MycoData

Energy & fatigueGut & microbiome

Reishi · 2024 · Journal Article · Journal of environmental management

Partitioning Ganoderma lucidum residue biochar differentially boosts anaerobic fermentation performance of cow manure via mediation of anaerobic microbiota assembly.

Immune supportEnergy & fatigueMetabolic healthLiver support

Lion's Mane · 2024 · Research Article · Poultry science

Polysaccharide from Hericium erinaceus improved laying performance of aged hens by promoting yolk precursor synthesis and follicle development via liver-blood-ovary axis.

Little information is available on the effect of Hericium erinaceus polysaccharides (HEP) on laying hens, especially on improving liver and ovarian health and function..

Immune supportEnergy & fatigueMetabolic health

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Polysaccharides extraction from Ganoderma lucidum using a ternary deep eutectic solvents of choline chloride/guaiacol/lactic acid.

In this study, a purposefully formulated ternary deep eutectic solvents (DESs), consisting of choline chloride, guaiacol, and lactic acid in a molar ratio of 1:1:1, was synthesized for the extraction of polysaccharides from Ganoderma lucidum..

Oyster Mushroom · 2024 · Journal Article · International journal of biological macromolecules

PoSnf1 affects cellulose utilization through interaction with cellobiose transporter in Pleurotus ostreatus.

Pleurotus ostreatus is one of the most cultivated edible fungi worldwide, but its lignocellulose utilization efficiency is relatively low (<50 %), which eventually affects the biological efficiency of P. ostreatus..

Immune supportCognition & nervesEnergy & fatigue

Reishi · 2024 · Research Article · BMC complementary medicine and therapies

Protective effect of Ganoderma lucidum-fermented crop extracts against hydrogen peroxide- or β-amyloid-induced damage in human neuronal SH-SY5Y cells.

BACKGROUND: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of stacked β-amyloid peptides in the brain and associated with the generation of oxidative stress. So far, there is no cure for AD or a way to stop its progression..

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

Chaga · 2024 · Research Article · Heliyon

Protective effect of Inonotus obliquus polysaccharide on MGO-induced nonenzymatic glycation fibroblasts.

BACKGROUND: The nonenzymatic glycation of fibroblasts causes functional downregulation and behavioral disorders in the skin. METHODS: To investigate the effect of Inonotus obliquus on the nonenzymatic glycation of skin, we examined the inhibition of advanced glycation end products (AGEs) using four extraction methods:….

Cognition & nervesEnergy & fatigueMetabolic health

Cordyceps · 2024 · Research Article · Current research in food science

Rapid discrimination between wild and cultivated Ophiocordyceps sinensis through comparative analysis of label-free SERS technique and mass spectrometry.

Ophiocordyceps sinensis is a genus of ascomycete fungi that has been widely used as a valuable tonic or medicine. However, due to over-exploitation and the destruction of natural ecosystems, the shortage of wild O.

Energy & fatigueMetabolic health

Oyster Mushroom · 2024 · Research Article · PeerJ

Regulation of dye-decolorizing peroxidase gene expression in Pleurotus ostreatus grown on glycerol as the carbon source.

Dye-decolorizing peroxidases (DyPs) (E.C. 1.11.1.19) are heme peroxidases that catalyze oxygen transfer reactions similarly to oxygenases.

Energy & fatigueMetabolic health

Reishi · 2024 · Journal Article · Chemosphere

Removal of pharmaceutical compounds and toxicology study in wastewater using Malaysian fungal Ganoderma lucidum.

Elevated usage of pharmaceutical products leads to the accumulation of emerging contaminants in sewage. In the current work, Ganoderma lucidum (GL) was used to remove pharmaceutical compounds (PCs), proposed as a tertiary method in sewage treatment plants (STPs)..

Enoki · 2024 · Research Article · International journal of molecular sciences

Renoprotective Effects of Brown-Strain Flammulina velutipes Singer in Chronic Kidney Disease-Induced Mice Through Modulation of Oxidative Stress and Inflammation and Regulation of Renal Transporters.

