MycoData
Medicinal fungi research database
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Cognition & nerves
Cognition, nerve growth factor, neuroprotection, memory, and brain-health papers.
Species records
Species record
Oyster Mushroom
Pleurotus ostreatus
- Studies
- 1,947
- Avg relevance
- 53
- Latest
- 2026
Species record
Reishi · Lingzhi
Ganoderma lucidum
- Studies
- 1,830
- Avg relevance
- 60
- Latest
- 2026
Species record
Turkey Tail · Yun Zhi
Trametes versicolor
- Studies
- 1,828
- Avg relevance
- 41
- Latest
- 2026
Species record
Shiitake · Hua Gu
Lentinula edodes
- Studies
- 1,766
- Avg relevance
- 60
- Latest
- 2026
Species record
Cordyceps · Scarlet Club
Cordyceps militaris
- Studies
- 1,635
- Avg relevance
- 67
- Latest
- 2026
Species record
Cordyceps · Caterpillar Fungus
Ophiocordyceps sinensis
- Studies
- 1,576
- Avg relevance
- 59
- Latest
- 2026
Species record
Almond Mushroom · ABM
Agaricus blazei
- Studies
- 1,441
- Avg relevance
- 54
- Latest
- 2026
Species record
Enoki · Winter Mushroom
Flammulina velutipes
- Studies
- 1,403
- Avg relevance
- 47
- Latest
- 2026
Species record
King Oyster · Eryngii
Pleurotus eryngii
- Studies
- 1,278
- Avg relevance
- 60
- Latest
- 2026
Species record
Maitake · Hen of the Woods
Grifola frondosa
- Studies
- 1,276
- Avg relevance
- 48
- Latest
- 2026
Species record
Snow Fungus · Silver Ear
Tremella fuciformis
- Studies
- 1,052
- Avg relevance
- 29
- Latest
- 2026
Species record
Lion's Mane · Yamabushitake
Hericium erinaceus
- Studies
- 862
- Avg relevance
- 67
- Latest
- 2026
Species record
Chaga
Inonotus obliquus
- Studies
- 738
- Avg relevance
- 65
- Latest
- 2026
Species record
Mesima · Sanghwang
Phellinus linteus
- Studies
- 722
- Avg relevance
- 58
- Latest
- 2026
Species record
Niu-Chang-Chih
Antrodia camphorata
- Studies
- 496
- Avg relevance
- 63
- Latest
- 2026
Species record
Nameko · Nametake
Pholiota microspora
- Studies
- 421
- Avg relevance
- 29
- Latest
- 2026
Species record
Yellow Morel
Morchella esculenta
- Studies
- 392
- Avg relevance
- 42
- Latest
- 2026
Species record
Zhu Ling · Umbrella Polypore
Polyporus umbellatus
- Studies
- 263
- Avg relevance
- 55
- Latest
- 2026
Species record
Wood Ear · Kikurage
Auricularia auricula-judae
- Studies
- 254
- Avg relevance
- 51
- Latest
- 2026
Species record
Agarikon · Quinine Conk
Fomitopsis officinalis
- Studies
- 47
- Avg relevance
- 55
- Latest
- 2026
Articles
1,418 results
Showing 601–650 of 1,418
Oyster Mushroom · 2025 · Journal Article · Molecular neurobiology
Golden Oyster Mushroom Extract Ameliorates Oxidative Stress-Induced Cell Death in Neurons and Scopolamine-Induced Cholinergic System Impairment in Mice.
Impaired cholinergic system is an important therapeutic target to develop drugs against Alzheimer's disease (AD), as cholinergic signal transduction is associated with the memory, learning, and behavior of an individual..
Shiitake · 2025 · Journal Article · Food Bioprocess Technol
Machine Learning Unveils Potential Taste Biomarkers Associated with Energy Status in Shiitake Mushrooms During Spore Release
Spore release, marking the initiation of mushroom taste quality deterioration, is associated with energy metabolism. To elucidate the role of energy status, shiitake mushrooms were subjected to different energy treatments (ATP and CCCP), and the dynamic changes in taste profile during spore release were monitored..
