MycoData

Cordyceps · 2026 · Research Article · Nutrients

Bifidobacterium animalis ssp. lactis 420 and Cordyceps militaris Synergistically Modulate the Gut Microbiota by Increasing Mucin 2 Production.

BACKGROUND: Probiotics and medicine food homology are known to offer gentle approaches to prevent obesity, although it is difficult with such approaches to satisfy consumers' requirements to lose weight quickly. The probiotic strain Bifidobacterium animalis ssp..

Immune supportGut & microbiomeLiver support

Reishi · 2026 · Journal Article · Food Research International

Comprehensive evaluation of Ganoderma lucidum extracts: digestion kinetics, gut microbiota modulation, and immunoregulatory mechanisms

Ganoderma lucidum (Reishi mushroom) exhibits medicinal–edible functionality mediated by bioactive components such as β-glucans and ganoderic acids that regulate immune responses through multiple pathways. However, the digestive transformation and microbiota-mediated interactions of G..

Immune supportGut & microbiomeLiver support

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Comprehensive evaluation of Ganoderma lucidum extracts: digestion kinetics, gut microbiota modulation, and immunoregulatory mechanisms.

Ganoderma lucidum (Reishi mushroom) exhibits medicinal-edible functionality mediated by bioactive components such as β-glucans and ganoderic acids that regulate immune responses through multiple pathways. However, the digestive transformation and microbiota-mediated interactions of G..

Energy & fatigueGut & microbiome

Lion's Mane · 2026 · Research Article · Food chemistry: X

Effect of lion's mane mushroom (Hericium erinaceus) on dough rheology, protein structure, and quality of steamed bread.

This study investigates how Hericium erinaceus powder (HE powder) modulates the gluten network and influences steamed bread quality. HE powder altered water distribution and mobility, consistent with changes in dough thermo-mechanical behavior, pasting properties, and crumb microstructure..

Reishi · 2026 · Journal Article · Biological & pharmaceutical bulletin

Ganoderic Acid A Derived from Reishi Mushroom Ganoderma lucidum Protects against Intestinal Immunity Reduction Due to Oxidative Stress in Rat

Reishi (Ganoderma lucidum) is known to enhance intestinal immunity, with ganoderic acid A (GA-A) identified as one of its active constituents. However, the specific role of GA-A in regulating immune components such as immunoglobulin A (IgA) from Peyer's patches (PPs) and α-defensin 5 from Paneth cells remains unclear..

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2026 · Review · Metabolites

Ganoderma lucidum as a Functional Bioactive Candidate for Glycemic Regulation: Mechanisms, Preclinical Evidence, and Clinical Translation.

Type 2 diabetes mellitus (T2DM) is a major global health challenge that has intensified interest in multi-target nutraceuticals with potential adjunctive benefits..

Cognition & nervesMetabolic healthGut & microbiome

Yellow Morel · 2026 · Research Article · Foods (Basel, Switzerland)

In Silico Structural Characterization and Hypoglycemic Potential of a Novel Fucose-Specific Lectin (MEP5) from Morchella esculenta.

Natural food-derived proteins are increasingly explored as alternatives to synthetic inhibitors for managing Type 2 diabetes mellitus. Despite the recognized health-promoting properties of Morchella esculenta, the potential of its bioactive proteins to modulate glucose metabolism remains largely unexplored..

Oyster Mushroom · 2026 · Research Article · Food chemistry: X

Innovative research of xian-Ling-Gu-bao herbal residue in regulating soluble carbon-to-nitrogen ratio to promote the growth and nutritional quality of Pleurotus ostreatus: A metabolomics and gut microbiota perspective.

This study evaluated the cultivation of Pleurotus ostreatus on a composite substrate consisting of Xin-Ling-Gu-Bao herbal residue (XLGB) and sauce-flavor Baijiu lees (SFL), both agro-industrial by-products rich in lignocellulose and bioactive compounds..

OncologyImmune supportMetabolic healthGut & microbiome

Chaga · 2026 · Review · Nutrients

Inonotus obliquus Polysaccharides: Preparation, Structural Characteristics, Structure-Activity Relationships, Biological Activities and Applications.