Cisplatin, widely used in chemotherapy, acts through mechanisms such as oxidative stress to damage the DNA and cause the apoptosis of cancer cells. Although effective, cisplatin treatment is associated with considerable side effects including chronic kidney disease (CKD)..

Immune supportEnergy & fatigueMetabolic health

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Roles of α-1,3-glucosyltransferase in growth and polysaccharides biosynthesis of Ganoderma lucidum.

Ganoderma lucidum polysaccharides are valuable natural compounds possessing significant biological activity, with glycosyltransferases playing a crucial role in their biosynthesis..

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Selenochemical modification of low molecular weight polysaccharides from Grifola frondosa and the mechanism of their inhibitory effects on gastric cancer cells.

An important micronutrient involved in immune response and antitumor is selenium. LMW-GFP, a polysaccharide extracted from Grifola frondosa seed bodies, has a relatively weak antitumor effect on BGC-823 and MFC cells in vitro, whereas selenium binding to LMW-GFP can significantly increase the in vitro antitumor….

OncologyEnergy & fatigueLiver support

Reishi · 2024 · Research Article · Frontiers in pharmacology

Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo.

BACKGROUND: Ganoderma lucidum (G. lucidum) is a famous medicinal mushroom that has been reported to prevent and treat a variety of diseases.

Reishi · 2024 · Journal Article · Industrial crops and products

Spent mushroom substrate of Ganoderma lucidum developed nanocatalyst (CSA/BaO@K2CO3) for efficient biodiesel synthesis from blended oil feedstock

The dietary and biological advantages of mushrooms are driving a global boom in the mushroom industry. The widespread production of mushrooms corresponds to disposal challenge, generating a significant volume of biowaste known as spent mushroom substrate..

Chaga · 2024 · Journal Article · International journal of biological macromolecules

Structural characterization of the polysaccharide from the black crystal region of Inonotus obliquus and its effect on AsPC-1 and SW1990 pancreatic cancer cell apoptosis.

In this study, one water soluble polysaccharide (IOP1-1) with a weight average molecular weight of 6886 Da was obtained from the black crystal region of Inonotus obliquus by hot water extraction, DEAE-52 cellulose extraction and Sephadex-100 column chromatography purification..

Immune supportEnergy & fatigueGut & microbiome

Reishi · 2024 · Research Article · Animals: an open access journal from MDPI

The Addition of Hot Water Extract of Juncao-Substrate Ganoderma lucidum Residue to Diets Enhances Growth Performance, Immune Function, and Intestinal Health in Broilers.

The purpose of this experiment was to investigate the effects of Hot Water Extract of Juncao-substrate Ganoderma lucidum Residue (HWE-JGLR) on the immune function and intestinal health of yellow-feather broilers..

Reishi · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

The Performance and Evolutionary Mechanism of Ganoderma lucidum in Enhancing Selenite Tolerance and Bioaccumulation.

BACKGROUND: Selenium (Se) pollution poses serious threats to terrestrial ecosystems. Mushrooms are important sources of Se with the potential for bioremediation.

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Maitake · 2024 · Research Article · Life (Basel, Switzerland)

The Role of Grifola frondosa Polysaccharide in Preventing Skeletal Muscle Atrophy in Type 2 Diabetes Mellitus.

Type 2 diabetes mellitus (T2DM) is a burgeoning public health challenge worldwide. Individuals with T2DM are at increased risk for skeletal muscle atrophy, a serious complication that significantly compromises quality of life and for which effective prevention measures are currently inadequate..

Energy & fatigueMetabolic healthSkin & hydration

Shiitake · 2024 · Journal Article · Journal of agricultural and food chemistry

Transcriptomic Communication between Nucleus and Mitochondria during the Browning Process of Lentinula edodes.

To explore the reason for cytoplasmic replacement's significant effect on browning, transcriptomic data of nuclear (N) and mitochondrial (M) mRNAs and long noncoding RNAs (lncRNAs) in L808 and two cytoplasmic hybrids (cybrids) (L808-A2 and L808-B) of Lentinula edodes at three different culturing times (80, 100, and….

OncologyImmune supportEnergy & fatigueLiver support

Reishi · 2023 · Review · Cancer cell international

Exploring the anti-cancer potential of Ganoderma lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer.

