MycoData

Energy & fatigueMetabolic health

Cordyceps · 2025 · Research Article · FEBS open bio

Effect of Cordyceps militaris extract containing cordycepin on the adipogenesis and lipolysis of adipocytes.

Obesity, a global health concern, results from an energy imbalance leading to lipid accumulation. In the present study, Cordyceps militaris extract (CM) and its primary component, cordycepin, were investigated to characterize their potential effects on adipogenesis and lipolysis..

Energy & fatigueMetabolic healthGut & microbiome

Oyster Mushroom · 2025 · Journal Article · Journal of applied poultry research

Effects of dietary inclusion of oyster mushroom (Pleurotus ostreatus) powder on live performance, physical meat quality, hemato-biochemical indices and cecal bacterial load in Sonali chickens

The current research aimed to assess the effects of oyster mushroom powder as potential alternative to antibiotic growth promoters on growth performance, physical meat quality, hemato-biochemical indices and cecal bacterial load in Sonali chickens..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Effects of Ganoderma lucidum fermentation on the structure of Tartary buckwheat polysaccharide and its impact on gut microbiota composition.

Fermentation modifies plant polysaccharides and enhances their bioactivity. In this study, polysaccharides were extracted from Ganoderma lucidum-fermented (FBP) and non-fermented (NBP) Tartary buckwheat.

King Oyster · 2025 · Research Article · Biomedicines

Effects of In Vitro Fermented Pleurotus eryngii on Intestinal Barrier Integrity and Immunomodulation in a Lipopolysaccharide-Induced Colonic Model.

Background: This study investigates the impact of fermentation supernatants (FSs) from Pleurotus eryngii whole mushrooms (PEWS), as well as its subcomponents, digested (PEWSD) and extracted (PEWSE) forms, on intestinal barrier function and immune modulation in lipopolysaccharide (LPS) -stimulated Caco-2 cells..

Cordyceps · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Effects of selenium enrichment on the nutritional components, metabolites, and flavor volatiles of fermented Cordyceps militaris juice

Selenium (Se) enrichment changes the nutritional composition and secondary metabolites of Cordyceps militaris (CM), but its effect on the fermentation process of CM is still unclear..

Almond Mushroom · 2025 · Research Article · Scientific reports

Effects of selenium nanoparticles on cadmium uptake, selenium transformation, and metabolomics in Agaricus Blazei murill.

Selenium nanoparticles (Se NPs) primarily reduce cadmium content in plants. However, the mechanism by which Se NPs affect the Cd content in edible mushrooms is unknown.

Immune supportMetabolic health

Chaga · 2025 · Research Article · International journal of molecular sciences

Elucidating the Anti-Diabetic Mechanisms of Mushroom Chaga (Inonotus obliquus) by Integrating LC-MS, Network Pharmacology, Molecular Docking, and Bioinformatics.

Diabetes mellitus is characterized by insulin resistance, impaired glucose homeostasis, and dysregulated glucose metabolism, leading to complications. Inonotus obliquus (Chaga) has shown potential anti-diabetic effects, but the bioactive compounds and molecular targets remain unclear..

OncologyImmune supportMetabolic healthGut & microbiome

King Oyster · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Enhancing the Nutritional and Health-Related Properties of Taralli Through the Use of Pleurotus eryngii: Focus on Antioxidant and Anti-Inflammatory Properties.

In this study, a portion of whole durum wheat semolina was replaced with Pleurotus eryngii powder (PeP) at concentrations of 5% and 10% (w/w) to produce two taralli variants, TPE5 and TPE10. The impact of PeP on the technological, chemical, physical, and sensory properties of taralli was evaluated..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · Review · International journal of biological macromolecules

Extraction, purification, structural characterization, biological activity, mechanism of action and application of polysaccharides from Ganoderma lucidum: A review.

Ganoderma lucidum is a traditional tonic medicine in China, known as the "fairy grass" and "spiritual grass". It contains various chemical components, such as polysaccharides, triterpenoids, alkaloids, nucleosides, sterols, and acid compounds, which have the effects of tonifying qi and calming the mind, stopping cough….

