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OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2026 · Review · Phytotherapy research: PTR

An Immunomodulatory Mushroom, Cordyceps militaris, and Its Constituents: A Review of In Vitro/In Vivo Studies and Clinical Trials.

Cordyceps, known as "winter-worm summer-grass", has been used as a medicinal mushroom to boost energy levels and immune activity. Among cordyceps types, Cordyceps militaris (CM) is the most commercially useful owing to its ease of artificial cultivation for mass production..

OncologyCognition & nerves

Lion's Mane · 2026 · Research Article · PloS one

Extracts from Cordyceps cicadae and Hericium erinaceus promote the neurite outgrowth of retinal ganglion cells.

The regenerative capacity of mammalian RGC neurites after damage, such as glaucoma, is limited. Numerous studies have utilized herbal extracts to promote neural regeneration and exert neuroprotective effects in the hope of mitigating glaucoma..

OncologyCognition & nerves

Reishi · 2026 · Research Article · Journal of Cancer

Ganoderma lucidum alcohol extract targets mutant p53 signaling to inhibit proliferation in triple-negative breast brain metastasis cancer.

Triple-negative breast cancer (TNBC) is among the most aggressive subtypes of breast cancer, frequently characterized by invasive growth, metastasis, and poor clinical outcomes. Brain metastasis, commonly observed in TNBC patients, significantly worsens prognosis and survival rates..

Reishi · 2026 · Research Article · Chinese medicine

Ganoderma lucidum mediates microglial polarization and ameliorates experimental autoimmune encephalomyelitis by reducing oxidative stress and inhibiting NF-κB/STAT3 pathway.

Multiple Sclerosis (MS) is a neuroinflammatory disease affecting the central nervous system (CNS), for which effective therapeutic strategies remain limited. Ganoderma Lucidum (GL) is a nature healthy food supplement whose effects on MS remain unknown..

Cognition & nervesMetabolic healthGut & microbiome

Yellow Morel · 2026 · Research Article · Foods (Basel, Switzerland)

In Silico Structural Characterization and Hypoglycemic Potential of a Novel Fucose-Specific Lectin (MEP5) from Morchella esculenta.

Natural food-derived proteins are increasingly explored as alternatives to synthetic inhibitors for managing Type 2 diabetes mellitus. Despite the recognized health-promoting properties of Morchella esculenta, the potential of its bioactive proteins to modulate glucose metabolism remains largely unexplored..

King Oyster · 2026 · Research Article · Nutrients

King Oyster Mushroom, Pleurotus eryngii, Inhibits Microglia Activation via the Interplay of NLRP3 to Alleviate Neuroinflammation.

Background: Mushrooms have gained attention for their potential to improve brain health. We evaluated extracts of king oyster mushroom, as well as two of its bioactive compounds-ergothioneine (ERG) and N-acetyltryptamine (NAT)-for their ability to prevent microglia activation by reducing neuroinflammation and….

Maitake · 2026 · Randomized Controlled Trial · Journal of nutritional science and vitaminology

Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial

Extended longevity has resulted in an increased number of patients with dementia. Therefore, new methods for treating and preventing dementia are highly desirable.

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2026 · Systematic Review · Frontiers in pharmacology

Mechanism of Ganoderma lucidum polysaccharides in the mangement of diabetes and its complications.

Characterized by a total or partial shortage of insulin, diabetes is a chronic metabolic condition. Its widespread occurrence and related complications present a significant global public health issue.

Cognition & nervesEnergy & fatigueMetabolic healthSkin & hydration

Lion's Mane · 2026 · Preprint · journal metadata

Methyl viologen boosts Erinacine A biosynthesis in Hericium erinaceus fermentation: Multi-omics insights

Abstract Erinacine A, a critical secondary metabolite of Hericium erinaceus, has garnered significant interest due to its bioactive properties. This study aimed to investigate the effects of methyl viologen (MV) on the synthesis of Erinacine A during liquid fermentation of Hericium erinaceus, employing a multi-omics….