Shiitake · 2025 · Research Article · Frontiers in plant science
Research on the method of shiitake mushroom picking robot based on CSO-ASTGCN human action prediction network.
INTRODUCTION: Automating shiitake mushroom picking is critical for modern agriculture, yet its biological traits hinder automation via target recognition, path planning, and precision challenges. Traditional manual picking is inefficient, labor-heavy, and unsuitable for large-scale production..
Cordyceps · 2025 · Journal Article · Pesticide biochemistry and physiology
Silencing the β-glucan recognition protein enhanced the pathogenicity of Cordyceps fumosorose against Hyphantria cunea Drury larvae.
The β-glucan recognition protein (βGRP) plays a crucial role in pathogen recognition by insects, thereby activating their innate immunity. However, the immune response of βGRP in Hyphantria cunea Drury (Lepidoptera: Noctuidae), an invasive pest of forests and agriculture, to pathogens remains unclear..
Cordyceps · 2024 · Journal Article · International journal of biological macromolecules
The effects of Cordyceps polysaccharides on ischemic brain injury in rats via intervening with IL-23/IL-17 axis and the intestinal barrier.
Cordyceps polysaccharide (CSP) has been shown to exhibit anti-inflammatory and antioxidant effects, with potential applications in ischemic stroke. This work is to explore the interventional potential of CSP in MCAO rats and the effects on the intestinal and cerebral IL-23/IL-17 axis..
Shiitake · 2017 · Other · Food & nutrition research
Lentinula edodes β-glucan enriched diet induces pro- and anti-inflammatory macrophages in rabbit.
β-glucans exhibited in cell walls of several pathogens as bacteria or fungi are sensed by pathogen recognition receptors such as scavenger receptors present in antigen presenting cells, i.e., macrophages. β-glucans obtained from Shiitake mushrooms were chemically characterized..
King Oyster · 2026 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Neuroprotection in the age of emerging infections: The untapped power of medicinal mushrooms.
Infections affecting the nervous system require a rapid expansion of effective therapeutic strategies. The emergence of new viral pathogens continues to pose a substantial threat to brain health worldwide, as evidenced by the recent pandemic..
Almond Mushroom · 2026 · Randomized Controlled Trial · Translational psychiatry
The role of the dorsal attention network in attention bias modification for social anxiety disorder.
Identifying reliable biomarkers of treatment response is central to advancing personalized psychiatry. While whole-brain functional connectivity models have shown promise in predicting clinical outcomes, especially for broad-spectrum interventions like cognitive-behavioral therapy, targeted treatments may benefit from….
Almond Mushroom · 2025 · Randomized Controlled Trial · Scientific reports
Effect of attention bias modification on depressive affect.
Cognitive interventions targeting depressive mood and major depressive disorder have emerged as a critical focus in mental health research. While studies on anxiety disorders, social phobia, eating disorders, and addiction have consistent findings, research on attentional bias modification in depression yields….
Cordyceps · 2025 · Review · Molecules (Basel, Switzerland)
Fungal Polysaccharides as Modulators of Molecular Pathways in Liver Health.
Fungal polysaccharides represent a structurally diverse group of bioactive compounds with increasing recognition for their hepatoprotective potential. This review synthesizes current evidence on their roles in the prevention and treatment of liver diseases, including alcohol-related liver disease (ALD), metabolic….
Lion's Mane · 2024 · Review · Neuroscience and biobehavioral reviews
A review of the effects of mushrooms on mood and neurocognitive health across the lifespan.
Mushrooms contain bioactive compounds with documented antioxidant and anti-inflammatory actions. Here, we present a systematic evaluation of epidemiological and clinical studies that investigate the role of mushrooms, either as a separate or integral dietary component, on neurocognition and mood..
Niu-Chang-Chih · 2023 · Published Erratum · Molecules (Basel, Switzerland)
Correction: Sun et al. Ergosterol Isolated from Antrodia camphorata Suppresses LPS-Induced Neuroinflammatory Responses in Microglia Cells and ICR Mice. Molecules 2023, 28, 2406.
