MycoData

Sextonia rubra is a tropical tree endemic to the Guiana Shield and the Brazilian Amazon. Despite its renowned wood durability, it remains susceptible to degradation by white-rot fungi such as Trametes versicolor..

Metabolic healthGut & microbiome

High relevance

Shiitake · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Screening of Lentinula edodes Strains for High Polysaccharide Production and In Vitro Antioxidant Activities.

Lentinan is one of the main metabolites of Lentinula edodes and exhibits numerous biological properties, such as antitumor and antioxidant activity. Despite recent advancements, its commercialization remains constrained by a lengthy cultivation cycle, low yield, and high cost..

OncologyImmune supportMetabolic health

High relevance

Shiitake · 2025 · Research Article · Polymers

Selenium-Enriched Polysaccharides from Lentinula edodes Mycelium: Biosynthesis, Chemical Characterisation, and Assessment of Antioxidant Properties.

Selenium-polysaccharides possess antioxidant properties, making them promising materials for functional foods, pharmaceuticals, and clinical applications. This study examines the incorporation of selenium into polysaccharides via mycelial biosynthesis and its effects on structure and antioxidant activity..

Immune supportMetabolic health

High relevance

Snow Fungus · 2025 · Journal Article · Journal of agricultural and food chemistry

Simulated Digestion and Metabolic Outcomes of Tremella fuciformis Polysaccharides and Their Effects on the Gut Microbiota.

Tremella fuciformis polysaccharides (TFP) were evaluated for their gastrointestinal stability and microbiota-modulating effects using in vitro digestion and fecal fermentation..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Simulated gut microbiota fermentation of polysaccharide extracts from Ganoderma lucidum and Ganoderma neo-japonicum.

This study compared the chemical composition and effects on the gut microbiota of hot-water extracts from two Ganoderma species: Ganoderma lucidum (GL), a well-studied medicinal mushroom, and Ganoderma neo-japonicum (GN), a lesser-known counterpart..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Applied biochemistry and biotechnology

Structural and Catalytic Characterization of β-1,3-Glucan Synthases of Mushroom Ganoderma lucidum.

β-Glucans are regarded as the key contributors to nutritional and supplementary credits of well-known edible/medicinal mushroom Ganoderma lucidum. However, the biosynthesis pathways of β-glucans and the involved key enzymes/genes in G.

Metabolic health

High relevance

Reishi · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Structural characterisation and cholesterol and bile salts adsorption properties of Ganoderma lucidum dietary fiber

This study prepared Ganoderma lucidum insoluble dietary fiber (GIDF) and soluble dietary fiber (GSDF) via enzymatic methods. The structural and physicochemical properties of GIDF and GSDF were systematically characterized using scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray….

Energy & fatigueMetabolic healthGut & microbiomeSkin & hydration

High relevance

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Structural Characterization and Gastrointestinal Fate of a High-Molecular-Weight Hericium erinaceus Polysaccharide during Digestion and Fermentation.

This study systematically isolated a high-molecular-weight polysaccharide (HHEP; 9.14 × 103 kDa) from Hericium erinaceus, consisting predominantly of glucose (59.16% ± 0.09%), galactose (26.29% ± 0.59%), and mannose (5.69% ± 0.58%)..

Immune supportMetabolic healthGut & microbiome

High relevance

Enoki · 2025 · Research Article · Foods (Basel, Switzerland)

Structural Characterization of Polysaccharide from Flammulina velutipes and Its Impact on Hyperlipidemia Through Modulation of Hepatic Cholesterol Metabolism and Gut Microbiota.

FVPB1, a novel heteropolysaccharide, was extracted from the Flammulina velutipes fruiting body, and its structure was determined by methylation analysis, nuclear magnetic resonance (NMR) spectroscopy..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Structural-functional relationship of soluble dietary Fiber from Ganoderma lucidum-fermented sweet potato residue and its regulatory effects on gut microbiota

Sweet potato residue (SPR), a by-product of sweet potato processing, is rich in dietary fiber and other is rich in dietary fiber and other essential nutrients; however, its industrial utilization remains limited..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Structural-functional relationship of soluble dietary Fiber from Ganoderma lucidum-fermented sweet potato residue and its regulatory effects on gut microbiota.

