushroom with a large fruiting body characterized by overlapping caps. The β-glucan is the major biologically active component in G. frondosa polysaccharide (GFP) or D-fraction, which has been studied extensively for nearly 30 years. GFP was approved as an adjunctive therapeutic drug in China for treating cancers in 2010. In this article, based on the search results of Chinese VIP, CNKI, and Wanfang databases, 105 independent animal studies were summarized. The chemical structure, the antitumor, immunomodulatory, anti-diabetic, anti-hyperlipidemia, and antiviral activities and molecular mechanisms of GFP are reviewed and discussed.
Citation
He Y, Li X, Hao C, Zeng P, Zhang M, Liu Y, et al. (2018). Grifola frondosa polysaccharide: a review of antitumor and other biological activity studies in China. Discovery medicine PMID: 29723488
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