MycoData

The Case Study Base Layer, described in this deliverable, is a harmonised geospatial database spanning across the five case study areas of BESTMAP: South Moravia (Czech Republic), Mulde (Germany), Humber (Great Britain), Backa (Serbia), and Catalonia (Spain)..

Liver support

Medium relevance

Almond Mushroom · 2024 · Preprint · journal metadata

D3.2 European Base Layer

The European Base Layer, described in this deliverable, is a harmonised geospatial database spanning across Europe. It builds upon the infrastructure created for the Case Study Base Layer (D3.1) and includes geospatial information on climatic and soil conditions, biodiversity, land use/land cover (including crop….

Liver support

Medium relevance

Chaga · 2024 · Preprint · journal metadata

Liver-X receptor β-selective agonist CE9A215 regulates Alzheimer’s disease- associated pathology in a 3xTg-AD mouse model

Abstract Background In Alzheimer's disease (AD), tau pathology is more closely associated with disease progression. Therefore, the development of agents that alleviate tau pathology is essential..

Immune supportCognition & nervesMetabolic healthLiver support

Medium relevance

Nameko · 2010 · Journal Article · Nutrition (Burbank, Los Angeles County, Calif.)

Hypolipidemic effect of the polysaccharide from Pholiota nameko.

OBJECTIVE: This study was conducted to investigate the hypolipidemic effect of the polysaccharide isolated from Pholiota nameko (PNPS-1). METHODS: Hyperlipidemic Wistar rats were treated with PNPS-1 (20, 40, and 60 mg/kg orally)..

Immune supportMetabolic healthLiver supportRespiratory

Medium relevance

Turkey Tail · 2004 · Comparative Study · International immunopharmacology

Immunomodulatory effects of yun zhi and danshen capsules in health subjects--a randomized, double-blind, placebo-controlled, crossover study.

Immunostimulating polysaccharides extracted from the Chinese medicinal plant Yun Zhi (Coriolus versicolor) have been found to enhance various immunological functions, and Danshen (Salvia miltiorrhiza) to show beneficial effects on the circulatory system..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Oyster Mushroom · 2026 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

An emulsion-based tracer solute method for visualizing surface and cross-sectional solute distributions in vacuum impregnated porous food matrices

Understanding solute behavior during vacuum impregnation (VI) is essential for optimizing functional food design, yet the spatial distribution of specific phases within porous matrices remains largely unexplored..

Liver support

Medium relevance

Almond Mushroom · 2026 · Research Article · Medicine

Bone marrow function in cervical cancer patients after concurrent chemoradiotherapy using 99mTc-SC SPECT/CT: A cross-sectional retrospective study.

99mTc-sulfur colloid (99mTc-SC) single-photon computed emission tomography/computed tomography (SPECT/CT) bone marrow (BM) scintigraphy is a key diagnostic tool for distinguishing active red BM from inactive yellow BM..

OncologyEnergy & fatigueLiver support

Medium relevance

Shiitake · 2026 · Journal Article · Environmental monitoring and assessment

Health risk assessment of cadmium exposure via multiple pathways in preschool children from the inland region of Northwest China.

Cadmium (Cd) is a toxic heavy metal that is important to consider because of its health risks to humans. Prolonged exposure to Cd in humans presents significant health hazards, including renal, hepatic, and neurological damage, and may also result in carcinogenic effects..

Cognition & nervesLiver support

Medium relevance

Reishi · 2026 · Journal Article · Biotechnology journal

Mycoponics: Controlled Bioproduction Utilizing Biophysical, Solid-State, Liquid Nutrient Delivery.

Mycoponic biotechnology, inspired by hydroponics-a vital technology for agriculture research and space exploration, is limited by innate substrate contamination commonplace in commercial mycoproduction..

Energy & fatigueGut & microbiomeLiver support

Medium relevance

Cordyceps · 2026 · Journal Article · Phytotherapy research: PTR

N6-(2-Hydroxyethyl) Adenosine Alleviates Hepatic Steatosis and Insulin Resistance by Inhibiting JunB+ Adipocytes.

N6-(2-hydroxyethyl) adenosine (HEA), the main active component of Cordyceps species, has garnered attention for its multifaceted hypolipidemic and antihyperglycemic activities. However, the influence by which HEA affects the progression of nonalcoholic fatty liver disease (NAFLD) remains unclear..

