MycoData

Lentinula edodes, known as shiitake, is the most cultivated edible mushroom worldwide, representing about 22% of the world’s output, with China being the major producer..

Gut & microbiome

High relevance

Reishi · 2018 · Journal Article · Journal of medicinal food

Hypolipidemic, Antioxidant, and Antiapoptotic Effects of Polysaccharides Extracted from Reishi Mushroom, Ganoderma lucidum (Leysser: Fr) Karst, in Mice Fed a High-Fat Diet.

The mechanisms underlying the effect of Ganoderma lucidum (Reishi mushroom) polysaccharides (GLP) on obesity are not clear. In this study, GLP were found to attenuate the oleic acid-induced cell viability loss and apoptosis dose dependently in splenic lymphocytes in vitro..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2018 · Journal Article · Food & function

In vitro bioaccessibility and speciation changes of selenium in Pleurotus eryngii during the growing stage.

The production of Pleurotus eryngii by selenium (Se) biofortification is an effective way to improve the demand for Se in humans. In order to investigate the Se bioaccessibility and speciation of Se-enriched P..

Energy & fatigueGut & microbiome

High relevance

Lion's Mane · 2018 · Journal Article · International journal of biological macromolecules

Isolation, purification and physicochemical properties of polysaccharide from fruiting body of Hericium erinaceus and its effect on colonic health of mice.

Hericium erinaceus was extracted with boiling water to obtain the crude polysaccharide (HECP) and refined polysaccharide (HERP). HERP was further purified using gradual ethanol precipitation to obtain five sub-fractions..

Immune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2018 · Journal Article · Food & function

Polyphenols-rich extract from Pleurotus eryngii with growth inhibitory of HCT116 colon cancer cells and anti-inflammatory function in RAW264.7 cells.

Edible mushrooms are rich sources of bioactive components. In this study, a polyphenol-rich extract, designated as PPEP, was isolated from an edible mushroom, Pleurotus eryngii..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Cordyceps · 2018 · Journal Article · World journal of microbiology & biotechnology

Preservation affects the vegetative growth and fruiting body production of Cordyceps militaris.

Cordyceps militaris is a model species of Cordyceps fungi, and has been traditionally used as an edible and medicinal fungus due to its richness of bioactive and pharmacological metabolites. The fruiting bodies of this fungus are widely used as healthy food and nutrition supply..

Gut & microbiome

High relevance

Oyster Mushroom · 2018 · Journal Article · International journal of medicinal mushrooms

Proximal Composition, Nutraceutical Properties, and Acute Toxicity Study of Culinary-Medicinal Oyster Mushroom Powder, Pleurotus ostreatus (Agaricomycetes).

A compositional study was performed on fruiting-body powder of the culinary-medicinal oyster mushroom Pleurotus ostreatus for applications as a nutraceutical/functional food..

Gut & microbiome

High relevance

Reishi · 2018 · Journal Article · Journal of ethnopharmacology

Reishi mushroom Ganoderma lucidum Modulates IgA production and alpha-defensin expression in the rat small intestine.

ETHNOPHARMACOLOGICAL RELEVANCE: Immunoglobulin A (IgA) secretion and alpha-defensins play a role in the innate immune system to protect against infection. Ganoderma lucidum (W.Curt.: Fr.) P.

Immune supportGut & microbiome

High relevance

King Oyster · 2018 · Research Article · International journal of molecular sciences

Spatial Distribution of Glucan Type and Content between Caps and Stalks in Pleurotus eryngii: Impact on the Anti-inflammatory Functionality.

: Pleurotus eryngii is recognized for its prominent nutritional and medicinal value. In our study, we tested the effect of glucans on lipopolysaccharide (LPS)-induced production of TNF-α.

Immune supportGut & microbiome

High relevance

Lion's Mane · 2018 · Research Article · Molecules (Basel, Switzerland)

The Prebiotic Activity of Simulated Gastric and Intestinal Digesta of Polysaccharides from the Hericium erinaceus.

Hericium erinaceus (HE) is a well-known edible and medicinal fungus widely grown in Asian countries. Polysaccharides from the Hericium erinaceus (HEP) are major biological macromolecules..

Immune supportGut & microbiome

High relevance

Turkey Tail · 2017 · Research Article · Materials (Basel, Switzerland)

Biological Degradation of Chinese Fir with Trametes Versicolor (L.) Lloyd.

Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.) has been an important afforestation species in northeast China. It has obvious defects of buckling and cracking easily, which are caused by its chemical components..

Gut & microbiomeSkin & hydration

High relevance

King Oyster · 2017 · Journal Article · Food & function

In vitro and in vivo inhibitory effects of a Pleurotus eryngii protein on colon cancer cells.

Edible mushrooms have been considered as a good source of bioactive components with various health benefits. Our previous study demonstrated the identity of a novel protein from Pleurotus eryngii, namely PEP, and its anti-inflammatory activities..

OncologyImmune supportGut & microbiome

High relevance

King Oyster · 2017 · Journal Article · Food & function

In vivo fermentation of a Pleurotus eryngii polysaccharide and its effects on fecal microbiota composition and immune response.

A novel, homogeneous Pleurotus eryngii polysaccharide (PEP) (molecular weight 426 kDa, purity 91.25 ± 3.14%) which mainly consisted of glucose with β-type glycosidic linkages was used to investigate in vivo fermentation behavior and effects on immune response in mice..

Immune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2017 · Journal Article · Food & function

Isolation of a novel bioactive protein from an edible mushroom Pleurotus eryngii and its anti-inflammatory potential.

Edible mushrooms are rich sources of bioactive components. In this study, a bioactive protein, PEP, was isolated from an edible mushroom, Pleurotus eryngii, through (NH4)2SO4 precipitation and ion-exchange chromatography..

Immune supportGut & microbiome

High relevance

Lion's Mane · 2016 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Analogy in selenium enrichment and selenium speciation between selenized yeast Saccharomyces cerevisiae and Hericium erinaceus (lion's mane mushroom)

Human selenium supplementation is vastly dominated by selenized yeasts based products not only due to regulation issues but due to the fact that yeasts convert inorganic selenium into organic forms up to 2000 μg g−1 through a well characterized selenium metabolism..

Metabolic healthGut & microbiome

High relevance

Lion's Mane · 2016 · Journal Article · International journal of medicinal mushrooms

Anti-Inflammatory Effects of Ethanol Extract of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), in Mice with Ulcerative Colitis.

This study investigated the anti-inflammatory activity of ethanol extracts of Hericium erinaceus in the inflammatory bowel disease (IBD) model. Twenty C57BL/6 mice were exposed to 2% (w/v) dextran sulfate sodium (DSS) in their drinking water for 7 d to induce acute intestinal inflammation..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2016 · Journal Article · International journal of medicinal mushrooms

Bioavailability and Digestibility of Nutrients from the Dried Oyster Culinary-Medicinal Mushroom, Pleurotus ostreatus (Agaricomycetes): In Vivo Experiments.

There is a limited number of publications on the bioavailability and digestibility of nutrients contained in macrofungi. The aim of this study was to assess the bioavailability and digestibility of macronutrients using in vivo experiments on laboratory animals..

Energy & fatigueMetabolic healthGut & microbiome

High relevance

Yellow Morel · 2016 · Research Article · International journal of molecular sciences

Characteristics and Antitumor Activity of Morchella esculenta Polysaccharide Extracted by Pulsed Electric Field.

Polysaccharides from Morchella esculenta have been proven to be functional and helpful for humans. The purpose of this study was to investigate the chemical structure and anti-proliferating and antitumor activities of a Morchella esculenta polysaccharide (MEP) extracted by pulsed electric field (PEF) in submerged….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2016 · Journal Article · Food chemistry

Characterization, antioxidative and bifidogenic effects of polysaccharides from Pleurotus eryngii after heat treatments.

Polysaccharides were extracted from freeze-dried-, oven-dried- and boiling-treated Pleurotus eryngii (FDPEPS, ODPEPS and BTPEPS). Yield of FDPEPS and its total carbohydrates, total polysaccharides, reducing sugars, phenolics and protein content were higher than ODPEPS and BTPEPS..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Cordyceps · 2016 · Journal Article · International journal of medicinal mushrooms

Cytological Characterization of Anamorphic Fungus Lecanicillium pui and Its Relationship with Chinese Caterpillar Mushroom, Ophiocordyceps sinensis (Ascomycetes).

Ophiocordyceps sinensis (syn. Cordyceps sinensis), one of the most valuable medicinal mushrooms, has great economic importance on the Tibetan Plateau.

Gut & microbiome

High relevance

King Oyster · 2016 · Research Article · AMB Express

Development of a simple, low-cost and eurytopic medium based on Pleurotus eryngii for lactic acid bacteria.

