MycoData

Cordyceps · 2026 · Journal Article · Fitoterapia

Comparative computational analysis of the hypolipidaemic potential of Cordyceps militaris and Ophiocordyceps sinensis, with in vivo validation of cordycepin.

Hyperlipidaemia (HLP) arises from impaired lipid homeostasis in the setting of chronic low-grade inflammation, yet mechanistic comparisons between the edible medicinal fungi Cordyceps militaris and Ophiocordyceps sinensis remain scarce..

Reishi · 2026 · Journal Article · Food Research International

Comprehensive evaluation of Ganoderma lucidum extracts: digestion kinetics, gut microbiota modulation, and immunoregulatory mechanisms

Ganoderma lucidum (Reishi mushroom) exhibits medicinal–edible functionality mediated by bioactive components such as β-glucans and ganoderic acids that regulate immune responses through multiple pathways. However, the digestive transformation and microbiota-mediated interactions of G..

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Comprehensive evaluation of Ganoderma lucidum extracts: digestion kinetics, gut microbiota modulation, and immunoregulatory mechanisms.

Ganoderma lucidum (Reishi mushroom) exhibits medicinal-edible functionality mediated by bioactive components such as β-glucans and ganoderic acids that regulate immune responses through multiple pathways. However, the digestive transformation and microbiota-mediated interactions of G..

Immune supportEnergy & fatigueMetabolic healthLiver support

Reishi · 2026 · Preprint · journal metadata

Exploring the effect and mechanism of Ganoderma lucidum Polysaccharides on improving Paediatric MASLD based on network pharmacology and animal experiment

Abstract Background Paediatric Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disorder resulting from chronic hepatic steatosis. Ganoderma lucidum polysaccharide (GLP) have several pharmacological effects..

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Reishi · 2026 · Review · Metabolites

Ganoderma lucidum as a Functional Bioactive Candidate for Glycemic Regulation: Mechanisms, Preclinical Evidence, and Clinical Translation.

Type 2 diabetes mellitus (T2DM) is a major global health challenge that has intensified interest in multi-target nutraceuticals with potential adjunctive benefits..

Chaga · 2026 · Research Article · Molecules (Basel, Switzerland)

Green Extraction and Liposomal Encapsulation of Inonotus obliquus (Chaga) Extracts: Comparative Phytochemical and Antioxidant Analysis.

Inonotus obliquus (Chaga) is a medicinal basidiomycete fungus with diverse bioactive compounds and pharmacological properties. This study systematically compared green extraction techniques: maceration, ultrasound-assisted extraction (UAE), and combined supercritical CO2-pressurized liquid extraction (ScCO2-PLE),….

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Cordyceps · 2026 · Journal Article · Bioscience, biotechnology, and biochemistry

Inhibition of hepatic lipogenesis and adipogenesis by cordyanhydride A isolated from Cordyceps Militaris cultivated on germinated soybeans.

Regulation of lipid homeostasis requires coordinated control of fatty acid (FA) oxidation, lipogenesis, and adipocyte differentiation. Cordyanhydride A (CA) was isolated from Cordyceps militaris (CM) extract cultivated on germinated soybean through bioactivity-guided fractionation and structurally characterized using….

Energy & fatigueMetabolic healthLiver support

Chaga · 2026 · Journal Article · Journal of ethnopharmacology

Inonotus obliquus (Ach. ex Pers.) Pilát aqueous extract alleviates acute cold exposure/rewarming-induced myocardial injury by regulating mitochondrial dynamics via liver kinase B1/adenosine monophosphate-activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator-1 alpha signaling pathway activation.

ETHNOPHARMACOLOGICAL RELEVANCE: Acute cold exposure affects the cardiovascular system substantially. Inonotus obliquus (Ach.

OncologyImmune supportGut & microbiomeLiver support

Reishi · 2026 · Research Article · Journal of nanobiotechnology

Multicomponent Ganoderma lucidum spore-based solid self-nanoemulsifying system of paclitaxel for improved lymphatic absorption and immune synergistic antitumor strategy.