Inonotus obliquus, a rare medicinal and edible fungus, is rich in bioactive polysaccharides. These polysaccharides exhibit diverse biological activities, including gut microbiota-modulating, hypoglycemic, immunomodulatory, antitumor, antioxidant, hypolipidemic, and antiviral activities..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Oyster Mushroom · 2026 · Research Article · Veterinary sciences

Investigation of Pleurotus Ostreatus Mushroom-Based Feed Supplementations on Growth Performance and Immune Function in Male Japanese Quails (Coturnix Japonica).

Growing concern over antibiotic resistance in poultry production has increased interest in natural feed additives such as Pleurotus ostreatus (oyster mushroom)-derived products..

Cordyceps · 2026 · Journal Article · International journal of medicinal mushrooms

LED Light Spectra Modulate Growth, Morphogenesis, and Bioactive Compound Production in Cordyceps militaris (Ascomycota).

Light is a crucial environmental factor influencing fungal development and secondary metabolite biosynthesis. In this study, we investigated the effects of nine different LED light spectra on the growth, morphogenesis, and production of bioactive compounds in Cordyceps militaris strain DT22..

Lion's Mane · 2026 · Journal Article · International journal of medicinal mushrooms

Lion's Mane Medicinal Mushroom Hericium erinaceus (Agaricomycetes) Polysaccharides for Improved In Vitro Probiotic Growth, Adhesion, Antioxidant Activity, and Cryoprotective Properties.

Hericium erinaceus, commonly known as lion's mane mushroom, is a rare edible and medicinal fungus that is highly valued in both the culinary and medical fields. Its primary bioactive component, polysaccharides, holds significant therapeutic potential, particularly in healthcare..

Energy & fatigueGut & microbiome

Oyster Mushroom · 2026 · Research Article · Foods (Basel, Switzerland)

Microbial Community Dynamics Driven by Different Nitrogen Sources During Forestry Waste Composting for Pleurotus ostreatus Cultivation.

Bioconversion of lignocellulosic biomass into edible, nutrient-rich products using low-cost forestry waste offers substantial ecological and economic benefits. Composting forestry waste as a substrate for oyster mushroom (Pleurotus ostreatus) cultivation is an effective recovery strategy..

OncologyImmune supportGut & microbiomeLiver support

Reishi · 2026 · Research Article · Journal of nanobiotechnology

Multicomponent Ganoderma lucidum spore-based solid self-nanoemulsifying system of paclitaxel for improved lymphatic absorption and immune synergistic antitumor strategy.

In colorectal cancer, the cancer-immunity cycle is often disrupted by the lack of effective tumor-associated antigens, impaired activation of antigen-presenting cells, and insufficient T cell infiltration, leading to tumor immune escape and disease progression..

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2026 · Journal Article · Food Research International

Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide

Diet-based modulation of the gut microbiota has emerged as a promising strategy to alleviate obesity and its related complications. Our previous study demonstrated that polysaccharide derived from Cordyceps militaris (CMP) exerts anti-obesity effects, yet the specific mechanism linking gut microbiota to its metabolic….

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide.

OncologyImmune supportGut & microbiomeLiver support

Cordyceps · 2026 · Journal Article · Current topics in medicinal chemistry

Ophiocordyceps sinensis in Cancer Therapy: Bridging Traditional Medicine and Modern Oncology.

INTRODUCTION: Ophiocordyceps sinensis, a parasitic fungus traditionally used in Asian medicine, has drawn attention for its potential anticancer properties. Its bioactive components- such as cordycepin, polysaccharides, and nucleosides-exhibit anti-inflammatory, antioxidant, immunomodulatory, and anticancer….

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Optimization of the Probiotic Fermentation Process of Ganoderma lucidum Juice and Its In Vitro Immune-Enhancing Potential.

Fermented products have recently garnered substantial interest in both research and commercial contexts. Although probiotic fermentation is predominantly practiced with dairy, fruits, vegetables, and grains, its application to dual-purpose food-medicine materials like Ganoderma lucidum has been comparatively….

Cordyceps · 2026 · Research Article · Frontiers in pharmacology

Peptidomics-based identification of endogenous free peptides from Ophiocordyceps sinensis and functional validation of immunomodulatory peptide WALGT.

