MycoData

The growth-specialized metabolism trade-off limits fungal natural product production. Here, we investigated cordycepin overproduction in Cordyceps militaris high-yield GYS60 and low-yield GYS80 via comparative proteomics, Post-Translational Modification (PTM) mapping, and metabolomics..

Metabolic health

High relevance

Cordyceps · 2026 · Research Article · Nutrients

Bifidobacterium animalis ssp. lactis 420 and Cordyceps militaris Synergistically Modulate the Gut Microbiota by Increasing Mucin 2 Production.

BACKGROUND: Probiotics and medicine food homology are known to offer gentle approaches to prevent obesity, although it is difficult with such approaches to satisfy consumers' requirements to lose weight quickly. The probiotic strain Bifidobacterium animalis ssp..

Immune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2026 · Journal Article · Fitoterapia

Comparative computational analysis of the hypolipidaemic potential of Cordyceps militaris and Ophiocordyceps sinensis, with in vivo validation of cordycepin.

Hyperlipidaemia (HLP) arises from impaired lipid homeostasis in the setting of chronic low-grade inflammation, yet mechanistic comparisons between the edible medicinal fungi Cordyceps militaris and Ophiocordyceps sinensis remain scarce..

Immune supportMetabolic healthLiver support

High relevance

Cordyceps · 2026 · Research Article · Life (Basel, Switzerland)

Cordyceps militaris Enhances Wound Repair Through Regulation of HIF-1α, TGF-β1, and SIRT1/Nrf2/HO-1 Signaling in Diabetic Skin.

Chronic diabetic wounds are characterized by persistent inflammation, impaired angiogenesis, oxidative stress, and defective tissue remodeling, leading to delayed healing..

Immune supportMetabolic healthSkin & hydration

High relevance

Reishi · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Development of a CRISPR/Cas9 Genome Editing System in Dikaryotic Ganoderma lucidum for Targeting Key CYP450 Gene Involved in Triterpenoid Synthesis.

Currently, most research on CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) gene editing in edible fungi focuses on monokaryotic strains. However, the biological mechanisms in a monokaryotic state often do not accurately reflect the actual physiological and metabolic conditions of dikaryotic….

Energy & fatigueMetabolic health

High relevance

Cordyceps · 2026 · Research Article · Synthetic and systems biotechnology

Discovery of functional compounds from dimorphic edible Ophiocordyceps sinensis fungus in host haemolymph.

Chinese cordyceps, with a fruiting body of Ophiocordyceps sinensis from insect cadaver, is well-known health food. During formation, O.

OncologyMetabolic health

High relevance

Cordyceps · 2026 · Research Article · International journal of endocrinology

Effect of Cordyceps militaris Extract on Visceral Adipose Tissue Changes After Ovariectomy in Rodents.

The increasing global prevalence of obesity, exacerbated by factors such as high-fat diets and reduced physical activity, poses a substantial risk for lifestyle-related diseases, particularly in postmenopausal women..

Metabolic health

High relevance

Shiitake · 2026 · Journal Article · Bioscience, biotechnology, and biochemistry

Excavation of Lentinula edodes-stem-derived peptides doubly inhibiting DPP-IV and ACE activity.

Type Ⅱ diabetes and hypertension often coexist, affecting each other. Suppressing dipeptidyl peptidase-4 (DPP-Ⅳ) and angiotensin-I-converting enzyme (ACE) activity is crucial for managing these conditions..

Metabolic health

High relevance

Reishi · 2026 · Preprint · journal metadata

Exploring the effect and mechanism of Ganoderma lucidum Polysaccharides on improving Paediatric MASLD based on network pharmacology and animal experiment

Abstract Background Paediatric Metabolic dysfunction-associated steatotic liver disease (MASLD) is a metabolic disorder resulting from chronic hepatic steatosis. Ganoderma lucidum polysaccharide (GLP) have several pharmacological effects..

Immune supportEnergy & fatigueMetabolic healthLiver support

High relevance

Reishi · 2026 · Review · Metabolites

Ganoderma lucidum as a Functional Bioactive Candidate for Glycemic Regulation: Mechanisms, Preclinical Evidence, and Clinical Translation.

