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OncologyImmune supportLiver support

Mesima · 2024 · Research Article · Cancer immunology, immunotherapy: CII

Phellinus linteus activates Treg cells via FAK to promote M2 macrophage polarization in hepatocellular carcinoma.

Hepatocellular carcinoma (HCC) is the most prevalent malignant tumor worldwide. Within HCC's tumor microenvironment, focal adhesion kinase (FAK) plays a critical role..

OncologyImmune supportGut & microbiomeSkin & hydration

Oyster Mushroom · 2024 · Journal Article · Environmental pollution (Barking, Essex: 1987)

Pleurotus ostreatus polysaccharide-mediated modulation of skin damage caused by microcystin-LR in tadpoles.

In this study, we aimed to evaluate the effect of dietary supplementation with edible mushroom (Pleurotus ostreatus)-derived polysaccharides on microcystin leucine-arginine (MC-LR)-induced skin damage in Pelophylax nigromaculatus tadpoles..

OncologyImmune supportMetabolic healthLiver support

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Polysaccharide with anticancer activity from Grifola frondosa cultured in industrial wastewater of Agaricus bisporus.

Culture conditions for Grifola frondosa using Agaricus bisporus industrial wastewater as a medium were optimized using Plackett-Burman and Box-Behnken methodologies. Plackett-Burman screening identified culture temperature, shaking speed, and wastewater solubility as the key factors influencing G.

OncologyImmune supportCognition & nervesMetabolic health

Oyster Mushroom · 2024 · Journal Article · Food Research International

Preparation, structural characterization and neuroprotective effects to against H2O2-induced oxidative damage in PC12 cells of polysaccharides from Pleurotus Ostreatus

Pleurotus ostreatus is one of the most common edible and medicinal fungi in life, and its polysaccharide has been a hot research topic in recent years. In this paper, a new intracellular polysaccharide component named P.

OncologyImmune supportCognition & nervesLiver support

Chaga · 2024 · Journal Article · International journal of biological macromolecules

Protective effect of Inonotus obliquus polysaccharide on mice infected with Neospora caninum.

The study aimed to explore the protective effects of Inonotus obliquus polysaccharide (IOP) on Neospora caninum (N. caninum) infection.

Reishi · 2024 · Research Article · Frontiers in pharmacology

Protective effects of Ganoderma lucidum spores on estradiol benzoate-induced TEC apoptosis and compromised double-positive thymocyte development.

Backgroud: Thymic atrophy marks the onset of immune aging, precipitating developmental anomalies in T cells. Numerous clinical and preclinical investigations have underscored the regulatory role of Ganoderma lucidum spores (GLS) in T cell development..

OncologyCognition & nerves

Reishi · 2024 · Journal Article · Journal of agricultural and food chemistry

Rapid Discovery of Aβ42 Fibril Disintegrators from Ganoderma lucidum via Ligand Fishing and Their Neuroprotective Effects on Alzheimer's Disease.

An amyloid-β (Aβ) fibril is a vital pathogenic factor of Alzheimer's disease (AD). Aβ fibril disintegrators possess great potential to be developed into novel anti-AD agents..

Oyster Mushroom · 2024 · Journal Article · Preparative biochemistry & biotechnology

Recovery and partial purification of fibrinolytic protease from Pleurotus ostreatus and P. eryngii and cytotoxic and antioxidant activity of their extracts.

Mushrooms are a source of primary and secondary metabolites. Little is known about the most suitable conditions for production of mushrooms by submerged fermentation..

Enoki · 2024 · Research Article · International journal of molecular sciences

Renoprotective Effects of Brown-Strain Flammulina velutipes Singer in Chronic Kidney Disease-Induced Mice Through Modulation of Oxidative Stress and Inflammation and Regulation of Renal Transporters.

Cisplatin, widely used in chemotherapy, acts through mechanisms such as oxidative stress to damage the DNA and cause the apoptosis of cancer cells. Although effective, cisplatin treatment is associated with considerable side effects including chronic kidney disease (CKD)..