Ophiocordyceps sinensis (formerly known as Cordyceps sinensis), commonly referred to as "dongchongxiacao" in Chinese, is a valuable traditional Chinese medicine whose bioactive small molecules form the essential material basis for its therapeutic effects..

Mesima · 2026 · Preprint · journal metadata

Phellinus linteus polysaccharides alleviate DSS-induced colitis in mice by restoring gut microbiota homeostasis, preserving intestinal barrier integrity, and attenuating JAK2/STAT3-associated inflammatory signaling

Abstract Background & aims Phellinus linteus polysaccharides (PLP), bioactive polysaccharides derived from the traditional medicinal fungus Phellinus linteus, have shown potential anti-inflammatory activity..

Immune supportEnergy & fatigueGut & microbiomeLiver support

King Oyster · 2026 · Journal Article · Food science and biotechnology

Preparation, characterization and anti-fatigue activity of polysaccharides from Pleurotus eryngii.

The Pleurotus eryngii polysaccharides (PEP1) were isolated and purified. The structure of PEP1 was characterized, and its anti-fatigue activity was studied.

OncologyImmune supportEnergy & fatigueGut & microbiome

Cordyceps · 2026 · Journal Article · Current drug metabolism

Strain Evaluation and Multi-Generational Stability of Cordyceps militaris for Functional Bioactive Compound Production.

BACKGROUND: Cordyceps militaris is a medicinal fungus known for producing bioactive compounds, including cordycepin, adenosine, and polysaccharides, that exhibit antioxidant, immunomodulatory, and anticancer properties..

King Oyster · 2025 · Journal Article · Food Hydrocolloids

A comparison study on compounding oat β-glucan onto Pleurotus eryngii protein by using different methods: In vitro digestion and fermentation characteristics

This study aimed to investigate the effects under four different composite methods (electrostatic self-assembly, ultrasonic cavitation, high-pressure homogenization, and wet glycosylation), oat β-glucan (OG) on the in vitro digestion properties and in vitro fermentation properties of Pleurotus eryngii protein (PEP)..

Lion's Mane · 2025 · Journal Article · Food & function

Absorption and immune-modulating effects of active peptides from Hericium erinaceus proteins in an in vitro gastrointestinal model.

The mechanism by which fungal proteins retain immunomodulatory activity after gastrointestinal digestion remains unknown. To shed light on the mechanism, the proteins and peptides from Hericium erinaceus were explored through in vitro digestion using a Caco-2/RAW264.7 co-culture model..

Oyster Mushroom · 2025 · Research Article · Scientific reports

Agri-food wastes as substrates for oyster mushroom (Pleurotus ostreatus) cultivation and their agricultural potential.

Fungi of the Pleurotus genus, are known for their health-promoting properties. They are grown on a wide range of lignocellulosic substrates, including i.e.

Lion's Mane · 2025 · Research Article · Nutrients

Alteration of Gastrointestinal Function and the Ameliorative Effects of Hericium erinaceus Polysaccharides in Tail Suspension Rats.

Background/Objectives: Long-term spaceflight in a microgravity environment frequently results in gastrointestinal dysfunction, presenting substantial challenges to astronauts' health..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Wood Ear · 2025 · Research Article · Frontiers in nutrition

Ameliorating potential of Auricularia auricula-judae polysaccharides in mitigating hypercaloric diet-induced behavioral disorders through gut microbiota regulation.

As a major nutraceutical component of a traditional edible fungus Auricularia auricula-judae, Auricularia auricula-judae polysaccharide (AAP) has been well-documented due to its outstanding hypolipidemic and hypoglycemic bioactivities..

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Anti-Allergic Effects of Dietary Caterpillar Mushroom Cordyceps militaris (Ascomycota) Derived from Eri Silkworm.

Allergic disorders affect a substantial proportion of the global population, and current treatments often focus on symptom management rather than addressing the underlying immunological imbalances. Cordyceps militaris (L.) Fr.

OncologyImmune supportEnergy & fatigueGut & microbiome

Turkey Tail · 2025 · Journal Article · Food chemistry

Antioxidant, anti-inflammatory, and antiproliferative properties of extracted Turkey tail (Trametes versicolor Lloyd) mushroom components microencapsulated with inulin.