In colorectal cancer, the cancer-immunity cycle is often disrupted by the lack of effective tumor-associated antigens, impaired activation of antigen-presenting cells, and insufficient T cell infiltration, leading to tumor immune escape and disease progression..

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2026 · Journal Article · Food Research International

Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide

Diet-based modulation of the gut microbiota has emerged as a promising strategy to alleviate obesity and its related complications. Our previous study demonstrated that polysaccharide derived from Cordyceps militaris (CMP) exerts anti-obesity effects, yet the specific mechanism linking gut microbiota to its metabolic….

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Cordyceps · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide.

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Cordyceps · 2026 · Research Article · Synthetic and systems biotechnology

OmniEdit: A unified CRISPR/Cas9 platform for precise genome engineering and strain optimization of the Cordyceps militaris cell factory.

Cordyceps militaris serves as a critical microbial cell factory for high-value bioactive compounds; however, the scarcity of versatile and sophisticated genome-editing toolsets significantly restricts its systematic metabolic engineering..

OncologyImmune supportGut & microbiomeLiver support

Cordyceps · 2026 · Journal Article · Current topics in medicinal chemistry

Ophiocordyceps sinensis in Cancer Therapy: Bridging Traditional Medicine and Modern Oncology.

INTRODUCTION: Ophiocordyceps sinensis, a parasitic fungus traditionally used in Asian medicine, has drawn attention for its potential anticancer properties. Its bioactive components- such as cordycepin, polysaccharides, and nucleosides-exhibit anti-inflammatory, antioxidant, immunomodulatory, and anticancer….

Immune supportEnergy & fatigueGut & microbiomeLiver support

King Oyster · 2026 · Journal Article · Food science and biotechnology

Preparation, characterization and anti-fatigue activity of polysaccharides from Pleurotus eryngii.

The Pleurotus eryngii polysaccharides (PEP1) were isolated and purified. The structure of PEP1 was characterized, and its anti-fatigue activity was studied.

OncologyLiver supportSkin & hydration

Cordyceps · 2025 · Journal Article · Microbial Pathogenesis

Bovine serum albumin-chitosan nanoparticles loaded with Cordyceps militaris extract: A novel approach to combat MDR bacteria

The application of Bovine Serum Albumin (BSA) nanoparticles in the medical field has gained substantial attention due to their biocompatibility and multifunctionality as drug delivery systems..

OncologyLiver supportSkin & hydration

Cordyceps · 2025 · Journal Article · Microbial pathogenesis

Bovine serum albumin-chitosan nanoparticles loaded with Cordyceps militaris extract: A novel approach to combat MDR bacteria.

The application of Bovine Serum Albumin (BSA) nanoparticles in the medical field has gained substantial attention due to their biocompatibility and multifunctionality as drug delivery systems..

OncologyEnergy & fatigueLiver supportSkin & hydration

Cordyceps · 2025 · Research Article · International journal of molecular sciences

Chitosan Nanoparticle-Encapsulated Cordyceps militaris Grown on Germinated Rhynchosia nulubilis Reduces Type II Alveolar Epithelial Cell Apoptosis in PM2.5-Induced Lung Injury.

Chitosan nanoparticles (CNPs) were synthesized in this study to enhance the limited bioactivity and stability of Cordyceps militaris grown on germinated Rhynchosia nulubilis (GRC) and effectively deliver it to target tissues..

Reishi · 2025 · Randomized Controlled Trial · Nutrients

Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.

Background: Ganoderma lucidum spore oil (GLSO) is widely recognized for its notable medicinal and nutritional properties. This study aimed to systematically evaluate the efficacy and safety of GLSO extract in individuals with dyslipidemia..

Cognition & nervesLiver support

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Cognition-Enhancing Effects of Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycota) and Cordycepin in a Scopolamine-Induced Mouse Model.

Cognitive deficit is caused by a variety of neurodegenerative diseases, which lead to declines in learning, memory, and concentration. Cordyceps militaris (CM) and its major component, cordycepin (CO), are attracting attention as functional food ingredients due to their beneficial health effects such as liver….

