MycoData

Oyster Mushroom · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Co-Infection of Three Novel Deltaflexiviruses in an Isolate of the Edible Fungus Pleurotus ostreatus Reduces Fruiting Body Yield by Inhibiting Cellulase Activity.

Pleurotus ostreatus, a globally cultivated oyster mushroom, is susceptible to viral infections that threaten yield and quality. This study reports the identification and characterization of three novel viruses from a symptomatic P..

Cordyceps · 2026 · Journal Article · Molecular and cellular biochemistry

Deciphering the anticancer potential of an entomopathogenic fungus, Cordyceps militaris in Dalton's Lymphoma transplanted murine model: a multidimensional approach involving computational methods and in vivo validation.

Cordyceps militaris, a medicinal mushroom in traditional Chinese medicine, emerged as a promising source of bioactive compounds, exhibiting potent antioxidant, anti-inflammatory, anticancer, antiviral and immunomodulatory properties..

Oyster Mushroom · 2026 · Journal Article · Bioorganic chemistry

Mushroom-mediated silver nanoparticles from Pleurotus ostreatus as antimicrobial candidates against multidrug-resistant bacteria: Physicochemical, in-silico, cytotoxicity, and immunobiological evaluation.

The rise of antimicrobial resistance has heightened the demand for alternatives to traditional antibiotics, especially against multidrug-resistant (MDR) strains of Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniaei, and Pseudomonas aeruginosa..

Cordyceps · 2026 · Preprint · journal metadata

Nano-Encapsulated Cordyceps militaris Grown on Germinated Black Bean Attenuates PM- and LPS-Induced Airway Inflammation

Exposure to particulate matter (PM) containing bacterial endotoxins triggers oxidative stress and inflammation in the respiratory epithelium. In this study, we investigated chitosan nanoparticle-encapsulated Cordyceps militaris grown on germinated Rhynchosia nulubilis (GCN) as a potential functional food–derived….

Immune supportEnergy & fatigueRespiratory

Cordyceps · 2026 · Review · Journal of food science and technology

Nature's marvel: unravelling the multiphase composition of Cordyceps militaris mushroom and its implications as a dietary supplement.

UNLABELLED: This review article delves into the multiphase composition of Cordyceps militaris mushroom and explores its implications as a dietary supplement. C.

Immune supportMetabolic healthRespiratory

Reishi · 2026 · Research Article · Metabolites

Phytochemical Profiling and Bioactivity Evaluation of Ganoderma lucidum (Reishi Mushroom) Fractions: In Vitro Antioxidant, Antimicrobial, and Antidiabetic Activities.

Background/Objectives:Ganoderma lucidum (Curtis) P. Karst.

Immune supportCognition & nervesEnergy & fatigueRespiratory

Oyster Mushroom · 2026 · Research Article · ACS omega

Screening of Natural Inhibitors from Pleurotus ostreatus against PHGDH for Enhancing Antiviral Innate Immunity through Mendelian Randomization, Machine Learning, Molecular Docking, Molecular Dynamics Simulation, and Binding Free Energy Calculation.

The human innate immune response plays a critical role in limiting and controlling viral infections. Consequently, therapeutic strategies that promote or modulate innate antiviral immunity are regarded as promising approaches to combating viral pathogens..

Cordyceps · 2026 · Journal Article · The Journal of pharmacy and pharmacology

Study on the potential mechanism of Cordyceps militaris in chronic obstructive pulmonary disease via integrating metabolomics and network pharmacology.

OBJECTIVE: This research aimed to evaluate the beneficial impact of Cordyceps militaris (CM) on chronic obstructive pulmonary disease (COPD) and methodically clarify its underlying processes. METHODS: The fingerprint analysis and content determination of CM were carried out by HPLC..

Lion's Mane · 2025 · Review · Molecules (Basel, Switzerland)

Bioactive Polysaccharides from Hericium erinaceus: Extraction, Structure, Bioactivities, and Applications.

Hericium erinaceus, an edible fungus belonging to the family Odontaceae, is predominantly found in Western Europe, North America, and East Asia. In China, it primarily thrives in the mountainous and forested regions in the northeast, north, and southwest..

