MycoData

Energy & fatigueGut & microbiomeLiver supportRespiratory

Cordyceps · 2024 · Research Support, Non U.S. Gov'T · Toxins

Functional Characterization and Toxicological Study of Cordyceps militaris in Weaned Pigs.

Cordyceps militaris (CM), a well-known parasitic fungus that grows on the larvae of Lepidoptera, has a variety of pharmacological activities. However, little is known about its safe dosage for animals, including pigs..

OncologyImmune supportSkin & hydrationRespiratory

Cordyceps · 2023 · Research Article · PloS one

Antimicrobial, antioxidant, anti-inflammatory, and cytotoxic activities of Cordyceps militaris spent substrate.

Cordyceps militaris is a medicinal mushroom and has been extensively used as a traditional medicine in East Asia. After the chrysalis seeds are matured and harvested, the spent substrate of C.

Immune supportGut & microbiomeRespiratory

Cordyceps · 2023 · Journal Article · International journal of biological macromolecules

Cordyceps militaris polysaccharide alleviates ovalbumin-induced allergic asthma through the Nrf2/HO-1 and NF-κB signaling pathways and regulates the gut microbiota.

Polysaccharides, as one of the main types of bioactive components of Cordyceps militaris, have anti-allergic asthma effects. Herein, an ovalbumin-induced allergic asthma mouse model was established to assess the potential mechanisms of the separated and purified Cordyceps militaris polysaccharide (CMP)..

Cordyceps · 2023 · Research Article · International journal of molecular sciences

Cordyceps militaris Solid Medium Extract Alleviates Lipoteichoic Acid-Induced MH-S Inflammation by Inhibiting TLR2/NF-κB/NLRP3 Pathways.

The aim of this study was to investigate the inhibitory effects of Cordyceps militaris solid medium extract (CME) and cordycepin (COR) on LTA-induced inflammation in MH-S cells and their mechanisms of action..

Turkey Tail · 2023 · Journal Article · International journal of medicinal mushrooms

Detection of Mitogenic and Genotoxic Effects of the Turkey Tail Medicinal Mushroom (Trametes versicolor, Agaricomycetes) Extracts from Mexico on Human Lymphocyte Cultures.

Diseases caused by a compromised immune system, characterized by decreased production and diversification of T lymphocytes, such as immunodeficiencies or chronic infections, are becoming increasingly prominent..

Cordyceps · 2023 · Research Article · Cureus

Early Trends to Show the Efficacy of Cordyceps militaris in Mild to Moderate COVID Inflammation.

Background/objective Cordyceps enhances animal survival against influenza by boosting the immune system. In animal studies, it also had anti-inflammatory and preventive properties.

King Oyster · 2023 · Journal Article · International journal of medicinal mushrooms

King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes), Extract Can Attenuate Doxorubicin-Induced Lung Damage by Inhibiting Oxidative Stress in Rats.

Doxorubicin (DOX), a broad spectrum chemotherapeutic, has toxic effects on healthy tissues. Mitochondrial processes and oxidative stress act in the DOX-induced toxicity, therefore antioxidant therapies are widely used..

Shiitake · 2023 · Research Article · Iranian journal of basic medical sciences

Lentinan and β-glucan extract from shiitake mushroom, Lentinula edodes, alleviate acute LPS-induced hematological changes in mice.

OBJECTIVES: Immunomodulatory activity of β-glucans of shiitake mushroom (Lentinula edodes) has been known. We investigated whether β-glucans from L.

Oyster Mushroom · 2023 · Journal Article · Archives of virology

Molecular characterization of a novel deltaflexivirus infecting the edible fungus Pleurotus ostreatus.

A novel positive single-stranded RNA virus, Pleurotus ostreatus deltaflexivirus 1 (PoDFV1), was isolated from the edible fungus Pleurotus ostreatus strain ZP6. The complete genome of PoDFV1 is 7706 nucleotides (nt) long and contains a short poly(A) tail..

Energy & fatigueMetabolic healthRespiratory

Mesima · 2023 · Journal Article · Fitoterapia

Phellinus linteus mycelia extract in COVID-19 prevention and identification of its key metabolic compounds profiling using UPLC-QTOF-MS/MS spectrometry.

For centuries, food, herbal medicines, and natural products have been valuable resources for discovering novel antiviral drugs, uncovering new structure-activity relationships, and developing effective strategies to prevent/treat viral infections..

Reishi · 2023 · Research Article · Frontiers in pharmacology

The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens.