Type 2 diabetes mellitus (T2DM) is a major global health challenge that has intensified interest in multi-target nutraceuticals with potential adjunctive benefits..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Yellow Morel · 2026 · Research Article · Foods (Basel, Switzerland)

In Silico Structural Characterization and Hypoglycemic Potential of a Novel Fucose-Specific Lectin (MEP5) from Morchella esculenta.

Natural food-derived proteins are increasingly explored as alternatives to synthetic inhibitors for managing Type 2 diabetes mellitus. Despite the recognized health-promoting properties of Morchella esculenta, the potential of its bioactive proteins to modulate glucose metabolism remains largely unexplored..

Cognition & nervesMetabolic healthGut & microbiome

High relevance

King Oyster · 2026 · Journal Article · Innovative Food Science and Emerging Technologies

Incorporation of yeast protein improves the textural properties of a fungal meat analogue from Pleurotus eryngii mycelium

The increasing demand for high-quality mycoprotein meat analogues necessitates the development of innovative ingredients and formulations. This study aimed to develop a novel mycoprotein meat analogue from Pleurotus eryngii mycelium (PM) produced via submerged fermentation and to systematically investigate the….

Metabolic health

High relevance

Cordyceps · 2026 · Journal Article · Bioscience, biotechnology, and biochemistry

Inhibition of hepatic lipogenesis and adipogenesis by cordyanhydride A isolated from Cordyceps Militaris cultivated on germinated soybeans.

Regulation of lipid homeostasis requires coordinated control of fatty acid (FA) oxidation, lipogenesis, and adipocyte differentiation. Cordyanhydride A (CA) was isolated from Cordyceps militaris (CM) extract cultivated on germinated soybean through bioactivity-guided fractionation and structurally characterized using….

Immune supportMetabolic healthLiver support

High relevance

Chaga · 2026 · Journal Article · Journal of ethnopharmacology

Inonotus obliquus (Ach. ex Pers.) Pilát aqueous extract alleviates acute cold exposure/rewarming-induced myocardial injury by regulating mitochondrial dynamics via liver kinase B1/adenosine monophosphate-activated protein kinase/peroxisome proliferator-activated receptor gamma coactivator-1 alpha signaling pathway activation.

ETHNOPHARMACOLOGICAL RELEVANCE: Acute cold exposure affects the cardiovascular system substantially. Inonotus obliquus (Ach.

Energy & fatigueMetabolic healthLiver support

High relevance

Chaga · 2026 · Review · Nutrients

Inonotus obliquus Polysaccharides: Preparation, Structural Characteristics, Structure-Activity Relationships, Biological Activities and Applications.

Inonotus obliquus, a rare medicinal and edible fungus, is rich in bioactive polysaccharides. These polysaccharides exhibit diverse biological activities, including gut microbiota-modulating, hypoglycemic, immunomodulatory, antitumor, antioxidant, hypolipidemic, and antiviral activities..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2026 · Research Article · Veterinary sciences

Investigation of Pleurotus Ostreatus Mushroom-Based Feed Supplementations on Growth Performance and Immune Function in Male Japanese Quails (Coturnix Japonica).

Growing concern over antibiotic resistance in poultry production has increased interest in natural feed additives such as Pleurotus ostreatus (oyster mushroom)-derived products..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Reishi · 2026 · Systematic Review · Frontiers in pharmacology

Mechanism of Ganoderma lucidum polysaccharides in the mangement of diabetes and its complications.

Characterized by a total or partial shortage of insulin, diabetes is a chronic metabolic condition. Its widespread occurrence and related complications present a significant global public health issue.

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Metabolomic and proteomic analysis reveals the metabolic changes of alkaloids in Ganoderma lucidum fermented tea.

Fermentation is the key to the quality formation of Ganoderma lucidum fermented tea (GLFT). This study reveals the metabolic changes of alkaloids and related metabolites during the fermentation process of Ganoderma lucidum tea..

Metabolic health

High relevance

Lion's Mane · 2026 · Preprint · journal metadata

Methyl viologen boosts Erinacine A biosynthesis in Hericium erinaceus fermentation: Multi-omics insights

Abstract Erinacine A, a critical secondary metabolite of Hericium erinaceus, has garnered significant interest due to its bioactive properties. This study aimed to investigate the effects of methyl viologen (MV) on the synthesis of Erinacine A during liquid fermentation of Hericium erinaceus, employing a multi-omics….