Immune supportGut & microbiomeRespiratory

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Cordyceps militaris alleviates COPD by regulating amino acid metabolism, gut microbiota and short chain fatty acids.

ETHNOPHARMACOLOGICAL RELEVANCE: Chronic obstructive pulmonary disease (COPD) is a global health challenge with the high morbidity and mortality. Cordyceps militaris (CM) is a medicinal fungus that has been widely used in Asia for centuries..

Immune supportEnergy & fatigueRespiratory

Reishi · 2025 · Journal Article · Journal of advanced research

Ganoderma lucidum spore powder enhances IFN-α-mediated antiviral capacity of COVID-19 vaccine boosters revealed by single-cell multi-omics sequencing.

INTRODUCTION: Reduced vaccine efficacy may hinder stable herd immunity. Traditional natural medicinal ingredients, such as Ganoderma lucidum products, have shown potential as safe and effective adjuvants to improve vaccine efficacy..

Almond Mushroom · 2025 · Research Article · Biomedicines

Immunomodulatory Effects of Multivitamin Complexes Containing Agaricus blazei in Patients Undergoing Curative Resection for Non-Small-Cell Lung Cancer: A Randomized, Double-Blind, Placebo-Controlled Multicenter Pilot Trial.

Background/Objectives: Surgical resection of non-small-cell lung cancer (NSCLC) often results in temporary suppression of natural killer cell activity (NKA), potentially increasing the risk of recurrence..

Immune supportGut & microbiomeRespiratory

Shiitake · 2025 · Journal Article · Biocatalysis and Agricultural Biotechnology

Immunomodulatory properties of a β-glucan-rich bioflour of Bactris gasipaes shells colonized by Lentinula edodes

Lentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived….

OncologyGut & microbiomeRespiratory

Cordyceps · 2025 · Journal Article · Anticancer research

Integrating Network Pharmacology and Optimization of Preparation Methods to Enhance the Anticancer Effect of Cordyceps militaris on Lung Cancer.

BACKGROUND/AIM: Cordyceps militaris, a medicinal fungus, is renowned for its anticancer properties. To maximize its therapeutic efficacy, this study aimed to optimize the extraction and preparation methods of Cordyceps militaris and evaluate its effects on non-small cell lung cancer (NSCLC)..

OncologyMetabolic healthRespiratory

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Internet of Things (IoT)-Driven Fermentation System for Enhanced Cordycepin Production in Cordyceps militaris (Ascomycetes) under Hypoxic Conditions.

Cordycepin, known for its tumor-suppressive and antiviral properties, has garnered attention due to its therapeutic and biological potential. Current Cordyceps militaris - based cordycepin production methods involve time-consuming and cost-intensive solid-state fermentation..

Energy & fatigueMetabolic healthRespiratory

Cordyceps · 2025 · Journal Article · Data in Brief

Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissues

Ophiocordyceps sinensis is a medicinal mushroom that has been traditionally used for promoting respiratory health and addressing diverse therapeutic needs. The data in this article provides insights into the metabolic profile of the cultivated fruiting body of Ophiocordyceps sinensis (xOs™) across different molecular….

Shiitake · 2025 · Research Article · Journal of virology

New insights into temperature-impacted mycovirus-fungus interactions regulated by a microRNA in Lentinula edodes.

The onset of symptoms in virus-infected mushrooms merits investigation. In this study, the influence of heat stress (HS) on the interaction between Lentinula edodes mycovirus HKB (LeV) and its mushroom host, Lentinula edodes, was explored, revealing that HS treatment facilitated LeV replication and compromised the….

Shiitake · 2025 · Journal Article · Virus genes

Rapid and visual detection of Lentinula edodes spherical virus using CRISPR/Cas12a-based RT-RPA.

Lentinula edodes (shiitake) is a globally important edible mushroom, but viral infections can hinder mycelial growth, reduce yield, and degrade quality, leading to economic losses. This study examined viral infections in L.

OncologyImmune supportSkin & hydrationRespiratory

Reishi · 2025 · Review · Pharmaceutics

Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer.

Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the major subtype, accounting for more than 85% of all lung cancer cases..

Reishi · 2025 · Research Article · Scientific reports

Selected strains of the Ganoderma lucidum complex from Finnish forests have excellent broadly acting antiviral properties.

