MycoData

Acute, monomyelogenous leukemia (AMML) was diagnosed in a patient with a derived 13;14 translocation and prior treatment for a cerebellar astrocytoma. A bone marrow aspirate at the time of diagnosis of leukemia showed abnormalities of chromosome 11, 12 and 16 in addition to the constitutional aberration..

Oncology

High relevance

Wood Ear · 1981 · Journal Article · Carbohydrate research

Studies on interrelation of structure and antitumor effects of polysaccharides: antitumor action of periodate-modified, branched (1 goes to 3)-beta-D-glucan of Auricularia auricula-judae, and other polysaccharides containing (1 goes to 3)-glycosidic linkages.

Antitumor activities of two (1 goes to 3)-beta-D-glucans, isolated from the fruiting body of Auricularia auricula-judae ("kikurage", an edible mushroom), and other branched polysaccharides containing a backbone chain of (1 goes to 2)-alpha-D-glucosidic or (1 goes to 3)-alpha-D-mannosidic linkage [and their….

OncologyImmune support

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Reishi · 2026 · Journal Article · International journal of biological macromolecules

Enhanced production and anti-inflammatory activity of exopolysaccharides through the overexpression of β-1,3-glucanosyltransferase gene in Ganoderma lingzhi.

This study aimed to enhance the production and anti-inflammatory activity of exopolysaccharides (EPS) in Ganoderma lingzhi through genetic engineering. The β-1,3-glucanosyltransferase gene of the glycosyl-hydrolase 72 family was cloned and overexpressed in G.

OncologyImmune support

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Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Ganoderma lingzhi Triterpenoids Ameliorate CCl4-Induced Acute Liver Injury in Mice.

The liver is a critical organ in drug metabolism and detoxification. Ganoderma lingzhi triterpenoids, a major class of bioactive compounds in G.

OncologyImmune supportLiver support

High relevance

Chaga · 2026 · Research Article · Journal of Korean medical science

Kidney Injury Induced by High-Dose Chaga Mushroom Consumption: Experimental Evidence in a Rat Model.

BACKGROUND: Kidney damage can result not only from the overproduction of endogenous oxalate but also from excessive dietary intake. This study investigated whether oxalate-rich Chaga mushroom induces kidney injury..

OncologyImmune supportMetabolic health

High relevance

Almond Mushroom · 2026 · Research Article · ESMO open

Phase I study of ABM-1310 as monotherapy and in combination with cobimetinib for BRAF-mutated advanced solid tumors: safety, efficacy, and dose expansion.

BACKGROUND: ABM-1310 is an investigational, orally bioavailable BRAF V600 inhibitor with high blood-brain barrier (BBB) penetration. PATIENTS AND METHODS: This first-in-human, phase I trial evaluated patients with BRAF V600-mutated advanced solid tumors, including brain metastases (≤3 cm) and primary central nervous….

OncologyCognition & nerves

High relevance

Cordyceps · 2026 · Journal Article · Applied biochemistry and biotechnology

Quantitative Proteomics Analysis Insights into the Cordyceps Polysaccharides Biosynthesis.

Cordyceps polysaccharides, as bioactive macromolecules derived from Cordyceps sinensis, exhibit pharmacological activities such as immune modulation and anti-tumor properties. However, the understanding of their biosynthetic mechanisms remains limited..

OncologyImmune supportMetabolic health

High relevance

Nameko · 2025 · Journal Article · Natural product research

A new illudane sesquiterpene from the edible fungus Pholiota nameko.

Fungi have different genetic expression abilities and biosynthetic pathways under different cultivation conditions, which can produce various secondary metabolites..

Oncology

High relevance

Cordyceps · 2025 · Research Article · Microbiology spectrum

A putative ABC transporter gene, CcT1, is involved in beauvericin synthesis, conidiation, and oxidative stress resistance in Cordyceps chanhua.

UNLABELLED: Cordyceps chanhua is a traditional Chinese medicinal fungus renowned for producing a variety of bioactive compounds, including beauvericin (BEA). BEA has garnered significant attention due to its therapeutic potential and associated food safety concerns..

Oncology

High relevance

Almond Mushroom · 2025 · Journal Article · Clinical chemistry and laboratory medicine

Artificial base mismatches-mediated PCR (ABM-PCR) for detecting clinically relevant single-base mutations.

OBJECTIVES: Detecting point mutations with high sensitivity and specificity can be technically very challenging, but it is crucial for early diagnosis and effective drug treatment of cancers..