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Enoki · 2025 · Journal Article · International journal of biological macromolecules

Flammulina velutipes protein-Flammulina velutipes soluble polysaccharide-tea polyphenols particles stabilized Pickering emulsions for the delivery of β-carotene.

The delivery vehicles based on protein-polysaccharide-polyphenol are promising methods to encapsulate bioactive components with the aim of improving their solubility and bioavailability..

OncologyImmune supportLiver support

Reishi · 2025 · Journal Article · Food Bioscience

Ganoderma lucidum polysaccharides: A comprehensive overview of pharmacological effects and future perspectives

Ganoderma lucidum polysaccharides (GLPs), derived from the medicinal mushroom Ganoderma lucidum, are recognized for their diverse pharmacological properties. This systematic review offers a detailed analysis of how the structure of GLPs influences their biological functions..

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Journal of pharmaceutical and biomedical analysis

Ganoderma lucidum spore oil attenuates acute liver injury by modulating lipid metabolism and gut microbiota.

The incidence of acute liver injury is increasing and poses a significant threat to human health. Ganoderma lucidum spore oil (GLSO), a lipid substance extracted from Ganoderma lucidum spore powder using supercritical CO2 technology, has been investigated for its potential to prevent acute liver injury..

OncologyImmune supportMetabolic healthLiver support

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum spore oil modulates immunity in hepatoma H22-bearing mice and restricts tumor growth by inhibiting eicosanoid metabolism pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum spore oil (GLSO) is a well-known health product that is beneficial for immuno-enhancement, which stems from a medicine fungus: Ganoderma lucidum (Curtis) P. Karst.

OncologyImmune supportMetabolic healthLiver support

Reishi · 2025 · Review · Antioxidants (Basel, Switzerland)

Ganoderma lucidum-From Ancient Remedies to Modern Applications: Chemistry, Benefits, and Safety.

Ganoderma lucidum (G. lucidum), commonly known as Reishi or Lingzhi, is a medicinal mushroom with a rich history in traditional Asian medicine.

OncologyImmune supportLiver supportSkin & hydration

Reishi · 2025 · Journal Article · Phytotherapy research: PTR

Inhibition of Hepatoblastoma by Ganoderma Lucidum Polysaccharide via the Induction of HDAC4-p16-RB Axis-Mediated Cellular Senescence.

Hepatoblastoma (HB), the most common primary malignant liver tumor in children, is characterized by high metastatic potential and poor prognosis. Ganoderma lucidum polysaccharide (GLP), the main bioactive compound of Ganoderma lucidum, has not been fully investigated for its therapeutic effects on HB..

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · International Journal of Biological Macromolecules

Inonotus obliquus polysaccharides improve hyperlipidemia with respect to lipid synthesis and intestinal flora modulation

Chronic high-fat diet can lead to fatty liver metabolism, hyperlipidemia disorders, and other diseases. Polysaccharides are natural lipid-lowering agents.

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Inonotus obliquus polysaccharides improve hyperlipidemia with respect to lipid synthesis and intestinal flora modulation.

Chronic high-fat diet can lead to fatty liver metabolism, hyperlipidemia disorders, and other diseases. Polysaccharides are natural lipid-lowering agents.

Mesima · 2025 · Journal Article · Microscopy research and technique

Mechanical Analysis of Phellinus Linteus-Induced Apoptosis of Hepatoma Cells.

Liver cancer is prevalent with the third highest mortality rate globally. The biomechanical properties of cancer cells play a crucial role in their proliferation and differentiation.

OncologyLiver support

Turkey Tail · 2025 · Journal Article · International journal of medicinal mushrooms

Mechanism of Antihyperglycemic Activity of Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes) in Type 2 Diabetic Rats.

The antihyperglycemic activity of extracellular polysaccharopeptides (ePSP) obtained from Trametes versicolor (TV) strain LH-1 has been demonstrated in hepatic cells and diabetic animals. This study further investigated the mechanisms of T..