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2026 · Research Article · International journal of molecular sciences

Neuroprotective Potential of Hericium erinaceus Through Modulation of Inflammatory Signaling in THP-1 Macrophages Under Low-Level Lead Exposure.

Exposure to lead is associated with microglial dysfunction and the development of neuroinflammation. This contributes to accelerated neurodegeneration.

Cordyceps · 2026 · Journal Article · Journal of basic microbiology

Predictive Modeling of Cordycepin Content in Cordyceps militaris Using Machine Learning Based on Cultivation Conditions.

Cordycepin, a nucleoside analog derived from Cordyceps militaris, is a bioactive compound with potent pharmacological properties and growing relevance in functional food and pharmaceutical industries..

Cordyceps · 2026 · Journal Article · Neurotoxicity research

Protective Effect of Cordyceps militaris Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model.

BACKGROUND AND OBJECTIVES: Neurodegenerative diseases are characterized by degeneration or progressive loss/death of neurons in specific areas of the brain, often worsened by cigarette smoke through oxidative stress and inflammation. Cordyceps militaris (C..

Oyster Mushroom · 2026 · Research Article · Sensors (Basel, Switzerland)

Research on Precise Detection Methods for the Maturity of Pleurotus ostreatus in Complex Mushroom Cultivation Environments.

Addressing the challenges of complex background interference, low lighting conditions, small target recognition, and difficulty in maturity grading in the automated detection of Pleurotus ostreatus, this study proposes a lightweight improved scheme based on color feature enhancement..

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2026 · Review · International journal of biological macromolecules

Research progress in polysaccharides from the Tremella fuciformis (silver ear): extraction, purification, structural features, health-promoting activities, and potential applications.

Tremella fuciformis polysaccharides (TFPs), as one of the pivotal functional constituents of T. fuciformis, have attracted increasing attention because of their diverse health-promoting activities..

Immune supportCognition & nervesEnergy & fatigueRespiratory

Oyster Mushroom · 2026 · Research Article · ACS omega

Screening of Natural Inhibitors from Pleurotus ostreatus against PHGDH for Enhancing Antiviral Innate Immunity through Mendelian Randomization, Machine Learning, Molecular Docking, Molecular Dynamics Simulation, and Binding Free Energy Calculation.

The human innate immune response plays a critical role in limiting and controlling viral infections. Consequently, therapeutic strategies that promote or modulate innate antiviral immunity are regarded as promising approaches to combating viral pathogens..

Lion's Mane · 2026 · Research Article · Molecules (Basel, Switzerland)

Simultaneous UHPLC-UV Determination of Hericenones, Hericenes, Erinacines and Ergosterol in Hericium erinaceus Raw Materials or Products.

This study describes a single-laboratory validation of an ultra-high-performance liquid chromatographic (UHPLC) method for the determination of key compounds like hericenones, hericenes, erinacines, and ergosterol in Hericium erinaceus (H. erinaceus, Lion's Mane) raw materials and finished products..

Shiitake · 2026 · Research Article · Applied microbiology and biotechnology

Transcriptomic insights into fruiting body malformations in Lentinula edodes.

Lentinula edodes (shiitake mushroom), the world's most cultivated edible fungus, frequently develops malformed fruiting bodies during commercial cultivation, leading to significant economic losses..

Cognition & nervesMetabolic health

Cordyceps · 2026 · Research Article · AMB Express

Transcriptomic insights into the role of CmLec4 in infection and development of Cordyceps militaris.

Entomopathogenic fungi are a diverse group of ascomycetes that infect insects and form fruiting bodies, with over 1,000 species reported globally. Among them, Cordyceps militaris has long been valued in East Asia as a traditional medicinal resource, reflecting its recognized pharmacological potential..

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2025 · Research Article · Journal of traditional and complementary medicine

A formulation of combined Poria cocos and Cordyceps militaris rice ameliorates depressive-like effects by downregulating p38 MAPK signaling pathways.