The stability, interactions, and bioaccessibility of bioactive components modify the potential functionality of newly developed inulin-based microcapsules containing polysaccharide (PF) and ethanol-extractable fractions (EEF) of turkey tail..

Maitake · 2025 · Preprint · journal metadata

Attenuative effect of Grifola frondosa (maitake mushroom) on severe DSS-induced colitis in vitamin D-deficient mice

Scope Vitamin D deficiency, which has been a global health issue for decades, is involved in gut health and diseases. We examined the health benefits of Grifola frondosa (maitake mushroom), a potent dietary source of fungal vitamin D (D 2 ), on DSS-induced colitis in vitamin D-deficient mice..

OncologyImmune supportCognition & nervesGut & microbiome

Lion's Mane · 2025 · Systematic Review · Frontiers in nutrition

Benefits, side effects, and uses of Hericium erinaceus as a supplement: a systematic review.

INTRODUCTION: Hericium erinaceus (HE), commonly known as the Lion's Mane mushroom, is an edible, medicinal fungus containing bioactive polysaccharides. It shows promising properties, including neuroprotective, anti-tumor, antioxidant, anti-proliferative, and anti-inflammatory effects..

Shiitake · 2025 · Research Article · Bioengineered

Biorefining spent substrates of shiitake (Lentinula edodes) and oyster mushroom (Pleurotus ostreatus): enzymatic saccharification of cellulose and xylan, with lignin recovery from residues.

Spent mushroom substrate (SMS), the main by-product of mushroom cultivation, is a source of sugars that can be released by saccharification. This work aimed at investigating the enzymatic saccharification of the polysaccharides of the SMS of shiitake (Lentinula edodes) and oyster mushroom (Pleurotus ostreatus) and….

Immune supportCognition & nervesMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies.

BACKGROUND: The human gut microbiota plays a crucial role in various aspects of health, extending beyond digestion and nutrient absorption. Ganoderma lucidum (Reishi) and Hericium erinaceus (Lion's Mane), traditional medicinal mushrooms, have garnered interest due to their potential to exert positive health effects..

Cordyceps · 2025 · Journal Article · Food Research International

Comparative analysis of nutritional and flavor compound alterations in Cordyceps militaris juice fermented by single or mixed Lactobacillus strains

Cordyceps militaris (CM) is a precious edible and medicinal mushroom known for its bioactive components, which can potentially be enhanced through microbial fermentation..

Immune supportGut & microbiomeRespiratory

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Cordyceps militaris alleviates COPD by regulating amino acid metabolism, gut microbiota and short chain fatty acids.

ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a global health challenge with the high morbidity and mortality. Cordyceps militaris (CM) is a medicinal fungus that has been widely used in Asia for centuries..

OncologyImmune supportMetabolic healthGut & microbiome

Cordyceps · 2025 · Research Article · Frontiers in immunology

Cordyceps militaris extract and cordycepin ameliorate LPS-challenged colonic damage in piglets by modulating the microbiota and metabolite profiles.

INTRODUCTION: Cordyceps militaris extract (CME) and cordycepin (CPN) are biomolecules with a wide range of biological activities, including anti-inflammatory, antioxidant and anti-tumour effects..

King Oyster · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Deciphering the yield limitation mechanisms in Pleurotus eryngii cultivation: A comparative study on red vs white corncob substrates

Asia's massive agricultural residues pose environmental challenges, yet their use in Pleurotus eryngii cultivation offers sustainable solutions. Red and white corncobs, despite structural similarities, exhibit distinct lignocellulose and bioactive profiles, influencing mushroom yield and nutrition..

Cordyceps · 2025 · Research Article · Microorganisms

Effect of Cordyceps militaris Residue and Lactiplantibacillus plantarum on Fermentation Quality and Bacterial Community of Alfalfa Silage.

In order to reduce the environmental burden associated with Cordyceps militaris residue, we conducted a study to explore the feasibility of Cordyceps militaris residue as a silage additive..

King Oyster · 2025 · Journal Article · Journal of agricultural and food chemistry

Effects and Mechanisms of Pleurotus eryngii Polysaccharide on Intestinal Barrier Damage: Based on the Perspective of Its Interaction with Intestinal Mucus during Gut Digestion.

