MycoData

OncologyImmune supportCognition & nervesGut & microbiome

Snow Fungus · 2026 · Review · Carbohydrate research

Advances in extraction, structural characteristics, bioactivities, structure-activity relationship, quality control and applications of polysaccharides from Tremella fuciformis: A review.

ETHNOPHARMACOLOGICAL RELEVANCE: Tremella fuciformis is an edible fungus with a cultivation and consumption history of over a thousand years in China. In traditional Chinese medicine, it has the effects of moistening the lungs, soothing the intestines, nourishing the skin, and prolonging life, and is often used as a….

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2026 · Review · Phytotherapy research: PTR

An Immunomodulatory Mushroom, Cordyceps militaris, and Its Constituents: A Review of In Vitro/In Vivo Studies and Clinical Trials.

Cordyceps, known as "winter-worm summer-grass", has been used as a medicinal mushroom to boost energy levels and immune activity. Among cordyceps types, Cordyceps militaris (CM) is the most commercially useful owing to its ease of artificial cultivation for mass production..

Shiitake · 2026 · Journal Article · Journal of ethnopharmacology

Anti-inflammatory potential of Lentinula edodes DMRO-356: Ethnopharmacological validation and multi-target molecular docking.

ETHNOPHARMACOLOGICAL RELEVANCE: Lentinula edodes (shiitake) has long been used in East Asian medicine to reduce inflammation, boost vitality, and support immune function..

Immune supportMetabolic healthGut & microbiome

Cordyceps · 2026 · Research Article · Nutrients

Bifidobacterium animalis ssp. lactis 420 and Cordyceps militaris Synergistically Modulate the Gut Microbiota by Increasing Mucin 2 Production.

BACKGROUND: Probiotics and medicine food homology are known to offer gentle approaches to prevent obesity, although it is difficult with such approaches to satisfy consumers' requirements to lose weight quickly. The probiotic strain Bifidobacterium animalis ssp..

Lion's Mane · 2026 · Journal Article · International journal of medicinal mushrooms

Bioactives of Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Targeting PPAR Signaling Pathway: An Experimental and In Silico Investigation.

Hericium erinaceus is a widely consumed edible mushroom with significant ethnopharmacological value. Nevertheless, the pharmacological understanding of H.

Immune supportSkin & hydration

Chaga · 2026 · Research Article · Journal of microbiology and biotechnology

Chaga Mushroom (Inonotus obliquus) Attenuates DNCB-Induced Atopic Dermatitis by Modulating Oxidative Stress and Cytokine Expression.

Recent studies highlight the immunomodulatory properties of Chaga mushrooms. Atopic dermatitis (AD) is a multifactorial skin disorder involving interactions between innate and adaptive immune responses..

Immune supportMetabolic healthLiver support

Cordyceps · 2026 · Journal Article · Fitoterapia

Comparative computational analysis of the hypolipidaemic potential of Cordyceps militaris and Ophiocordyceps sinensis, with in vivo validation of cordycepin.

Hyperlipidaemia (HLP) arises from impaired lipid homeostasis in the setting of chronic low-grade inflammation, yet mechanistic comparisons between the edible medicinal fungi Cordyceps militaris and Ophiocordyceps sinensis remain scarce..

Immune supportGut & microbiomeLiver support

Reishi · 2026 · Journal Article · Food Research International

Comprehensive evaluation of Ganoderma lucidum extracts: digestion kinetics, gut microbiota modulation, and immunoregulatory mechanisms

Ganoderma lucidum (Reishi mushroom) exhibits medicinal–edible functionality mediated by bioactive components such as β-glucans and ganoderic acids that regulate immune responses through multiple pathways. However, the digestive transformation and microbiota-mediated interactions of G..

Immune supportGut & microbiomeLiver support

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Comprehensive evaluation of Ganoderma lucidum extracts: digestion kinetics, gut microbiota modulation, and immunoregulatory mechanisms.

Ganoderma lucidum (Reishi mushroom) exhibits medicinal-edible functionality mediated by bioactive components such as β-glucans and ganoderic acids that regulate immune responses through multiple pathways. However, the digestive transformation and microbiota-mediated interactions of G..