Lactic acid bacteria (LAB) are a group of important beneficial microorganisms for human, but their growth is restricted to the habitats with rich nutrients. In order to develop a simple, low-cost and efficient medium based on the mushroom Pleurotus eryngii, this study evaluated the effects of different treatment….

Gut & microbiome

High relevance

King Oyster · 2016 · Journal Article · Fish physiology and biochemistry

Effects of Eryngii mushroom (Pleurotus eryngii) and Lactobacillus plantarum on growth performance, immunity and disease resistance of Pangasius catfish (Pangasius bocourti, Sauvage 1880).

This study was conducted to evaluate the effects of Eryngii mushroom, Pleurotus eryngii (PE), and Lactobacillus plantarum single or combined on growth, innate immune response and disease resistance of the Pangasius catfish, Pangasius bocourti..

Immune supportEnergy & fatigueGut & microbiomeRespiratory

High relevance

Shiitake · 2016 · Journal Article · FEMS microbiology letters

Incidence of diverse dsRNA mycoviruses in Trichoderma spp. causing green mold disease of shiitake Lentinula edodes.

A total of 315 fungal isolates causing green mold disease were collected from contaminated artificial logs and sawdust bags used for cultivating shiitake Lentinula edodes in Korea and were analyzed for the presence of double-stranded RNA (dsRNA)..

Gut & microbiomeRespiratory

High relevance

Oyster Mushroom · 2016 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Oral administration of an aqueous extract from the oyster mushroom Pleurotus ostreatus enhances the immunonutritional recovery of malnourished mice.

Mushroom nutriceutical components have lately attracted interest for developing immunonutritional support. However, there is relatively little information pertaining to the use of mushroom preparations for modulating the metabolic and immunological disorders associated to malnutrition..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Almond Mushroom · 2016 · Research Article · PloS one

The Agaricus blazei-Based Mushroom Extract, Andosan™, Protects against Intestinal Tumorigenesis in the A/J Min/+ Mouse.

BACKGROUND: The novel A/J Min/+ mouse, which is a model for human Familial Adenomatous Polyposis (FAP), develops spontaneously multiple adenocarcinomas in the colon as well as in the small intestine..

OncologyImmune supportGut & microbiome

High relevance

Yellow Morel · 2026 · Comparative Study · International journal of biological macromolecules

A comparative study of protein extraction methods from Morchella esculenta stipes: Comprehensive analysis of physicochemical, nutritional, digestive, and functional properties.

This study systematically compared four extraction methods-alkaline extraction (AE), ultrasound-assisted alkaline extraction (UAE), subcritical water extraction (SWE), and deep eutectic solvent extraction (DES)-for their effects on the extraction efficiency, structural characteristics, functional properties and….

Gut & microbiome

High relevance

Reishi · 2026 · Comparative Study · Australian endodontic journal: the journal of the Australian Society of Endodontology Inc

Comparative In Vitro Evaluation of Antibacterial Activity of Ganoderma lucidum- and Psidium guajava-Loaded Drug Delivery Scaffolds Against Enterococcus faecalis Biofilms.

This in vitro study evaluated the antibacterial efficacy of novel herbal intracanal medicaments, specifically Ganoderma lucidum (GL) and Psidium guajava (PG) extracts, incorporated into Pluronic F127 drug delivery scaffolds, against Enterococcus faecalis biofilms..

Energy & fatigueGut & microbiomeLiver support

High relevance

Shiitake · 2026 · Evaluation Study · Food chemistry

Intense pulsed light-assisted water extraction of polysaccharides from Lentinula edodes: In vitro structural characterization and verification of antioxidant activities.

Polysaccharides from Lentinula edodes (L. edodes) exhibit antioxidant and immunomodulatory activities, but conventional extraction is limited by low efficiency and potential loss of bioactivity..

Immune supportGut & microbiomeSkin & hydration

High relevance

Reishi · 2026 · Research Support, Non U.S. Gov'T · Biomolecules

Study on the Mechanism of Ganoderma lucidum Polysaccharides for Ameliorating Dyslipidemia via Regulating Gut Microbiota and Fecal Metabolites.

In today's world, unhealthy living habits have contributed to the rise in metabolic disorders like hyperlipidemia. Recognized as a popular edible and medicinal mushroom in China and various eastern nations, Ganoderma lucidum is a promising high-value functional and medicinal food with multiple biological activities..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Efficacy of Ganoderma lucidum spores in invigorating spleen via spleen meridian].