Immune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2025 · Research Article · NPJ science of food

Structure characterization of Grifola frondosa polysaccharide and its effect on insulin resistance in HFD-fed mice.

Polysaccharide extracted from Grifola frondosa (GFP) was selected in this study. After preliminary separation, four factions were collected, named GFP-F1, GFP-F2, GFP-F3 and GFP-F4.

Immune supportMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2025 · Journal Article · Journal of food science

Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review

Tremella fuciformis (TF) is a valuable edible fungus rich in various nutrients, with TF polysaccharide (TFP) as its primary bioactive component. Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory‐enhancing, anti‐inflammatory,….

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Oyster Mushroom · 2025 · Journal Article · International journal of radiation biology

The role of polysaccharide POM extracted from Pleurotus ostreatus in curbing and treating the harmful effects on liver and kidney resulting from radiation exposure.

PURPOSE: This research assesses the radioprotective and antioxidant activity of polysaccharide (POM) derived from Pleurotus ostreatus strain on rats suffering from metabolic problems due to irradiation..

Immune supportMetabolic healthLiver support

High relevance

Shiitake · 2025 · Research Article · Frontiers in microbiology

Two sexually compatible monokaryons from a heterokaryotic Lentinula edodes strain respond differently to heat stress.

BACKGROUND: Despite the extensive research conducted on heat responses of Lentinula edodes heterokaryotic cells, the responses of the two sexually compatible monokaryons to heat stress (HS) remain largely unknown..

Metabolic health

High relevance

Oyster Mushroom · 2025 · Journal Article · Food Research International

Understanding the impact of different post-digestion enzymatic inhibition methods and storage conditions on standardized gastrointestinal model (INFOGEST): A case study of Pleurotus ostreatus mushroom biomass

INFOGEST became the standard digestion protocol to address inconsistencies in gastrointestinal tract (GIT) digestion protocols. However, sample collection, enzymatic inactivation methods, and storage conditions can significantly impact the accurate assessment of food compounds..

Metabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Understanding the impact of different post-digestion enzymatic inhibition methods and storage conditions on standardized gastrointestinal model (INFOGEST): A case study of Pleurotus ostreatus mushroom biomass.

Metabolic healthGut & microbiome

High relevance

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Untargeted Metabolomics-Based Characterization of the Metabolic Profile and Antioxidant Activity of Ophiocordyceps sinensis and Its Substitutes.

Ophiocordyceps sinensis represents a valuable medicinal resource. In this study, mechanisms underlying differences in chemical composition and antioxidant capacity among wild O.

Metabolic health

High relevance

Reishi · 2024 · Journal Article · Gene

4-Coumarate-CoA ligase (4-CL) enhances flavonoid accumulation, lignin synthesis, and fruiting body formation in Ganoderma lucidum.

It is now understood that 4-Coumarate-CoA ligases (4-CL) are pivotal in bridging the phenylpropanoid metabolic pathway and the lignin biosynthesis pathway in plants. However, limited information on 4-CL genes and their functions in fungi is available..

Metabolic health

High relevance

Reishi · 2024 · Journal Article · Talanta

A nanozyme multifunctional platform based on iron doped carbon dots derived from Tibetan Ganoderma lucidum waste for glucose sensing, anti-counterfeiting applications, and anticancer cell effect.

Implementing the concept of turning waste into treasure, the conversion of biomass waste into high-value carbon materials, especially carbon dots (CDs), has pointed out a new direction for disease diagnosis, tumor treatment, and other aspects..

OncologyMetabolic health

High relevance

Maitake · 2024 · Journal Article · Molecular nutrition & food research

A Water Polysaccharide-Protein Complex from Grifola frondosa Inhibit the Growth of Subcutaneous but Not Peritoneal Colon Tumor under Fasting Condition.

SCOPE: Grifola frondosa has been shown to induce immune modulatory, modulate autophagy, and apoptosis in cancer cells. However, little is known about its potential for managing tumor progression as an adjunct to nutrient restriction.

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Plant foods for human nutrition (Dordrecht, Netherlands)

Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice.

