MycoData

Enhancing the phagocytosis of immune cells with medicines provides benefits to the physiological balance by removing foreign pathogens and apoptotic cells. The fungal immunomodulatory protein (FIP) possessing various immunopotentiation functions may be a good candidate for such drugs..

Immune support

High relevance

Cordyceps · 2021 · Research Article · Microorganisms

Culture Degeneration Reduces Sex-Related Gene Expression, Alters Metabolite Production and Reduces Insect Pathogenic Response in Cordyceps militaris.

Cordyceps militaris is an entomopathogenic ascomycete, known primarily for infecting lepidopteran larval (caterpillars) and pupal hosts. Cordycepin, a secondary metabolite produced by this fungus has anti-inflammatory properties and other pharmacological activities..

Immune support

High relevance

Reishi · 2021 · Journal Article · International journal of medicinal mushrooms

Effect of Continuous Cropping Soil on the Biosynthesis of Bioactive Compounds and the Antioxidant Activity of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes).

Continuous monoculture can increase plant morbidity and reduce crop yields. However, the Ganoderma lucidum mushroom possesses unique nutrient acquisition methods and displays an altered response to the generation of reactive oxygen species (ROS).

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2021 · Journal Article · Pakistan journal of biological sciences: PJBS

Effects of Edible Insects on the Mycelium Formation of Cordyceps militaris.

Background and Objective: Cordyceps militaris is a potential edible medicinal mushroom which containing various biological activity such as anti-inflammatory, anti-ageing, anti-protozoal and anti-microbial. The compositions of C.

Immune supportGut & microbiome

High relevance

Chaga · 2021 · Journal Article · Journal of applied microbiology

Effects of supplementation of sea buckthorn press cake on mycelium growth and polysaccharides of Inonotus obliquus in submerged cultivation.

AIMS: Investigation of the influence of cultivation time and sea buckthorn press cake (Hippophaë rhamnoides) dosage on mycelium yield of Inonotus obliquus in submerged cultivation and on the yield, monomer composition, and macromolecular properties of the exopolysaccharides (EPS) from culture media and intracellular….

Immune support

High relevance

Reishi · 2021 · Journal Article · Food & function

Extraction kinetics, physicochemical properties and immunomodulatory activity of the novel continuous phase transition extraction of polysaccharides from Ganoderma lucidum.

Ganoderma lucidum polysaccharides (GLP) possess remarkable bioactivity and have been studied widely. However, the application of new technologies in the polysaccharide extraction has not been investigated..

Immune support

High relevance

King Oyster · 2021 · Research Article · Microorganisms

Fermentation Supernatants of Pleurotus eryngii Mushroom Ameliorate Intestinal Epithelial Barrier Dysfunction in Lipopolysaccharide-Induced Caco-2 Cells via Upregulation of Tight Junctions.

In recent years, modulation of gut microbiota through prebiotics has garnered interest as a potential to ameliorate intestinal barrier dysfunction. The aim of the study was to examine the in vitro effect of fermentation supernatants (FSs) from rich in β-glucan Pleurotus eryngii mushrooms on the expression levels of….

Immune supportGut & microbiome

High relevance

Enoki · 2021 · Journal Article · International journal of biological macromolecules

Green fabrication of seedbed-like Flammulina velutipes polysaccharides-derived scaffolds accelerating full-thickness skin wound healing accompanied by hair follicle regeneration.

A novel seedbed-like scaffold was firstly fabricated by the "frozen sectioning" processing method using Flammulina velutipes as a raw material. The Flammulina velutipes polysaccharides scaffold is composed of a natural structure imitating the "ground" (connected and aligned hollow tubes with porous walls)..

Immune supportSkin & hydration

High relevance

Maitake · 2021 · Research Article · Nutrients

Grifola frondosa (Maitake) Extract Reduces Fat Accumulation and Improves Health Span in C. elegans through the DAF-16/FOXO and SKN-1/NRF2 Signalling Pathways.

In recent years, food ingredients rich in bioactive compounds have emerged as candidates to prevent excess adiposity and other metabolic complications characteristic of obesity, such as low-grade inflammation and oxidative status..

Immune supportMetabolic health

High relevance

Lion's Mane · 2021 · Research Article · Antioxidants (Basel, Switzerland)

Hericium erinaceus and Coriolus versicolor Modulate Molecular and Biochemical Changes after Traumatic Brain Injury.

