MycoData

Shiitake · 2026 · Journal Article · Journal of ethnopharmacology

Anti-inflammatory potential of Lentinula edodes DMRO-356: Ethnopharmacological validation and multi-target molecular docking.

ETHNOPHARMACOLOGICAL RELEVANCE: Lentinula edodes (shiitake) has long been used in East Asian medicine to reduce inflammation, boost vitality, and support immune function..

Lion's Mane · 2026 · Journal Article · International journal of medicinal mushrooms

Bioactives of Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Targeting PPAR Signaling Pathway: An Experimental and In Silico Investigation.

Hericium erinaceus is a widely consumed edible mushroom with significant ethnopharmacological value. Nevertheless, the pharmacological understanding of H.

OncologyEnergy & fatigueSkin & hydration

Reishi · 2026 · Journal Article · International journal of cosmetic science

Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation.

OBJECTIVE: The primary objective of this study was to investigate the biological activities of freeze-dried Ganoderma lucidum (Reishi) extract obtained from hazelnut pruning waste and to compare its antioxidant, tyrosinase inhibitory and cytotoxic properties with two widely used cosmetic actives-argireline peptide and….

Cordyceps · 2026 · Review · Nutrients

Current Evidence of Ergogenic and Post-Exercise Recovery Effects of Dietary Supplementation with Cordyceps militaris in Humans-A Narrative Review.

Cordyceps militaris is an entomopathogenic fungus traditionally used in Asian ethnomedicine and increasingly investigated for its potential health-promoting properties, including immunomodulatory and anti-inflammatory activities..

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2026 · Journal Article · Molecular and cellular biochemistry

Deciphering the anticancer potential of an entomopathogenic fungus, Cordyceps militaris in Dalton's Lymphoma transplanted murine model: a multidimensional approach involving computational methods and in vivo validation.

Cordyceps militaris, a medicinal mushroom in traditional Chinese medicine, emerged as a promising source of bioactive compounds, exhibiting potent antioxidant, anti-inflammatory, anticancer, antiviral and immunomodulatory properties..

Energy & fatigueMetabolic health

Reishi · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Development of a CRISPR/Cas9 Genome Editing System in Dikaryotic Ganoderma lucidum for Targeting Key CYP450 Gene Involved in Triterpenoid Synthesis.

Currently, most research on CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing in edible fungi focuses on monokaryotic strains. However, the biological mechanisms in a monokaryotic state often do not accurately reflect the actual physiological and metabolic conditions of dikaryotic….

Energy & fatigueGut & microbiome

Lion's Mane · 2026 · Research Article · Food chemistry: X

Effect of lion's mane mushroom (Hericium erinaceus) on dough rheology, protein structure, and quality of steamed bread.

This study investigates how Hericium erinaceus powder (HE powder) modulates the gluten network and influences steamed bread quality. HE powder altered water distribution and mobility, consistent with changes in dough thermo-mechanical behavior, pasting properties, and crumb microstructure..

Immune supportEnergy & fatigueMetabolic healthLiver support

Reishi · 2026 · Preprint · journal metadata

Exploring the effect and mechanism of Ganoderma lucidum Polysaccharides on improving Paediatric MASLD based on network pharmacology and animal experiment

Abstract Background Paediatric Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disorder resulting from chronic hepatic steatosis. Ganoderma lucidum polysaccharide (GLP) have several pharmacological effects..

Turkey Tail · 2026 · Research Article · Applied and environmental microbiology

Functional characterization of a novel p-coumarate 3-hydroxylase from Trametes versicolor.

UNLABELLED: Lignin degradation by white-rot fungi proceeds through oxidative depolymerization of lignin polymers, followed by metabolism of the resulting low-molecular-weight aromatic fragments. Among these, the catabolism of the hydroxyphenyl (H) unit of p-coumaric acid (p-CA) remains poorly understood in fungi..

Cordyceps · 2026 · Journal Article · International journal of biological macromolecules

Identification of differential proteins in Cordyceps militaris cultured with different nitrogen sources via proteomic analysis.