OncologyEnergy & fatigueSkin & hydrationRespiratory

High relevance

Cordyceps · 2025 · Research Article · Immunity, inflammation and disease

Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient-Gene-Disease Interaction.

OBJECTIVE: Cordyceps sinensis (CS) is a fungus that parasitizes the larvae and corpses of Batmadaceae insects. CS is used as a traditional Chinese medicine and has shown promising clinical efficacy in the treatment of chronic obstructive pulmonary disease (COPD)..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Cordyceps · 2025 · Research Article · Journal of inflammation research

Cordyceps Sinensis Reduces Inflammation and Protects BEAS-2B Cells From LPS-Induced THP-1 Cell Injury.

INTRODUCTION: Cordyceps sinensis, an entomogenous fungus with unique biological properties, has demonstrated significant anti-inflammatory potential. However, its effects on inflammation regulation need to be further investigated in detail..

OncologyImmune support

High relevance

Reishi · 2025 · Research Article · Integrative cancer therapies

Patients' Expectations and Barriers Toward Reishi Mushroom Use in Cancer Care: A Cross-Sectional Survey.

BACKGROUND: Reishi mushroom is one of the most commonly used supplements among cancer patients. However, limited data exists on why patients choose Reishi.

OncologyImmune support

High relevance

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Purification, structural characterization, and in vitro immunomodulatory activity of a low-molecular-weight polysaccharide from cultivated Chinese cordyceps.

Cultivated Chinese cordyceps, an optimal substitute for the endangered wild resource, has recently been produced on a large scale. This work sought to explore the structural features and immunomodulatory activity of a novel low-molecular-weight polysaccharide (CSP1a, 15.7 kDa) isolated from cultivated Chinese….

OncologyImmune supportMetabolic health

High relevance

Shiitake · 2025 · Journal Article · Food Chemistry

Shiitake mushroom-derived extracellular nanovesicles: Preparation, characterization, and inhibition of Caco-2 cells

In this study, Shiitake mushroom-derived extracellular nanovesicles (SMDENVs) were isolated from fresh Shiitake mushrooms by ultracentrifugation and sucrose gradient ultracentrifugation..

OncologyEnergy & fatigue

High relevance

Shiitake · 2025 · Journal Article · Food chemistry

Shiitake mushroom-derived extracellular nanovesicles: Preparation, characterization, and inhibition of Caco-2 cells.

In this study, Shiitake mushroom-derived extracellular nanovesicles (SMDENVs) were isolated from fresh Shiitake mushrooms by ultracentrifugation and sucrose gradient ultracentrifugation..

OncologyEnergy & fatigue

High relevance

Cordyceps · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

The Cordyceps Genus as a Potential Source of Bioactive Compounds for Adjuvant Cancer Therapy: A Network Pharmacology Approach.

Background/Objectives: Cancer remains one of the leading causes of mortality globally, underscoring the need for novel therapeutic strategies capable of targeting multiple molecular pathways simultaneously..

OncologyRespiratory

High relevance

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Unleashing the power within: Enhancing hydrogel bio-mimetic polymer actuators (HBPA) through sodium alginate crosslinking with cordyceps polysaccharide (CO-PS).

Hydrogel crosslinking varies in properties and stability, with many physiochemical crosslinkers boosting hydrogel performance but raising issues about biotoxicity, sourcing, and compatibility..

OncologyImmune supportEnergy & fatigue

High relevance

Cordyceps · 2024 · Research Article · Journal of diabetes investigation

Cordyceps cicadae polysaccharides attenuate diabetic nephropathy via the miR-30a-3p/TRIM16 axis.

OBJECTIVE: The molecular mechanism of the protective effect of Cordyceps cicadae polysaccharides (CCPs) on renal tubulointerstitial fibrosis in diabetic nephropathy (DN) is still unclear. This study aims to further understand the molecular mechanisms behind the therapeutic benefits of CCP on diabetic nephropathy..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Maitake · 2024 · Journal Article · Basic & clinical pharmacology & toxicology

Ehrlich ascites carcinoma provokes renal toxicity and DNA injury in mice: Therapeutic impact of chitosan and maitake nanoparticles.

In this study, the impact of chitosan (CS) and maitake (GF) nanoparticles towards the renal toxicity induced by Ehrlich ascites carcinoma (EAC) in vivo model was conducted. Besides benchmark negative control group, EAC model was constructed by intraperitoneal injection (i.p.) of 2.5 × 106 cells..