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Selenochemical modification of low molecular weight polysaccharides from Grifola frondosa and the mechanism of their inhibitory effects on gastric cancer cells.

An important micronutrient involved in immune response and antitumor is selenium. LMW-GFP, a polysaccharide extracted from Grifola frondosa seed bodies, has a relatively weak antitumor effect on BGC-823 and MFC cells in vitro, whereas selenium binding to LMW-GFP can significantly increase the in vitro antitumor….

OncologyEnergy & fatigueLiver support

Reishi · 2024 · Research Article · Frontiers in pharmacology

Senolytic effect of triterpenoid complex from Ganoderma lucidum on adriamycin-induced senescent human hepatocellular carcinoma cells model in vitro and in vivo.

BACKGROUND: Ganoderma lucidum (G. lucidum) is a famous medicinal mushroom that has been reported to prevent and treat a variety of diseases.

Chaga · 2024 · Journal Article · International journal of biological macromolecules

Structural characterization of the polysaccharide from the black crystal region of Inonotus obliquus and its effect on AsPC-1 and SW1990 pancreatic cancer cell apoptosis.

In this study, one water soluble polysaccharide (IOP1-1) with a weight average molecular weight of 6886 Da was obtained from the black crystal region of Inonotus obliquus by hot water extraction, DEAE-52 cellulose extraction and Sephadex-100 column chromatography purification..

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Synthesis and characterization of selenium nanoparticles stabilized by Grifola frondosa polysaccharides and gallic acid conjugates.

Selenium nanoparticles (SeNPs) are of interest for their versatility and low toxicity, but bare SeNPs are unstable and tend to aggregate and precipitate as black elemental Se, which limits the application of SeNPs..

OncologyImmune supportLiver supportSkin & hydration

Reishi · 2024 · Journal Article · Carbohydrate polymers

Targeting TGFβ receptor-mediated snail and twist: WSG, a polysaccharide from Ganoderma lucidum, and it-based dissolvable microneedle patch suppress melanoma cells

Cutaneous melanoma is a lethal skin cancer variant with pronounced aggressiveness and metastatic potential. However, few targeted medications inhibit the progression of melanoma.

OncologyImmune supportLiver supportSkin & hydration

Reishi · 2024 · Journal Article · Carbohydrate polymers

Targeting TGFβ receptor-mediated snail and twist: WSG, a polysaccharide from Ganoderma lucidum, and it-based dissolvable microneedle patch suppress melanoma cells.

Cutaneous melanoma is a lethal skin cancer variant with pronounced aggressiveness and metastatic potential. However, few targeted medications inhibit the progression of melanoma.

Reishi · 2024 · Research Article · Reproductive sciences (Thousand Oaks, Calif.)

The Efficacy of Ganoderma lucidum Extracts on Treating Endometrial Cancer: A Network Pharmacology Approach.

Ganoderma lucidum (GL) is a prominent medicinal mushroom in traditional Chinese medicine, known for its potent antitumor properties. This study aimed to illustrate the efficacy of GL extracts (GLE) on treating endometrial cancer (EC) and explore the underlying mechanisms via network pharmacology and experimental….

Shiitake · 2024 · Journal Article · Biological & pharmaceutical bulletin

The Tumor Growth Inhibitory Effect of a Standardized Extract of Cultured Lentinula edodes Mycelia Using Patient Derived Xenograft Model

Patient derived xenograft (PDX) is a powerful tool to confirm pharmacological efficacy in non-clinical studies for the development of various drugs including anti-cancer agents and therapeutic research. A standardized extract of cultured Lentinula edodes mycelia, a product name AHCC® is produced by Amino Up Co., Ltd..

Reishi · 2024 · Journal Article · Phytochemistry

Triterpenes from antler-shaped fruiting body of Ganoderma lucidum and their hepatoprotective activities.

Seven previously undescribed triterpenes (1-7), as well as one triterpene (8) previously described as a synthetic product, were isolated from the antler-shaped fruiting body of Ganoderma lucidum. Their structures were established based on comprehensive spectroscopy analysis..