OncologyImmune supportEnergy & fatigueMetabolic health

Enoki · 2025 · Research Article · Journal of dental sciences

Flammulina velutipes polysaccharides exhibit potent antioxidant and anti-pyroptotic properties in diabetes-associated periodontitis: A preliminary in vitro study.

BACKGROUND/PURPOSE: Diabetes-associated periodontitis (DAP) is a complicated illness characterized by elevated oxidative stress and a pro-inflammatory response. There is a bidirectional relationship between diabetes and periodontitis..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2025 · Journal Article · Journal of agricultural and food chemistry

Functional Characterization of a β-1,3-Glucanosyltransferase CmGel4 in Cordyceps militaris Using a Precise CRISPR-Cas9 Genome-Editing System.

Cordyceps militaris polysaccharides, especially β-glucans, have presented significant antitumor, hypoglycemic, and immunomodulatory activities. However, the enzymes involved in the branching formation of C.

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Journal of pharmaceutical and biomedical analysis

Ganoderma lucidum spore oil attenuates acute liver injury by modulating lipid metabolism and gut microbiota.

The incidence of acute liver injury is increasing and poses a significant threat to human health. Ganoderma lucidum spore oil (GLSO), a lipid substance extracted from Ganoderma lucidum spore powder using supercritical CO2 technology, has been investigated for its potential to prevent acute liver injury..

OncologyImmune supportMetabolic healthLiver support

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum spore oil modulates immunity in hepatoma H22-bearing mice and restricts tumor growth by inhibiting eicosanoid metabolism pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum spore oil (GLSO) is a well-known health product that is beneficial for immuno-enhancement, which stems from a medicine fungus: Ganoderma lucidum (Curtis) P. Karst.

OncologyImmune supportMetabolic healthLiver support

Reishi · 2025 · Review · Antioxidants (Basel, Switzerland)

Ganoderma lucidum-From Ancient Remedies to Modern Applications: Chemistry, Benefits, and Safety.

Ganoderma lucidum (G. lucidum), commonly known as Reishi or Lingzhi, is a medicinal mushroom with a rich history in traditional Asian medicine.

Cordyceps · 2025 · Journal Article · Biotechnology journal

Gene purA, a Key Upstream Target for Cordycepin Overproduction in Cordyceps militaris.

BACKGROUND: Cordycepin, a bioactive compound derived from Cordyceps militaris with diverse pharmacological properties, is predominantly produced using this fungus for industrial applications..

Oyster Mushroom · 2025 · Randomized Controlled Trial · Molecular nutrition & food research

GLP-1 Responses to a Single Meal Fortified With Oyster Mushroom Powder in Adults With Impaired Glucose Tolerance Depend on the Gut Microbiota Composition Before the Meal.

Fortification of a single meal with β-glucan-rich oyster mushroom (Pleurotus ostreatus) powder has been shown to increase the response of glucagon-like peptide 1 (GLP-1) and reduce concentrations of non-esterified fatty acids (NEFAs) in adults with impaired glucose tolerance (IGT)..

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

Grifola frondosa Polysaccharide F2 Ameliorates Disordered Glucose and Lipid Metabolism in Prediabetic Mice by Modulating Bile Acids.

Prediabetes (pre-DM) is the buffer period before developing overt type 2 diabetes (T2DM), and the search for novel food agents to protect against pre-DM is in high demand..

Immune supportMetabolic health

Reishi · 2025 · Review · International journal of biological macromolecules

Health benefits of Ganoderma lucidum polysaccharides: A review of potential cardiovascular protective effects.

Ganoderma lucidum polysaccharides (GLPs) are a diverse class of bioactive compounds abundantly present in the mycelia, fruiting bodies, and spores of Ganoderma lucidum (G. lucidum).

OncologyImmune supportMetabolic healthSkin & hydration

Shiitake · 2025 · Review · Chemistry & biodiversity

Holistic Evaluation of Shiitake mushrooms (Lentinula edodes): Unraveling Its Medicinal and Therapeutic Potentials.

Lentinula edodes (Shiitake mushroom [SM]), a Basidiomycete with extensive ethnomedicinal use, exhibits significant nutraceutical and pharmaceutical potential. This review critically discusses findings from multidisciplinary sources, including ScienceDirect, PubMed, Scopus, Web of Science, Google Scholar, and classical….