Energy & fatigueMetabolic healthLiver support

Medium relevance

Shiitake · 2026 · Journal Article · Food Research International

Self-assembled Lentinus edodes ergosterol-amyloid fiber hydrogel for zebrafish enteritis mitigation: Role of intestinal flora regulation and metabolomic remodeling

Inflammatory bowel disease (IBD) necessitates the development of effective and safe therapeutic strategies derived from food sources. Ergosterol from Lentinus edodes (Shiitake) exhibits anti-colitic properties but is limited by its poor bioavailability..

Immune supportGut & microbiomeLiver support

Medium relevance

Shiitake · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Self-assembled Lentinus edodes ergosterol-amyloid fiber hydrogel for zebrafish enteritis mitigation: Role of intestinal flora regulation and metabolomic remodeling.

Immune supportGut & microbiomeLiver support

Medium relevance

Cordyceps · 2026 · Journal Article · The Journal of pharmacy and pharmacology

The CGA combination enhances bile acids alternative biosynthesis pathway and alleviates MASH induced by methionine-choline-deficient diet.

OBJECTIVE: CGA combination consisting of Cordyceps sinensis polysaccharide, gypenosides, and amygdalin, is derived from Fuzheng Huayu capsule (a traditional Chinese medicine approved for liver fibrosis) via previous Uniform Design Experimentation..

Immune supportEnergy & fatigueMetabolic healthLiver support

Medium relevance

Cordyceps · 2025 · Research Article · Chemical science

Cordycepin: a dual-function molecular element for aptamer engineering with enhanced anticancer activity.

Cordycepin (3'-deoxyadenosine, 3'-dA), derived from the fungus Cordyceps sinensis, has shown significant bioactivity as an inhibitor of enzymes related to 2'-deoxyadenosine (dA). However, its therapeutic efficacy is insufficient for clinical use, which may be addressed through targeted delivery systems..

OncologyGut & microbiomeLiver support

Medium relevance

Cordyceps · 2025 · Journal Article · Phytomedicine

Ginsenoside F2-modified liposomes delivering FTY720 enhance glioblastoma targeting and antitumor activity via ferroptosis

Glioblastoma (GBM) is the most malignant primary intracranial tumor. Owing to its unfavorable prognosis and frequent recurrence, patient outcomes are poor even with standard treatment..

OncologyCognition & nervesEnergy & fatigueLiver support

Medium relevance

Cordyceps · 2025 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ginsenoside F2-modified liposomes delivering FTY720 enhance glioblastoma targeting and antitumor activity via ferroptosis.

BACKGROUND: Glioblastoma (GBM) is the most malignant primary intracranial tumor. Owing to its unfavorable prognosis and frequent recurrence, patient outcomes are poor even with standard treatment..

OncologyCognition & nervesEnergy & fatigueLiver support

Medium relevance

Reishi · 2025 · Journal Article · Current issues in molecular biology

Sublingual Dripping Pill Formulation of Ganoderma amboinense Fruiting Body Extract Attenuates CCl4-Induced Liver Fibrosis via Multi-Pathway Regulation.

Liver fibrosis remains difficult to treat, in part because many hepatoprotective triterpenoids suffer from poor oral bioavailability and lack of optimized delivery formats..

Immune supportMetabolic healthLiver supportSkin & hydration

Medium relevance

Almond Mushroom · 2024 · Research Article · eLife

Agent-based model demonstrates the impact of nonlinear, complex interactions between cytokinces on muscle regeneration.

Muscle regeneration is a complex process due to dynamic and multiscale biochemical and cellular interactions, making it difficult to identify microenvironmental conditions that are beneficial to muscle recovery from injury using experimental approaches alone..

OncologyImmune supportEnergy & fatigueLiver support

Medium relevance

Shiitake · 2024 · Research Article · Poultry science

Application of lentinan in suppression of Marek's disease virus infection.

Marek's disease virus (MDV) is an extremely widespread avian immunosuppressive virus. In recent years, many reports have shown that there are still cases of MDV infection and immunosuppression after immunization with the vaccine..

Immune supportLiver supportRespiratory

Medium relevance

Enoki · 2024 · Journal Article · Journal of the science of food and agriculture

Complex insoluble dietary fiber alleviates obesity and liver steatosis, and modulates the gut microbiota in C57BL/6J mice fed a high-fat diet.

