MycoData

Summary Plants and fungi are major sources of natural products beneficial to society, making the study of distinct species essential for discovering new drugs and bioactive compounds..

OncologyImmune support

High relevance

Reishi · 2026 · Journal Article · Analytica chimica acta

A label-free magnetic bead affinity approach for direct target identification of herbal extract: Ganoderma lucidum as a case.

Ganoderma lucidum (Chinese name: Lingzhi) has been used for the treatment of diverse liver disorders for centuries in traditional Chinese medicinal practices. Ganoderic acids (GAs) have been well-established as the key bioactive constituents responsible for the hepatoprotective potential and the ability to alleviate….

OncologyLiver support

High relevance

Snow Fungus · 2026 · Review · Carbohydrate research

Advances in extraction, structural characteristics, bioactivities, structure-activity relationship, quality control and applications of polysaccharides from Tremella fuciformis: A review.

ETHNOPHARMACOLOGICAL RELEVANCE: Tremella fuciformis is an edible fungus with a cultivation and consumption history of over a thousand years in China. In traditional Chinese medicine, it has the effects of moistening the lungs, soothing the intestines, nourishing the skin, and prolonging life, and is often used as a….

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Cordyceps · 2026 · Review · Phytotherapy research: PTR

An Immunomodulatory Mushroom, Cordyceps militaris, and Its Constituents: A Review of In Vitro/In Vivo Studies and Clinical Trials.

Cordyceps, known as "winter-worm summer-grass", has been used as a medicinal mushroom to boost energy levels and immune activity. Among cordyceps types, Cordyceps militaris (CM) is the most commercially useful owing to its ease of artificial cultivation for mass production..

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

King Oyster · 2026 · Journal Article · Scientific reports

Biological activity of Pleurotus eryngii based on antioxidant, anticholinesterase and antiproliferative effects using optimized extraction methods.

This study aims to evaluate the antioxidant potential, anticholinesterase activity, antiproliferative effects, and phenolic contents of optimized extracts derived from Pleurotus eryngii. Single-objective and multi-objective optimized extracts of P..

OncologyRespiratory

High relevance

Shiitake · 2026 · Research Article · Journal of cosmetic dermatology

Cosmeceutical and Dermatological Potential of Shiitake Mushroom (Lentinula edodes) Extract.

BACKGROUND: Shiitake mushroom (Lentinula edodes) contains polysaccharides, phenolics, and β-glucans known for their antioxidant and nutraceutical properties; however, its dermatological applications remain limited..

OncologyImmune supportSkin & hydration

High relevance

Reishi · 2026 · Journal Article · International journal of cosmetic science

Cosmetic potential of Ganoderma lucidum (Reishi) extract in a topical cream formulation.

OBJECTIVE: The primary objective of this study was to investigate the biological activities of freeze-dried Ganoderma lucidum (Reishi) extract obtained from hazelnut pruning waste and to compare its antioxidant, tyrosinase inhibitory and cytotoxic properties with two widely used cosmetic actives-argireline peptide and….

OncologyEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2026 · Journal Article · Molecular and cellular biochemistry

Deciphering the anticancer potential of an entomopathogenic fungus, Cordyceps militaris in Dalton's Lymphoma transplanted murine model: a multidimensional approach involving computational methods and in vivo validation.

Cordyceps militaris, a medicinal mushroom in traditional Chinese medicine, emerged as a promising source of bioactive compounds, exhibiting potent antioxidant, anti-inflammatory, anticancer, antiviral and immunomodulatory properties..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Cordyceps · 2026 · Research Article · Synthetic and systems biotechnology

Discovery of functional compounds from dimorphic edible Ophiocordyceps sinensis fungus in host haemolymph.

Chinese cordyceps, with a fruiting body of Ophiocordyceps sinensis from insect cadaver, is well-known health food. During formation, O.

OncologyMetabolic health

High relevance

Lion's Mane · 2026 · Research Article · PloS one

Extracts from Cordyceps cicadae and Hericium erinaceus promote the neurite outgrowth of retinal ganglion cells.

The regenerative capacity of mammalian RGC neurites after damage, such as glaucoma, is limited. Numerous studies have utilized herbal extracts to promote neural regeneration and exert neuroprotective effects in the hope of mitigating glaucoma..