Broadly acting antivirals are needed to complement vaccines in present and future pandemics and outbreaks as safe and sustainable tools for combating virus infections..

Cordyceps · 2025 · Research Article · Journal of microbiology and biotechnology

The Inhibitory Effects of Cordyceps militaris ARA301 Extract on Lipopolysaccharide-Induced Lung Injury in vivo.

Lung injury is a critical health concern associated with severe inflammatory responses and tissue damage that can weaken respiratory function and potentially become life-threatening in severe cases..

King Oyster · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Therapeutic Potential of Bioactive Compounds in Edible Mushroom-Derived Extracellular Vesicles: Isolation and Characterization of EVs from Pleurotus eryngii.

Background/Objectives: Over the past twenty years, there has been a rapid increase in studies aimed at comprehending how cells communicate with each other via Extracellular Vesicles (EVs), accompanied by a heightened interest in plant-derived extracellular vesicles due to their potential relevance in dietary….

OncologyEnergy & fatigueLiver supportRespiratory

Reishi · 2025 · Research Article · AMB Express

Unlocking Reishi's secrets: nutritional and medicinal traits of Ganoderma lucidum isolated from tree bark in Egypt.

Ganoderma lucidum is an edible mushroom with high consumption rates in many cultures especially East Asian. This study assessed the in-vitro antimicrobial, antitumor, antiviral as well as antioxidant capacity of Ganoderma lucidum water extract (GLWE)..

Cordyceps · 2024 · Journal Article · Archives of virology

A novel betapartitivirus isolated from Cordyceps militaris, an edible-medicinal mushroom.

In this study, we identified a novel partitivirus, named "Cordyceps militaris partitivirus 1" (CmPV1), in Cordyceps militaris strain RCEF7506. The complete genome of CmPV1 comprises two segments, dsRNA1 and dsRNA2, each encoding a single protein..

Immune supportCognition & nervesMetabolic healthRespiratory

Cordyceps · 2024 · Research Article · Heliyon

Adjuvant activity of cordycepin, a natural derivative of adenosine from Cordyceps militaris, on an inactivated rabies vaccine in an animal model.

Vaccination is the most feasible way of preventing rabies, an ancient zoonosis that remains a major public health concern globally. However, administration of inactivated rabies vaccination without adjuvants is always inefficient and necessitates four to five injections..

Immune supportGut & microbiomeRespiratory

Cordyceps · 2024 · Research Article · International journal of molecular sciences

Cordyceps militaris Grown on Germinated Rhynchosia nulubilis (GRC) Encapsulated in Chitosan Nanoparticle (GCN) Suppresses Particulate Matter (PM)-Induced Lung Inflammation in Mice.

Cordyceps militaris grown on germinated Rhynchosia nulubilis (GRC) exerts various biological effects, including anti-allergic, anti-inflammatory, and immune-regulatory effects..

Cordyceps · 2024 · Journal Article · International journal of medicinal mushrooms

Enhancing Cordycepin in Functional Porridge through Rice Varietal Fermentation with Cordyceps militaris (Ascomycetes) and Utilizing Non-Targeted Metabolomics for Process Enhancement.

Cordyceps militaris, a medicinal fungus rich in cordycepin, shows promise in treating diseases such as cancer, respiratory issues, and COVID-19. This study examines the impact of different Taiwanese rice varieties on its solid-state fermentation, focusing on optimizing cordycepin production..

OncologyRespiratory

Immune supportEnergy & fatigueMetabolic healthRespiratory

Cordyceps · 2024 · Journal Article · Journal of biomolecular structure & dynamics

Evaluation of Cordyceps militaris steroids as anti-inflammatory agents to combat the Covid-19 cytokine storm: a bioinformatics and structure-based drug designing approach.

Since the SARS-CoV-2 epidemic, researchers have been working on figuring out ways to tackle multi-organ failure and hyperinflation, which are brought on by a cytokine storm..

Immune supportMetabolic healthRespiratory

Turkey Tail · 2024 · Journal Article · Journal of AOAC International

Influence of Organic and Inorganic Compounds of Various Metals on the Synthesis of Polysaccharides by the Medicinal Mushroom Trametes versicolor.