Maitake · 2025 · Journal Article · Journal of functional foods

Identification and characterization of antihypertensive peptides from edible Grifola frondosa (maitake) mushroom hydrolysates: Suppression of vascular remodeling in angiotensin II-induced zebrafish model

Grifola frondosa (maitake), a widely consumed edible fungus with documented cardiovascular benefits, is rich in protein and serves as a valuable natural source for bioactive peptide production. Despite its potential, studies on blood pressure-lowering peptides derived from G.

Cordyceps · 2025 · Journal Article · Journal of biomolecular structure & dynamics

Identification of potential anti-hyperglycemic compounds in Cordyceps militaris ethyl acetate extract: in vitro and in silico studies.

Cordyceps militaris has been long known for valuable health benefits by folk experience and was recently reported with diabetes-tackling evidences, thus deserving extending efforts on screening for component-activity relationship..

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2025 · Review · Current issues in molecular biology

Immunomodulatory Effects of Ganoderma lucidum Bioactive Compounds on Gut-Brain and Gut-Liver Axis Disorders.

Ganoderma lucidum (Lingzhi), a traditional medicinal mushroom, is renowned for its immunomodulatory, anti-inflammatory, and antioxidant properties, primarily attributed to its bioactive components such as polysaccharides and triterpenoids..

Immune supportEnergy & fatigueMetabolic health

Oyster Mushroom · 2025 · Research Article · Current research in food science

Implications of Pleurotus ostreatus solid-state bioprocessing on the nutritional composition, protein structure, and anti-hypertensive and anti-inflammatory potential of local beans (Phaseolus vulgaris L.).

Improving snacks formulation to make them more nutritionally balanced can support healthy growth and development in children. Specifically, this approach can be beneficial for preventing obesity and promoting overall metabolic health..

King Oyster · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Incorporating Fresh Durum Wheat Semolina Pasta Fortified with Cardoncello (Pleurotus eryngii) Mushroom Powder as a Mediterranean Diet Staple.

Pasta made from durum wheat semolina has a medium-high glycemic index score, high starch digestibility, and limited nutritional value due to its low fiber, vitamin, and bioactive compound content..

Chaga · 2025 · Research Article · Scientific reports

Independent evolution of betulin biosynthesis in Inonotus obliquus.

Chaga mushroom (Inonotus obliquus) is a fungal species in the family Hymenochaetaceae (Basidiomycota) and the causative agent of white rot decay in Betula species..

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · International Journal of Biological Macromolecules

Inonotus obliquus polysaccharides improve hyperlipidemia with respect to lipid synthesis and intestinal flora modulation

Chronic high-fat diet can lead to fatty liver metabolism, hyperlipidemia disorders, and other diseases. Polysaccharides are natural lipid-lowering agents.

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Inonotus obliquus polysaccharides improve hyperlipidemia with respect to lipid synthesis and intestinal flora modulation.

Chronic high-fat diet can lead to fatty liver metabolism, hyperlipidemia disorders, and other diseases. Polysaccharides are natural lipid-lowering agents.

OncologyMetabolic healthRespiratory

Cordyceps · 2025 · Journal Article · International journal of medicinal mushrooms

Internet of Things (IoT)-Driven Fermentation System for Enhanced Cordycepin Production in Cordyceps militaris (Ascomycetes) under Hypoxic Conditions.

Cordycepin, known for its tumor-suppressive and antiviral properties, has garnered attention due to its therapeutic and biological potential. Current Cordyceps militaris - based cordycepin production methods involve time-consuming and cost-intensive solid-state fermentation..

OncologyImmune supportCognition & nervesMetabolic health

Cordyceps · 2025 · Research Article · PloS one

Investigation of biometabolites and novel antimicrobial peptides derived from promising source Cordyceps militaris and effect of non-small cell lung cancer genes computationally.

Mushrooms are considered one of the safe and effective medications because they have great economic importance due to countless biological properties. Cordyceps militaris contains bioactive compounds with antioxidant, antimicrobial and anti-cancerous properties..