OncologyCognition & nerves

High relevance

Reishi · 2026 · Research Article · Journal of Cancer

Ganoderma lucidum alcohol extract targets mutant p53 signaling to inhibit proliferation in triple-negative breast brain metastasis cancer.

Triple-negative breast cancer (TNBC) is among the most aggressive subtypes of breast cancer, frequently characterized by invasive growth, metastasis, and poor clinical outcomes. Brain metastasis, commonly observed in TNBC patients, significantly worsens prognosis and survival rates..

OncologyCognition & nerves

High relevance

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum polysaccharides alleviate doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through modulation of the Nrf2/SLC7A11/GPX4 signaling pathway.

Doxorubicin (Dox) is a chemotherapeutic agent widely used in clinical oncology; however, its application is limited by dose-dependent cardiotoxicity, in which ferroptosis has been identified as a key mechanism of myocardial injury..

OncologyImmune support

High relevance

Reishi · 2026 · Research Article · Scientific reports

Ganoderma lucidum spore oil with Ganoderma lucidum and Ganoderma sinense extracts (G2SO) shows antitumor and Immunomodulatory effects in mice.

Ganoderma is a highly valued medicinal fungus, especially in Traditional Chinese Medicine (TCM). A formulation of Ganoderma lucidum spore oil and aqueous extracts from the fruiting bodies of Ganoderma lucidum and Ganoderma sinense (G2SO) has been developed as a functional formulation proposed to support immune….

OncologyImmune support

High relevance

Chaga · 2026 · Journal Article · Photochemical & photobiological sciences: Official journal of the European Photochemistry Association and the European Society for Photobiology

Inonotus obliquus polysaccharides alleviate UVB-irradiated skin photodamage by regulating calcium homeostasis through endoplasmic reticulum-mitochondria crosstalk.

Skin photodamage is closely related to mitochondrial dysfunction, and endoplasmic reticulum (ER) stress can induce excessive mitochondrial reactive oxygen species (ROS) accumulation, triggering inflammation, and inducing cell apoptosis..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Chaga · 2026 · Review · Nutrients

Inonotus obliquus Polysaccharides: Preparation, Structural Characteristics, Structure-Activity Relationships, Biological Activities and Applications.

Inonotus obliquus, a rare medicinal and edible fungus, is rich in bioactive polysaccharides. These polysaccharides exhibit diverse biological activities, including gut microbiota-modulating, hypoglycemic, immunomodulatory, antitumor, antioxidant, hypolipidemic, and antiviral activities..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2026 · Systematic Review · Frontiers in pharmacology

Mechanism of Ganoderma lucidum polysaccharides in the mangement of diabetes and its complications.

Characterized by a total or partial shortage of insulin, diabetes is a chronic metabolic condition. Its widespread occurrence and related complications present a significant global public health issue.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Reishi · 2026 · Research Article · Journal of nanobiotechnology

Multicomponent Ganoderma lucidum spore-based solid self-nanoemulsifying system of paclitaxel for improved lymphatic absorption and immune synergistic antitumor strategy.

In colorectal cancer, the cancer-immunity cycle is often disrupted by the lack of effective tumor-associated antigens, impaired activation of antigen-presenting cells, and insufficient T cell infiltration, leading to tumor immune escape and disease progression..

OncologyImmune supportGut & microbiomeLiver support

High relevance

Oyster Mushroom · 2026 · Journal Article · Bioorganic chemistry

Mushroom-mediated silver nanoparticles from Pleurotus ostreatus as antimicrobial candidates against multidrug-resistant bacteria: Physicochemical, in-silico, cytotoxicity, and immunobiological evaluation.

The rise of antimicrobial resistance has heightened the demand for alternatives to traditional antibiotics, especially against multidrug-resistant (MDR) strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniaei, and Pseudomonas aeruginosa..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Cordyceps · 2026 · Preprint · journal metadata

Nano-Encapsulated Cordyceps militaris Grown on Germinated Black Bean Attenuates PM- and LPS-Induced Airway Inflammation

Exposure to particulate matter (PM) containing bacterial endotoxins triggers oxidative stress and inflammation in the respiratory epithelium. In this study, we investigated chitosan nanoparticle-encapsulated Cordyceps militaris grown on germinated Rhynchosia nulubilis (GCN) as a potential functional food–derived….