In this study, pathways and mechanisms of action of a new type of Pleurotus eryngii polysaccharide (PEP) with known structural characteristics and probiotic properties in the intestine were investigated..

Immune supportEnergy & fatigueGut & microbiome

Cordyceps · 2025 · Research Article · Animal bioscience

Effects of Cordyceps militaris solid medium on the growth performance, immunity parameters and intestinal health of broilers.

OBJECTIVE: This study aimed to investigate the impact of Cordyceps militaris solid medium (CMM) on the growth performance, immunity parameters, intestinal health and gut microbiota of broilers..

Energy & fatigueMetabolic healthGut & microbiome

Oyster Mushroom · 2025 · Journal Article · Journal of applied poultry research

Effects of dietary inclusion of oyster mushroom (Pleurotus ostreatus) powder on live performance, physical meat quality, hemato-biochemical indices and cecal bacterial load in Sonali chickens

The current research aimed to assess the effects of oyster mushroom powder as potential alternative to antibiotic growth promoters on growth performance, physical meat quality, hemato-biochemical indices and cecal bacterial load in Sonali chickens..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Effects of Ganoderma lucidum fermentation on the structure of Tartary buckwheat polysaccharide and its impact on gut microbiota composition.

Fermentation modifies plant polysaccharides and enhances their bioactivity. In this study, polysaccharides were extracted from Ganoderma lucidum-fermented (FBP) and non-fermented (NBP) Tartary buckwheat.

King Oyster · 2025 · Research Article · Biomedicines

Effects of In Vitro Fermented Pleurotus eryngii on Intestinal Barrier Integrity and Immunomodulation in a Lipopolysaccharide-Induced Colonic Model.

Background: This study investigates the impact of fermentation supernatants (FSs) from Pleurotus eryngii whole mushrooms (PEWS), as well as its subcomponents, digested (PEWSD) and extracted (PEWSE) forms, on intestinal barrier function and immune modulation in lipopolysaccharide (LPS) -stimulated Caco-2 cells..

Metabolic healthGut & microbiome

Cordyceps · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Effects of selenium enrichment on the nutritional components, metabolites, and flavor volatiles of fermented Cordyceps militaris juice

Selenium (Se) enrichment changes the nutritional composition and secondary metabolites of Cordyceps militaris (CM), but its effect on the fermentation process of CM is still unclear..

OncologyImmune supportMetabolic healthGut & microbiome

King Oyster · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Enhancing the Nutritional and Health-Related Properties of Taralli Through the Use of Pleurotus eryngii: Focus on Antioxidant and Anti-Inflammatory Properties.

In this study, a portion of whole durum wheat semolina was replaced with Pleurotus eryngii powder (PeP) at concentrations of 5% and 10% (w/w) to produce two taralli variants, TPE5 and TPE10. The impact of PeP on the technological, chemical, physical, and sensory properties of taralli was evaluated..

Oyster Mushroom · 2025 · Journal Article · Environmental monitoring and assessment

Exploring bioremediation potential: sustainable treatment of landfill leachate with oyster mushroom (Pleurotus ostreatus) grown on different agro-industrial waste.

Landfill leachate poses significant environmental risks due to its high concentrations of heavy metals and harmful physicochemical properties, which threaten ecosystems and human health..

Shiitake · 2025 · Research Article · PloS one

Formulation of silages from spent mushroom substrates of Pleurotus ostreatus and Lentinula edodes: Organoleptic properties, phenolic content, in vitro digestibility, gas production and ruminal kinetics.

To fulfill the global demand for sustainable livestock production and the implementation of circular economy models, the search for alternative feed sources to lower production cost has increased significantly. The use of agro-industrial waste has proven to be a low-cost strategy for animal feed..

Energy & fatigueGut & microbiome

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Fusarium pseudonygamai Promotes Blastospore Transformation in Ophiocordyceps sinensis: Insights into Microbial Interaction and Key Mechanisms.

Chinese cordyceps, a highly valued traditional medicine, is formed when the fungal parasite Ophiocordyceps sinensis infects an underground caterpillar (Thitarodes). This interaction progresses slowly, as the larvae have a long developmental period and the fungus requires several months to complete its growth..