OncologyLiver support

OncologyImmune supportGut & microbiome

Reishi · 2023 · Review · Chinese medicine

A review of anti-tumour effects of Ganoderma lucidum in gastrointestinal cancer.

Gastrointestinal (GI) cancer is the most common cancer in the world and one of the main causes of cancer-related death. Clinically, surgical excision and chemotherapy are the main treatment methods for GI cancer, which is unfortunately accompanied with serious adverse reactions and drug toxicity, bringing irreversible….

OncologyImmune supportEnergy & fatigueLiver support

Reishi · 2023 · Review · Cancer cell international

Exploring the anti-cancer potential of Ganoderma lucidum polysaccharides (GLPs) and their versatile role in enhancing drug delivery systems: a multifaceted approach to combat cancer.

There has been a growing global interest in the potential health benefits of edible natural bioactive products in recent years. Ganoderma lucidum, a medicinal mushroom, has gained attention for its decadent array of therapeutic and pharmaceutical compounds.

OncologyImmune supportEnergy & fatigueMetabolic health

Yellow Morel · 2023 · Review · International journal of medicinal mushrooms

Food and Antioxidant Supplements with Therapeutic Properties of Morchella esculenta (Ascomycetes): A Review.

Morchella esculenta, commonly known as yellow morels, is an edible and medicinal mushroom popular worldwide for its unique flavor and culinary purposes. The traditional medical system effectively uses morels against infertility, fatigue, cancer, muscular pain, cough, and cold.

OncologyImmune supportLiver supportRespiratory

Reishi · 2023 · Review · Nutrients

Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action.

Ganoderma lucidum (G. lucidum) has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries.

OncologyImmune supportGut & microbiome

Lion's Mane · 2023 · Review · World journal of gastroenterology

Hericium erinaceus, a medicinal fungus with a centuries-old history: Evidence in gastrointestinal diseases.

Hericium erinaceus is an edible and medicinal mushroom commonly used in traditional Chinese medicine for centuries. Several studies have highlighted its therapeutic potential for gastrointestinal disorders such as gastritis and inflammatory bowel diseases..

Reishi · 2023 · Review · Antioxidants (Basel, Switzerland)

Natural Bio-Compounds from Ganoderma lucidum and Their Beneficial Biological Actions for Anticancer Application: A Review.

Ganoderma lucidum (G. lucidum) has been known for many centuries in Asian countries under different names, varying depending on the country.

OncologyImmune supportCognition & nerves

Lion's Mane · 2023 · Review · International journal of molecular sciences

Neurotrophic and Neuroprotective Effects of Hericium erinaceus.

Hericium erinaceus is a valuable mushroom known for its strong bioactive properties. It shows promising potential as an excellent neuroprotective agent, capable of stimulating nerve growth factor release, regulating inflammatory processes, reducing oxidative stress, and safeguarding nerve cells from apoptosis..

OncologyImmune supportMetabolic healthLiver support

Reishi · 2023 · Review · Cureus

Pharmacological Activities and Safety of Ganoderma lucidum Spores: A Systematic Review.

Ganoderma lucidum is traditionally used to prevent and treat some diseases such as liver disorders, hypertension, insomnia, diabetes, and cancer. G.

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2023 · Review · Archives of dermatological research

The potential cutaneous benefits of Tremella fuciformis.

Tremella fuciformis, also known as snow mushroom, is an edible mushroom that has historically been popular in herbal and Asian medicine and cuisine. The main polysaccharide ingredients have been extracted and used as treatment in a variety of conditions, demonstrating positive effects in a range of biological….

OncologyImmune supportRespiratory

Reishi · 2022 · Review · Frontiers in pharmacology

Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview.

Ganoderma lucidum is a very medicinal mushroom that has been utilized in Oriental medicine for many years. It has a wide range of pharmacological and therapeutic properties, and has been used for many years as a health promoter..