Cordyceps militaris is a rare edible and medicinal fungus rich in functional components. To clarify the regulatory mechanisms of different nitrogen sources on protein synthesis and functional properties, the study established a differential culture system using three supplementary nitrogen sources with wheat as the….

Energy & fatigueMetabolic healthLiver support

Chaga · 2026 · Journal Article · Journal of ethnopharmacology

Inonotus obliquus (Ach. ex Pers.) Pilát aqueous extract alleviates acute cold exposure/rewarming-induced myocardial injury by regulating mitochondrial dynamics via liver kinase B1/adenosine monophosphate-activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator-1 alpha signaling pathway activation.

ETHNOPHARMACOLOGICAL RELEVANCE: Acute cold exposure affects the cardiovascular system substantially. Inonotus obliquus (Ach.

OncologyImmune supportEnergy & fatigueSkin & hydration

Chaga · 2026 · Journal Article · Photochemical & photobiological sciences: Official journal of the European Photochemistry Association and the European Society for Photobiology

Inonotus obliquus polysaccharides alleviate UVB-irradiated skin photodamage by regulating calcium homeostasis through endoplasmic reticulum-mitochondria crosstalk.

Skin photodamage is closely related to mitochondrial dysfunction, and endoplasmic reticulum (ER) stress can induce excessive mitochondrial reactive oxygen species (ROS) accumulation, triggering inflammation, and inducing cell apoptosis..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Oyster Mushroom · 2026 · Research Article · Veterinary sciences

Investigation of Pleurotus Ostreatus Mushroom-Based Feed Supplementations on Growth Performance and Immune Function in Male Japanese Quails (Coturnix Japonica).

Growing concern over antibiotic resistance in poultry production has increased interest in natural feed additives such as Pleurotus ostreatus (oyster mushroom)-derived products..

Cognition & nervesEnergy & fatigueMetabolic healthSkin & hydration

Lion's Mane · 2026 · Preprint · journal metadata

Methyl viologen boosts Erinacine A biosynthesis in Hericium erinaceus fermentation: Multi-omics insights

Abstract Erinacine A, a critical secondary metabolite of Hericium erinaceus, has garnered significant interest due to its bioactive properties. This study aimed to investigate the effects of methyl viologen (MV) on the synthesis of Erinacine A during liquid fermentation of Hericium erinaceus, employing a multi-omics….

Energy & fatigueGut & microbiome

Oyster Mushroom · 2026 · Research Article · Foods (Basel, Switzerland)

Microbial Community Dynamics Driven by Different Nitrogen Sources During Forestry Waste Composting for Pleurotus ostreatus Cultivation.

Bioconversion of lignocellulosic biomass into edible, nutrient-rich products using low-cost forestry waste offers substantial ecological and economic benefits. Composting forestry waste as a substrate for oyster mushroom (Pleurotus ostreatus) cultivation is an effective recovery strategy..

Reishi · 2026 · Journal Article · International journal of medicinal mushrooms

Microwave-Assisted Extraction Optimization, Solubility, and Bioactivity Evaluation of Polysaccharides from Broken Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Spore Powder.

One of the main active components of broken Ganoderma lucidum spore powder was polysaccharide (BGSPP), but the extraction time was long, and the yield was low at present. Therefore, the extraction and activity of BGSPP were studied in this paper..

Cordyceps · 2026 · Research Article · Journal of ginseng research

Multi-omics and compositional analysis of bidirectional solid fermentation products from Cordyceps militaris and Panax quinquefolius L.

BACKGROUND: Ginsenosides, the main active compounds in American ginseng, have notable pharmacological effects, with rare ginsenosides offering higher bioavailability and bioactivity despite low abundance..

OncologyImmune supportEnergy & fatigueRespiratory

Oyster Mushroom · 2026 · Journal Article · Bioorganic chemistry

Mushroom-mediated silver nanoparticles from Pleurotus ostreatus as antimicrobial candidates against multidrug-resistant bacteria: Physicochemical, in-silico, cytotoxicity, and immunobiological evaluation.

The rise of antimicrobial resistance has heightened the demand for alternatives to traditional antibiotics, especially against multidrug-resistant (MDR) strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniaei, and Pseudomonas aeruginosa..