There has been a growing global interest in the potential health benefits of edible natural bioactive products in recent years. Ganoderma lucidum, a medicinal mushroom, has gained attention for its decadent array of therapeutic and pharmaceutical compounds.

OncologyImmune supportEnergy & fatigueMetabolic health

Yellow Morel · 2023 · Review · International journal of medicinal mushrooms

Food and Antioxidant Supplements with Therapeutic Properties of Morchella esculenta (Ascomycetes): A Review.

Morchella esculenta, commonly known as yellow morels, is an edible and medicinal mushroom popular worldwide for its unique flavor and culinary purposes. The traditional medical system effectively uses morels against infertility, fatigue, cancer, muscular pain, cough, and cold.

OncologyImmune supportEnergy & fatigueGut & microbiome

Chaga · 2021 · Review · Journal of ethnopharmacology

Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus.

ETHNOPHARMACOLOGICAL RELEVANCE: The crude extracts of the medicinal mushroom Inonotus obliquus have been used as an effective traditional medicine to treat malicious tumors, gastritis, gastric ulcers, and other inflammatory conditions in Russia and most Baltic countries..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2021 · Review · Journal of traditional and complementary medicine

Inonotus obliquus - from folk medicine to clinical use.

The Inonotus obliquus (I. obliquus) mushroom was traditionally used to treat various gastrointestinal diseases.

OncologyImmune supportCognition & nervesEnergy & fatigue

Maitake · 2026 · Journal Article · Journal of complementary & integrative medicine

Black maitake induces apoptosis and enhances the efficacy of standard chemotherapy in 2D and 3D U-87 MG glioblastoma cell models.

OBJECTIVES: Glioblastoma is an aggressive primary brain tumor marked by rapid growth, invasiveness, poor prognosis, and an over 90 % tumor recurrence rate. Current radiation and chemotherapy treatments are limited by non-selectivity and toxicity, creating a need for safer complementary treatments..

Nameko · 2026 · Journal Article · Fungal biology

Proteomic insights into Pholiota nameko mycelial response to wood-based substrates.

Pholiota microspora (Berk.) Sacc., commonly known as "nameko," is an edible mushroom widely cultivated in East Asia for both culinary and medicinal purposes. This study aimed to investigate how substrate composition influences the expression of lignocellulolytic enzymes in Pholiota nameko using label-free quantitative….

Chaga · 2025 · Research Article · The Journal of veterinary medical science

Anticancer potentials of chaga and notoginseng against dog bladder cancer organoids.

Muscle-invasive bladder cancer (MIBC) is a common form of BC in dogs. Adjuvant chemotherapy administration is commonly applied in MIBC cases, but patients sometimes experience treatment failure and recurrence..

OncologyEnergy & fatigue

Energy & fatigueMetabolic healthLiver support

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Amino Acid Profiling and 4D-DIA Proteomics Reveal Protein Quality Divergence and Metabolic Adaptation in Cordyceps Species.

To explore the differences in protein quality among classic medicinal entomopathogenic fungi and to evaluate their metabolic adaptability, we analyzed the amino acid composition and proteomic characteristics of Cordyceps sinensis (CS), Cordyceps militaris (CM), and Cordyceps cicadae (CC)..

Cognition & nervesEnergy & fatigueSkin & hydration

Shiitake · 2025 · Research Article · PloS one

Sustainable memristors from shiitake mycelium for high-frequency bioelectronics.

Neuromorphic computing, inspired by the structure of the brain, offers advantages in parallel processing, memory storage, and energy efficiency. However, current semiconductor-based neuromorphic chips require rare-earth materials and costly fabrication processes, whereas neural organoids need complex bioreactor….

Cognition & nervesEnergy & fatigueMetabolic health

Lion's Mane · 2023 · Randomized Controlled Trial · Nutrients

Acute Effects of Naturally Occurring Guayusa Tea and Nordic Lion's Mane Extracts on Cognitive Performance.

The aim of this study was to assess the effects of guayusa extract and Nordic Lion's Mane (LM) on cognition. Using a randomized, double-blind, placebo-controlled, crossover design, we examined the effects of a single dose of 650 mg guayusa extract (AMT: AmaTea® Max) vs.