The original version of this article unfortunately contains an error in Figures 4B,C,H-J and 5C,D [...]..
Lion's Mane · 2023 · Research Support, Non U.S. Gov'T · Free radical biology & medicine
The protective effect of erinacine A-enriched Hericium erinaceus mycelium ethanol extract on oxidative Stress-Induced neurotoxicity in cell and Drosophila models of spinocerebellar ataxia type 3.
Metadata-grounded summary: This research support, non u.s. gov't indexes research on Hericium erinaceus in Free radical biology & medicine in 2023.
Lion's Mane · 2022 · Retracted Publication · Brain research
RETRACTED: Improvement of extraction from Hericium erinaceus on the gut-brain axis in AD-like mice.
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). This article has been retracted at the request of the lead author, Dr.
Lion's Mane · 2021 · Published Erratum · Scientific reports
Author Correction: Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein.
Metadata-grounded summary: This published erratum indexes research on Hericium erinaceus in Scientific reports in 2021. MycoData maps the paper to cognition & nerves based on its title, species context, article metadata, and study classification..
Reishi · 2021 · Published Erratum · Applied microbiology and biotechnology
Correction to: Antidepressant‑like effect of Ganoderma lucidum spore polysaccharide‑peptide mediated by upregulation of prefrontal cortex brain‑derived neurotrophic factor.
Metadata-grounded summary: This published erratum indexes research on Ganoderma lucidum in Applied microbiology and biotechnology in 2021. MycoData maps the paper to immune support, cognition & nerves based on its title, species context, article metadata, and study classification..
Lion's Mane · 2021 · Research Support, Non U.S. Gov'T · Scientific reports
Hericium erinaceus mycelium and its small bioactive compounds promote oligodendrocyte maturation with an increase in myelin basic protein.
Oligodendrocytes (OLs), myelin-producing glia in the central nervous system (CNS), produce a myelin extension that enwraps axons to facilitate action potential propagation..
Lion's Mane · 2021 · Retraction Notice · Journal of translational medicine
Retraction Note to: Hericium erinaceus mycelium and its isolated erinacine A protection from MPTP-induced neurotoxicity through the ER stress, triggering an apoptosis cascade.
Metadata-grounded summary: This retraction notice indexes research on Hericium erinaceus in Journal of translational medicine in 2021. MycoData maps the paper to oncology, cognition & nerves based on its title, species context, article metadata, and study classification..
Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry letters
Chemical constituents from Hericium erinaceus and their ability to stimulate NGF-mediated neurite outgrowth on PC12 cells.
One new meroterpenoid, named hericenone K (11), along with 10 known compounds (1-10), ergosterol peroxide (1), cerevisterol (2), 3β,5α,9α-trihydroxy-ergosta-7,22-dien-6-one (3), inoterpene A (4), astradoric acid C (5), betulin (6), oleanolic acid (7), ursolic acid (8), hemisceramide (9), and….
Snow Fungus · 2015 · Comparative Study · The American journal of Chinese medicine
Comparison of Immunomodulatory and Anticancer Activities in Different Strains of Tremella fuciformis Berk.
Tremella fuciformis Berk (TF) is a common edible and medicinal mushroom, and has long been used in food and in Chinese medicine. It possesses anticancer, anti-inflammation, anti-oxidative, and neuroprotective abilities..
Maitake · 2015 · Research Support, Non U.S. Gov'T · Pharmaceutical biology
Effects of Grifola frondosa non-polar bioactive components on high-fat diet fed and streptozotocin-induced hyperglycemic mice.
CONTEXT: Consumption of medicinal mushrooms for disease prevention and maintaining health has a very long history in Asia. Grifola frondosa (Fr) S.F.
Lion's Mane · 2015 · Evaluation Study · Fungal biology
Erinacine C: A novel approach to produce the secondary metabolite by submerged cultivation of Hericium erinaceus.