The hepatoprotective effect of the alcoholic extracts of Ganoderma lucidum fermentation products (GFE) was investigated. C57BL/6 mice were pretreated with GFE for 7 days and then subjected to the chronic-binge ethanol feeding model..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Agarikon · 2024 · Journal Article · International journal of biological macromolecules

An antitumor fungal polysaccharide from Fomitopsis officinalis by activating immunity and inhibiting angiogenesis.

Macrofungi, a class of unique natural resources, are gaining popularity owing to their potential therapeutic benefits and edibility. From Fomitopsis officinalis, a medicinal macrofungus with anticancer activity, a homogeneous heteropolysaccharide (FOBP50-1) with a molecular weight of 2.21 × 104 g/mol has been….

OncologyImmune supportMetabolic health

High relevance

Yellow Morel · 2024 · Journal Article · International journal of medicinal mushrooms

Antioxidation and Hepatoprotection of Selenium Mycelium Polysaccharides Against Alcoholic Liver Diseases from the Cultivated Morel Mushroom Morchella esculenta (Ascomycota).

The liver was regarded as the most important metabolic and detoxification organ in vivo, and Morchella esculenta had been reported as the admittedly rare edible fungus belonging to Ascomycetes contributing to the abundant bioactivities..

Immune supportMetabolic healthLiver support

High relevance

Wood Ear · 2024 · Research Article · Foods (Basel, Switzerland)

Auricularia auricula-judae Attenuates the Progression of Metabolic Syndrome in High-Fat Diet-Induced Obese Rats: Enzymatic Pre-Digestion Technology Is Superior to Superfine Grinding Method.

Auricularia auricula-judae (AAJ) has been cultivated for food in China for centuries, and is also used as a folk medicine for the regulation of glucose and lipid metabolism. However, there are few studies on the effects of different processing technologies on the therapeutic efficacy of AAJ to date..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2024 · Journal Article · Heliyon

Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review

Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. Its popularity as a dietary supplement, herbal remedy, and wellness product is steadily on the rise..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Carbon starvation drives biosynthesis of high mannose-composition polysaccharides in Ganoderma lucidum.

Polysaccharides with high mannose composition exhibit favorable antitumor activity, but there is currently a lack of well-defined and practical approaches to efficiently manufacture this type of polysaccharide..

OncologyImmune supportMetabolic health

High relevance

Shiitake · 2024 · Journal Article · Food chemistry

Changes in flavor and biological activities of Lentinula edodes hydrolysates after Maillard reaction.

This study aimed to elucidate how the Maillard reaction (MR) affects the flavor and bioactivities of Lentinula edodes hydrolysates (LEHs). Changes in flavor were investigated using non-targeted metabolomics techniques (GC-MS and LC-MS/MS) and sensory evaluation..

Metabolic health

High relevance

Reishi · 2024 · Research Article · Molecules (Basel, Switzerland)

Changes of Active Substances in Ganoderma lucidum during Different Growth Periods and Analysis of Their Molecular Mechanism.

Ganoderma lucidum, renowned as an essential edible and medicinal mushroom in China, remains shrouded in limited understanding concerning the intrinsic mechanisms governing the accumulation of active components and potential protein expression across its diverse developmental stages..

Immune supportMetabolic health

High relevance

Reishi · 2024 · Journal Article · Food Research International

Combined NMR and MS-based metabonomics and real-time PCR analyses reveal dynamic metabolic changes of Ganoderma lucidum during fruiting body growing

Ganoderma lucidum (G. lucidum) is a rare medicinal fungus with various beneficial properties.

OncologyEnergy & fatigueMetabolic healthLiver support

High relevance

Reishi · 2024 · Journal Article · Food research international (Ottawa, Ont.)

Combined NMR and MS-based metabonomics and real-time PCR analyses reveal dynamic metabolic changes of Ganoderma lucidum during fruiting body growing.

Ganoderma lucidum (G. lucidum) is a rare medicinal fungus with various beneficial properties.

OncologyEnergy & fatigueMetabolic healthLiver support

High relevance

Reishi · 2024 · Journal Article · Food chemistry

Comparative investigation of selenium-enriched Pleurotus ostreatus and Ganoderma lucidum as natural sources of selenium supplementation.