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2024 · Journal Article · Fitoterapia

New flavonoid and their anti-A549 cell activity from the bi-directional solid fermentation products of Astragalus membranaceus and Cordyceps kyushuensis.

Astragalus membranaceus and Cordyceps kyushuensis were used to obtain Astragalus membranaceus-Cordyceps kyushuensis bi-directional solid fermentation products using the bi-directional solid fermentation technique..

OncologyRespiratory

High relevance

Reishi · 2024 · Research Article · Integrative medicine research

Symptom improvements and adverse effects with Reishi mushroom use: A Cross-Sectional survey of cancer patients.

BACKGROUND: Reishi, a medicinal mushroom, is increasingly used for symptom control by cancer patients worldwide. However, data around patients' experiences with Reishi in oncology are lacking, limiting safe, effective clinical applications..

OncologyCognition & nervesEnergy & fatigue

High relevance

Cordyceps · 2022 · Review · Molecules (Basel, Switzerland)

Chinese Cordyceps: Bioactive Components, Antitumor Effects and Underlying Mechanism-A Review.

Chinese Cordyceps is a valuable source of natural products with various therapeutic effects. It is rich in various active components, of which adenosine, cordycepin and polysaccharides have been confirmed with significant immunomodulatory and antitumor functions..

OncologyImmune support

High relevance

Cordyceps · 2022 · Review · Frontiers in pharmacology

Mechanism of Cordyceps sinensis and its Extracts in the Treatment of Diabetic Kidney Disease: A Review.

Diabetic kidney disease (DKD) is the major reason of chronic kidney disease (CKD)-caused end-stage renal failure (ESRF), and leads to high mortality worldwide. At present, the treatment of DKD is mainly focused on controlling the hyperglycemia, proteinuria, and hypertension, but is insufficient on the effective delay….

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Cordyceps · 2022 · Review · Frontiers in pharmacology

Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and Related Products.

At present, there is no effective drug for the treatment of renal fibrosis; in particular, a safe and effective treatment for renal fibrosis should be established..

OncologyImmune supportLiver support

High relevance

Oyster Mushroom · 2021 · Review · International journal of biological macromolecules

Promising anticancer activity of polysaccharides and other macromolecules derived from oyster mushroom (Pleurotus sp.): An updated review.

Cancer dominates among many causes of mortality worldwide. Traditional chemotherapeutic agents are powerful anti-cancer agents employed for treatment of this deadly disease.

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2021 · Review · Medicinal chemistry (Shariqah (United Arab Emirates))

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy.

BACKGROUND: Some species of Cordyceps sensu lato are famous Chinese herbs with significant biological activities, often used as edible food and traditional medicine in China..

OncologyImmune supportCognition & nervesMetabolic health

High relevance

Reishi · 2020 · Research Article · RSC advances

LingZhi oligopeptides amino acid sequence analysis and anticancer potency evaluation.

LingZhi (Ganoderma lucidum) has been used as a therapeutic agent for decades, but the antitumor potency of LingZhi oligopeptides (LZOs) was not well explored. In current study, ten novel LZO amino acid sequences were identified, and anticancer potency was evaluated..

OncologyEnergy & fatigueRespiratory

High relevance

Mesima · 2020 · Research Article · International journal of molecular sciences

The Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma.

The tropical basidiomycete fungus Phellinus linteus (Mesima) exhibits anti-tumor, anti-angiogenic, and immunomodulatory properties in various cancers including prostate, colon, and lung cancer along with melanoma by, for example, inducing apoptosis or cell cycle arrest..

OncologyImmune supportGut & microbiomeLiver support

High relevance

Shiitake · 2019 · Research Article · Journal of Indian Society of Periodontology

To detect the minimum inhibitory concentration and time-kill curve of shiitake mushroom on periodontal pathogens: An in vitro study.

INTRODUCTION: Shiitake (Lentinula edodes) is an Asian edible mushroom with the second-largest cultivation percentages among edible mushrooms in the world. Previous studies have shown its nutritional richness such as high quantities of proteins, minerals, and vitamins..

OncologyMetabolic healthRespiratory

High relevance

Chaga · 2018 · Journal Article · Nanoscale

Synthesis of porous Pd nanoparticles by therapeutic chaga extract for highly efficient tri-modal cancer treatment.

Porous palladium nanoparticles were designed and synthesized to maximize the pharmacological activity of the chaga mushroom (Inonotus obliquus) extract, which has anticancer and antibacterial activities..