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Lion's Mane · 2026 · Research Article · International journal of molecular sciences

Neuroprotective Potential of Hericium erinaceus Through Modulation of Inflammatory Signaling in THP-1 Macrophages Under Low-Level Lead Exposure.

Exposure to lead is associated with microglial dysfunction and the development of neuroinflammation. This contributes to accelerated neurodegeneration.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2026 · Journal Article · Current topics in medicinal chemistry

Ophiocordyceps sinensis in Cancer Therapy: Bridging Traditional Medicine and Modern Oncology.

INTRODUCTION: Ophiocordyceps sinensis, a parasitic fungus traditionally used in Asian medicine, has drawn attention for its potential anticancer properties. Its bioactive components- such as cordycepin, polysaccharides, and nucleosides-exhibit anti-inflammatory, antioxidant, immunomodulatory, and anticancer….

OncologyImmune supportGut & microbiomeLiver support

High relevance

Oyster Mushroom · 2026 · Journal Article · Burns: journal of the International Society for Burn Injuries

Oral Pleurotus ostreatus supplementation modulates systemic inflammation and enhances collagen density in a full-thickness burn rat model.

Severe burn injuries cause hypermetabolic and inflammatory responses characterized by hypoalbuminemia and elevated cytokines that delay wound healing. Pleurotus ostreatus, known for its bioactive compounds and high-quality protein, may support recovery by improving systemic nutritional and inflammatory balance..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Cordyceps · 2026 · Preprint · journal metadata

Pleiotropic Bioactivity of Caterpillar Fungus and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework

The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus) is one of the most popular medicines in Asian traditional medical systems for its pleiotropic indications, including an ability to enhance “vitality”. However, the polyvalent adaptogenic potential of O..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2026 · Review · Pharmaceuticals (Basel, Switzerland)

Pleiotropic Bioactivity of Caterpillar Fungus, Orange Cordyceps, and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework.

Background/Objectives: The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus), known for its ability to enhance "vitality," is one of the most popular medicines in Asian traditional medical systems. According to the Chinese Pharmacopeia, O..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Snow Fungus · 2026 · Review · International journal of biological macromolecules

Research progress in polysaccharides from the Tremella fuciformis (silver ear): extraction, purification, structural features, health-promoting activities, and potential applications.

Tremella fuciformis polysaccharides (TFPs), as one of the pivotal functional constituents of T. fuciformis, have attracted increasing attention because of their diverse health-promoting activities..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2026 · Journal Article · Current drug metabolism

Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production.

BACKGROUND: Cordyceps militaris is a medicinal fungus known for producing bioactive compounds, including cordycepin, adenosine, and polysaccharides, that exhibit antioxidant, immunomodulatory, and anticancer properties..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Reishi · 2025 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Research progress on chemical constituents and pharmacological effects of Ganoderma lucidum spore oil].

Originating from sporoderm-broken Ganoderma lucidum spores, Ganoderma lucidum spore oil(GLSO) is prepared by supercritical fluid extraction. Chemical composition studies show that GLSO mainly contains nonpolar substances, such as fatty acids, triglycerides, and steroids..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2025 · Research Article · Journal of traditional and complementary medicine

A formulation of combined Poria cocos and Cordyceps militaris rice ameliorates depressive-like effects by downregulating p38 MAPK signaling pathways.

BACKGROUND AND AIM: Poria cocos (PC) is traditional Chinese medicine with sedative, diuretic, and tonic properties. Cordyceps militaris rice (CMR) is a matrix used for the solid-state culture of C.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Journal of Ethnopharmacology

A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/Caspase 3 signaling pathway

According to the Sheng Nong's herbal classic, one of the components Ganoderma lucidum (Leyss. ex Fr.) "benefits waterways and kidney qi".

OncologyImmune supportEnergy & fatigue

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

A network pharmacology approach and experimental validation to investigate the protection mechanism of Ganoderma lucidum (Leyss. ex Fr.) Karst spore for acute kidney injury through induction of apoptosis via p53/Caspase 3 signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: According to the Sheng Nong's herbal classic, one of the components Ganoderma lucidum (Leyss. ex Fr.) "benefits waterways and kidney qi".

OncologyImmune supportEnergy & fatigue

High relevance

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

A polysaccharide from Morchella esculenta mycelia: Structural characterization and protective effect on antioxidant stress on PC12 cells against H2O2-induced oxidative damage.