Selenium (Se) is an essential trace element for human health, but its nutritional supply is insufficient in large parts of the world. Mushrooms can be enriched in selenium and can serve as alternative and natural source of selenium supplementation..

Metabolic health

High relevance

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Cuttlefish ink-derived melanin nanoparticle-embedded tremella fuciformis polysaccharide hydrogels for the treatment of MRSA-infected diabetic wounds.

Diabetic wounds arise great attention as they are difficult to heal and easily suffer from serious bacterial infection. However, the overuse of antibiotics increases the resistance of bacteria and makes common drugs ineffective..

Immune supportMetabolic healthSkin & hydration

High relevance

Oyster Mushroom · 2024 · Research Article · International journal of food science

Effect of Culture Media on the Yield and Protein Content of Pleurotus ostreatus (Jacq.) Kumm Mycelia.

The development of alternative proteins derived from fungi-based sources is gaining recognition due to their health benefits and lower environmental impact, compared to traditional animal-based sources..

Cognition & nervesMetabolic health

High relevance

Enoki · 2024 · Journal Article · International journal of food science & technology

Effect of extraction and purification on the structure and activity of Flammulina velutipes polysaccharides: a review

Flammulina velutipes (F. velutipes) is one of the most widely consumed edible mushrooms worldwide.

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Effect of steam explosion modified soluble dietary fiber from Tremella fuciformis stem on the quality and digestibility of biscuits.

Steam explosion (SE) technology is an effective modification method for improving resource utilization of edible fungi processing by-products. In this study, the effect of SE-modified Tremella fuciformis (T.

Metabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2024 · Journal Article · The Science of the total environment

Effective degradation of zearalenone by dye-decolorizing peroxidases from Pleurotus ostreatus and its metabolic pathway and toxicity analysis.

The widespread detection of zearalenone (ZEN) in cereal crops and feeds poses a significant threat to both humans and animals. Consequently, the urgency for the international community to address this issue is evident in the demand for safe and effective measures to mitigate zearalenone contamination and explore….

OncologyMetabolic health

High relevance

Chaga · 2024 · Journal Article · Chemistry & biodiversity

Effects of Chemical Modification on the Structure and Biological Activities of Polysaccharides Extracted from Inonotus Obliquus by Microwave.

A novel polysaccharide, Inonotus obliquus polysaccharide (IOP), was extracted using a microwave extraction method and subsequently subjected to modifications through sulfation, carboxymethylation, phosphorylation, and acetylation..

Immune supportMetabolic healthSkin & hydration

High relevance

Lion's Mane · 2024 · Journal Article · Fish physiology and biochemistry

Effects of dietary Hericium erinaceus extract on growth, nutrient utilization, hematology, expression of genes related immunity response, and disease resistance of Nile tilapia (Oreochromis niloticus).

In recent years, there has been a growing focus on using herbal extracts as immune enhancers for aquatic species, replacing antibiotics. In the present study, the effects of dietary supplementation of Hericium erinaceus extract (HE) on growth, feed utilization, hematology, expression of immunity-related genes, and….

Immune supportMetabolic health

High relevance

Almond Mushroom · 2024 · Research Article · Animal bioscience

Effects of dietary supplementation of polysaccharide from Agaricus blazei Murr on productive performance, egg quality, blood metabolites, intestinal morphology and microbiota of Korean quail.

OBJECTIVE: This study aimed to investigate the effects of dietary supplementation with Agaricus blazei polysaccharide (ABP) at varying concentrations on the performance, egg quality, blood biochemistry, intestinal morphology, and microflora of quail..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Journal of applied poultry research

Effects of Ganoderma Lucidum supplementation on the growth performance, biochemical blood parameters, antioxidant and immunity status, and meat quality in slow-growing broilers

Ganoderma Lucidum (G. lucidum) is an edible mushroom and it has been used as a medicinal fungus for centuries.

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Oyster Mushroom · 2024 · Research Article · Applied microbiology and biotechnology

Effects of hap2 deletion on mnp/vp transcription in Pleurotus ostreatus grown on lignocellulosic substrates.