Ganoderma lucidum (GL), commonly known as "Lingzhi", is a well-known medicinal mushroom with antioxidant and anti-cancer activity. This study examined the effects of a commercial GL product (GLSF) containing the spore and fruiting body in a 30:8 ratio on tobacco smoke carcinogen-induced lung toxicity and….

Metabolic healthRespiratory

Cordyceps · 2023 · Research Article · Frontiers in nutrition

Transcriptome and metabolome profiling unveils the mechanisms of naphthalene acetic acid in promoting cordycepin synthesis in Cordyceps militaris.

Cordycepin, an important active substance in Cordyceps militaris, possesses antiviral and other beneficial activities. In addition, it has been reported to effectively promote the comprehensive treatment of COVID-19 and thus has become a research hotspot..

OncologyMetabolic healthRespiratory

Cordyceps · 2022 · Journal Article · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Mechanism of Cordyceps militaris against non-small cell lung cancer: based on serum metabolomics].

This study investigated the potential mechanism of Cordyceps militaris(CM) against non-small cell lung cancer(NSCLC) based on serum untargeted metabolomics. Specifically, Balb/c nude mice were used to generate the human lung cancer A549 xenograft mouse model..

Immune supportEnergy & fatigueGut & microbiomeRespiratory

King Oyster · 2022 · Journal Article · Fish & shellfish immunology

A synbiotic containing prebiotic prepared from a by-product of king oyster mushroom, Pleurotus eryngii and probiotic, Lactobacillus plantarum incorporated in diet to improve the growth performance and health status of white shrimp, Litopenaeus vannamei.

This study aimed to evaluate the effects of a synbiotic composite an extract from a by-product of king oyster mushroom, Pleurotus eryngii (KOME), and probiotic Lactobacillus plantarum 7-40 on the growth performance and health status of white shrimp, Litopenaeus vannamei..

Shiitake · 2022 · Journal Article · International journal of environmental health research

Antibacterial activity and antibacterial mechanism of ethanol extracts of Lentinula edodes (Shiitake) and Agaricus bisporus (button mushroom).

The aim of the present work was the comparison of antimicrobial activity, mechanism and components of the ethanol extract (EE) from Lentinula edodes Berk (Pegler) and Agaricus bisporus Sing (Lange). The main component of EE of A..

Enoki · 2022 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Carboxymethyl chitosan-based coatings loaded with glutathione extend the shelf-life of harvested enoki mushrooms (Flammulina velutipes)

Carboxymethyl chitosan has anti-bacterial activity and good coating forming ability, and glutathione has antioxidant and browning-inhibiting capacity. This study investigated the effects of carboxymethyl chitosan-based coatings alone (1% carboxymethyl chitosan) or loaded with glutathione (1% carboxymethyl chitosan +….

OncologyEnergy & fatigueRespiratory

Cordyceps · 2022 · Research Article · Food science & nutrition

Cordyceps militaris extract induces apoptosis and pyroptosis via caspase-3/PARP/GSDME pathways in A549 cell line.

Cordyceps militaris (CM) is traditionally used as dietary therapy for lung cancer patients in China. CM extract (CME) is hydrosoluble fraction of CM and extensively investigated.

Cordyceps · 2022 · Research Article · Antioxidants (Basel, Switzerland)

Cordyceps militaris Reduces Oxidative Stress and Regulates Immune T Cells to Inhibit Metastatic Melanoma Invasion.

In this study, the water extract of Cordyceps militaris (Linn.) Link (CM) was used as a functional material to investigate the inhibitory mechanisms on B16F10 and lung metastatic melanoma (LMM) cells..

Immune supportEnergy & fatigueRespiratory

Shiitake · 2022 · Research Article · BMC complementary medicine and therapies

Edible algae (Ecklonia cava) bioprocessed with mycelia of shiitake (Lentinula edodes) mushrooms in liquid culture and its isolated fractions protect mice against allergic asthma.

BACKGROUND: Ecklonia cava is an edible marine brown alga harvested from the ocean that is widely consumed in Asian countries as a health-promoting medicinal food The objective of the present study is to evaluate the anti-asthma mechanism of a new functional food produced by bioprocessing edible algae Ecklonia cava and….

Cognition & nervesEnergy & fatigueMetabolic healthRespiratory

Lion's Mane · 2022 · Research Article · International journal of exercise science

Four Weeks of Hericium erinaceus Supplementation Does Not Impact Markers of Metabolic Flexibility or Cognition.