BACKGROUND AND AIM: Poria cocos (PC) is traditional Chinese medicine with sedative, diuretic, and tonic properties. Cordyceps militaris rice (CMR) is a matrix used for the solid-state culture of C.

OncologyImmune supportCognition & nervesEnergy & fatigue

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

A polysaccharide from Morchella esculenta mycelia: Structural characterization and protective effect on antioxidant stress on PC12 cells against H2O2-induced oxidative damage.

Morchella esculenta (L.) Pers. is considered a precious edible and medicinal fungus due to its strict growth environment requirements, difficult to cultivate, resulted in expensive in the market.

Lion's Mane · 2025 · Research Article · Frontiers in nutrition

Acute effects of a standardised extract of Hericium erinaceus (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study.

INTRODUCTION: Animal studies have suggested that Lion's Mane mushroom [Hericium erinaceus (Bull.) Pers.] can enhance cognitive function and mood due to its bioactive metabolites, including erinacines and hericenones..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Wood Ear · 2025 · Research Article · Frontiers in nutrition

Ameliorating potential of Auricularia auricula-judae polysaccharides in mitigating hypercaloric diet-induced behavioral disorders through gut microbiota regulation.

As a major nutraceutical component of a traditional edible fungus Auricularia auricula-judae, Auricularia auricula-judae polysaccharide (AAP) has been well-documented due to its outstanding hypolipidemic and hypoglycemic bioactivities..

OncologyImmune supportCognition & nerves

Snow Fungus · 2025 · Research Article · Nutrients

Anti-Stress Effects of Tremella fuciformis Berk. Enzymatic Extracts: A Preclinical Study.

Background/Objectives: Chronic stress disrupts neurochemical balance, triggers inflammation, and compromises neuronal integrity, contributing to the development of stress-related disorders..

OncologyImmune supportCognition & nervesGut & microbiome

Lion's Mane · 2025 · Systematic Review · Frontiers in nutrition

Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review.

INTRODUCTION: Hericium erinaceus (HE), commonly known as the Lion's Mane mushroom, is an edible, medicinal fungus containing bioactive polysaccharides. It shows promising properties, including neuroprotective, anti-tumor, antioxidant, anti-proliferative, and anti-inflammatory effects..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies.

BACKGROUND: The human gut microbiota plays a crucial role in various aspects of health, extending beyond digestion and nutrient absorption. Ganoderma lucidum (Reishi) and Hericium erinaceus (Lion's Mane), traditional medicinal mushrooms, have garnered interest due to their potential to exert positive health effects..

Cognition & nervesLiver support

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Cognition-Enhancing Effects of Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycota) and Cordycepin in a Scopolamine-Induced Mouse Model.

Cognitive deficit is caused by a variety of neurodegenerative diseases, which lead to declines in learning, memory, and concentration. Cordyceps militaris (CM) and its major component, cordycepin (CO), are attracting attention as functional food ingredients due to their beneficial health effects such as liver….

King Oyster · 2025 · Journal Article · Computers and Electronics in Agriculture

Combining DeepLabV3 + and LSTM for intelligent drying strategy optimization in fruits and vegetables based on appearance quality: A case study of Pleurotus eryngii

Based on the DeepLabV3 + semantic segmentation model, this research incorporated the Content-Aware Reassembly of Features (CARAFE) module, Concurrent Spatial and Channel Squeeze and Channel Excitation (scSE) attention mechanism, and Improved-MobileNetV2 backbone network, proposing the DeepLab-CSB model to detect the….

Enoki · 2025 · Preprint · journal metadata

Comparative Analysis of Methanol and Ethanol Extract of Flammulina velutipes on Primary Hippocampal Culture: From Neurodevelopment to Neuroprotection

Flammulina velutipes is a well-known edible mushroom which is consumed for its nutri-tional value. F.