BACKGROUND: Obesity has been demonstrated as a risk factor that seriously affects health. Insoluble dietary fiber (IDF), as a major component of dietary fiber, has positive effects on obesity, inflammation and diabetes..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Enoki · 2024 · Journal Article · Journal of the science of food and agriculture

Complex insoluble dietary fiber alleviates obesity and liver steatosis, and modulates the gut microbiota in C57BL/6J mice fed a high‐fat diet

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Shiitake · 2024 · Journal Article · Chemical & pharmaceutical bulletin

Discovery of a Novel Lidocaine Metabolite by Human Liver Microsome and Identification of Microbial Species Which Produces the Same Metabolite.

Preparation of drug metabolites at the milligram scale is essential for determining the structure and toxicity of drug metabolites. However, their preparation using recombinant proteins and human liver microsomes (HLM) is often difficult because of technical and ethical issues..

Metabolic healthLiver support

Medium relevance

Cordyceps · 2024 · Journal Article · Veterinary parasitology

Efficacy of cordycepin against Neospora caninum infection in vitro and in vivo.

Neospora caninum (N. caninum) is an obligate intracellular Apicomplexa parasite that causes abortions in dairy cows and incurs substantial to significant economic losses in the global dairy farming industry..

Immune supportMetabolic healthLiver support

Medium relevance

Reishi · 2024 · Journal Article · Scientific reports

Ganoderma tsuage promotes pain sensitivity in aging mice.

Advances in modern medicine have extended human life expectancy, leading to a world with a gradually aging society. Aging refers to a natural decline in the physiological functions of a species over time, such as reduced pain sensitivity and reaction speed..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Cordyceps · 2024 · Journal Article · Journal of the Chinese Medical Association: JCMA

Hirsutella sinensis intensifies testicular function and spermatogenesis in male mice with high-fat diet-induced obesity.

BACKGROUND: Hirsutella sinensis (HS) is a mycelium isolated from the fruiting body of the medicinal mushroom Cordyceps sinensis. This study explored whether HS treatment affects reproductive dysfunction in a high-fat diet (HFD)-induced mouse model and regulates various mechanisms, focusing on oxidative stress,….

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Shiitake · 2024 · Journal Article · International journal of biological macromolecules

Lentinan-loaded GelMA hydrogel accelerates diabetic wound healing through enhanced angiogenesis and immune microenvironment modulation.

Diabetic wound healing is a substantial clinical challenge, characterized by delayed angiogenesis and unresolved inflammation. Lentinan, a polysaccharide extracted from shiitake mushrooms, has the potential to regulate both macrophage polarization and angiogenesis, though this aspect remains inadequately explored..

Immune supportMetabolic healthLiver supportSkin & hydration

Medium relevance

Turkey Tail · 2023 · Scoping Review · Cureus

Therapeutic Effects of Medicinal Mushrooms on Gastric, Breast, and Colorectal Cancer: A Scoping Review.

Cancer is the leading cause of mortality globally. With anticancer medications causing severe adverse effects, understanding the role of alternative and efficacious anticancer treatments with minimal or no side effects can be beneficial..

OncologyImmune supportLiver support

Medium relevance

Turkey Tail · 2023 · Preprint · journal metadata

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Mushrooms are unexploited treasures of secondary metabolites. Analysis of the chemical constituents of these mushrooms would be necessary for the assessment of their pharmacological and biological activities..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

King Oyster · 2020 · Research Article · Nutrients

Anti-Obesity Effect of DKB-117 through the Inhibition of Pancreatic Lipase and α-Amylase Activity.

This study sought to evaluate the effects of Phaseolus multiflorus var. albus Bailey extract (PM extract) and Pleurotus eryngii var.

Metabolic healthGut & microbiomeLiver support

Medium relevance

Cordyceps · 2020 · Research Article · Nanotechnology, science and applications

Cordycepin Nanoencapsulated in Poly(Lactic-Co-Glycolic Acid) Exhibits Better Cytotoxicity and Lower Hemotoxicity Than Free Drug.

PURPOSE: Cordycepin, a natural product isolated from the fungus Cordyceps militaris, is a potential candidate for breast cancer therapy. However, due to its structural similarity with adenosine, cordycepin is rapidly metabolized into an inactive form in the body, hindering its development as a therapeutic agent..

OncologyLiver support

Medium relevance

Shiitake · 2018 · Journal Article · Food & function

Effect of traditional and modern culinary processing, bioaccessibility, biosafety and bioavailability of eritadenine, a hypocholesterolemic compound from edible mushrooms.