Immune supportMetabolic health

Snow Fungus · 2025 · Research Article · Frontiers in fungal biology

Lignocellulose adaptation drives polysaccharide biosynthesis in Tremella fuciformis: metabolomic and proteomic insights into CAZyme regulation.

BACKGROUND/OBJECTIVES: Tremella fuciformis is an edible fungus prized for its culinary value. The polysaccharide content of T.

Cordyceps · 2025 · Research Article · Food chemistry: X

Low-glycemic index cookies supplemented with Cordyceps militaris substrate: Nutritional values, physicochemical properties, antioxidant activity, bioactive constituents, and bioaccessibility.

Cordyceps militaris substrate (CMS) is a novel ingredient rich in dietary fibers and bioactive compounds; however, its application in food products remains largely unexplored..

Metabolic healthLiver support

Turkey Tail · 2025 · Journal Article · International journal of medicinal mushrooms

Mechanism of Antihyperglycemic Activity of Extracellular Polysaccharopeptides from Fermented Turkey Tail Medicinal Mushroom Trametes versicolor (Agaricomycetes) in Type 2 Diabetic Rats.

The antihyperglycemic activity of extracellular polysaccharopeptides (ePSP) obtained from Trametes versicolor (TV) strain LH-1 has been demonstrated in hepatic cells and diabetic animals. This study further investigated the mechanisms of T..

Immune supportEnergy & fatigueMetabolic healthLiver support

Chaga · 2025 · Journal Article · Journal of ethnopharmacology

Mechanisms of Inonotus obliquus (Fr.) Pilát polysaccharides in ameliorating lipid-induced skeletal muscle insulin resistance via PI3K/AKT and AMPK/ACC1/CPT1 signaling pathways.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus (Fr.) Pilát, a traditional medicinal fungi, has been used to treat diabetes in China and Russia since the 16th century..

Reishi · 2025 · Research Article · Diabetes, metabolic syndrome and obesity: targets and therapy

Mechanistic Insights Into Ganoderma Lucidum for Diabetes Treatment via Network Pharmacology and Validation.

PURPOSE: There is an urgent need to develop antidiabetic medications with minimal side effects and low toxicity. Ganoderma lucidum, a food-medicine homologous in China, has been used to treat diabetes.

OncologyMetabolic health

Zhu Ling · 2025 · Journal Article · Natural product research

Metabolic profiling of Polyporus umbellatus (Pers.) Fr.

Polyporus umbellatus (Pers.) Fr. (Sin.

Energy & fatigueMetabolic healthRespiratory

Cordyceps · 2025 · Journal Article · Data in Brief

Metabolomic data on molecular weight fractions of the cultivated fruiting body of Ophiocordyceps sinensis and their pharmacological effects on airway tissues

Ophiocordyceps sinensis is a medicinal mushroom that has been traditionally used for promoting respiratory health and addressing diverse therapeutic needs. The data in this article provides insights into the metabolic profile of the cultivated fruiting body of Ophiocordyceps sinensis (xOs™) across different molecular….

Cordyceps · 2025 · Journal Article · Fungal biology

Metabolomic profiles of the infection pathways of Calcarisporium cordycipiticola on the cultivated and medicinal mushroom, Cordyceps militaris.

Cordyceps militaris is a widely cultivated mushroom with multiple medicinal properties. However, the emergence of white mildew disease caused by Calcarisporium cordycipiticola has become a serious dilemma, leading to economic losses in its industrial production.

Cordyceps · 2025 · Journal Article · Food chemistry

Metabolomics analysis reveals the changes of metabolites in Cordyceps militaris during subculture.

Cordyceps militaris (C. militaris) strain is highly prone to degeneration during subculture.

Cordyceps · 2025 · Journal Article · Food chemistry

Metabolomics analysis reveals the formation mechanism of Cordyceps militaris fruiting bodies in liquid culture.

Cordyceps militaris is a functional fungus renowned for its significant nutritional and therapeutic value. However, the mechanisms governing its growth and fruiting body formation in liquid culture remain poorly understood..

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Metabolomics and Transcriptomics Reveal the Effects of Different Fermentation Times on Antioxidant Activities of Ophiocordyceps sinensis.