Immune supportMetabolic healthSkin & hydration

Cordyceps · 2026 · Research Article · Life (Basel, Switzerland)

Cordyceps militaris Enhances Wound Repair Through Regulation of HIF-1α, TGF-β1, and SIRT1/Nrf2/HO-1 Signaling in Diabetic Skin.

Chronic diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, oxidative stress, and defective tissue remodeling, leading to delayed healing..

OncologyImmune supportSkin & hydration

Shiitake · 2026 · Research Article · Journal of cosmetic dermatology

Cosmeceutical and Dermatological Potential of Shiitake Mushroom (Lentinula edodes) Extract.

BACKGROUND: Shiitake mushroom (Lentinula edodes) contains polysaccharides, phenolics, and β-glucans known for their antioxidant and nutraceutical properties; however, its dermatological applications remain limited..

Cordyceps · 2026 · Review · Nutrients

Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans-A Narrative Review.

Cordyceps militaris is an entomopathogenic fungus traditionally used in Asian ethnomedicine and increasingly investigated for its potential health-promoting properties, including immunomodulatory and anti-inflammatory activities..

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2026 · Journal Article · Molecular and cellular biochemistry

Deciphering the anticancer potential of an entomopathogenic fungus, Cordyceps militaris in Dalton's Lymphoma transplanted murine model: a multidimensional approach involving computational methods and in vivo validation.

Cordyceps militaris, a medicinal mushroom in traditional Chinese medicine, emerged as a promising source of bioactive compounds, exhibiting potent antioxidant, anti-inflammatory, anticancer, antiviral and immunomodulatory properties..

Immune supportEnergy & fatigueMetabolic healthLiver support

Reishi · 2026 · Preprint · journal metadata

Exploring the effect and mechanism of Ganoderma lucidum Polysaccharides on improving Paediatric MASLD based on network pharmacology and animal experiment

Abstract Background Paediatric Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disorder resulting from chronic hepatic steatosis. Ganoderma lucidum polysaccharide (GLP) have several pharmacological effects..

Reishi · 2026 · Journal Article · Biological & pharmaceutical bulletin

Ganoderic Acid A Derived from Reishi Mushroom Ganoderma lucidum Protects against Intestinal Immunity Reduction Due to Oxidative Stress in Rat

Reishi (Ganoderma lucidum) is known to enhance intestinal immunity, with ganoderic acid A (GA-A) identified as one of its active constituents. However, the specific role of GA-A in regulating immune components such as immunoglobulin A (IgA) from Peyer's patches (PPs) and α-defensin 5 from Paneth cells remains unclear..

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2026 · Review · Metabolites

Ganoderma lucidum as a Functional Bioactive Candidate for Glycemic Regulation: Mechanisms, Preclinical Evidence, and Clinical Translation.

Type 2 diabetes mellitus (T2DM) is a major global health challenge that has intensified interest in multi-target nutraceuticals with potential adjunctive benefits..

Immune supportCognition & nerves

Reishi · 2026 · Research Article · Chinese medicine

Ganoderma lucidum mediates microglial polarization and ameliorates experimental autoimmune encephalomyelitis by reducing oxidative stress and inhibiting NF-κB/STAT3 pathway.

Multiple Sclerosis (MS) is a neuroinflammatory disease affecting the central nervous system (CNS), for which effective therapeutic strategies remain limited. Ganoderma Lucidum (GL) is a nature healthy food supplement whose effects on MS remain unknown..

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum polysaccharides alleviate doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through modulation of the Nrf2/SLC7A11/GPX4 signaling pathway.

Doxorubicin (Dox) is a chemotherapeutic agent widely used in clinical oncology; however, its application is limited by dose-dependent cardiotoxicity, in which ferroptosis has been identified as a key mechanism of myocardial injury..

OncologyImmune support

Reishi · 2026 · Research Article · Scientific reports

Ganoderma lucidum spore oil with Ganoderma lucidum and Ganoderma sinense extracts (G2SO) shows antitumor and Immunomodulatory effects in mice.

Ganoderma is a highly valued medicinal fungus, especially in Traditional Chinese Medicine (TCM). A formulation of Ganoderma lucidum spore oil and aqueous extracts from the fruiting bodies of Ganoderma lucidum and Ganoderma sinense (G2SO) has been developed as a functional formulation proposed to support immune….