Immune supportEnergy & fatigueMetabolic healthLiver support

Chaga · 2025 · Journal Article · Journal of ethnopharmacology

Mechanisms of Inonotus obliquus (Fr.) Pilát polysaccharides in ameliorating lipid-induced skeletal muscle insulin resistance via PI3K/AKT and AMPK/ACC1/CPT1 signaling pathways.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus (Fr.) Pilát, a traditional medicinal fungi, has been used to treat diabetes in China and Russia since the 16th century..

OncologyEnergy & fatigueLiver support

Chaga · 2025 · Journal Article · International journal of medicinal mushrooms

Mechanistic Study of Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Phenolic Compounds in the Treatment of Liver Cancer: A Database and Simulation Approach.

Inonotus obliquus is a large fungus with high phenolic content that has demonstrated promising potential for the treatment of liver cancer. However, studies investigating its mechanism of action in the treatment of liver cancer are scarce..

OncologyImmune supportMetabolic healthLiver support

Chaga · 2025 · Journal Article · Environmental toxicology and pharmacology

Mitigation of experimental hepatocellular Carcinoma by Inonotus obliquus Mushroom extract in association with oxidative stress and inflammation signaling.

Chaga mushroom (Inonotus obliquus) has been a component of folk medicine treating several disorders mainly through its anti-inflammatory and antioxidant properties, yet its effects on liver carcinoma needed elucidation..

Maitake · 2025 · Research Article · Nutrients

Network Pharmacology-Based Elucidation of the Hypoglycemic Mechanism of Grifola frondosa GF5000 Polysaccharides via GCK modulation in Diabetic Rats.

BACKGROUND/OBJECTIVES: Our lab has previously reported that Grifola frondosa (maitake mushroom) GF5000 has antidiabetic potential owing to its ability to improve insulin resistance..

OncologyGut & microbiomeLiver support

Cordyceps · 2025 · Journal Article · Food and Bioproducts Processing

Novel advanced nanoliposomes incorporating adenosine, cordycepin from riched-Cordyceps militaris extract, and curcumin: Formulation, stability, in vitro digestion, and enhanced biological activities

This study details the development and evaluation of novel nanoliposomes for the co-delivery of adenosine and cordycepin from Cordyceps militaris extract, alongside curcumin..

Metabolic healthGut & microbiomeLiver support

Cordyceps · 2025 · Journal Article · Food & function

Novel double nanoemulsion loading of Cordyceps militaris extract: formulation, stability, in vitro digestion, and in vivo evaluation for regulation of acute lipid disorders.

This study explores a novel approach for addressing acute lipid disorders using a double nanoemulsion system (NCMs) loading Cordyceps militaris extract. Cordyceps militaris, a medicinal mushroom, is valued for its bioactive compounds, particularly adenosine (ADE) and cordycepin (COR), which possess lipid-regulating….

King Oyster · 2025 · Research Article · Food science & nutrition

Pleurotus eryngii Culture Filtrate and Aqueous Extracts Alleviate Aflatoxin B1 Synthesis.

Mycotoxins in food and feed are a significant health risk, even more so than pesticides and synthetic waste. These toxic secondary metabolites are produced by various fungal species, particularly after fungal colonization of crops..

Metabolic healthGut & microbiomeLiver support

Lion's Mane · 2025 · Research Article · Applied and environmental microbiology

Puerarin combined with Hericium erinaceus insoluble dietary fiber alleviates obesity induced by high-fat diet through regulating the glycerophospholipid metabolism pathway influenced by gut microbiota.

The purpose of this study was to evaluate the combined effects of puerarin (Pue) and insoluble dietary fiber from Hericium erinaceus (HEIDF) on obesity induced by a high-fat diet (HFD) in mice, focusing on their effects on lipid and glucose metabolism, gut microbiota (GM), and serum metabolites..

King Oyster · 2025 · Research Article · Bioresources and bioprocessing

Revitalizing Pleurotus eryngii polysaccharides: gamma irradiation boosts antidiabetic and antioxidant potential.

Polysaccharides derived from Pleurotus eryngii possess various bioactive properties, including antioxidant, antidiabetic, anti-inflammatory, and immunomodulatory effects. In this study, polysaccharides were extracted from P..

OncologyImmune supportLiver support

Chaga · 2025 · Journal Article · Bioscience, biotechnology, and biochemistry

The aqueous extracts of Inonotus obliquus (Chaga) augment host defense against Listeria monocytogenes infection.