Traumatic brain injury (TBI) is a major health and socioeconomic problem affecting the world. This condition results from the application of external physical force to the brain which leads to transient or permanent structural and functional impairments..

Immune supportCognition & nerves

High relevance

Cordyceps · 2021 · Research Article · PeerJ

Identification and functional analysis of bacteria in sclerotia of Cordyceps militaris.

BACKGROUND: Cordyceps militaris is a fungus that parasitizes insects. Compounds from C.

Immune support

High relevance

Cordyceps · 2021 · Journal Article · Journal of ethnopharmacology

Immunostimulatory effects of the intracellular polysaccharides isolated from liquid culture of Ophiocordyceps sinensis (Ascomycetes) on RAW264.7 cells via the MAPK and PI3K/Akt signaling pathways.

ETHNOPHARMACOLOGICAL RELEVANCE: Chinese Cordyceps (DongChong XiaCao), a parasitic complex of a fungus Ophiocordyceps sinensis and a caterpillar, is a traditional Chinese medicine. Polysaccharides extracted from O.

Immune supportMetabolic health

High relevance

Cordyceps · 2021 · Research Article · Frontiers in microbiology

Improving Hypoxia Adaption Causes Distinct Effects on Growth and Bioactive Compounds Synthesis in an Entomopathogenic Fungus Cordyceps militaris.

Cordyceps militaris is an entomopathogenic fungus producing a variety of bioactive compounds. To meet the huge demand for medicinal and edible products, industrialized fermentation of mycelia and cultivation of stromata have been widely developed in China.

Immune support

High relevance

Reishi · 2021 · Research Article · Precision clinical medicine

Inhibitory activity of medicinal mushroom Ganoderma lucidum on colorectal cancer by attenuating inflammation.

The medicinal mushroom Ganoderma lucidum (GL, Reishi or Lingzhi) exhibits an inhibitory effect on cancers. However, the underlying mechanism of the antitumor activity of GL is not fully understood..

OncologyImmune support

High relevance

King Oyster · 2021 · Journal Article · Food & function

Inhibitory effects of β-type glycosidic polysaccharide from Pleurotus eryngii on dextran sodium sulfate-induced colitis in mice.

The aim of the present study was to determine the inhibitory effects and the potential underlying mechanisms of a novel Pleurotus eryngii β-type glycosidic polysaccharide (WPEP) on colitis..

Immune supportGut & microbiome

High relevance

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Integrated bioinformatics analysis of the anti-atherosclerotic mechanisms of the polysaccharide CM1 from Cordyceps militaris.

Cordyceps militaris is a well-known traditional Chinese medicine. Studies have demonstrated that the polysaccharides of C.

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2021 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Investigation of the molecular mechanism underlying the inhibitory activities of ethanol extract of Bombyx mori pupa-incubated Cordyceps militaris fruiting bodies toward allergic rhinitis.

Cordyceps militaris has been widely studied for its various pharmacological activities such as antitumor, anti-inﬂammation, and immune regulation. The binding of an allergen to IgE-sensitized mast cells in nasal mucosa triggers allergic rhinitis..

OncologyImmune support

High relevance

King Oyster · 2021 · Journal Article · Food & function

JNK pathway and heat shock response mediate the survival of C26 colon carcinoma bearing mice fed with the mushroom Pleurotus eryngii var. eryngii without affecting tumor growth or cachexia.

In the last few years, there has been emerging interest in developing treatments against human diseases using natural bioactive content. Here, the powder of the edible mushroom Pleurotus eryngii var.

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2021 · Research Article · Antioxidants (Basel, Switzerland)

Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer's Disease.

Alzheimer's disease (AD) is the principal cause of dementia, and its incidence increases with age. Altered antioxidant systems and inflammation have an important role in the etiology of neurodegenerative disorders..

Immune supportCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2021 · Research Article · Nutrients

Lactic Acid Bacteria Fermented Cordyceps militaris (GRC-SC11) Suppresses IgE Mediated Mast Cell Activation and Type I Hypersensitive Allergic Murine Model.

Cordyceps militaris (C. militaris) has various biomedical applications in traditional oriental medicine for different diseases including inflammatory and immune-dysregulated diseases.

OncologyImmune support

High relevance

Lion's Mane · 2021 · Journal Article · International journal of medicinal mushrooms

Liver and Brain Protective Effect of Sulfated Polysaccharides from Residue of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), on D-Galactose-Induced Aging Mice.