Eritadenine is a hypocholesterolemic compound that is found in several mushroom species such as Lentinula edodes, Marasmius oreades, and Amanita caesarea (1.4, 0.7 and 0.6 mg per g dry weight, respectively)..

Metabolic healthGut & microbiomeLiver supportSkin & hydration

Medium relevance

King Oyster · 2017 · Journal Article · Journal of agricultural and food chemistry

Occurrence of the (2R,3S)-Isomer of 2-Amino-3,4-dihydroxybutanoic Acid in the Mushroom Hypsizygus marmoreus.

Here, we report the occurrence of the (2R,3S)-isomer of 2-amino-3,4-dihydroxybutanoic acid (d-ADHB) in the fruiting body of an edible mushroom, Hypsizygus marmoreus. This is an unusual example of the accumulation of a d-amino acid whose enantiomer is not a proteinogenic amino acid..

Liver support

Medium relevance

King Oyster · 2016 · Journal Article · ACS applied materials & interfaces

Prolonged Three-Dimensional Co-Delivery of Yamanaka Factors for Cell Reprogramming.

Reprogramming somatic cells into a pluripotent state has been widely investigated in two-dimensional (2D) systems but not described in the more biologically faithful three-dimensional (3D) scaffolds..

Immune supportGut & microbiomeLiver supportSkin & hydration

Medium relevance

Shiitake · 2026 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Active Hexose Correlated Compound Modulates Gut Microbiota and Improves Intestinal Barrier Function in a High-Fat Diet-Induced NAFLD in Rats.

Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, correlating with increased obesity and metabolic disorders. Gut microbiota dysbiosis and impaired intestinal barrier integrity are key factors in NAFLD pathogenesis..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Reishi · 2023 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

A tri-herb formulation protects against ethanol-induced mouse liver injury and downregulates mitogen-activated protein kinase phosphatase 1.

BACKGROUND: A tri-herb formulation comprising Ganoderma (the dried fruiting body of Ganoderma lucidum), Puerariae Thomsonii Radix (the dried root of Pueraria thomsonii) and Hoveniae Semen (the dried mature seed of Hovenia acerba) -GPH for short- has been using for treating liver injury; however, the pharmacological….

Energy & fatigueLiver support

Medium relevance

Reishi · 2023 · Journal Article · BMC cancer

AGA induces sub-G1 cell cycle arrest and apoptosis in human colon cancer cells through p53-independent/p53-dependent pathway.

BACKGROUND: Despite the advancement in chemotherapeutic drugs for colon cancer treatment, it is still a life-threatening disease worldwide due to drug resistance. Therefore, an urgently needed to develop novel drugs for colon cancer therapies..

OncologyImmune supportGut & microbiomeLiver support

Medium relevance

Oyster Mushroom · 2023 · Journal Article · Frontiers in bioengineering and biotechnology

Biohybrids: Textile fibres provide scaffolds and highways for microbial translocation.

Introduction: Living materials (biohybrids, textile-microbial hybrids, hybrid living materials) have gained much attention in recent years with enormous potential for applications in biomedical science, the built environment, construction and architecture, drug delivery and as environmental biosensors..

Liver support

Medium relevance

Reishi · 2023 · Journal Article · Frontiers in pharmacology

G. lucidum triterpenes restores intestinal flora balance in non-hepatitis B virus-related hepatocellular carcinoma: evidence of 16S rRNA sequencing and network pharmacology analysis.

Background: Ganoderma lucidum (G. lucidum) is a popular traditional remedy medicine used in Asia to promote health and longevity, which has also been highlighted for anti-cancer effects.

OncologyEnergy & fatigueGut & microbiomeLiver support

Medium relevance

Turkey Tail · 2023 · Research Article · Polymers

Lignin Nanoparticles with Entrapped Thymus spp. Essential Oils for the Control of Wood-Rot Fungi.

After decades of utilization of fossil-based and environmentally hazardous compounds for wood preservation against fungal attack, there is a strong need to substitute those compounds with bio-based bioactive solutions, such as essential oils..

Liver support

Medium relevance

Reishi · 2023 · Journal Article · Frontiers in nutrition

Network pharmacology-based analysis of Resinacein S against non-alcoholic fatty liver disease by modulating lipid metabolism.

BACKGROUND: Ganoderma lucidum is reportedly the best source of traditional natural bioactive constituents. Ganoderma triterpenoids (GTs) have been verified as an alternative adjuvant for treating leukemia, cancer, hepatitis and diabetes..