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2026 · Preprint · journal metadata

Nano-Encapsulated Cordyceps militaris Grown on Germinated Black Bean Attenuates PM- and LPS-Induced Airway Inflammation

Exposure to particulate matter (PM) containing bacterial endotoxins triggers oxidative stress and inflammation in the respiratory epithelium. In this study, we investigated chitosan nanoparticle-encapsulated Cordyceps militaris grown on germinated Rhynchosia nulubilis (GCN) as a potential functional food–derived….

Immune supportEnergy & fatigueRespiratory

Cordyceps · 2026 · Review · Journal of food science and technology

Nature's marvel: unravelling the multiphase composition of Cordyceps militaris mushroom and its implications as a dietary supplement.

UNLABELLED: This review article delves into the multiphase composition of Cordyceps militaris mushroom and explores its implications as a dietary supplement. C.

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2026 · Research Article · International journal of molecular sciences

Neuroprotective Potential of Hericium erinaceus Through Modulation of Inflammatory Signaling in THP-1 Macrophages Under Low-Level Lead Exposure.

Exposure to lead is associated with microglial dysfunction and the development of neuroinflammation. This contributes to accelerated neurodegeneration.

Energy & fatigueMetabolic healthLiver support

Cordyceps · 2026 · Research Article · Synthetic and systems biotechnology

OmniEdit: A unified CRISPR/Cas9 platform for precise genome engineering and strain optimization of the Cordyceps militaris cell factory.

Cordyceps militaris serves as a critical microbial cell factory for high-value bioactive compounds; however, the scarcity of versatile and sophisticated genome-editing toolsets significantly restricts its systematic metabolic engineering..

Cordyceps · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Pelletized Growth in Cordyceps militaris Is Associated with Coordinated Cell Wall Remodeling and Stress Defense.

Morphological control in submerged fermentation is a well-established method for enhancing bioactive metabolite production in filamentous fungi. However, the molecular mechanisms linking morphology to fermentation efficiency remain insufficiently understood..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2026 · Preprint · journal metadata

Pleiotropic Bioactivity of Caterpillar Fungus and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework

The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus) is one of the most popular medicines in Asian traditional medical systems for its pleiotropic indications, including an ability to enhance “vitality”. However, the polyvalent adaptogenic potential of O..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2026 · Review · Pharmaceuticals (Basel, Switzerland)

Pleiotropic Bioactivity of Caterpillar Fungus, Orange Cordyceps, and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework.

Background/Objectives: The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus), known for its ability to enhance "vitality," is one of the most popular medicines in Asian traditional medical systems. According to the Chinese Pharmacopeia, O..

Cognition & nervesEnergy & fatigue

Cordyceps · 2026 · Journal Article · Journal of basic microbiology

Predictive Modeling of Cordycepin Content in Cordyceps militaris Using Machine Learning Based on Cultivation Conditions.

Cordycepin, a nucleoside analog derived from Cordyceps militaris, is a bioactive compound with potent pharmacological properties and growing relevance in functional food and pharmaceutical industries..

Immune supportEnergy & fatigueGut & microbiomeLiver support

King Oyster · 2026 · Journal Article · Food science and biotechnology

Preparation, characterization and anti-fatigue activity of polysaccharides from Pleurotus eryngii.

The Pleurotus eryngii polysaccharides (PEP1) were isolated and purified. The structure of PEP1 was characterized, and its anti-fatigue activity was studied.

Immune supportCognition & nervesEnergy & fatigue

Cordyceps · 2026 · Journal Article · Neurotoxicity research

Protective Effect of Cordyceps militaris Extract Against Cigarette Smoke Extract Induced Neurodegeneration in Zebrafish Model.

BACKGROUND AND OBJECTIVES: Neurodegenerative diseases are characterized by degeneration or progressive loss/death of neurons in specific areas of the brain, often worsened by cigarette smoke through oxidative stress and inflammation. Cordyceps militaris (C..

Lion's Mane · 2026 · Journal Article · Journal of agricultural and food chemistry

Proteomic Evidence Indicates Ultrasound-Assisted Extraction Enhances Recovery of Membrane-Associated Proteins in Hericium erinaceus.