This work describes the preparation of sulfated Hericium erinaceus residue polysaccharides (SHRPs) and investigates their antioxidant and antiaging effects on D-galactose-induced aging mice. The results indicated that the degree of SO42- substitution was 0.47 ± 0.22 for SHRPs..

Immune supportCognition & nervesLiver support

High relevance

Cordyceps · 2021 · Research Article · Journal of pharmaceutical analysis

Matrix-assisted laser desorption ionization mass spectrometry based quantitative analysis of cordycepin from Cordyceps militaris.

Cordycepin, which has great immunomodulatory activities such as anticancer, antifungal, antivirus, antileukemia and lipid-lowering ones, is the secondary metabolite of Cordyceps militaris (C. militaris).

OncologyImmune supportRespiratory

High relevance

Cordyceps · 2021 · Research Article · Molecules (Basel, Switzerland)

Molecular Cloning, Expression and Macrophage Activation of an Immunoregulatory Protein from Cordyceps militaris.

Protein components of C. militaris have been reported to possess various biological activities.

OncologyImmune support

High relevance

Turkey Tail · 2021 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Musarin, a novel protein with tyrosine kinase inhibitory activity from Trametes versicolor, inhibits colorectal cancer stem cell growth.

Colorectal cancer is the second deadly cancer in the world. Trametes versicolor is a traditional Chinese medicinal mushroom with a long history of being used to regulate immunity and prevent cancer..

OncologyImmune supportGut & microbiome

High relevance

King Oyster · 2021 · Journal Article · International journal of biological macromolecules

Pleurotus eryngii polysaccharide nanofiber containing pomegranate peel polyphenol/chitosan nanoparticles for control of E. coli O157:H7.

Pomegranate peel polyphenols (PPP), which are natural, safe, and green antibacterial agents, were introduced and embedded in chitosan to form stable nanoparticles. The PPP@chitosan nanoparticles (PPP@CNPs) were further electrospun into nanofibers based on Pleurotus eryngii polysaccharide (PEP)..

Immune support

High relevance

Cordyceps · 2021 · Research Article · Lipids in health and disease

Polysaccharide CM1 from Cordyceps militaris hinders adipocyte differentiation and alleviates hyperlipidemia in LDLR(+/-) hamsters.

BACKGROUND: Cordyceps militaris is cultured widely as an edible mushroom and accumulating evidence in mice have demonstrated that the polysaccharides of Cordyceps species have lipid-lowering effects..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Yellow Morel · 2021 · Journal Article · Food & function

Polysaccharide MCP extracted from Morchella esculenta reduces atherosclerosis in LDLR-deficient mice.

The pharmaceutical application of fungal polysaccharides has been extensively studied based on their multiple biological activities. However, the effect of Morchella esculenta polysaccharides on the development of atherosclerosis remains unknown..

Immune supportMetabolic healthLiver support

High relevance

King Oyster · 2021 · Journal Article · Carbohydrate polymers

Polysaccharides from Pleurotus eryngii: Selective extraction methodologies and their modulatory effects on THP-1 macrophages.

Polysaccharides from P. eryngii mushroom were selectively extracted using low-cost technologies (water at different conditions of temperature and pressure).

OncologyImmune support

High relevance

Cordyceps · 2021 · Research Article · Foods (Basel, Switzerland)

Polysaccharides Obtained from Cordyceps militaris Alleviate Hyperglycemia by Regulating Gut Microbiota in Mice Fed a High-Fat/Sucrose Diet.

Polysaccharides isolated from fungus Cordyceps militaris display multi-biofunctions, such as immunostimulation, down-regulation of hyperlipidemia, and anti-cancer function. The occurrence of obesity and metabolic syndrome is related to the imbalance of gut microbiota.

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2021 · Research Article · Molecules (Basel, Switzerland)

Postharvest Drying Techniques Regulate Secondary Metabolites and Anti-Neuroinflammatory Activities of Ganoderma lucidum.

Ganoderma lucidum extract is a potent traditional remedy for curing various ailments. Drying is the most important postharvest step during the processing of Ganoderma lucidum.

Immune supportCognition & nerves

High relevance

Wood Ear · 2021 · Journal Article · International journal of medicinal mushrooms

Preparation of Wood Ear Mushroom, Auricularia auricula-judae (Agaricomycetes), Polysaccharides by Neutral Protease and Their Antioxidant Stress Capacity.