OncologyEnergy & fatigueMetabolic healthLiver support

Medium relevance

Niu-Chang-Chih · 2023 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ovatodiolide and antrocin synergistically inhibit the stemness and metastatic potential of hepatocellular carcinoma via impairing ribosome biogenesis and modulating ERK/Akt-mTOR signaling axis.

Activation of mitogen-activated protein kinase (MAPK) and PI3K signaling confers resistance against sorafenib, a mainstay treatment for advanced hepatocellular carcinoma (HCC)..

OncologyGut & microbiomeLiver support

Medium relevance

Reishi · 2023 · Journal Article · Frontiers in endocrinology

Proteomics and network pharmacology of Ganshu Nuodan capsules in the prevention of alcoholic liver disease.

INTRODUCTION: Ganshu Nuodan is a liver-protecting dietary supplement composed of Ganoderma lucidum (G. lucidum) spore powder, Pueraria montana (Lour.) Merr.

OncologyLiver support

Medium relevance

Snow Fungus · 2023 · Research Article · Food science & nutrition

Synergistic mediating effect of edible fungal polysaccharides (Auricularia and Tremellan) and Crataegus flavonoids in hyperlipidemic rats.

Both edible fungal polysaccharides (Auricularia and Tremellan) and Crataegus flavonoids promote the balance of dyslipidemia, which have a positive biological regulating effect on intestinal flora..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Maitake · 2022 · Research Article · Oxidative medicine and cellular longevity

Ameliorating Effect on Glycolipid Metabolism of Spirulina Functional Formulation Combination from Traditional Chinese Medicine.

Insulin resistance is the major factor involved in the pathogenesis of type 2 diabetes. Although the oral drug metformin (MH) is widely used to reduce hyperglycemia, it is associated with adverse effects..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Reishi · 2022 · Journal Article · Frontiers in microbiology

Christensenella regulated by Huang-Qi-Ling-Hua-San is a key factor by which to improve type 2 diabetes.

There is a lot of evidence that oral hypoglycemic drugs work by affecting gut microbes, but the key strains responsible for this effect are not well known. Huang-Qi-Ling-Hua-San (HQLHS), composed of Astragalus Membranaceus, Ganoderma lucidum, Inonotus obliquus, and Momordica charantia L., is a specially designed….

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Reishi · 2022 · Journal Article · Plants (Basel, Switzerland)

Cytotoxic Activities and Fingerprint Analysis of Triterpenes by HPTLC Technique for Distinguishing Ganoderma Species from Vietnam and other Asian Countries.

Ganoderma lucidum (Fr.) P. Karst.

OncologyMetabolic healthLiver supportRespiratory

Medium relevance

Enoki · 2022 · Research Article · Journal of fungi (Basel, Switzerland)

Establishment of CRISPR/Cas9 Genome-Editing System Based on Dual sgRNAs in Flammulina filiformis.

Flammulina filiformis, previously known as Asian Flammulina velutipes, is one of the most commercially important edible fungi, with nutritional value and medicinal properties worldwide..

Liver support

Medium relevance

Shiitake · 2022 · Research Article · Journal of personalized medicine

Experience with Photodynamic Therapy Using Indocyanine Green Liposomes for Refractory Cancer.

We reported the development of an effective cancer treatment using a multidisciplinary treatment, including photodynamic therapy (PDT) with indocyanine green (ICG) liposomes and a combination of Lentinula edodes mycelia (LEM) and hydrogen gas inhalation therapy..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Enoki · 2022 · Research Article · Frontiers in microbiology

Flammulina velutipes Polysaccharides Modulate Gut Microbiota and Alleviate Carbon Tetrachloride-Induced Hepatic Oxidative Injury in Mice.

A carbon tetrachloride-induced acute liver injury mouse model is used to study the regulation of gut microbiota and hepatoprotective effect of polysaccharides from Flammulina velutipes (FVPs)..

Immune supportMetabolic healthGut & microbiomeLiver support

Medium relevance

Mesima · 2022 · Research Article · International journal of molecular sciences

Hispolon Cyclodextrin Complexes and Their Inclusion in Liposomes for Enhanced Delivery in Melanoma Cell Lines.

Hispolon, a phenolic pigment isolated from the mushroom species Phellinus linteus, has been investigated for anti-inflammatory, antioxidant, and anticancer properties; however, low solubility and poor bioavailability have limited its potential clinical translation..

OncologyImmune supportLiver support