OncologyImmune supportMetabolic healthLiver support

Yellow Morel · 2022 · Review · Food research international (Ottawa, Ont.)

Mycochemical profile and health-promoting effects of morel mushroom Morchella esculenta (L.) - A review.

Mushrooms have been well known for centuries in traditional Chinese medicine for their medicinal properties. Morchella esculenta (L.) Pers.

OncologyImmune supportMetabolic healthLiver support

Enoki · 2021 · Review · International journal of biological macromolecules

Advances in the extraction, purification, structural-property relationships and bioactive molecular mechanism of Flammulina velutipes polysaccharides: A review.

With the further research in recent years, Flammulina velutipes (F. velutipes), an edible mushroom, has great application value in many fields.

OncologyImmune supportEnergy & fatigueGut & microbiome

Chaga · 2021 · Review · Journal of ethnopharmacology

Deciphering the antitumoral potential of the bioactive metabolites from medicinal mushroom Inonotus obliquus.

ETHNOPHARMACOLOGICAL RELEVANCE: The crude extracts of the medicinal mushroom Inonotus obliquus have been used as an effective traditional medicine to treat malicious tumors, gastritis, gastric ulcers, and other inflammatory conditions in Russia and most Baltic countries..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2021 · Review · Journal of traditional and complementary medicine

Inonotus obliquus - from folk medicine to clinical use.

The Inonotus obliquus (I. obliquus) mushroom was traditionally used to treat various gastrointestinal diseases.

OncologyImmune supportMetabolic healthRespiratory

Cordyceps · 2021 · Review Article · 3 Biotech

Novel formulation development from Ophiocordyceps sinensis (Berk.) for management of high-altitude maladies.

Ophiocordyceps sinensis (Berk.) is a fungus closely related to medicinal mushroom, which belongs to the family Ophiocordycipitaceae. It is a well-known and rich herbal source of bioactive active constituents.

OncologyImmune supportLiver supportSkin & hydration

Zhu Ling · 2021 · Review · International journal of biological macromolecules

Polysaccharides from Polyporus umbellatus: A review on their extraction, modification, structure, and bioactivities.

Polyporus umbellatus (Pers.) Fries, a well-known medicinal fungus, has been reported to exhibit important functions of diuresis and dampness infiltration in traditional Chinese Medicine. Accumulating evidences have demonstrated that the P..

OncologyImmune supportMetabolic health

Yellow Morel · 2021 · Review · Applied biochemistry and biotechnology

Recent Advances on Bioactive Ingredients of Morchella esculenta.

Morchella esculenta (M. esculenta) is a delicious edible mushroom prized for its special flavor and strong health promoting abilities.

OncologyImmune supportCognition & nerves

Turkey Tail · 2021 · Review · Acta pharmaceutica (Zagreb, Croatia)

The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges in medicine. Fungi are the most common organisms in the ecosystem and the most interesting in this respect..

OncologyImmune supportCognition & nervesEnergy & fatigue

Maitake · 2026 · Journal Article · Journal of complementary & integrative medicine

Black maitake induces apoptosis and enhances the efficacy of standard chemotherapy in 2D and 3D U-87 MG glioblastoma cell models.

OBJECTIVES: Glioblastoma is an aggressive primary brain tumor marked by rapid growth, invasiveness, poor prognosis, and an over 90 % tumor recurrence rate. Current radiation and chemotherapy treatments are limited by non-selectivity and toxicity, creating a need for safer complementary treatments..

Chaga · 2025 · Research Article · The Journal of veterinary medical science

Anticancer potentials of chaga and notoginseng against dog bladder cancer organoids.

Muscle-invasive bladder cancer (MIBC) is a common form of BC in dogs. Adjuvant chemotherapy administration is commonly applied in MIBC cases, but patients sometimes experience treatment failure and recurrence..

OncologyEnergy & fatigue

Reishi · 2025 · Research Article · RSC advances

Encapsulation of progesterone in reishi mushroom composite for optimized hormone replacement and targeted anticancer therapy.