Erinacine C is a cyathane scaffold-based secondary metabolite, which is naturally produced by the filamentous fungus Hericium erinaceus and has a high potential to treat nervous diseases such as Alzheimer's disease. The investigated approach consists of combining an optimised precultivation of H..
Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of nanomedicine
Neurite outgrowth stimulatory effects of myco synthesized AuNPs from Hericium erinaceus (Bull.: Fr.) Pers. on pheochromocytoma (PC-12) cells.
BACKGROUND: Hericium erinaceus has been reported to have a wide range of medicinal properties such as stimulation of neurite outgrowth, promotion of functional recovery of axonotmetic peroneal nerve injury, antioxidant, antihypertensive, and antidiabetic properties..
Snow Fungus · 2015 · Research Support, Non U.S. Gov'T · World journal of microbiology & biotechnology
Optimal codons in Tremella fuciformis end in C/G, a strong difference with known Tremella species.
Tremella fuciformis is a popular edible fungus with fruiting bodies that can be produced in large quantities at low costs, while it is easy to transform and cultivate as yeast. This makes it an attractive potential bioreactor..
Lion's Mane · 2015 · Case Reports · Fungal biology and biotechnology
Production of cyathane type secondary metabolites by submerged cultures of Hericium erinaceus and evaluation of their antibacterial activity by direct bioautography.
BACKGROUND: Fungi of the phylum Basidiomycota are well-known to form a broad spectrum of biologically active secondary metabolites, especially low molecular weight compounds such as terpenoids. Hericium erinaceus produces various cyathane type diterpenoids including erinacines..
Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Analytical and bioanalytical chemistry
Analysis of cyathane-type diterpenoids from Cyathus striatus and Hericium erinaceus by high-resolution MALDI MS imaging.
Fungal secondary metabolites in both fruiting bodies and pellets from submerged cultures of basidiomycetes were analyzed by atmospheric pressure matrix-assisted laser desorption/ionization-mass spectrometry imaging at a lateral resolution of 15 μm, a mass resolution of 140,000 at m/z 200 and a mass accuracy of better….
Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)
Effects of the continuous administration of an Agaricus blazei extract to rats on oxidative parameters of the brain and liver during aging.
An investigation of the effects of an aqueous extract of Agaricus blazei, a medicinal mushroom, on the oxidative state of the brain and liver of rats during aging (7 to 23 months) was conducted. The treatment consisted in the daily intragastric administration of 50 mg/kg of the extract.
Almond Mushroom · 2014 · Research Support, Non U.S. Gov'T · Oxidative medicine and cellular longevity
Effects of treating old rats with an aqueous Agaricus blazei extract on oxidative and functional parameters of the brain tissue and brain mitochondria.
Dysfunction of the mitochondrial respiratory chain and increased oxidative stress is a striking phenomenon in the brain of aged individuals. For this reason there has been a constant search for drugs and natural products able to prevent or at least to mitigate these problems..
Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · TheScientificWorldJournal
Extract of Antrodia camphorata exerts neuroprotection against embolic stroke in rats without causing the risk of hemorrhagic incidence.
In this study, the neuroprotective effect of an extract of Antrodia camphorata (A. camphorata), a fungus commonly used in Chinese folk medicine for treatment of viral hepatitis and cancer, alone or in combination with aspirin was investigated in a rat embolic stroke model..
Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · Food & function
Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways.
Hericium erinaceus (Bull.: Fr.) Pers. is an edible and medicinal mushroom used traditionally to improve memory.
Mesima · 2014 · Research Support, Non U.S. Gov'T · Chemico-biological interactions
Hispidin derived from Phellinus linteus affords protection against acrylamide-induced oxidative stress in Caco-2 cells.
Acrylamide (AA), a well-known toxicant, has attracted numerous attentions for its presumably carcinogenesis, neurotoxicity and cytotoxicity. Oxidative stress was considered to be associated with acrylamide cytotoxicity, but the link between oxidative stress and acrylamide cytotoxicity is still unclear..
Almond Mushroom · 2013 · Research Support, Non U.S. Gov'T · BioMed research international
Effects of an Agaricus blazei aqueous extract pretreatment on paracetamol-induced brain and liver injury in rats.
