Chaga · 1996 · Journal Article
Medium relevanceAntimitotic activity of aqueous extracts of Inonotus obliquus.
Inonotus obliquus
Key points
- The cytotoxic effect of two aqueous extracts of Inonotus obliquus on human cervical uteri cancer cells (Hela S3) in vitro was evaluated
- It was concluded that Inonotus extracts at a concentration of 10 micrograms/ml to 2000 micrograms/ml inhibited cancer cells growth
- In cultures with extracts of the fungus a decrease of the cell proteins and mitotic index was observed
- Moreover, the extracts disturbed mitoses by elevating the number of mitotic cells in metaphase
- Aqueous extracts of Inonotus effected not only mitoses but also the 8/G phase of the cell cycle
Metadata-grounded summary
Citation abstract
The cytotoxic effect of two aqueous extracts of Inonotus obliquus on human cervical uteri cancer cells (Hela S3) in vitro was evaluated. It was concluded that Inonotus extracts at a concentration of 10 micrograms/ml to 2000 micrograms/ml inhibited cancer cells growth. In cultures with extracts of the fungus a decrease of the cell proteins and mitotic index was observed. Moreover, the extracts disturbed mitoses by elevating the number of mitotic cells in metaphase. Aqueous extracts of Inonotus effected not only mitoses but also the 8/G phase of the cell cycle.
Citation
Burczyk J, Gawron A, Slotwinska M, Smietana B, Terminska K (1996). Antimitotic activity of aqueous extracts of Inonotus obliquus. Bollettino chimico farmaceutico PMID: 8942059
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