OncologyImmune support

King Oyster · 2026 · Journal Article · International journal of medicinal mushrooms

In Vitro Antioxidant and Anti-Inflammatory Activity and Phenolic Compound Determination of King Oyster Mushroom Pleurotus eryngii (Agaricomycetes) from Algeria.

The current study investigates the biological efficacy and polyphenol and flavonoid content of aqueous and ethanolic 80% extracts of Pleurotus eryngii from the western region of Algeria. Total phenolic content (TPC) and total flavonoid content (TFC) were determined using colorimetric methods..

Immune supportMetabolic healthLiver support

Cordyceps · 2026 · Journal Article · Bioscience, biotechnology, and biochemistry

Inhibition of hepatic lipogenesis and adipogenesis by cordyanhydride A isolated from Cordyceps Militaris cultivated on germinated soybeans.

Regulation of lipid homeostasis requires coordinated control of fatty acid (FA) oxidation, lipogenesis, and adipocyte differentiation. Cordyanhydride A (CA) was isolated from Cordyceps militaris (CM) extract cultivated on germinated soybean through bioactivity-guided fractionation and structurally characterized using….

OncologyImmune supportEnergy & fatigueSkin & hydration

Chaga · 2026 · Journal Article · Photochemical & photobiological sciences: Official journal of the European Photochemistry Association and the European Society for Photobiology

Inonotus obliquus polysaccharides alleviate UVB-irradiated skin photodamage by regulating calcium homeostasis through endoplasmic reticulum-mitochondria crosstalk.

Skin photodamage is closely related to mitochondrial dysfunction, and endoplasmic reticulum (ER) stress can induce excessive mitochondrial reactive oxygen species (ROS) accumulation, triggering inflammation, and inducing cell apoptosis..

OncologyImmune supportMetabolic healthGut & microbiome

Chaga · 2026 · Review · Nutrients

Inonotus obliquus Polysaccharides: Preparation, Structural Characteristics, Structure-Activity Relationships, Biological Activities and Applications.

Inonotus obliquus, a rare medicinal and edible fungus, is rich in bioactive polysaccharides. These polysaccharides exhibit diverse biological activities, including gut microbiota-modulating, hypoglycemic, immunomodulatory, antitumor, antioxidant, hypolipidemic, and antiviral activities..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Oyster Mushroom · 2026 · Research Article · Veterinary sciences

Investigation of Pleurotus Ostreatus Mushroom-Based Feed Supplementations on Growth Performance and Immune Function in Male Japanese Quails (Coturnix Japonica).

Growing concern over antibiotic resistance in poultry production has increased interest in natural feed additives such as Pleurotus ostreatus (oyster mushroom)-derived products..

Immune supportCognition & nerves

King Oyster · 2026 · Research Article · Nutrients

King Oyster Mushroom, Pleurotus eryngii, Inhibits Microglia Activation via the Interplay of NLRP3 to Alleviate Neuroinflammation.

Background: Mushrooms have gained attention for their potential to improve brain health. We evaluated extracts of king oyster mushroom, as well as two of its bioactive compounds-ergothioneine (ERG) and N-acetyltryptamine (NAT)-for their ability to prevent microglia activation by reducing neuroinflammation and….

Lion's Mane · 2026 · Journal Article · International journal of medicinal mushrooms

Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Polysaccharides for Improved In Vitro Probiotic Growth, Adhesion, Antioxidant Activity, and Cryoprotective Properties.

Hericium erinaceus, commonly known as lion's mane mushroom, is a rare edible and medicinal fungus that is highly valued in both the culinary and medical fields. Its primary bioactive component, polysaccharides, holds significant therapeutic potential, particularly in healthcare..

Immune supportCognition & nerves

Maitake · 2026 · Randomized Controlled Trial · Journal of nutritional science and vitaminology

Maitake Mushroom (Grifola frondosa) Enhances Cognitive Function in Healthy Older Japanese: A Randomized, Double-Blind, Placebo-Controlled Trial

Extended longevity has resulted in an increased number of patients with dementia. Therefore, new methods for treating and preventing dementia are highly desirable.

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2026 · Systematic Review · Frontiers in pharmacology

Mechanism of Ganoderma lucidum polysaccharides in the mangement of diabetes and its complications.