Hericium erinaceus (HE), also known as Lion's Mane mushroom, has been found to enhance cognition and metabolic flexibility in various animal models. To date however, only four studies exist in humans and none have evaluated the effects of HE on markers of metabolic flexibility or cognitive performance..

Oyster Mushroom · 2022 · Research Article · Current issues in molecular biology

Multiplex Detection of Pleurotus ostreatus Mycoviruses.

Mycoviruses are viruses that specifically infect and replicate in fungi. Several mycoviruses have been previously reported in Pleurotus ostreatus, including the oyster mushroom spherical virus (OMSV), oyster mushroom isometric virus (OMIV), Pleurotus ostreatus spherical virus (POSV), and Pleurotus ostreatus virus 1….

Oyster Mushroom · 2022 · Research Article · Biology

Preliminary Studies on the Effects of Oyster Mushroom Spherical Virus China Strain on the Mycelial Growth and Fruiting Body Yield of the Edible Mushroom Pleurotus ostreatus.

Oyster mushroom spherical virus (OMSV) is a positive-sense single-stranded RNA mycovirus which is associated with a devastating oyster mushroom die-back disease. However, little is known about its diversity, and the effects of OMSV infection on its fungal host are not well understood..

Chaga · 2022 · Journal Article · International journal of medicinal mushrooms

Water Extract of the Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Inhibits SARS-CoV-2 Replication in Vero E6 and Vero Cell Culture Experiments.

The antiviral properties of water extracts from pharmaceutical raw materials of the chaga mushroom, Inonotus obliquus, were studied against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)..

Immune supportCognition & nervesRespiratory

Chaga · 2021 · Journal Article · International journal of medicinal mushrooms

Chaga Medicinal Mushroom Inonotus obliquus (Agaricomycetes) Terpenoids May Interfere with SARS-CoV-2 Spike Protein Recognition of the Host Cell: A Molecular Docking Study.

The most challenging threat facing the global community today is the coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)..

Reishi · 2021 · Journal Article · International journal of medicinal mushrooms

Chemical Compounds and Computational Prediction of Their Inhibitory Effects on the HIV-1 gp120 Receptor by Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), with Antler-Like Morphology of Fruiting Bodies.

In this study, crude extracts of Ganoderma lucidum (NGCs) were compared to the crude extracts of G. lucidum that has antler-like fruiting bodies (AGCs) for their cytotoxicity, inhibitory effects on the attachment of human immunodeficiency virus (HIV)-1 glycoprotein 120 (gp120) to cluster of differentiation 4 (CD4),….

Almond Mushroom · 2021 · Journal Article · Chemistry & biodiversity

Chemically Sulfated Polysaccharides from Agaricus blazei Murill: Synthesis, Characterization and Anti-HIV Activity.

AIDS, caused by HIV-1, is one of the most dangerous infectious diseases in the world. Therefore, it is necessary to develop new drugs with more potent bioactivities, less toxicity and higher tolerability for controlling the viral load, particularly by using the raw materials that are widely available..

Cognition & nervesRespiratory

Lion's Mane · 2021 · Research Article · BMC complementary medicine and therapies

Hericium erinaceus mycelium ameliorate anxiety induced by continuous sleep disturbance in vivo.

BACKGROUND: Sleep disruption is a major public health issue and may increase the risk of mortality by ten-folds if an individual is sleeping less than 6 h per night. Sleep has changed dramatically during to the COVID-19 pandemic because COVID symptoms can lead to psychological distress including anxiety..

Cordyceps · 2021 · Research Article · Journal of pharmaceutical analysis

Matrix-assisted laser desorption ionization mass spectrometry based quantitative analysis of cordycepin from Cordyceps militaris.

Cordycepin, which has great immunomodulatory activities such as anticancer, antifungal, antivirus, antileukemia and lipid-lowering ones, is the secondary metabolite of Cordyceps militaris (C. militaris).

Shiitake · 2021 · Research Article · Molecules (Basel, Switzerland)

Proteome Analysis and In Vitro Antiviral, Anticancer and Antioxidant Capacities of the Aqueous Extracts of Lentinula edodes and Pleurotus ostreatus Edible Mushrooms.

In this study, we examined aqueous extracts of the edible mushrooms Pleurotus ostreatus (oyster mushroom) and Lentinula edodes (shiitake mushroom). Proteome analysis was conducted using LC-Triple TOF-MS and showed the expression of 753 proteins by Pleurotus ostreatus, and 432 proteins by Lentinula edodes..

