Zhu Ling, Umbrella Polypore · 1993 · Research Support, Non U.S. Gov'T
Low relevanceImmunosuppression in murine brucellosis.
Polyporus umbellatus
Key points
- Brucellosis in mice results in a distinct immunosuppression which may be abrogated by immunomodulators, such as levamisole, bestatin, interleukin-2 (IL-2) and Polyporus umbellatus
- The data presented here provide evidence that immunosuppression in addition to infection of target tissues and allergic reactions (including types 3 and 4) contributes to the pathogenesis of brucellosis
- The present study also provides some basic data regarding the value of this animal model, and criteria for observing the effect of therapy on chronic brucellosis
Metadata-grounded summary
Citation abstract
Brucellosis in mice results in a distinct immunosuppression which may be abrogated by immunomodulators, such as levamisole, bestatin, interleukin-2 (IL-2) and Polyporus umbellatus. The data presented here provide evidence that immunosuppression in addition to infection of target tissues and allergic reactions (including types 3 and 4) contributes to the pathogenesis of brucellosis. The present study also provides some basic data regarding the value of this animal model, and criteria for observing the effect of therapy on chronic brucellosis.
Citation
Zhang J, Gao B, Cun C, Lu X, Wang H, Chen X, et al. (1993). Immunosuppression in murine brucellosis. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih PMID: 8142626
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