Based on the model of spleen deficiency, this study investigated the medicinal properties of spleen meridian tropism of Ganoderma lucidum spores and their efficacy of strengthening the spleen..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Zhu Ling · 2025 · Comparative Study · International journal of biological macromolecules

Comparative study of physicochemical properties, antioxidant activity, antitumor activity and in vitro fermentation prebiotic properties of Polyporus umbellatus (Pers.) Fries polysaccharides at different solvent extractions.

Polyporus umbellatus (Pers.) Fries (PU), a medicinal fungus, contains polysaccharides (PUPs) as its primary bioactive components. In this paper, physicochemical properties, biological activities and in vitro fermentation prebiotic properties of PUPs, extracted by 90 °C hot water (PUP-W), 0.9 % NaCl (PUP-N), citric….

OncologyImmune supportGut & microbiome

High relevance

Lion's Mane · 2025 · Letter · World journal of gastroenterology

Potential of traditional Chinese medicine in gastrointestinal disorders: Hericium erinaceus in chronic atrophic gastritis.

Traditional Chinese medicine (TCM) has been extensively explored with various naturally derived compounds as a potential therapeutic agent for chronic atrophic gastritis (CAG)..

OncologyCognition & nervesGut & microbiome

High relevance

Almond Mushroom · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

The Age-Dependent Anticancer Efficacy of Agaricus blazei Murill Polysaccharide in Colon Cancer.

Agaricus blazei Murill polysaccharide (ABMP) has been found to exhibit significant immune regulatory effects, making them a promising candidate for complementary to the pharmacological treatment of colorectal cancer immune-related diseases..

OncologyImmune supportGut & microbiome

High relevance

Yellow Morel · 2024 · Comparative Study · International journal of biological macromolecules

Comparative study on physicochemical properties and hypoglycemic activities of intracellular and extracellular polysaccharides from submerged fermentation of Morchella esculenta.

The structural characteristic, physicochemical properties and structure-hypoglycemic activity relationship of intracellular (IPS) and extracellular (EPS) from submerged fermentation of Morchella esculenta were systematically compared and assessed..

Immune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2024 · Published Erratum · Food & function

Correction: Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats.

Correction for 'Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats' by Lu Li et al., Food Funct., 2019, 10, 2560-2572, https://doi.org/10.1039/C9FO00075E..

Immune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2024 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Grifola frondosa polysaccharide's therapeutic potential in oxazolone-induced ulcerative colitis.

Grifola frondosa polysaccharide (GFP) is a consumable fungus recognized for its potential health advantages. The present study aimed to investigate the development and potential etiologies of ulcerative colitis (UC) utilizing oxazolone (OXZ) as an inducer in mice, along with assessing the therapeutic effects of GFP at….

Immune supportGut & microbiome

High relevance

Maitake · 2023 · Journal Article · International journal of biological macromolecules

A cold-water extracted polysaccharide-protein complex from Grifola frondosa exhibited anti-tumor activity via TLR4-NF-κB signaling activation and gut microbiota modification in H22 tumor-bearing mice.

Grifola frondosa polysaccharide-protein complex (G. frondosa PPC) is a polymer which consists of polysaccharides and proteins/peptides linked by covalent bonds.

OncologyImmune supportGut & microbiomeLiver support

High relevance

Shiitake · 2023 · Research Article · Veterinary sciences

A Supplement with Bromelain, Lentinula edodes, and Quercetin: Antioxidant Capacity and Effects on Morphofunctional and Fecal Parameters (Calprotectin, Cortisol, and Intestinal Fermentation Products) in Kennel Dogs.

Oxidative stress causes several pathological conditions in humans and animals, including gastrointestinal disorders. The aim of this study was to analyze the antioxidant capacity of three natural powdered raw materials containing quercetin, bromelain, and Lentinula edodes and develop a new feed supplement for dogs….

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2023 · Journal Article · International journal of biological macromolecules

An antioxidative, green and safe nanofibers-based film containing pullulan, sodium hyaluronate and Ganoderma lucidum fermentation for enhanced skincare.

Dry masks made of natural active ingredients that are packaged in sustainable paper and free of irritating additives (e.g. preservatives, stabilizers) are a trend in the concept of healthy skincare, which possess the advantages of portability, safety and environmental friendliness..