OncologyRespiratory

Almond Mushroom · 2021 · Research Article · Journal of fungi (Basel, Switzerland)

Subcritical Water Extracts from Agaricus blazei Murrill's Mycelium Inhibit the Expression of Immune Checkpoint Molecules and Axl Receptor.

Agaricus blazei Murrill or Himematsutake is an edible and medicinal mushroom. Agaricus blazei Murrill's fruiting body extracts have anticancer properties, although the mechanism is unknown..

OncologyImmune supportLiver supportRespiratory

Maitake · 2021 · Journal Article · Food & function

The polysaccharides from the Grifola frondosa fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury via the miR-122-Nrf2/ARE pathways.

Polysaccharides can be used as a potential hepatoprotective agent in the treatment of acute liver injury. However, the underlying mechanism governing how polysaccharides protect against acute liver injury induced by lipopolysaccharide/d-galactosamine (LPS/d-GalN) remains unclear..

Reishi · 2022 · Journal Article · Molecular biology reports

Investigation of HER-3 gene expression under the influence of carbohydrate biopolymers extract of shiitake and reishi in MCF-7 cell line.

INTRODUCTION: Edible-medicinal fungi are mainly used in Asian countries to prevent various diseases. These mushrooms are also used to treat lung diseases and cancer.

OncologyLiver supportRespiratory

Oyster Mushroom · 2026 · Preprint · journal metadata

Integrated in silico pharmacology of Pleurotus ostreatus derived bioactive compounds targeting EGFR using network pharmacology and molecular simulations

Abstract Cancer remains a most important worldwide health burden, demanding the progress of pioneering and mechanism-driven therapeutic strategies. In this study, we employed an consolidative in silico pharmacology approach combination network pharmacology, molecular docking, ADMET profiling, and molecular dynamics….

Cordyceps · 2025 · Comparative Study · Applied biochemistry and biotechnology

GC-MS Analysis of Polysaccharides from an Intergeneric Hybrid of Pleurotus florida and Cordyceps militaris: A Comparative Study.

Edible and medicinal mushrooms are valuable sources of polysaccharides, known for their dual roles as immunostimulants and immunosuppressants. This study aimed to enhance polysaccharide content by fusing two mushroom species, P.

Reishi · 2025 · Preprint · journal metadata

Synergistic Anti-Tumor and Immunomodulatory Effects of Sporoderm-Removed Ganoderma Lucidum Spore Powder and Anti-PD-L1 Antibody in Lung Cancer Mice

Abstract Background The therapeutic efficacy of PD-1/PD-L1 inhibitors in lung cancer management remains suboptimal. Sporoderm-removed Ganoderma Lucidum Spore Powder (RGLS), an immunostimulant, has been shown to amplify the anti-tumor effects of anti-PD-L1 antibodies (αPD-L1)..

Immune supportCognition & nervesRespiratory

Cordyceps · 2024 · Preprint · journal metadata

The Preventive Potential of the Mycelial Submerged Culture of Ophiocordyceps sinensis against Neurodegenerative Diseases and Its Possible Active Compounds

The pharmacological effects of the fruiting body of Ophiocordyceps sinensis (Os) exerted antioxidant, anti-virus, and immunomodulatory, whereas the anti-inflammatory effects and active components of Os mycelial submerged culture (OMSC) are not known..

Cordyceps · 2022 · Journal Article · Journal of biomolecular structure & dynamics

Cordycepin: a bioactive metabolite of Cordyceps militaris and polyadenylation inhibitor with therapeutic potential against COVID-19.

Spike protein and main proteases of SARS-CoV-2 have been identified as potential therapeutic targets and their inhibition may lead to the reticence of viral entry and replication in the host body. Despite several efforts; till now no specific drugs are available to treat SARS-CoV-2..

Cordyceps · 2022 · Research Article · Microorganisms

Immunostimulatory Activity of Cordyceps militaris Fermented with Pediococcus pentosaceus SC11 Isolated from a Salted Small Octopus in Cyclophosphamide-Induced Immunocompromised Mice and Its Inhibitory Activity against SARS-CoV 3CL Protease.

In this study, we investigated the immune-enhancing and anti-viral effects of germinated Rhynchosia nulubilis (GRC) fermented with Pediococcus pentosaceus SC11 (GRC-SC11) isolated from a salted small octopus. The cordycepin, β-glucan, and total flavonoid contents increased in GRC after SC11 fermentation..