Ophiocordyceps sinensis is a fungus that is cultured through fermentation from wild Chinese cordyceps. While studies have examined its metabolites, the evaluation of its antioxidant capacity remains to be conducted.

Energy & fatigueMetabolic healthGut & microbiome

Reishi · 2025 · Research Article · Veterinary world

Microencapsulated Ganoderma lucidum extract improves antioxidant capacity, intestinal morphology, and nutrient digestibility in free-range laying hens under tropical conditions.

BACKGROUND AND AIM: Free-range laying hens raised under tropical climates are susceptible to heat stress (HS), which compromises intestinal integrity, nutrient absorption, and egg quality..

OncologyImmune supportMetabolic healthLiver support

Chaga · 2025 · Journal Article · Environmental toxicology and pharmacology

Mitigation of experimental hepatocellular Carcinoma by Inonotus obliquus Mushroom extract in association with oxidative stress and inflammation signaling.

Chaga mushroom (Inonotus obliquus) has been a component of folk medicine treating several disorders mainly through its anti-inflammatory and antioxidant properties, yet its effects on liver carcinoma needed elucidation..

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2025 · Review · Brazilian journal of biology = Revista brasleira de biologia

Morphology, anticancer and neurological activities of Hericium erinaceus.

Hericium erinaceus, commonly known as Lion's Mane, is a species of medicinal mushroom that possesses remarkable therapeutic properties and has been extensively employed in the practice of traditional Chinese medicine. H..

Immune supportMetabolic healthLiver support

Maitake · 2025 · Research Article · Nutrients

Network Pharmacology-Based Elucidation of the Hypoglycemic Mechanism of Grifola frondosa GF5000 Polysaccharides via GCK modulation in Diabetic Rats.

BACKGROUND/OBJECTIVES: Our lab has previously reported that Grifola frondosa (maitake mushroom) GF5000 has antidiabetic potential owing to its ability to improve insulin resistance..

Metabolic healthRespiratory

Shiitake · 2025 · Research Article · Journal of virology

New insights into temperature-impacted mycovirus-fungus interactions regulated by a microRNA in Lentinula edodes.

The onset of symptoms in virus-infected mushrooms merits investigation. In this study, the influence of heat stress (HS) on the interaction between Lentinula edodes mycovirus HKB (LeV) and its mushroom host, Lentinula edodes, was explored, revealing that HS treatment facilitated LeV replication and compromised the….

Immune supportEnergy & fatigueMetabolic health

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

New insights of rotenone targeting cordycepin synthetase 1-cordycepin synthetase 2-glyceraldehyde-3-phosphate dehydrogenase (Cns1-Cns2-GAPDH) triple complex to enhance cordycepin synthesis in Cordyceps militaris.

Cordycepin isolated from Cordyceps militaris is an adenosine analogue with various biological activities, and its synthesis is dependent on cordycepin synthetase 1 (Cns1) and cordycepin synthetase 2 (Cns2)..

Metabolic healthGut & microbiomeLiver support

Cordyceps · 2025 · Journal Article · Food & function

Novel double nanoemulsion loading of Cordyceps militaris extract: formulation, stability, in vitro digestion, and in vivo evaluation for regulation of acute lipid disorders.

This study explores a novel approach for addressing acute lipid disorders using a double nanoemulsion system (NCMs) loading Cordyceps militaris extract. Cordyceps militaris, a medicinal mushroom, is valued for its bioactive compounds, particularly adenosine (ADE) and cordycepin (COR), which possess lipid-regulating….

Reishi · 2025 · Journal Article · Carbohydrate polymers

Novel galactose-rich polysaccharide from Ganoderma lucidum: structural characterization and immunomodulatory activities

Galactose-rich polysaccharides from Ganoderma lucidum have emerged as promising immunomodulatory agents, yet their structural characteristics and mechanisms of action remain poorly understood. Here, we isolated and characterized a novel galactose-rich polysaccharide (GLP-1b, 16.79 kDa) from Ganoderma lucidum..

Reishi · 2025 · Journal Article · Carbohydrate polymers

Novel galactose-rich polysaccharide from Ganoderma lucidum: structural characterization and immunomodulatory activities.