Cognition & nervesEnergy & fatigueMetabolic healthSkin & hydration

High relevance

Cordyceps · 2026 · Journal Article · Food Research International

Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide

Diet-based modulation of the gut microbiota has emerged as a promising strategy to alleviate obesity and its related complications. Our previous study demonstrated that polysaccharide derived from Cordyceps militaris (CMP) exerts anti-obesity effects, yet the specific mechanism linking gut microbiota to its metabolic….

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Cordyceps · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide.

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Cordyceps · 2026 · Research Article · Synthetic and systems biotechnology

OmniEdit: A unified CRISPR/Cas9 platform for precise genome engineering and strain optimization of the Cordyceps militaris cell factory.

Cordyceps militaris serves as a critical microbial cell factory for high-value bioactive compounds; however, the scarcity of versatile and sophisticated genome-editing toolsets significantly restricts its systematic metabolic engineering..

Energy & fatigueMetabolic healthLiver support

High relevance

Cordyceps · 2026 · Journal Article · Scientific reports

Optimization of cordycepin fermentation by Cordyceps militaris via response surface methodology.

Cordycepin is a bioactive compound with demonstrated immunoregulatory, antioxidant, and organ-protective properties. This study aimed to significantly enhance the production of cordycepin in Cordyceps militaris fermentation through systematic process optimization..

Immune supportMetabolic health

High relevance

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Optimization of the Probiotic Fermentation Process of Ganoderma lucidum Juice and Its In Vitro Immune-Enhancing Potential.

Fermented products have recently garnered substantial interest in both research and commercial contexts. Although probiotic fermentation is predominantly practiced with dairy, fruits, vegetables, and grains, its application to dual-purpose food-medicine materials like Ganoderma lucidum has been comparatively….

Immune supportMetabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2026 · Journal Article · Burns: journal of the International Society for Burn Injuries

Oral Pleurotus ostreatus supplementation modulates systemic inflammation and enhances collagen density in a full-thickness burn rat model.

Severe burn injuries cause hypermetabolic and inflammatory responses characterized by hypoalbuminemia and elevated cytokines that delay wound healing. Pleurotus ostreatus, known for its bioactive compounds and high-quality protein, may support recovery by improving systemic nutritional and inflammatory balance..

OncologyImmune supportMetabolic healthSkin & hydration

High relevance

Cordyceps · 2026 · Journal Article · Bioresource technology

Pheromone-mediated quorum sensing enables dynamic regulation of cordycepin biosynthesis in Cordyceps militaris.

Cordycepin is a nucleoside compound with broad pharmacological activities, whose biosynthesis is tightly regulated by multilayered metabolic mechanisms. Dynamic regulation strategies allow for precise modulation of target product synthesis while maintaining cell growth, thus overcoming the limitations of static….

Metabolic health

High relevance

Reishi · 2026 · Research Article · Metabolites

Phytochemical Profiling and Bioactivity Evaluation of Ganoderma lucidum (Reishi Mushroom) Fractions: In Vitro Antioxidant, Antimicrobial, and Antidiabetic Activities.

Background/Objectives:Ganoderma lucidum (Curtis) P. Karst.

Immune supportMetabolic healthRespiratory

High relevance

Cordyceps · 2026 · Preprint · journal metadata

Pleiotropic Bioactivity of Caterpillar Fungus and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework

The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus) is one of the most popular medicines in Asian traditional medical systems for its pleiotropic indications, including an ability to enhance “vitality”. However, the polyvalent adaptogenic potential of O..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2026 · Review · Pharmaceuticals (Basel, Switzerland)

Pleiotropic Bioactivity of Caterpillar Fungus, Orange Cordyceps, and Cordycepin: Insight from Integrated Network Pharmacology and Food and Drug Regulatory Framework.

Background/Objectives: The medical mushroom Ophiocordyceps sinensis (Caterpillar Fungus), known for its ability to enhance "vitality," is one of the most popular medicines in Asian traditional medical systems. According to the Chinese Pharmacopeia, O..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Snow Fungus · 2026 · Review · International journal of biological macromolecules

Research progress in polysaccharides from the Tremella fuciformis (silver ear): extraction, purification, structural features, health-promoting activities, and potential applications.

Tremella fuciformis polysaccharides (TFPs), as one of the pivotal functional constituents of T. fuciformis, have attracted increasing attention because of their diverse health-promoting activities..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2026 · Journal Article · Bioresource technology

Role of the global regulatory factor VeA in Cordyceps militaris and its overexpression combined with tea polyphenols to enhance cordycepin production.