Membrane-associated fungal proteins mediate essential functions and contain bioactive proteins with therapeutic potential but are underrepresented in aqueous extracts due to hydrophobicity and lipid associations..

Immune supportCognition & nervesEnergy & fatigueRespiratory

Oyster Mushroom · 2026 · Research Article · ACS omega

Screening of Natural Inhibitors from Pleurotus ostreatus against PHGDH for Enhancing Antiviral Innate Immunity through Mendelian Randomization, Machine Learning, Molecular Docking, Molecular Dynamics Simulation, and Binding Free Energy Calculation.

The human innate immune response plays a critical role in limiting and controlling viral infections. Consequently, therapeutic strategies that promote or modulate innate antiviral immunity are regarded as promising approaches to combating viral pathogens..

Cognition & nervesEnergy & fatigue

Lion's Mane · 2026 · Research Article · Molecules (Basel, Switzerland)

Simultaneous UHPLC-UV Determination of Hericenones, Hericenes, Erinacines and Ergosterol in Hericium erinaceus Raw Materials or Products.

This study describes a single-laboratory validation of an ultra-high-performance liquid chromatographic (UHPLC) method for the determination of key compounds like hericenones, hericenes, erinacines, and ergosterol in Hericium erinaceus (H. erinaceus, Lion's Mane) raw materials and finished products..

OncologyImmune supportEnergy & fatigueGut & microbiome

Cordyceps · 2026 · Journal Article · Current drug metabolism

Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production.

BACKGROUND: Cordyceps militaris is a medicinal fungus known for producing bioactive compounds, including cordycepin, adenosine, and polysaccharides, that exhibit antioxidant, immunomodulatory, and anticancer properties..

Chaga · 2026 · Research Article · Antioxidants (Basel, Switzerland)

Three Polyphenolic Compounds from Inonotus obliquus: Antioxidant Activity, Xanthine Oxidase Inhibition, and Regulatory Effects on MyD88/TLR4/NF-κB Pathway in MSU-Induced RAW 264.7 Macrophages.

BACKGROUND: Inonotus obliquus (Chaga), a medicinal and edible macrofungus abundant in bioactive polyphenols, is a potential source of natural antioxidants and anti-inflammatory agents for functional foods..

Shiitake · 2026 · Research Article · Foods (Basel, Switzerland)

Transcriptome Analysis of Postharvest Lentinula edodes Cell Wall Metabolism During Storage Indicating a Laccase-Mediated Regulatory Network.

Postharvest Lentinula edodes (shiitake mushroom) undergoes rapid textural deterioration, which is primarily driven by complex cell wall remodeling. This study investigates the physiological and transcriptomic changes in L.

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Research progress on chemical constituents and pharmacological effects of Ganoderma lucidum spore oil].

Originating from sporoderm-broken Ganoderma lucidum spores, Ganoderma lucidum spore oil(GLSO) is prepared by supercritical fluid extraction. Chemical composition studies show that GLSO mainly contains nonpolar substances, such as fatty acids, triglycerides, and steroids..

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2025 · Research Article · Journal of traditional and complementary medicine

A formulation of combined Poria cocos and Cordyceps militaris rice ameliorates depressive-like effects by downregulating p38 MAPK signaling pathways.

BACKGROUND AND AIM: Poria cocos (PC) is traditional Chinese medicine with sedative, diuretic, and tonic properties. Cordyceps militaris rice (CMR) is a matrix used for the solid-state culture of C.

OncologyImmune supportEnergy & fatigue

Reishi · 2025 · Journal Article · Journal of Ethnopharmacology

A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/Caspase 3 signaling pathway

According to the Sheng Nong's herbal classic, one of the components Ganoderma lucidum (Leyss. ex Fr.) "benefits waterways and kidney qi".

OncologyImmune supportEnergy & fatigue

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/Caspase 3 signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: According to the Sheng Nong's herbal classic, one of the components Ganoderma lucidum (Leyss. ex Fr.) "benefits waterways and kidney qi".