OncologyCognition & nervesMetabolic health

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Cordycepin Extracted from Cordyceps militaris mitigated CUMS-induced depression of rats via targeting GSK3β/β-catenin signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordycepin, the main active component of Cordyceps militaris, exhibits various pharmacological activities, including anti-tumor and antioxidant effects. However, its antidepressant effect and the underlying mechanisms remain unclear..

Cordyceps · 2025 · Research Article · Journal of traditional and complementary medicine

Cordyceps militaris and Armillaria mellea formula alleviates depressive behaviors via microglia regulation in an unpredictable chronic mild stress animal model.

BACKGROUND AND AIM: Cordyceps militaris (CM) and Armillaria mellea (AM) are medicinal mushrooms with potential applications in the treatment of mood disorders, including depression and anxiety..

Lion's Mane · 2025 · Research Article · Food chemistry: X

Decoding of novel umami-enhancing peptides from Hericium Erinaceus and its mechanisms by virtual screening, multisensory techniques, and molecular simulation approaches.

This study applied integrated sensory-guided, ultrafiltration fractionation, machine learning and bioinformatics approaches to identify peptides that enhance umami in Hericium erinaceus, investigate their mechanisms of action..

OncologyImmune supportCognition & nerves

Reishi · 2025 · Research Article · Frontiers in cell and developmental biology

Developmental and reproductive toxicity assessment of sporoderm-removed Ganoderma lucidum spores.

INTRODUCTION: Ganoderma lucidum is a fungus used in traditional Chinese medicine with high medicinal value and is also widely used in modern healthcare. Its spores are reported to contain antitumor and anti-inflammatory properties, among other biological benefits; however, the thick spore wall limits its….

Reishi · 2025 · Journal Article · International journal of medicinal mushrooms

Effects of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Triterpene on Motor and Spatial Learning Disorders in 5xFAD Mice.

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that gradually destroys cognitive, memory, and thinking skills. Although increasing evidence has demonstrated that Ganoderma lucidum triterpenoids (GLT) can ameliorate the motor and spatial learning disorders of AD, the underlying mechanism remains….

Yellow Morel · 2025 · Research Article · Journal of food science

Evaluating the antioxidant, anti-inflammatory, and neuroprotective potential of fruiting body and mycelium extracts from edible yellow morel (Morchella esculenta L. Pers.).

SCOPE: This study aimed to assess the antioxidant, anti-inflammatory, and acetylcholinesterase activities of fruiting bodies (FB) and mycelium (M) extracts of Morchella esculenta L. collected from various regions of Pakistan..

Immune supportCognition & nervesGut & microbiome

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum polysaccharide alleviates cognitive dysfunction by inhibiting neuroinflammation via NLRP3/NF-κB signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum), a traditional Chinese medicinal herb, is commonly recommended for its potential to promote mental relaxation and alleviate memory impairment..

Reishi · 2025 · Research Article · Biochemistry and biophysics reports

Ganoderma lucidum polysaccharide attenuates retinal ischemia-reperfusion injury by regulating microglial M1/M2 polarization, suppressing neuroinflammation and inhibiting JAK2/STAT3 pathway.

Retinal ischemia-reperfusion (RIR) injury is implicated in the pathogenesis of numerous retinal degenerative disorders, resulting in visual impairment or even blindness in millions of individuals worldwide..

Lion's Mane · 2025 · Journal Article · Food Research International

Hericium erinaceus ethanol extract exhibits potent DNA-protective and antioxidant action: Evidence from in vitro and Drosophila melanogaster studies

Lion's mane (Hericium erinaceus (Bull.: Fr.) Pers.) is a highly valued edible fungus recognized for its diverse health benefits. This study investigated the in vitro DNA-protective effects and in vivo genotoxicity and antioxidant activity of an ethanol extract from the fruiting bodies of cultivated H..

Lion's Mane · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Hericium erinaceus ethanol extract exhibits potent DNA-protective and antioxidant action: Evidence from in vitro and Drosophila melanogaster studies.

Lion's Mane · 2025 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Hericium erinaceus extracts promote neuronal differentiation and excitability through nootropic metabolite activity.