Conventional hormone replacement therapy (HRT) and hormone-dependent cancer treatments face significant challenges, including poor bioavailability, rapid metabolism, and adverse side effects of progesterone, as well as limited targeting efficiency and systemic toxicity..

OncologyImmune supportMetabolic healthSkin & hydration

Cordyceps · 2025 · Research Article · Scientific reports

Quantitative detection of β-glucans in Cordyceps species using a validated Congo red assay.

β-Glucan is extensively utilized in the food industry for its functional benefits, including blood glucose and lipid regulation, enhanced food texture, and a prolonged shelf life..

OncologyImmune supportMetabolic healthSkin & hydration

Chaga · 2023 · Review · Frontiers in pharmacology

Chaga mushroom: a super-fungus with countless facets and untapped potential.

Inonotus obliquus (Chaga mushroom) is an inexpensive fungus with a broad range of traditional and medicinal applications. These applications include therapy for breast, cervix, and skin cancers, as well as treating diabetes..

Maitake · 2022 · Randomized Controlled Trial · Acta biochimica Polonica

Effect of Maitake D-fraction in advanced laryngeal and pharyngeal cancers during concurrent chemoradiotherapy: A randomized clinical trial.

BACKGROUND: Concurrent chemo-radiotherapy (CCRT) is an ideal treatment for advanced head and neck squamous cell carcinoma (HNSCC). The performance of CCRT induces severe toxicities in HNSCC patients and decreases the quality of life (QOL)..

OncologyImmune supportRespiratory

Chaga · 2023 · English Abstract · Voprosy virusologii

[Screening of antiviral activity of samples from chaga Inonotus obliquus and humic acid from brown coal on Vero cell culture against ectromelia virus (Poxviridae: Orthopoxvirus; ECTV)].

INTRODUCTION: The mouse-specific orthopoxvirus, ectromelia virus, is one of the best models that can be used to study key issues of pathogenesis, prevention, and treatment of smallpox, and to develop measures to increase virulence, transmissibility, or the ability to overcome vaccine immunity..

Almond Mushroom · 2023 · English Abstract · Zhongguo shi yan xue ye xue za zhi

[Study on the Mechanism of Multi-Drug Resistance of Agaricus Blazei Extract FA-2-b-β Mediated Wnt Signaling Pathway to Reverse Acute T Lymphoblastic Leukemia].

OBJECTIVE: To investigate the mechanism of drug reversing resistance of Agaricus blazei extract FA-2-b-β on T cell acute lymphoblastic leukemia (T-ALL) cell lines..

Turkey Tail · 2023 · Research Support, Non U.S. Gov'T · Scientific reports

Anti-Toxoplasma gondii activity of Trametes versicolor (Turkey tail) mushroom extract.

Toxoplasma gondii (T. gondii) infection continues to rise globally in humans and animals with high socioeconomic and public health challenges.

OncologyEnergy & fatigue

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2023 · Research Support, Non U.S. Gov'T · International journal of biological sciences

Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism.

Skeletal muscle wasting related to aging or pathological conditions is critically associated with the increased incidence and prevalence of secondary diseases including cardiovascular diseases, metabolic syndromes, and chronic inflammations..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2023 · Research Support, Non U.S. Gov'T · Microbiology spectrum

Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice.

Cachexia is a lethal muscle-wasting syndrome associated with cancer and chemotherapy use. Mounting evidence suggests a correlation between cachexia and intestinal microbiota, but there is presently no effective treatment for cachexia..

Shiitake · 2023 · Research Support, Non U.S. Gov'T · Protein science: a publication of the Protein Society

Structural and functional characterization of the cytotoxic protein ledodin, an atypical ribosome-inactivating protein from shiitake mushroom (Lentinula edodes).

We have purified ledodin, a cytotoxic 22-kDa protein from shiitake mushroom (Lentinula edodes) consisting of a 197 amino acid chain. Ledodin possessed N-glycosylase activity on the sarcin-ricin loop of mammalian 28S rRNA and inhibited protein synthesis..