The action of an Agaricus blazei aqueous extract pretreatment on paracetamol injury in rats was examined not only in terms of the classical indicators (e.g., levels of hepatic enzymes in the plasma) but also in terms of functional and metabolic parameters (e.g., gluconeogenesis)..
Mesima · 2013 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology
Phellinus linteus mushroom protects against tacrine-induced mitochondrial impairment and oxidative stress in HepG2 cells.
Tacrine (THA) was the first drug licensed for the treatment of Alzheimer's disease. Unfortunately, reversible hepatotoxicity is evident in about 30% of patients and limits its clinical use.
Mesima · 2012 · Research Support, Non U.S. Gov'T · Chemico-biological interactions
Hispidin produced from Phellinus linteus protects against peroxynitrite-mediated DNA damage and hydroxyl radical generation.
Oxidative stress plays an important role in the progression of many chronic diseases including cardiovascular diseases, diabetes, cancer and neurodegenerative disorders..
Niu-Chang-Chih · 2012 · Comparative Study · Applied microbiology and biotechnology
In vitro and in vivo comparisons of the effects of the fruiting body and mycelium of Antrodia camphorata against amyloid β-protein-induced neurotoxicity and memory impairment.
Antrodia camphorata is a particular and precious medicinal mushroom, and its fruiting body was found to provide more efficient protection from oxidative stress and inflammation than its mycelium because of its higher content of triterpenoids, total phenols, and so on..
Snow Fungus · 2012 · Research Support, Non U.S. Gov'T · Behavioural brain research
Tremella fuciformis enhances the neurite outgrowth of PC12 cells and restores trimethyltin-induced impairment of memory in rats via activation of CREB transcription and cholinergic systems.
The present study examined the effects of Tremella fuciformis (TF) on the learning and memory function and the neural activity in rats with trimethyltin (TMT)-induced memory deficits. The rats were administered saline or TF (TF 25, 50, 100 mg/kg, p.o.) daily for 21 days..
Enoki · 2011 · Comparative Study · PloS one
Comparative genomics of the mating-type loci of the mushroom Flammulina velutipes reveals widespread synteny and recent inversions.
BACKGROUND: Mating-type loci of mushroom fungi contain master regulatory genes that control recognition between compatible nuclei, maintenance of compatible nuclei as heterokaryons, and fruiting body development..
Lion's Mane · 2011 · Research Support, Non U.S. Gov'T · Biomedical research (Tokyo, Japan)
Effects of Hericium erinaceus on amyloid β(25-35) peptide-induced learning and memory deficits in mice
The mushroom Hericium erinaceus has been used as a food and herbal medicine since ancient times in East Asia. It has been reported that H.
Mesima · 2011 · Research Support, Non U.S. Gov'T · Journal of nutritional science and vitaminology
Effects of Phellinus linteus Administration on Serotonin Synthesis in the Brain and Expression of Monocarboxylate Transporters in the Muscle during Exhaustive Exercise in Rats
This study was conducted to determine the effects of Phellinus linteus (PL) on serotonin synthesis in the brain and on the expression of monocarboxylate transporters (MCTs) in muscles during exhaustive exercise in rats..
Mesima · 2011 · Other · Evidence-based complementary and alternative medicine: eCAM
Filtrate of Phellinus linteus Broth Culture Reduces Infarct Size Significantly in a Rat Model of Permanent Focal Cerebral Ischemia.
Phellinus linteus, a natural growing mushroom, has been known to exhibit anti-tumor, anti-inflammatory, anti-allergic and anti-oxidant effects. Aiming to exploit the neuroprotective effects of P.
Lion's Mane · 2011 · Other · Evidence-based complementary and alternative medicine: eCAM
Peripheral Nerve Regeneration Following Crush Injury to Rat Peroneal Nerve by Aqueous Extract of Medicinal Mushroom Hericium erinaceus (Bull.: Fr) Pers. (Aphyllophoromycetideae).