This study investigates the effects of a blend of Hericium erinaceus (lion's mane mushroom) extract on the differentiation of SH-SY5Y cells, a human neuroblastoma cell line, revealing potential therapeutic implications for neuroblastoma management..

Cordyceps · 2025 · Research Article · Scientific reports

Identification and functional analysis of the SET domain-containing gene family in Cordyceps militaris.

The SET domain is the core domain catalyzing histone lysine methyltransferases. The SET domain-containing genes family plays an important role in various developmental and physiological processes of fungi, such as regulating fungal pathogenicity, affecting the synthesis of secondary metabolites, and responding to….

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2025 · Review · Current issues in molecular biology

Immunomodulatory Effects of Ganoderma lucidum Bioactive Compounds on Gut-Brain and Gut-Liver Axis Disorders.

Ganoderma lucidum (Lingzhi), a traditional medicinal mushroom, is renowned for its immunomodulatory, anti-inflammatory, and antioxidant properties, primarily attributed to its bioactive components such as polysaccharides and triterpenoids..

Lion's Mane · 2025 · Research Article · Fungal biology and biotechnology

Influences of substrate and tissue type on erinacine production and biosynthetic gene expression in Hericium erinaceus.

BACKGROUND: Lion's mane (Hericium erinaceus) mycelium produces erinacines, a suite of cyathane diterpenoids with established neuroactivities. While H.

OncologyImmune supportCognition & nervesEnergy & fatigue

Chaga · 2025 · Research Article · Animal microbiome

Inonotus obliquus fermentation product improves growth performance and meat quality probably through intestine and antioxidant capacity enhanced by gut microbes and metabolites regulation in rabbits.

BACKGROUND: Inonotus obliquus is a medicinal edible fungus that contains a variety of biologically active ingredients and has multiple physiological effects. When supplemented in avian diet, Inonotus obliquus has proved to be beneficial.

OncologyImmune supportCognition & nerves

Reishi · 2025 · Journal Article · Biochemical and biophysical research communications

Investigating the therapeutic potential of Ganoderma lucidum in treating optic nerve atrophy through network pharmacology and experimental validation.

OBJECTIVE: The aim of this study is to employ network pharmacology to identify potential therapeutic targets for Ganoderma lucidum in the treatment of optic atrophy, and elucidate the underlying pharmacological mechanism. METHODS: This study is mainly divided into two parts..

OncologyImmune supportCognition & nervesMetabolic health

Cordyceps · 2025 · Research Article · PloS one

Investigation of biometabolites and novel antimicrobial peptides derived from promising source Cordyceps militaris and effect of non-small cell lung cancer genes computationally.

Mushrooms are considered one of the safe and effective medications because they have great economic importance due to countless biological properties. Cordyceps militaris contains bioactive compounds with antioxidant, antimicrobial and anti-cancerous properties..

Cordyceps · 2025 · Journal Article · Food Chemistry

Investigation of the solid-state fermentation of Astragalus membranaceus residue with Cordyceps militaris: effects on phenolic profile and in vitro neuroprotective activity

We developed a Cordyceps militaris-mediated solid-state fermentation (SSF) strategy to enhance phenolic antioxidants in Astragalus membranaceus residue (AR) and confer neuroprotective effects against oxidative stress..

Cordyceps · 2025 · Journal Article · Food chemistry

Investigation of the solid-state fermentation of Astragalus membranaceus residue with Cordyceps militaris: effects on phenolic profile and in vitro neuroprotective activity.

Lion's Mane · 2025 · Review · Nutrients

Lion's Mane Mushroom (Hericium erinaceus): A Neuroprotective Fungus with Antioxidant, Anti-Inflammatory, and Antimicrobial Potential-A Narrative Review.

Hericium erinaceus, commonly known as lion's mane mushroom, has gained increasing scientific interest due to its rich composition of bioactive compounds and diverse health-promoting properties. This narrative review provides a comprehensive overview of the nutritional and therapeutic potential of H..