Cordyceps militaris has recently been regarded as a promising chassis for high-value compound production owing to its advantage in liquid fermentation, while further exploration of genetic targets and exogenous effectors is needed to enhance its productivity..

Metabolic health

High relevance

Cordyceps · 2026 · Journal Article · The Journal of pharmacy and pharmacology

Study on the potential mechanism of Cordyceps militaris in chronic obstructive pulmonary disease via integrating metabolomics and network pharmacology.

OBJECTIVE: This research aimed to evaluate the beneficial impact of Cordyceps militaris (CM) on chronic obstructive pulmonary disease (COPD) and methodically clarify its underlying processes. METHODS: The fingerprint analysis and content determination of CM were carried out by HPLC..

Metabolic healthRespiratory

High relevance

Shiitake · 2026 · Research Article · Foods (Basel, Switzerland)

Synergistic Mechanistic Insights into Anti-T2DM Benefits of Lentinula edodes: A Peptide- and Polysaccharide-Based Network Pharmacology and Molecular Docking Study.

In recent years, dietary intervention has garnered significant attention for T2DM prevention and adjunctive treatment. Lentinula edodes (commonly known as shiitake mushroom), a common edible fungus, has been demonstrated to improve T2DM, primarily attributed to its main bioactive components like peptides and….

Immune supportMetabolic health

High relevance

Cordyceps · 2026 · Research Article · AMB Express

Transcriptomic insights into the role of CmLec4 in infection and development of Cordyceps militaris.

Entomopathogenic fungi are a diverse group of ascomycetes that infect insects and form fruiting bodies, with over 1,000 species reported globally. Among them, Cordyceps militaris has long been valued in East Asia as a traditional medicinal resource, reflecting its recognized pharmacological potential..

Cognition & nervesMetabolic health

High relevance

Cordyceps · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Understanding the integral stereoselectivity of Cordyceps militaris lipase for medium-chain triglycerides: Tricaprylin-based kinetic and molecular docking analysis.

Medium-chain triglycerides (MCTs) have garnered considerable attention in the food and health industries due to their rapid absorption, efficient metabolism, and nutritional benefits compared to long-chain triglycerides..

Metabolic health

High relevance

Cordyceps · 2026 · Preprint · journal metadata

Untargeted metabolomics reveals species-specific metabolic signatures in Pholiota nameko, Cordyceps militaris and Lentinula edodes

Abstract Edible fungi are increasingly valued for their nutritional and medicinal properties, yet systematic comparisons of metabolic profiles among commercially important species remain limited..

Metabolic health

High relevance

Reishi · 2025 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Research progress on chemical constituents and pharmacological effects of Ganoderma lucidum spore oil].

Originating from sporoderm-broken Ganoderma lucidum spores, Ganoderma lucidum spore oil(GLSO) is prepared by supercritical fluid extraction. Chemical composition studies show that GLSO mainly contains nonpolar substances, such as fatty acids, triglycerides, and steroids..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Reishi · 2025 · Review · Naunyn-Schmiedeberg's archives of pharmacology

A review of the extraction technologies, structural characterization, chemical modification, and pharmacological effects of Ganoderma lucidum polysaccharides.

Ganoderma lucidum (GL) is a medicinal and edible fungal material with a long history. Ganoderma lucidum polysaccharides (GLPs), as one of the primary bioactive components in GL, exhibit multiple pharmacological effects including anti-tumor, anti-inflammatory, immunomodulatory, antioxidant, and metabolic regulatory….

OncologyImmune supportMetabolic health

High relevance

Turkey Tail · 2025 · Research Article · Frontiers in toxicology

A toxicological assessment of Hericium erinaceus (Lion's mane) and Trametes versicolor (Turkey tail) mushroom powders.

Hericium erinaceus (Lion's mane) and Trametes versicolor (Turkey Tail) mushrooms have an extensive history of use in traditional medicine and as food. Oftentimes, they are available as extract preparations produced from selected life stages such as fruiting body or mycelium..

Metabolic health

High relevance

Yellow Morel · 2025 · Journal Article · Food Chemistry

ACE-inhibitory peptides from Morchella esculenta: screening, kinetics, and molecular dynamics simulation

The global prevalence of hypertension has doubled over the past three decades and it is projected to escalate further. Hypertension is a global health concern that is closely linked to angiotensin-converting enzyme (ACE) regulation..