BACKGROUND: To date, basidiomycetes are considered to be promising objects of biotechnology, due to a number of biologically active compounds, such as polysaccharides and triterpenes. These compounds have a high therapeutic potential and demonstrate immunomodulatory, antiviral, and antifungal activities..

Cordyceps · 2024 · Journal Article · Journal of basic microbiology

Optimization of Fermentation Conditions of Cordyceps militaris and In Silico Analysis of Antifungal Property of Cordycepin Against Plant Pathogens.

Cordyceps militaris, a medicinal fungus, has gained considerable attention owing to its potential health benefits, notably the production of bioactive compounds such as cordycepin. Cordycepin possesses significant antifungal, antibacterial, and antiviral properties..

Immune supportRespiratory

Cordyceps · 2024 · Research Article · Journal of Ayurveda and integrative medicine

Quest for Anti-SARS-CoV-2 antiviral therapeutics: in-silico and in-vitro analysis of edible mushroom- Cordyceps militaris.

BACKGROUND: The emergence and evolution of SARS-CoV-2 resulted a severe threat to public health globally. Due to the lack of an effective vaccine with durable immunity, the disease transited into the endemic phase, necessitating potent antiviral therapy including a scientific basis for current traditional herbal….

Energy & fatigueRespiratory

Chaga · 2024 · Journal Article · Journal of separation science

Rapid screening and isolation of 5-lipoxygenase inhibitors in Inonotus obliquus and mechanism of action in the treatment of asthma.

Accurate screening and targeted preparative isolation of active substances in natural medicines have long been two technical challenges in natural medicine research..

Cordyceps · 2024 · Research Article · Polymers

Structural Elucidation and Anti-Tumor Activity of a Polysaccharide (CP2-S) from Cordyceps militaris Fruit Bodies.

A polysaccharide (CP2-S), consisting of glucose with a weight average molecular weight of 5.9 × 106, was purified from the fruit bodies of Cordyceps militaris. In this work, the corresponding structure and anti-tumor activity in vivo were investigated..

Immune supportLiver supportRespiratory

Reishi · 2024 · Research Article · Toxics

The Protective Effects of Ganoderma lucidum Active Peptide GLP4 on Lung Injury Induced by Cadmium Poisoning in Mice.

Ganoderma triterpenes and spore powder have shown promising results in mitigating cadmium-induced renal and hepatic injuries. Ganoderma lucidum active peptide GLP4 is a natural protein with dual antioxidant activities derived from the mycelium of Ganoderma lucidum..

Oyster Mushroom · 2024 · Research Article · International journal of molecular sciences

Transcriptome Analysis Reveals the Effect of Oyster Mushroom Spherical Virus Infection in Pleurotus ostreatus.

Oyster mushroom spherical virus (OMSV) is a mycovirus that inhibits mycelial growth, induces malformation symptoms, and decreases the yield of fruiting bodies in Pleurotus ostreatus. However, the pathogenic mechanism of OMSV infection in P.

Cordyceps · 2024 · Research Article · Frontiers in microbiology

Unveiling mycoviral diversity in Ophiocordyceps sinensis through transcriptome analyses.

Ophiocordyceps sinensis, an entomopathogenic fungus, infects larvae from the Lepidoptera: Hepialidae family, forming the valuable Chinese cordyceps. Mycoviruses are widespread across major lineages of filamentous fungi, oomycetes, and yeasts and have the potential to influence fungal biology and ecology..

Immune supportRespiratory

Reishi · 2023 · Review · International journal of medicinal mushrooms

The Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Can Combat Cytokine Storm and Other COVID-19 Related Pathologies: A Review.

Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is characterized by acute respiratory distress syndrome (ARDS) facilitated by cytokine storm and other risk factors that increase susceptibility and complications leading to death..

Skin & hydrationRespiratory

Reishi · 2022 · Review · Foods (Basel, Switzerland)

Nutritional Profile and Health Benefits of Ganoderma lucidum "Lingzhi, Reishi, or Mannentake" as Functional Foods: Current Scenario and Future Perspectives.

Ganoderma lucidum has a long history of medicinal uses in the Far East countries of more than 2000 years due to its healing properties. Recently, G.