OncologyEnergy & fatigueMetabolic healthRespiratory

Cordyceps · 2020 · Review · Sheng wu gong cheng xue bao = Chinese journal of biotechnology

[Advances in biosynthesis of cordycepin from Cordyceps militaris].

Cordycepin as the main active ingredient of Cordyceps militaris, a traditional medicinal fungus in China, has many physiological functions such as anti-cancer, anti-tumor and anti-virus activity. The most potential route for effective cordycepin production has been considered as liquid fermentation of C..

Reishi · 2020 · Review · International journal of biological macromolecules

Molecular mechanisms of bioactive polysaccharides from Ganoderma lucidum (Lingzhi), a review.

Ganoderma lucidum, commonly known as "Lingzhi" in Chinese, are well-known medicinal mushrooms. Lingzhi has been used in traditional Chinese herbal medicines for more than two thousand years.

OncologyImmune supportGut & microbiomeRespiratory

Agarikon · 2019 · Review · Mycology

Antimicrobial properties of Fomitopsis officinalis in the light of its bioactive metabolites: a review.

Fomitopsis officinalis, also known as Laricifomes officinalis, is a medicinal polypore used for millennia (Agarikon) to contrast several diseases, particularly the pulmonary ones..

Maitake · 2019 · Review · Progress in molecular biology and translational science

The biological activities of the antitumor drug Grifola frondosa polysaccharide.

Grifola frondosa, a polypore fungus that grows at the base of trees, is an edible and medicinal mushroom with a large fruiting body characterized by overlapping caps..

OncologyImmune supportLiver supportRespiratory

Zhu Ling · 2019 · Review · Progress in molecular biology and translational science

The efficacy of Polyporus Umbellatus polysaccharide in treating hepatitis B in China.

Polyporus umbellatus polysaccharide (PUPS) has been identified as the major bioactive component in the mushroom Polyporus umbellatus that has immuno-enhancing, anti-tumor, anti-inflammatory, and hepatoprotective activities..

Reishi · 2026 · Research Article · Discover oncology

Additive anti-tumor and immunomodulatory effects of Sporoderm-removed Ganoderma lucidum spore powder and anti-PD-L1 antibody in lung cancer mice.

BACKGROUND: The therapeutic efficacy of programmed cell death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) inhibitors in lung cancer management remains suboptimal..

Reishi · 2026 · Journal Article · Phytochemistry

Anti-influenza virus activities of triterpenes from the antler-shaped fruiting bodies of Ganoderma lucidum.

Ganoderma, a famous fungus, has traditionally been used in China for thousands of years. Fourteen previously undescribed triterpenes were isolated from the antler-shaped fruiting bodies of Ganoderma lucidum..

Shiitake · 2026 · Journal Article · Journal of microbiological methods

Exploration of the optimum reaction conditions for the reverse transcription of mycoviral RNA from Lentinula edodes.

Reverse transcription (RT) of viral RNA to complementary DNA (cDNA) is essential for mycovirus detection; however, the stable secondary structures of double-stranded RNA (dsRNA) and the genomic diversity of viruses complicate this process..

OncologyImmune supportLiver supportRespiratory

Reishi · 2026 · Research Article · Materials today. Bio

Ganoderma lucidum polysaccharide-decorated extracellular vesicle enables synergistical antitumor immunotherapy.

Ganoderma lucidum polysaccharide (GLP) holds considerable promise for tumor therapy, but its clinical application is limited by its poor tumor-targeting capability..

Immune supportLiver supportRespiratory

Reishi · 2026 · Journal Article · Carbohydrate polymers

Virus-inspired Ganoderma lucidum polysaccharide-functionalized adjuvant with pseudo-zwitterionic interface for potentiated nasal immunization.

Intranasal vaccination is promising against respiratory infections but hindered by the mucus barrier. To overcome the adhesion-penetration dilemma, we developed a virus-inspired hybrid nanoparticle (GHNP) by functionalizing a cationic polymer/lipid core (HNP) with Ganoderma lucidum polysaccharide (GLP)..

Oyster Mushroom · 2025 · Research Article · Current research in food science

Bioactive properties of selenium-enriched polysaccharides extracted from Pleurotus ostreatus using ultrasonic-assisted extraction.

Mushrooms are well recognized as functional foods owing to their rich nutritional and medicinal properties, particularly polysaccharides with notable therapeutic potential..