Characterized by a total or partial shortage of insulin, diabetes is a chronic metabolic condition. Its widespread occurrence and related complications present a significant global public health issue.

Reishi · 2026 · Journal Article · International journal of medicinal mushrooms

Microwave-Assisted Extraction Optimization, Solubility, and Bioactivity Evaluation of Polysaccharides from Broken Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Spore Powder.

One of the main active components of broken Ganoderma lucidum spore powder was polysaccharide (BGSPP), but the extraction time was long, and the yield was low at present. Therefore, the extraction and activity of BGSPP were studied in this paper..

Reishi · 2026 · Journal Article · Journal of food science

Morphology Engineering: Uniform Ganoderma lucidum Pellet Formation in Coconut Juice by Bidirectional Submerged Fermentation.

Two different mycelia morphologies (clumps and pellets) of Ganoderma lucidum can be produced by bidirectional submerged fermentation (BSF) with coconut water. No mycelia growth was observed when coconut milk was used as the substrate..

OncologyImmune supportGut & microbiomeLiver support

Reishi · 2026 · Research Article · Journal of nanobiotechnology

Multicomponent Ganoderma lucidum spore-based solid self-nanoemulsifying system of paclitaxel for improved lymphatic absorption and immune synergistic antitumor strategy.

In colorectal cancer, the cancer-immunity cycle is often disrupted by the lack of effective tumor-associated antigens, impaired activation of antigen-presenting cells, and insufficient T cell infiltration, leading to tumor immune escape and disease progression..

OncologyImmune supportEnergy & fatigueRespiratory

Oyster Mushroom · 2026 · Journal Article · Bioorganic chemistry

Mushroom-mediated silver nanoparticles from Pleurotus ostreatus as antimicrobial candidates against multidrug-resistant bacteria: Physicochemical, in-silico, cytotoxicity, and immunobiological evaluation.

The rise of antimicrobial resistance has heightened the demand for alternatives to traditional antibiotics, especially against multidrug-resistant (MDR) strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniaei, and Pseudomonas aeruginosa..

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2026 · Preprint · journal metadata

Nano-Encapsulated Cordyceps militaris Grown on Germinated Black Bean Attenuates PM- and LPS-Induced Airway Inflammation

Exposure to particulate matter (PM) containing bacterial endotoxins triggers oxidative stress and inflammation in the respiratory epithelium. In this study, we investigated chitosan nanoparticle-encapsulated Cordyceps militaris grown on germinated Rhynchosia nulubilis (GCN) as a potential functional food–derived….

Immune supportEnergy & fatigueRespiratory

Cordyceps · 2026 · Review · Journal of food science and technology

Nature's marvel: unravelling the multiphase composition of Cordyceps militaris mushroom and its implications as a dietary supplement.

UNLABELLED: This review article delves into the multiphase composition of Cordyceps militaris mushroom and explores its implications as a dietary supplement. C.

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2026 · Journal Article · Food Research International

Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide

Diet-based modulation of the gut microbiota has emerged as a promising strategy to alleviate obesity and its related complications. Our previous study demonstrated that polysaccharide derived from Cordyceps militaris (CMP) exerts anti-obesity effects, yet the specific mechanism linking gut microbiota to its metabolic….

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide.

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2026 · Research Article · International journal of molecular sciences

Neuroprotective Potential of Hericium erinaceus Through Modulation of Inflammatory Signaling in THP-1 Macrophages Under Low-Level Lead Exposure.

Exposure to lead is associated with microglial dysfunction and the development of neuroinflammation. This contributes to accelerated neurodegeneration.

OncologyImmune supportGut & microbiomeLiver support

Cordyceps · 2026 · Journal Article · Current topics in medicinal chemistry

Ophiocordyceps sinensis in Cancer Therapy: Bridging Traditional Medicine and Modern Oncology.

INTRODUCTION: Ophiocordyceps sinensis, a parasitic fungus traditionally used in Asian medicine, has drawn attention for its potential anticancer properties. Its bioactive components- such as cordycepin, polysaccharides, and nucleosides-exhibit anti-inflammatory, antioxidant, immunomodulatory, and anticancer….

Immune supportMetabolic health

Cordyceps · 2026 · Journal Article · Scientific reports

Optimization of cordycepin fermentation by Cordyceps militaris via response surface methodology.