Immune supportEnergy & fatigueRespiratory

Cordyceps · 2021 · Review · Foods (Basel, Switzerland)

Cordyceps militaris: An Overview of Its Chemical Constituents in Relation to Biological Activity.

Cordyceps spp. mushrooms have a long tradition of use as a natural raw material in Asian ethnomedicine because of their adaptogenic, tonic effects and their ability to reduce fatigue and stimulate the immune system in humans..

Cordyceps · 2021 · Review · Frontiers in bioengineering and biotechnology

New Insights Into the Biosynthesis of Typical Bioactive Components in the Traditional Chinese Medicinal Fungus Cordyceps militaris.

Cordyceps militaris, a traditional medicinal ingredient with a long history of application in China, is regarded as a high-value fungus due to its production of various bioactive ingredients with a wide range of pharmacological effects in clinical treatment..

Chaga · 2021 · Review · Polymers

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application.

Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries. Among the extracts from Inonotus obliquus, Inonotus obliquus polysaccharide (IOPS) is supposed to be one of the major bioactive components in Inonotus obliquus, which….

Cordyceps · 2025 · Journal Article · Plant science

Overexpression of Cordyceps militaris Cmcns1/cns2 gene to produce cordycepin results in increased resistance to Ralstonia solawacearum, Alternaria alternate and TMV in tobacco(Nicotiana tabacum L.)

Cordycepin (COR), the first nucleoside antibiotic isolated from fungi, exhibits antibacterial, antitumor, antiviral, and anti-inflammatory activities. In this study, we constructed a Cmcns1/cns2 fusion gene vector and transformed tobacco using Agrobacterium tumefaciens-mediated genetic transformation..

Cordyceps · 2025 · Journal Article · Plant science: an international journal of experimental plant biology

Overexpression of Cordyceps militaris Cmcns1/cns2 gene to produce cordycepin results in increased resistance to Ralstonia solawacearum, Alternaria alternate and TMV in tobacco(Nicotiana tabacum L.).

Chaga · 2024 · Review · Fungal biology and biotechnology

A review on the cultivation, bioactive compounds, health-promoting factors and clinical trials of medicinal mushrooms Taiwanofungus camphoratus, Inonotus obliquus and Tropicoporus linteus.

Medicinal mushrooms, such as Taiwanofungus camphoratus, Inonotus obliquus, and Tropicoporus linteus, have been used in traditional medicine for therapeutic purposes and promotion of overall health in China and many East Asian countries for centuries..

Oyster Mushroom · 2023 · Preprint · journal metadata

Molecular characterization of a novel deltaflexivirus infecting the edible fungus Pleurotus ostreatus

Abstract A novel positive single-stranded RNA virus, Pleurotus ostreatus deltaflexivirus 1 (PoDFV1), was isolated from an edible fungus Pleurotus ostreatus strain ZP6. The complete genome of PoDFV1 is 7706 nucleotides (nt) longand contains a short poly(A) tail..

Cordyceps · 2023 · Preprint · journal metadata

Therapeutic potential of Cordyceps militaris mushroom against SARS-CoV-2: Virtual screening against Mpro and in vitro validation

Pathogenic coronavirus, including COVID-19, threatens human health, and there are strong demands for efficient therapeutics. Cordyceps militaris is a medicinal mushroom that has long been used for immune enhancement, anticancer, and antiviral effects.

Almond Mushroom · 2021 · Preprint · journal metadata

Subcritical Water Extracts from Agaricus blazei Murrill's Mycelium Inhibits the Expression of Immune Checkpoint Molecules and Axl receptor

Agaricus blazei Murrill or Himematsutake is an edible and medicinal mushroom. Agaricus blazei Murrill's fruiting body extracts have anticancer properties, although the mechanism is unknown..

OncologyEnergy & fatigueRespiratory

Cordyceps · 2026 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Cordycepin-Enriched Cordyceps militaris Extract ARA815 Induces Ferroptosis in Lung Cancer Cells In Vivo and In Vitro.

Cordyceps militaris, a traditional medicinal fungus and a promising food supplement, has demonstrated anticancer potential, yet its underlying mechanisms and in vivo efficacy remain poorly defined. Previously, we developed an optimized extraction and preparation protocol to enrich the bioactive content of C..