Response surface methodology with a Box-Behnken design was used to investigate the effects of a neutral protease on Auricularia auricula-judae polysaccharide (AAP) extraction yield. Four ethanol concentrations (30%, 50%, 70%, and 90%) were used to grade AAPs..

Immune support

High relevance

Chaga · 2021 · Journal Article · International journal of medicinal mushrooms

Protective Effects of Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Extract on β-Amyloid-Induced Neurotoxicity in PC12 Cells and Aging Rats: In Vitro and In Vivo Studies.

Modulation of β-amyloid (Aβ)-induced neurotoxicity has emerged as a possible therapeutic approach to ameliorate the onset and progression of Alzheimer's disease. The present study aimed to evaluate the protective effect of Inonotus obliquus extracts (IOEs) on Aβ-induced neurotoxicity in cultured rat pheochromocytoma….

OncologyImmune supportCognition & nerves

High relevance

Lion's Mane · 2021 · Journal Article · International journal of medicinal mushrooms

Screening and Comparison of Anti-Intestinal Inflammatory Activities of Three Polysaccharides from the Mycelium of Lion's Mane Culinary-Medicinal Mushroom, Hericium erinaceus (Agaricomycetes).

Three major polysaccharides (wHEP-1, wHEP-2, and wHEP-3) were isolated from the mycelium of Hericium erinaceus. This study assessed their chemical and physical properties, molecular weight, monosaccharide compositions, and anti-ulcerative colitis ability to protect Caco-2 cells from lipopolysaccharide (LPS)-induced….

Immune supportMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2021 · Journal Article · International journal of biological macromolecules

Structural characterization of enzymatic modification of Hericium erinaceus polysaccharide and its immune-enhancement activity.

In this study, the enzyme degradation of Hericium erinaceus polysaccharide (HEP) was successfully modified with endo-rhamnosidase to obtain the enzymatic hydrolysis of Hericium erinaceus polysaccharide product (EHEP)..

Immune supportEnergy & fatigue

High relevance

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Structure analysis and antioxidant activity of polysaccharide-iron (III) from Cordyceps militaris mycelia.

Iron-enriched Cordyceps militaris was obtained by adding FeSO4 solution to the mycelia for biotransformation. The polysaccharide-iron (III) was extracted by water extraction and alcohol precipitation.

Immune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2021 · Journal Article · International journal of biological macromolecules

Structure and hypoglycemic activity of a novel exopolysaccharide of Cordyceps militaris.

A novel neutral exopolysaccharide (EPS-III) was isolated from culture broth of Cordyceps militaris (C. militaris).

Immune supportMetabolic health

High relevance

Lion's Mane · 2021 · Research Article · Food chemistry: X

Study on the interaction of Hericium erinaceus mycelium polysaccharides and its degradation products with food additive silica nanoparticles.

Gastric mucosal injury is a common gastrointestinal disorder. Hericium erinaceus polysaccharide, the major active ingredient in Hericium erinaceus, can reduce gastric mucosal damage to some extent..

Immune supportGut & microbiome

High relevance

Almond Mushroom · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Subcritical Water Extracts from Agaricus blazei Murrill's Mycelium Inhibit the Expression of Immune Checkpoint Molecules and Axl Receptor.

Agaricus blazei Murrill or Himematsutake is an edible and medicinal mushroom. Agaricus blazei Murrill's fruiting body extracts have anticancer properties, although the mechanism is unknown..

OncologyImmune supportRespiratory

High relevance

Reishi · 2021 · Journal Article · Tissue & cell

The association between testicular toxicity induced by Li2Co3 and protective effect of Ganoderma lucidum: Alteration of Bax & c-Kit genes expression.

Ganoderma lucidum has received a lot of attention recently due to its medicinal potential activities. The aim of this designed experiment was to evaluate the beneficial effects of Ganoderma lucidum extract against lithium carbonate induced testicular toxicity and related lesions in mice testis..

OncologyImmune support

High relevance

Yellow Morel · 2021 · Journal Article · Food & function

The chemical structure and immunomodulatory activity of an exopolysaccharide produced by Morchella esculenta under submerged fermentation.

The extracellular polysaccharide of Morchella esculenta cultivated under submerged fermentation was extracted. A single polysaccharide was purified through DEAE-Cellulose 52 and Sephadex G 100, and named as MEP 2a.