The regulatory mechanisms governing expression of genes encoding lignin-modifying enzymes (LME) in white-rot fungi remain largely unexplored. Although molecular cloning has identified CCAAT-boxes frequently located 5'-upstream of these genes, their role in transcriptional regulation is not well understood..

Metabolic health

High relevance

Chaga · 2024 · Research Article · Frontiers in pharmacology

Effects of Inonotus obliquus on ameliorating podocyte injury in ORG mice through TNF pathway and prediction of active compounds.

BACKGROUND: Podocyte injury is a common pathologic mechanism in diabetic kidney disease (DKD) and obesity-related glomerulopathy (ORG). Our previous study confirmed that Inonotus obliquus (IO) improved podocyte injury on DKD rats..

Immune supportCognition & nervesEnergy & fatigueMetabolic health

High relevance

Enoki · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

Effects of Light on the Fruiting Body Color and Differentially Expressed Genes in Flammulina velutipes.

Light plays vital roles in fungal growth, development, reproduction, and pigmentation. In Flammulina velutipes, the color of the fruiting body exhibits distinct changes in response to light; however, the underlying molecular mechanisms remain unknown.

Energy & fatigueMetabolic health

High relevance

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Efficient conversion of cane molasses into Tremella fuciformis polysaccharides with enhanced bioactivity through repeated batch culture.

Tremella fuciformis polysaccharide (TFPS) is a natural mushroom mucopolysaccharide widely used in health foods, medical care, cosmetic and surgical materials. In this study, we developed an efficient strategy for the repeated batch production of highly bioactive TFPS from the agro-industrial residue cane molasses..

Immune supportMetabolic healthSkin & hydration

High relevance

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Electrochemiluminescent evaluation of GLUT4 expression in rat adipocytes induced by Ganoderma lucidum polysaccharides.

Glucose transporter 4 (GLUT4) directly facilitates cellular uptake of glucose and plays a crucial role in mammalian adipose tissue glucose metabolism. In this work, we constructed a cytosensor for sensitive electrochemiluminescence (ECL) detection of GLUT4 in rat adipocytes (RA cells)..

Immune supportMetabolic health

High relevance

Oyster Mushroom · 2024 · Journal Article · International journal of biological macromolecules

Enhanced mycelium biomass and polysaccharide production in genetically modified Pleurotus ostreatus using agricultural wastes.

Edible fungi, healthier for humans and sustainable for the planet, attract unprecedented attention. In the study, the genetically modified Pleurotus ostreatus overexpression phosphoglucomutase (PGM) was constructed.

Immune supportMetabolic health

High relevance

Oyster Mushroom · 2024 · Journal Article · Journal of agricultural and food chemistry

Exogenous Salicylic Acid Regulates Fruiting Body Development, Secondary Metabolite Accumulation, Cell Wall Integrity, and Endogenous Salicylic Acid Content under Heat Stress in Pleurotus ostreatus.

High-temperature or heat stress (HS) represents a significant environmental challenge that adversely affects crop growth and poses a substantial threat to agricultural production..

Metabolic health

High relevance

Enoki · 2024 · Journal Article · International journal of biological macromolecules

Extraction of chitin from flammulina velutipes waste: A low-concentration acid pretreatment and aspergillus Niger fermentation approach.

In recent years, with the booming of the edible mushroom industry, chitin production has become increasingly dependent on fungi and other non-traditional sources. Fungal chitin has advantages including superior performance, simpler separation processes, abundant raw materials, and the absence of shellfish allergens..

Energy & fatigueMetabolic health

High relevance

Reishi · 2024 · Research Article · Medical principles and practice: international journal of the Kuwait University, Health Science Centre

Ganoderma lucidum and Hypericum perforatum Exhibit Anti-Inflammatory, Antioxidant, and Anti-Androgen Effect in Rat Model of Experimental Polycystic Ovarian Syndrome.

OBJECTIVE: Chronic inflammation is considered to be of key importance in the pathogenesis of polycystic ovarian syndrome (PCOS). Ganoderma lucidum polysaccharide (GLP) and Hypericum perforatum (HP) have been reported to have anti-inflammatory and antioxidant activities..

OncologyImmune supportMetabolic health