Metabolic health

High relevance

Yellow Morel · 2025 · Journal Article · Food chemistry

ACE-inhibitory peptides from Morchella esculenta: screening, kinetics, and molecular dynamics simulation.

Metabolic health

High relevance

Lion's Mane · 2025 · Research Article · Nutrients

Alteration of Gastrointestinal Function and the Ameliorative Effects of Hericium erinaceus Polysaccharides in Tail Suspension Rats.

Background/Objectives: Long-term spaceflight in a microgravity environment frequently results in gastrointestinal dysfunction, presenting substantial challenges to astronauts' health..

Immune supportMetabolic healthGut & microbiome

High relevance

Wood Ear · 2025 · Research Article · Frontiers in nutrition

Ameliorating potential of Auricularia auricula-judae polysaccharides in mitigating hypercaloric diet-induced behavioral disorders through gut microbiota regulation.

As a major nutraceutical component of a traditional edible fungus Auricularia auricula-judae, Auricularia auricula-judae polysaccharide (AAP) has been well-documented due to its outstanding hypolipidemic and hypoglycemic bioactivities..

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Shiitake · 2025 · Research Article · Food chemistry: X

Assessment of the correlations among 1,2-dicarbonyl compounds, advanced glycation end products, and raw material chemical components of fried shiitake mushroom (Lentinula edodes) crisps.

This study investigated the formation of harmful Maillard reaction products (MRPs), particularly advanced glycation end products (AGEs) and 1,2-dicarbonyl compounds, in fried shiitake mushroom crisps prepared from ten types of Lentinula edodes, in relation to their inherent chemical components..

Metabolic health

High relevance

Lion's Mane · 2025 · Review · Molecules (Basel, Switzerland)

Bioactive Polysaccharides from Hericium erinaceus: Extraction, Structure, Bioactivities, and Applications.

Hericium erinaceus, an edible fungus belonging to the family Odontaceae, is predominantly found in Western Europe, North America, and East Asia. In China, it primarily thrives in the mountainous and forested regions in the northeast, north, and southwest..

OncologyImmune supportMetabolic healthRespiratory

High relevance

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB/BDNF signaling and microbiota-driven synergies.

BACKGROUND: The human gut microbiota plays a crucial role in various aspects of health, extending beyond digestion and nutrient absorption. Ganoderma lucidum (Reishi) and Hericium erinaceus (Lion's Mane), traditional medicinal mushrooms, have garnered interest due to their potential to exert positive health effects..

Immune supportCognition & nervesMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Journal of pharmaceutical and biomedical analysis

Characterization of metabolites of ganoderic acids extract from Ganoderma lucidum in rats using UHPLC-MS/MS.

Ganoderic acids, the primary active compound cluster in Ganoderma lucidum (Chinese name: Lingzhi), one of the most reputed herbal medicines, play a crucial role in its immunomodulatory, anti-inflammatory, and anticancer properties..

OncologyImmune supportMetabolic health

High relevance

Reishi · 2025 · Randomized Controlled Trial · Nutrients

Clinical Evaluation of Ganoderma lucidum Spore Oil for Triglyceride Reduction: A Randomized, Double-Blind, Crossover Study.

Background: Ganoderma lucidum spore oil (GLSO) is widely recognized for its notable medicinal and nutritional properties. This study aimed to systematically evaluate the efficacy and safety of GLSO extract in individuals with dyslipidemia..

Metabolic healthLiver support

High relevance

Shiitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Comparative Analysis of Volatile Aroma Compounds, Fatty Acids, and LOX Pathway Gene Expression of Two Lentinula edodes Mycelia.

Although the aroma profile of Lentinula edodes has been extensively studied in fruiting bodies, the mycelial stage provides a distinct context for elucidating the fundamental metabolic pathways, free from the complexities of organismal development. To elucidate the mechanism underlying aroma differences between L..

Metabolic health

High relevance

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Cordycepin Extracted from Cordyceps militaris mitigated CUMS-induced depression of rats via targeting GSK3β/β-catenin signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordycepin, the main active component of Cordyceps militaris, exhibits various pharmacological activities, including anti-tumor and antioxidant effects. However, its antidepressant effect and the underlying mechanisms remain unclear..

OncologyCognition & nervesMetabolic health