Immune supportMetabolic health

High relevance

Chaga · 2021 · Research Article · Food science & nutrition

The difference of regulatory effect of two Inonotus obliquus extracts on high-fat diet mice in relation to the fatty acid elongation function of gut microbiota.

Obesity is a disease that causes metabolic disorders in the human body and is closely related to intestinal microbes. This experiment compares the therapeutic effects of two Inonotus obliquus extracts on high-fat diet (HFD) mice and explores the effects and mechanisms of intestinal flora and its metabolites..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Maitake · 2021 · Journal Article · Food & function

The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways.

Polysaccharides can be used as a potential hepatoprotective agent in the treatment of acute liver injury. However, the underlying mechanism governing how polysaccharides protect against acute liver injury induced by lipopolysaccharide/d-galactosamine (LPS/d-GalN) remains unclear..

OncologyImmune supportLiver supportRespiratory

High relevance

Snow Fungus · 2021 · Journal Article · Journal of cosmetic dermatology

Tremella fuciformis polysaccharides inhibit UVA-induced photodamage of human dermal fibroblast cells by activating up-regulating Nrf2/Keap1 pathways.

BACKGROUND: UVA radiation can cause skin oxidative stress. Tremella fuciformis polysaccharides (TFPS) are the main active ingredient in Tremella.

Immune supportEnergy & fatigueSkin & hydration

High relevance

King Oyster · 2021 · Journal Article · Carbohydrate polymers

Water-soluble polysaccharides from Pleurotus eryngii fruiting bodies, their activity and affinity for Toll-like receptor 2 and dectin-1.

The mushroom cell wall contains polysaccharides that can activate cells of the innate immune system through receptors such as Toll-like receptors (TLR) and dectin-1..

Immune support

High relevance

Cordyceps · 2023 · Preprint · journal metadata

Evaluation of the biological activity of Cordyceps militaris as an antioxidant, anti-bacterial, and anti-inflammatory agent for natural healthcare

Abstract This study presents the bioactive compounds and the antioxidant, anti-bacteria, and anti-inflammatory activities of C. militaris fruiting body (FB) and fruiting body with substrate (FBS).

Immune supportGut & microbiome

High relevance

Reishi · 2022 · Journal Article · Molecular biology reports

Investigation of HER-3 gene expression under the influence of carbohydrate biopolymers extract of shiitake and reishi in MCF-7 cell line.

INTRODUCTION: Edible-medicinal fungi are mainly used in Asian countries to prevent various diseases. These mushrooms are also used to treat lung diseases and cancer.

OncologyImmune supportRespiratory

High relevance

Maitake · 2009 · Systematic Review · Journal of the Society for Integrative Oncology

Maitake mushroom (Grifola frondosa): systematic review by the natural standard research collaboration.

The objective of this study was to evaluate the scientific evidence on maitake, including expert opinion, folkloric precedent, history, pharmacology, kinetics/dynamics, interactions, adverse effects, toxicology, and dosing. This review serves as a clinical support tool..

OncologyImmune supportMetabolic health

High relevance

Snow Fungus · 2026 · Preprint · journal metadata

Beyond Conventional Drying: Improving the Quality of Dried Tremella fuciformis via a Heat-Integrated Pretreatment

Abstract Hot-air drying (HAD) of Tremella fuciformis often leads to poor rehydration, yellowing, and long preparation times, lowering its industrial value. This study introduces a heat-integrated pretreatment (HIP) as a simple and viable strategy to enhance the quality of dried product..

Immune supportSkin & hydration

High relevance

Cordyceps · 2026 · Published Erratum · Food research international (Ottawa, Ont.)

Corrigendum to "Neomycin-sensitive gut bacteria-derived brassicasterol mediates the anti-obesity effects of Cordyceps militaris polysaccharide" [Food Res. Int. 230 (2026) 118574].

Metadata-grounded summary: This published erratum indexes research on Cordyceps militaris in Food research international (Ottawa, Ont.) in 2026. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Immune supportGut & microbiome

High relevance

Reishi · 2026 · Preprint · journal metadata

Research on the Structural Features and Regulatory Effect of Polysaccharides in Ganoderma lucidum on TAMs

Abstract This experiment purified GLAP-2 from Ganoderma lucidum through Sepharose 6B and Sephacryl S-300 HR gradient elution, collected it by freeze-drying, and obtained GLAP-2 with a uniform molecular weight of 3.7×10⁴ Da. Its total polysaccharide content was 79.79%, and the content of galacturonic acid was 23.82%..

Immune support