Cognition & nervesEnergy & fatigue

Snow Fungus · 2023 · Randomized Controlled Trial · Nutrients

Effectiveness of Fish Roe, Snow Fungus, and Yeast Supplementation for Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

The brain is one of the most critical organs in the human body, regulating functions such as thinking, memory, learning, and perception. Studies have indicated that fish roe, snow fungus, and yeast may have the potential to modulate cognitive, memory, and emotional functions..

Maitake · 2022 · Randomized Controlled Trial · Acta biochimica Polonica

Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: A randomized clinical trial.

BACKGROUND: Concurrent chemo-radiotherapy (CCRT) is an ideal treatment for advanced head and neck squamous cell carcinoma (HNSCC). The performance of CCRT induces severe toxicities in HNSCC patients and decreases the quality of life (QOL)..

Almond Mushroom · 2023 · English Abstract · Zhongguo shi yan xue ye xue za zhi

[Study on the Mechanism of Multi-Drug Resistance of Agaricus Blazei Extract FA-2-b-β Mediated Wnt Signaling Pathway to Reverse Acute T Lymphoblastic Leukemia].

OBJECTIVE: To investigate the mechanism of drug reversing resistance of Agaricus blazei extract FA-2-b-β on T cell acute lymphoblastic leukemia (T-ALL) cell lines..

Turkey Tail · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Anti-Toxoplasma gondii activity of Trametes versicolor (Turkey tail) mushroom extract.

Toxoplasma gondii (T. gondii) infection continues to rise globally in humans and animals with high socioeconomic and public health challenges.

OncologyEnergy & fatigue

Reishi · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Comparison of the dried properties of Ganoderma lucidum produced by the convective dryer and infrared dryer.

Ganoderma lucidum is a promising medicine with a high amount of antioxidants and calcium. The selection of appropriate drying process methods in food science has a chief role to reach the best final characteristics..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2023 · Research Support, Non U.S. Gov'T · International journal of biological sciences

Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism.

Skeletal muscle wasting related to aging or pathological conditions is critically associated with the increased incidence and prevalence of secondary diseases including cardiovascular diseases, metabolic syndromes, and chronic inflammations..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2023 · Research Support, Non U.S. Gov'T · Microbiology spectrum

Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice.

Cachexia is a lethal muscle-wasting syndrome associated with cancer and chemotherapy use. Mounting evidence suggests a correlation between cachexia and intestinal microbiota, but there is presently no effective treatment for cachexia..

Energy & fatigueMetabolic health

King Oyster · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Production performance and rumen bacterial community structure of Hu sheep fed fermented spent mushroom substrate from Pleurotus eryngii.

This study aimed to investigate the effect of fermented spent mushroom substrate from Pleurotus eryngii (SMPE) supplementation on production performance, meat quality and rumen bacterial community structure of Hu sheep..

Oyster Mushroom · 2023 · Data Paper · Wellcome open research

The genome sequence of the oyster mushroom, Pleurotus ostreatus ((Jacq.) P. Kummer, 1871).

We present a genome assembly from a Pleurotus ostreatus specimen (the oyster mushroom; Basidiomycota; Agaricomycetes; Agaricales; Pleurotaceae). The genome sequence is 40.6 megabases in span.

King Oyster · 2022 · Research Support, Non U.S. Gov'T · Microbiology spectrum

Bacterial Infection Induces Ultrastructural and Transcriptional Changes in the King Oyster Mushroom (Pleurotus eryngii).

Pleurotus eryngii (king oyster mushroom) is a commercially important mushroom with high nutritional and economic value. However, soft rot disease, caused by the pathogenic bacterium Erwinia beijingensis, poses a threat to its quality and production.

Reishi · 2022 · Research Support, Non U.S. Gov'T · Microbiology spectrum

Cross Talk between GlAQP and NOX Modulates the Effects of ROS Balance on Ganoderic Acid Biosynthesis of Ganoderma lucidum under Water Stress.