Cordycepin is a bioactive compound with demonstrated immunoregulatory, antioxidant, and organ-protective properties. This study aimed to significantly enhance the production of cordycepin in Cordyceps militaris fermentation through systematic process optimization..

Immune supportMetabolic healthGut & microbiome

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Optimization of the Probiotic Fermentation Process of Ganoderma lucidum Juice and Its In Vitro Immune-Enhancing Potential.

Fermented products have recently garnered substantial interest in both research and commercial contexts. Although probiotic fermentation is predominantly practiced with dairy, fruits, vegetables, and grains, its application to dual-purpose food-medicine materials like Ganoderma lucidum has been comparatively….

OncologyImmune supportMetabolic healthSkin & hydration

Oyster Mushroom · 2026 · Journal Article · Burns: journal of the International Society for Burn Injuries

Oral Pleurotus ostreatus supplementation modulates systemic inflammation and enhances collagen density in a full-thickness burn rat model.

Severe burn injuries cause hypermetabolic and inflammatory responses characterized by hypoalbuminemia and elevated cytokines that delay wound healing. Pleurotus ostreatus, known for its bioactive compounds and high-quality protein, may support recovery by improving systemic nutritional and inflammatory balance..

Cordyceps · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Pelletized Growth in Cordyceps militaris Is Associated with Coordinated Cell Wall Remodeling and Stress Defense.

Morphological control in submerged fermentation is a well-established method for enhancing bioactive metabolite production in filamentous fungi. However, the molecular mechanisms linking morphology to fermentation efficiency remain insufficiently understood..

Cordyceps · 2026 · Research Article · Frontiers in pharmacology

Peptidomics-based identification of endogenous free peptides from Ophiocordyceps sinensis and functional validation of immunomodulatory peptide WALGT.

Ophiocordyceps sinensis (formerly known as Cordyceps sinensis), commonly referred to as "dongchongxiacao" in Chinese, is a valuable traditional Chinese medicine whose bioactive small molecules form the essential material basis for its therapeutic effects..

Mesima · 2026 · Preprint · journal metadata

Phellinus linteus polysaccharides alleviate DSS-induced colitis in mice by restoring gut microbiota homeostasis, preserving intestinal barrier integrity, and attenuating JAK2/STAT3-associated inflammatory signaling

Abstract Background & aims Phellinus linteus polysaccharides (PLP), bioactive polysaccharides derived from the traditional medicinal fungus Phellinus linteus, have shown potential anti-inflammatory activity..

Immune supportMetabolic healthRespiratory

Reishi · 2026 · Research Article · Metabolites

Phytochemical Profiling and Bioactivity Evaluation of Ganoderma lucidum (Reishi Mushroom) Fractions: In Vitro Antioxidant, Antimicrobial, and Antidiabetic Activities.

Background/Objectives:Ganoderma lucidum (Curtis) P. Karst.

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2026 · Preprint · journal metadata

Pleiotropic Bioactivity of Caterpillar Fungus and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework

The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus) is one of the most popular medicines in Asian traditional medical systems for its pleiotropic indications, including an ability to enhance “vitality”. However, the polyvalent adaptogenic potential of O..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2026 · Review · Pharmaceuticals (Basel, Switzerland)

Pleiotropic Bioactivity of Caterpillar Fungus, Orange Cordyceps, and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework.

Background/Objectives: The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus), known for its ability to enhance "vitality," is one of the most popular medicines in Asian traditional medical systems. According to the Chinese Pharmacopeia, O..

Reishi · 2026 · Research Article · Biomolecules

Polysaccharide Peptide from Ganoderma lucidum Reduces Acute Kidney Injury Through Regulating the Integrin β3/Fn1 Axis.

Acute kidney injury (AKI) continues to pose a significant clinical challenge due to its high morbidity rates and limited therapeutic options. Recent evidence suggests that natural compounds may provide renoprotective benefits by modulating oxidative stress and inflammation..

King Oyster · 2026 · Research Article · Food chemistry: X

Polysaccharides from Pleurotus eryngii: sequential extraction and structural characterization.

Polysaccharides, a primary component from Pleurotus eryngii (P. eryngii), have diverse biological activities.