Morchella esculenta (L.) Pers. is considered a precious edible and medicinal fungus due to its strict growth environment requirements, difficult to cultivate, resulted in expensive in the market.

OncologyImmune supportCognition & nervesEnergy & fatigue

High relevance

Reishi · 2025 · Review · Naunyn-Schmiedeberg's archives of pharmacology

A review of the extraction technologies, structural characterization, chemical modification, and pharmacological effects of Ganoderma lucidum polysaccharides.

Ganoderma lucidum (GL) is a medicinal and edible fungal material with a long history. Ganoderma lucidum polysaccharides (GLPs), as one of the primary bioactive components in GL, exhibit multiple pharmacological effects including anti-tumor, anti-inflammatory, immunomodulatory, antioxidant, and metabolic regulatory….

OncologyImmune supportMetabolic health

High relevance

Snow Fungus · 2025 · Research Article · Nutrients

Anti-Stress Effects of Tremella fuciformis Berk. Enzymatic Extracts: A Preclinical Study.

Background/Objectives: Chronic stress disrupts neurochemical balance, triggers inflammation, and compromises neuronal integrity, contributing to the development of stress-related disorders..

OncologyImmune supportCognition & nerves

High relevance

Turkey Tail · 2025 · Journal Article · Food chemistry

Antioxidant, anti-inflammatory, and antiproliferative properties of extracted Turkey tail (Trametes versicolor Lloyd) mushroom components microencapsulated with inulin.

The stability, interactions, and bioaccessibility of bioactive components modify the potential functionality of newly developed inulin-based microcapsules containing polysaccharide (PF) and ethanol-extractable fractions (EEF) of turkey tail..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Lion's Mane · 2025 · Systematic Review · Frontiers in nutrition

Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review.

INTRODUCTION: Hericium erinaceus (HE), commonly known as the Lion's Mane mushroom, is an edible, medicinal fungus containing bioactive polysaccharides. It shows promising properties, including neuroprotective, anti-tumor, antioxidant, anti-proliferative, and anti-inflammatory effects..

OncologyImmune supportCognition & nervesGut & microbiome

High relevance

Lion's Mane · 2025 · Review · Molecules (Basel, Switzerland)

Bioactive Polysaccharides from Hericium erinaceus: Extraction, Structure, Bioactivities, and Applications.

Hericium erinaceus, an edible fungus belonging to the family Odontaceae, is predominantly found in Western Europe, North America, and East Asia. In China, it primarily thrives in the mountainous and forested regions in the northeast, north, and southwest..

OncologyImmune supportMetabolic healthRespiratory

High relevance

Oyster Mushroom · 2025 · Journal Article · Biodegradation

Bioremediation of methotrexate by Pleurotus ostreatus pellets: effects on morphology and biotransformation insights.

Methotrexate (MTX), a widely used antineoplastic drug, poses significant environmental risks due to its persistence and toxicity. This study evaluated the potential of Pleurotus ostreatus fungal pellets for MTX degradation and investigated the underlying removal mechanisms and morphological effects..

Oncology

High relevance

Cordyceps · 2025 · Journal Article · Microbial Pathogenesis

Bovine serum albumin-chitosan nanoparticles loaded with Cordyceps militaris extract: A novel approach to combat MDR bacteria

The application of Bovine Serum Albumin (BSA) nanoparticles in the medical field has gained substantial attention due to their biocompatibility and multifunctionality as drug delivery systems..

OncologyLiver supportSkin & hydration

High relevance

Cordyceps · 2025 · Journal Article · Microbial pathogenesis

Bovine serum albumin-chitosan nanoparticles loaded with Cordyceps militaris extract: A novel approach to combat MDR bacteria.

The application of Bovine Serum Albumin (BSA) nanoparticles in the medical field has gained substantial attention due to their biocompatibility and multifunctionality as drug delivery systems..

OncologyLiver supportSkin & hydration

High relevance

Reishi · 2025 · Journal Article · Journal of pharmaceutical and biomedical analysis

Characterization of metabolites of ganoderic acids extract from Ganoderma lucidum in rats using UHPLC-MS/MS.

Ganoderic acids, the primary active compound cluster in Ganoderma lucidum (Chinese name: Lingzhi), one of the most reputed herbal medicines, play a crucial role in its immunomodulatory, anti-inflammatory, and anticancer properties..