OncologyGut & microbiomeSkin & hydration

High relevance

Reishi · 2023 · Journal Article · International journal of biological macromolecules

Anti-inflammatory and intestinal microbiota modulation properties of Ganoderma lucidum β-d-glucans with different molecular weight in an ulcerative colitis model.

This study systematically investigated the therapeutic effects and the corresponding mechanisms of β-D-glucans from Ganoderma lucidum (G. lucidum) with different molecular weights (Mws) on ulcerative colitis (UC).

Immune supportGut & microbiome

High relevance

Lion's Mane · 2023 · Research Article · Polymers

Antioxidant Activities and Prebiotic Activities of Water-Soluble, Alkali-Soluble Polysaccharides Extracted from the Fruiting Bodies of the Fungus Hericium erinaceus.

In this study, the digestion and fermentation properties of the bioactive water-soluble polysaccharide (HEP-W), and alkali-soluble polysaccharide (HEP-A) from Hericium erinaceus and the impact on the human colonic microbiota were determined using simulated saliva-gastrointestinal digestion and human fecal fermentation….

Immune supportGut & microbiome

High relevance

Yellow Morel · 2023 · Research Article · Foods (Basel, Switzerland)

Antioxidative and Protective Effect of Morchella esculenta against Dextran Sulfate Sodium-Induced Alterations in Liver.

Morchella esculenta is an edible mushroom with special flavor and high nutritional value for humans, primarily owing to its polysaccharide constituents. M.

Immune supportGut & microbiomeLiver support

High relevance

Reishi · 2023 · Research Article · Veterinary world

Antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against Blastocystis hominis.

BACKGROUND AND AIM: Blastocystis hominis is an intestinal protozoan in humans and animals. The parasite causes mild-to-severe intestinal complications, such as diarrhea, in healthy humans and immunocompromised hosts..

Immune supportGut & microbiome

High relevance

Wood Ear · 2023 · Journal Article · International journal of biological macromolecules

Auricularia auricula-judae (Bull.) polysaccharides improve obesity in mice by regulating gut microbiota and TLR4/JNK signaling pathway.

Obesity has emerged as a crucial factor impacting people's lives, and gut microbiota disorders contribute to its development and progression. Auricularia auricula-judae (Bull.) polysaccharides (AAPs), a traditional functional food in Asia, exhibit potential anti-obesity effects..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2023 · Journal Article · Food & function

Combined Ganoderma lucidum polysaccharide and ciprofloxacin therapy alleviates Salmonella enterica infection, protects the intestinal barrier, and regulates gut microbiota.

Clinical antibiotics used worldwide could diminish the intestinal barrier, enhance contact with microbiota and intestinal immune cells, and induce inflammation. We found that ciprofloxacin treatment of Salmonella enterica serovar Typhimurium infection resulted in the destruction of the intestinal barrier, with….

Immune supportGut & microbiome

High relevance

Shiitake · 2023 · Research Article · Frontiers in microbiology

Comparative analysis of simulated in-situ colonization and degradation by Lentinula edodes on oak wafer and corn stalk.

INTRODUCTION: The depolymerization of lignocellulose biomass by white-rot fungi has been an important research topic. However, few simulated in-situ analyses have been conducted to uncover the decay..

Immune supportEnergy & fatigueGut & microbiome

High relevance

Yellow Morel · 2023 · Journal Article · Journal of the science of food and agriculture

Digestion profile, antioxidant, and antidiabetic capacity of Morchella esculenta exopolysaccharide: in vitro, in vivo and microbiota analysis

BACKGROUND: Novel functional polysaccharides from fungi are important nutraceuticals. An exopolysaccharide, Morchella esculenta exopolysaccharide (MEP 2), was extracted and purified from the fermentation liquor of M.

Immune supportMetabolic healthGut & microbiome

High relevance

Yellow Morel · 2023 · Journal Article · Journal of the science of food and agriculture

Digestion profile, antioxidant, and antidiabetic capacity of Morchella esculenta exopolysaccharide: in vitro, in vivo and microbiota analysis.

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2023 · Journal Article · Food & function

Edible and medicinal mushrooms (Pleurotus ostreatus, Ustilago maydis, Ganoderma lucidum) reduce endoplasmic reticulum stress and inflammation in adipose tissue of obese Wistar rats fed with a high fat plus saccharose diet.

Obesity is an increasing global public health problem. A strategy to treat obesity is the use of functional foods.

Immune supportMetabolic healthGut & microbiomeSkin & hydration