Water stress affects both the growth and development of filamentous fungi; however, the mechanisms underlying their response to water stress remain unclear. In this study, water stress was found to increase intracellular reactive oxygen species (ROS) level, ganoderic acid (GA) content, and NADPH oxidase (NOX) activity….

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2022 · Research Support, Non U.S. Gov'T · Frontiers in endocrinology

Methanol extract of Inonotus obliquus improves type 2 diabetes mellitus through modifying intestinal flora.

Type 2 diabetes mellitus (T2DM) poses a significant risk to human health. Previous research demonstrated that Inonotus obliquus possesses good hypolipidemic, anti-inflammatory, and anti-tumor properties..

Immune supportEnergy & fatigueMetabolic healthLiver support

Chaga · 2022 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Triterpenoid acids from medicinal mushroom Inonotus obliquus (Chaga) alleviate hyperuricemia and inflammation in hyperuricemic mice: Possible inhibitory effects on xanthine oxidase activity.

The purpose of this study was to explore the hypouricemic effect in hyperuricemia mice of triterpenoid acids from Inonotus obliquus (TAIO), and decipher of the underlying xanthine oxidase inhibitory mechanism. Measurement of xanthine oxidase (XO) inhibitory activity was assayed..

Immune supportCognition & nervesEnergy & fatigueSkin & hydration

Almond Mushroom · 2021 · Research Support, Non U.S. Gov'T · Journal of food biochemistry

Agaricus blazei polypeptide exerts a protective effect on D-galactose-induced aging mice via the Keap1/Nrf2/ARE and P53/Trim32 signaling pathways.

This experiment mainly optimized the extraction technology of Agaricus blazei polypeptide (ABp) and evaluated its protective effect on aging mice. In this study, a novel single component, the M is 3 kD, was isolated and purified from Agaricus blazei.

King Oyster · 2021 · Research Support, Non U.S. Gov'T · Fungal biology

Environmental implications of the organic matter structure for white-rot fungus Pleurotus eryngii growth in a tropical climate.

White-rot fungi (Pleurotus eryngii) are decomposers of lignocellulosic substrates. The relationship between the structure of humified organic matter and P.

Oyster Mushroom · 2019 · Preprint · journal metadata

Yield performance of Oyster mushroom ( Pleurotus ostreatus ) on various crop residues as substrate.

Substrate type is an important factor determining growth and yield of oyster mushroom. Five different substrates namely rice straw, maize husks, banana leaves, fingermillet husk and mixture of rice straw & black gram pod shell (1:1) were evaluated for the yield and related attributes of Pleurotus ostreatus..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

Oyster Mushroom · 2026 · Randomized Controlled Trial · Food & function

A randomised controlled study to investigate the cognitive, mood, metabolic and anti-inflammatory effects of acute oyster mushroom intervention in healthy older adults.

The Pleurotus oyster is a common edible mushroom rich in ergothioneine, a bioactive that has shown benefits to cognition in animals when administered in extract form. The OYSACO study investigated the acute effects of oyster mushroom (OM) on cognition, mood, inflammation and metabolism in healthy older adults..

Oyster Mushroom · 2026 · Research Article · Foods (Basel, Switzerland)

Formulation and Nutritional Evaluation of Instant Vegan Mushroom (Pleurotus ostreatus) Soup Powder Enriched with Moringa (Moringa oleifera), Mung Bean (Vigna radiata), and Pumpkin (Cucurbita maxima).

Although plant-based convenience foods have gained significant market share, many are high in fat, salt, and sugar while low in nutrients. The current study aimed to develop a vegan oyster mushroom soup powder enriched with moringa, mung bean, and pumpkin..

Immune supportEnergy & fatigue

Shiitake · 2025 · Research Article · Foods (Basel, Switzerland)

Lentinula edodes Stalk Polysaccharide Coating Extends the Shelf-Life of Agaricus bisporus by Modulating Respiration and Energy Metabolism.

This study comprehensively evaluated the effect of a Shiitake Stalk Isolated Polysaccharide (LEP) coating on Agaricus bisporus. The study findings revealed that the application of 1.5% LEP reduced weight loss, maintained firmness and chewiness, as well as the nutritional indices of mushrooms, extended the shelf life….