Nerve crush injury is a well-established axonotmetic model in experimental regeneration studies to investigate the impact of various pharmacological treatments. Hericium erinaceus is a temperate mushroom but is now being cultivated in tropical Malaysia..
Lion's Mane · 2010 · Research Support, Non U.S. Gov'T · Phytomedicine: international journal of phytotherapy and phytopharmacology
Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation.
Platelet aggregation in the blood vessel causes thrombosis. Therefore, inhibitors of platelet aggregation promise to be preventive or therapeutic agents of various vascular diseases, including myocardial infarction and stroke..
Niu-Chang-Chih · 2009 · Patent · journal metadata
Diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof
The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorata, especially to the new compounds of following structural formula: and pharmaceutically acceptable salt, solvate, hydrate or biologically active equivalent thereof..
Chaga · 2009 · Research Support, Non U.S. Gov'T · Microbiology (Reading, England)
Nitric oxide mediates the fungal-elicitor-enhanced biosynthesis of antioxidant polyphenols in submerged cultures of Inonotus obliquus.
A fungal elicitor prepared from the cell debris of the plant-pathogenic ascomycete Alternaria alternata induces multiple responses by Inonotus obliquus cells, including an increase in generation of nitric oxide (NO), activity of phenylalanine ammonia lyase (PAL) and accumulation of total mycelial phenolic compounds….
Chaga · 2009 · Research Support, Non U.S. Gov'T · Bioresource technology
NMR-based metabonomic analysis on effect of light on production of antioxidant phenolic compounds in submerged cultures of Inonotus obliquus.
This study was designed to investigate the light effect on biosynthesis of antioxidant phenolic compounds by Inonotus obliquus grown in submerged cultures using (1)H NMR spectroscopy combining multivariate pattern recognition strategies. I..
Niu-Chang-Chih · 2008 · Patent · journal metadata
Novel diterpenes from the fruiting body of Antrodia camphorata and pharmaceutical compositions thereof
The present invention relates to novel diterpene compounds isolated from the fruiting body of Antrodia camphorata, especially to the new compounds of following structural formula: and pharmaceutically acceptable salt, solvate, hydrate or biologically active equivalent thereof..
Snow Fungus · 2007 · Research Support, Non U.S. Gov'T · Biological & pharmaceutical bulletin
Effect of Tremella fuciformis on the Neurite Outgrowth of PC12h Cells and the Improvement of Memory in Rats
We investigated the neuritogenic effects of Tremella fuciformis (TF), which has been valued in traditional Chinese medicine as a remedy with nutritive and tonic actions, on PC12h cells..
Niu-Chang-Chih · 2006 · Research Support, Non U.S. Gov'T · Journal of natural products
Neuroprotective diterpenes from the fruiting body of Antrodia camphorata.
Three new compounds, 19-hydroxylabda-8(17)-en-16,15-olide (1), 3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (2), and 13-epi-3beta,19-dihydroxylabda-8(17),11E-dien-16,15-olide (3), together with four known compounds, 19-hydroxylabda-8(17),13-dien-16,15-olide (4), 14-deoxy-11,12-didehydroandrographolide (5),….
Reishi · 2026 · Journal Article · Journal of ethnopharmacology
Lucidenic acid A drives PI3K/AKT/BDNF signaling to improve memory impairment in mice and alleviate cellular nerve damage.
ETHNOPHARMACOLOGICAL RELEVANCE: Enhancing memory and alleviating amnesia are among the conditions that Ganoderma lucidum has historically been used to treat. However, there are relatively few studies on the potential therapeutic effects of active ingredients derived from Ganoderma lucidum in the treatment of memory….
Lion's Mane · 2026 · Journal Article · Computational biology and chemistry
Modulation of ABCB1 by Erinacerin S: Binding dynamics and transmembrane helix remodeling.
Erinacerins are a group of bioactive heterocyclic organic compounds known as Isoindolin-1-one metabolites with the molecular formula C8H9N, derived from the mycelia or fruiting bodies of the mushroom Hericium erinaceus. They are known for their neuroprotective, anti-inflammatory, and anticancer properties..