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2025 · Research Article · International journal of molecular sciences

Chitosan Nanoparticle-Encapsulated Cordyceps militaris Grown on Germinated Rhynchosia nulubilis Reduces Type II Alveolar Epithelial Cell Apoptosis in PM2.5-Induced Lung Injury.

Chitosan nanoparticles (CNPs) were synthesized in this study to enhance the limited bioactivity and stability of Cordyceps militaris grown on germinated Rhynchosia nulubilis (GRC) and effectively deliver it to target tissues..

OncologyEnergy & fatigueLiver supportSkin & hydration

High relevance

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Cordycepin Extracted from Cordyceps militaris mitigated CUMS-induced depression of rats via targeting GSK3β/β-catenin signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordycepin, the main active component of Cordyceps militaris, exhibits various pharmacological activities, including anti-tumor and antioxidant effects. However, its antidepressant effect and the underlying mechanisms remain unclear..

OncologyCognition & nervesMetabolic health

High relevance

Cordyceps · 2025 · Research Article · Frontiers in immunology

Cordyceps militaris extract and cordycepin ameliorate LPS-challenged colonic damage in piglets by modulating the microbiota and metabolite profiles.

INTRODUCTION: Cordyceps militaris extract (CME) and cordycepin (CPN) are biomolecules with a wide range of biological activities, including anti-inflammatory, antioxidant and anti-tumour effects..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Review · Gels (Basel, Switzerland)

Cordyceps militaris-Derived Bioactive Gels: Therapeutic and Anti-Aging Applications in Dermatology.

Cordyceps militaris is a medicinal mushroom widely utilized in traditional East Asian medicine, recognized for its diverse therapeutic properties. This review explores the potential of C..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Cordyceps · 2025 · Journal Article · Journal of natural products

Cordycepsterols A-C, Anti-Inflammatory C30 Ergosterols with a 6/6/6/5/6-Fused Ring System from Cordyceps militaris.

Cordyceps militaris is a valuable edible and medicinal fungus. Its chemical composition and biological activity have become the focus of attention.

OncologyImmune support

High relevance

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Dectin-1-Dependent Activation of Flt3 Ligand-Induced Dendritic Cells by the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes) Fruiting Body.

Cordyceps militaris, an entomopathogenic fungus traditionally used in East Asian medicine, contains 1,3-β-glucans with well-known immunomodulatory properties. Our previous research has demonstrated that both fruit body powder and hot water extract of C..

OncologyImmune support

High relevance

Reishi · 2025 · Research Article · Frontiers in cell and developmental biology

Developmental and reproductive toxicity assessment of sporoderm-removed Ganoderma lucidum spores.

INTRODUCTION: Ganoderma lucidum is a fungus used in traditional Chinese medicine with high medicinal value and is also widely used in modern healthcare. Its spores are reported to contain antitumor and anti-inflammatory properties, among other biological benefits; however, the thick spore wall limits its….

OncologyImmune supportCognition & nerves

High relevance

King Oyster · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Enhancing the Nutritional and Health-Related Properties of Taralli Through the Use of Pleurotus eryngii: Focus on Antioxidant and Anti-Inflammatory Properties.

In this study, a portion of whole durum wheat semolina was replaced with Pleurotus eryngii powder (PeP) at concentrations of 5% and 10% (w/w) to produce two taralli variants, TPE5 and TPE10. The impact of PeP on the technological, chemical, physical, and sensory properties of taralli was evaluated..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Review · International journal of biological macromolecules

Extraction, purification, structural characterization, biological activity, mechanism of action and application of polysaccharides from Ganoderma lucidum: A review.

Ganoderma lucidum is a traditional tonic medicine in China, known as the "fairy grass" and "spiritual grass". It contains various chemical components, such as polysaccharides, triterpenoids, alkaloids, nucleosides, sterols, and acid compounds, which have the effects of tonifying qi and calming the mind, stopping cough….

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Enoki · 2025 · Research Article · Journal of dental sciences

Flammulina velutipes polysaccharides exhibit potent antioxidant and anti-pyroptotic properties in diabetes-associated periodontitis: A preliminary in vitro study.

BACKGROUND/PURPOSE: Diabetes-associated periodontitis (DAP) is a complicated illness characterized by elevated oxidative stress and a pro-inflammatory response. There is a bidirectional relationship between diabetes and periodontitis..

OncologyImmune supportEnergy & fatigueMetabolic health