OncologyImmune supportCognition & nervesEnergy & fatigue

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

A polysaccharide from Morchella esculenta mycelia: Structural characterization and protective effect on antioxidant stress on PC12 cells against H2O2-induced oxidative damage.

Morchella esculenta (L.) Pers. is considered a precious edible and medicinal fungus due to its strict growth environment requirements, difficult to cultivate, resulted in expensive in the market.

Cognition & nervesEnergy & fatigue

Lion's Mane · 2025 · Research Article · Frontiers in nutrition

Acute effects of a standardised extract of Hericium erinaceus (Lion's Mane mushroom) on cognition and mood in healthy younger adults: a double-blind randomised placebo-controlled study.

INTRODUCTION: Animal studies have suggested that Lion's Mane mushroom [Hericium erinaceus (Bull.) Pers.] can enhance cognitive function and mood due to its bioactive metabolites, including erinacines and hericenones..

Cordyceps · 2025 · Preprint · journal metadata

Analysis of codon usage bias between Ophiocordyceps sinensis and Thitarodes xiaojinensis

Abstract Background Ophiocordyceps sinensis is a well - known entomogenous fungus, which has attracted much attention due to its unique medicinal value and complex ecological relationships..

Enoki · 2025 · Journal Article · Food Research International

Antimicrobial effect of lauroyl arginate ethyl on Listeria monocytogenes and its application in controlling microbial contamination of enoki mushrooms (Flammulina velutipes)

The aim of this study was to investigate the antimicrobial activity and antimicrobial mechanisms of lauroyl arginate ethyl (LAE) against Listeria monocytogenes and its practical application in controlling microbial growth on enoki mushrooms. LAE showed strong antimicrobial activity against L.

Enoki · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Antimicrobial effect of lauroyl arginate ethyl on Listeria monocytogenes and its application in controlling microbial contamination of enoki mushrooms (Flammulina velutipes).

OncologyImmune supportEnergy & fatigueGut & microbiome

Turkey Tail · 2025 · Journal Article · Food chemistry

Antioxidant, anti-inflammatory, and antiproliferative properties of extracted Turkey tail (Trametes versicolor Lloyd) mushroom components microencapsulated with inulin.

The stability, interactions, and bioaccessibility of bioactive components modify the potential functionality of newly developed inulin-based microcapsules containing polysaccharide (PF) and ethanol-extractable fractions (EEF) of turkey tail..

Immune supportEnergy & fatigueSkin & hydration

King Oyster · 2025 · Journal Article · Carbohydrate polymers

Carboxymethyl chitosan-induced modification of the structure and regulation of the thermal aggregation of Pleurotus eryngii protein fractions to improve gel properties

In recent years, interactions between polysaccharides and proteins have been widely considered for use to improve protein gel performances. We previously found carboxymethyl chitosan (CMCS) can increase Pleurotus eryngii protein (PEP) gel properties, but the contributions of different key PEP fractions to overall gel….

Immune supportEnergy & fatigueSkin & hydration

King Oyster · 2025 · Journal Article · Carbohydrate polymers

Carboxymethyl chitosan-induced modification of the structure and regulation of the thermal aggregation of Pleurotus eryngii protein fractions to improve gel properties.

OncologyEnergy & fatigueLiver supportSkin & hydration

Cordyceps · 2025 · Research Article · International journal of molecular sciences

Chitosan Nanoparticle-Encapsulated Cordyceps militaris Grown on Germinated Rhynchosia nulubilis Reduces Type II Alveolar Epithelial Cell Apoptosis in PM2.5-Induced Lung Injury.

Chitosan nanoparticles (CNPs) were synthesized in this study to enhance the limited bioactivity and stability of Cordyceps militaris grown on germinated Rhynchosia nulubilis (GRC) and effectively deliver it to target tissues..

Immune supportEnergy & fatigueSkin & hydration

King Oyster · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Comparative analysis of electrohydrodynamic, hot air, and natural air drying techniques on quality attributes and umami enhancement in king oyster mushroom (Pleurotus eryngii)

This study systematically examined the impacts of three distinct drying techniques (Electrohydrodynamics, Hot air and Natural air) on the physicochemical characteristics of king oyster mushroom..