Listeria monocytogenes, which grows in host cells intracellularly, is important as an opportunistic pathogen. Extracts of Chaga mushroom, Inonotus obliquus, have been shown to possess various biological activities.

Cordyceps · 2025 · Journal Article · Journal of food science

The fermentation of Cordyceps militaris polysaccharide influenced gut bacterial LPS structure formation and changed its antigenicity.

Gut bacterial lipopolysaccharide (LPS) could be released into the circulatory system via the gut-liver axis and cause inflammatory immune response, while Cordyceps militaris polysaccharide (CMP40) has been reported to be effective in alleviating this inflammatory response..

Reishi · 2025 · Review · Food science & nutrition

The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.

This study aimed to assess the impact of Ganoderma lucidum supplementation (200-11,200 mg/day, 1-24 weeks) on health-related indices in populations including healthy, at-risk, and chronic disease individuals..

Cordyceps · 2025 · Research Article · Frontiers in pharmacology

Therapeutic potential of Cordyceps militaris cultivated with Ginkgo biloba seeds for alleviating western diet-induced type 2 diabetes and diabetic nephropathy.

BACKGROUND: Diabetic nephropathy (DN), a leading cause of chronic kidney disease and end-stage renal disease, is a serious complication of type 2 diabetes mellitus (T2DM). Current therapies primarily slow disease progression but are unable to reverse kidney damage, highlighting the need for novel therapy to treat DN..

OncologyEnergy & fatigueLiver supportRespiratory

Reishi · 2025 · Research Article · AMB Express

Unlocking Reishi's secrets: nutritional and medicinal traits of Ganoderma lucidum isolated from tree bark in Egypt.

Ganoderma lucidum is an edible mushroom with high consumption rates in many cultures especially East Asian. This study assessed the in-vitro antimicrobial, antitumor, antiviral as well as antioxidant capacity of Ganoderma lucidum water extract (GLWE)..

Cordyceps · 2024 · Randomized Controlled Trial · Scientific reports

A randomized controlled clinical trial examining the effects of Cordyceps militaris beverage on the immune response in healthy adults.

Cordyceps militaris (L.) Link (C. militaris) contains various beneficial substances, including polysaccharides (galactomannan), nucleotides (adenosine and cordycepin), cordycepic acid, amino acids, and sterols (ergosterol and beta-sitosterol)..

Cordyceps · 2024 · Research Article · Frontiers in toxicology

A toxicological assessment of Ganoderma lucidum and Cordyceps militaris mushroom powders.

Gonoderma lucidum (G. lucidum) and Cordyceps militaris (C.

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Immune supportCognition & nervesLiver supportSkin & hydration

King Oyster · 2024 · Journal Article · International journal of biological macromolecules

Antibacterial and hemostatic chitin sponge directly constructed from Pleurotus Eryngii via top-down approach.

Chitin, the second most abundant polysaccharide on earth, possesses unique characteristics, including biosafety, biodegradability, and procoagulant activity, making it an attractive material for hemostasis. However, the conventional bottom-up construction of chitin-based materials is intricate and time-consuming..

Chaga · 2024 · Journal Article · Journal of complementary & integrative medicine

Antidiabetic activity of Inonotus obliquus water extract in alloxan-induced diabetic mice.

OBJECTIVES: The Inonotus obliquus is a medicinal mushroom that grows on mature birch trees and is commonly used in traditional medicine for various ailments. The current study aimed to explore the hypoglycemic, hypolipidemic, and pancreatic protective effects of the water extract of Mongolian natural Inonotus obliquus….

OncologyMetabolic healthLiver support

Maitake · 2024 · Research Article · Toxicology research

Chitosan and Grifola Frondosa nanoparticles insulate liver dysfunction in EAC-bearing mice.

BACKGROUND: Ehrlich ascites carcinoma (EAC) is a rapidly growing and undifferentiated tumor that can prompt oxidative stress and liver toxicity, whereas chitosan and Grifola Frondosa have widely recognized biological qualities..