OncologyLiver supportSkin & hydration

High relevance

Shiitake · 2018 · Journal Article · Journal of food biochemistry

Valorization of spent shiitake substrate for recovery of antitumor fungal sterols by ultrasound‐assisted extraction

The ongoing expansion of mushroom industries has generated enormous spent mushroom substrate with the potential for production of valuable chemicals. This study aimed to investigate ultrasound‐assisted extraction (UAE) of fungal sterols from spent shiitake (Lentinula edodes) substrate (SSS) by response surface….

Oncology

High relevance

Cordyceps · 2017 · Research Article · PloS one

Isolation, Culture and Characterization of Hirsutella sinensis Mycelium from Caterpillar Fungus Fruiting Body.

The caterpillar fungus Ophiocordyceps sinensis (previously called Cordyceps sinensis) has been used for centuries in Asia as a tonic to improve health and longevity. Recent studies show that O..

OncologyImmune supportEnergy & fatigue

High relevance

Maitake · 2016 · Journal Article · International journal of medicinal mushrooms

Characterization of Cross-Flow Ultrafiltration Fractions from Maitake Medicinal Mushroom, Grifoia frondosa (Agaricomycetes), Reveals Distinct Cytotoxicity in Tumor Cells.

β-glucans from Basidiomycetes like Grifola frondosa (the maitake mushroom) are well known for their health benefits. Polysaccharide preparations from medicinal mushrooms such as G.

OncologyImmune support

High relevance

Maitake · 2016 · Research Article · Cancer medicine

Maitake Pro4X has anti-cancer activity and prevents oncogenesis in BALBc mice.

The understanding of the molecular mechanisms of the immune tolerance induced by the tumoral microenvironment is fundamental to prevent cancer development or to treat cancer patients using immunotherapy. Actually, there are investigations about "addressed-drugs" against cancer cells without affecting normal cells..

OncologyImmune support

High relevance

Cordyceps · 2014 · Review Article · Journal of functional foods

Recent advances in Cordyceps sinensis polysaccharides: Mycelial fermentation, isolation, structure, and bioactivities: A review.

Cordyceps (Ophiocordyceps sinensis) sinensis, the Chinese caterpillar fungus, is a unique and precious medicinal fungus in traditional Chinese medicine which has been used as a prestigious tonic and therapeutic herb in China for centuries. Polysaccharides are bioactive constituents of C..

OncologyImmune supportMetabolic health

High relevance

Cordyceps · 2026 · Review · Molecules (Basel, Switzerland)

Medicinal Mushrooms and Their Bioactive Compounds: From Traditional Use to Therapeutic Potential.

Medicinal mushrooms have become an important component of modern dietary supplementation and functional nutrition due to their diverse biological activities and long-standing use in traditional medicine..

OncologyImmune support

High relevance

Cordyceps · 2025 · Review · Frontiers in nutrition

Effects of fungal supplementation on endurance, immune function, and hematological profiles in adult athletes: a systematic review and meta-analysis.

Edible fungi are rich in a wide array of bioactive compounds, and a growing body of evidence suggests that they possess anti-inflammatory, antioxidant, antitumor, anti-aging, and other beneficial properties..

OncologyImmune supportEnergy & fatigueSkin & hydration

High relevance

Niu-Chang-Chih · 2025 · Review · Naunyn-Schmiedeberg's archives of pharmacology

Unlocking the biological potential of methyl antcinate A: a new frontier in cancer and inflammation application.

Antrodia camphorata is a valued and scarce parasitic mushroom that exclusively proliferates on the inner cavity wall of the endangered tree Cinnamomum kanehirai Hay (Lauraceae), endemic to Taiwan..

OncologyImmune supportMetabolic healthLiver support

High relevance

Reishi · 2024 · Review · Mycology

Bibliometric, taxonomic, and medicinal perspectives of Ganoderma neo-japonicum Imazeki: A mini review.

Ganoderma, a traditional medicine in Asian countries, has been used to prevent and treat various ailments for centuries. Ganoderma neo-japonicum (synonym Ganoderma bambusicola), also known as purple Lingzhi, is a species that is currently underutilised when compared to Ganoderma lucidum (Lingzhi)..

OncologyImmune supportMetabolic healthLiver support

High relevance

Maitake · 2023 · Journal Article · Life sciences

Maitake α-glucan promotes differentiation of monocytic myeloid-derived suppressor cells into M1 macrophages.

AIMS: Myeloid-derived suppressor cells (MDSCs) are major components of the tumor microenvironment and systemically accumulate in tumor-bearing hosts and patients with cancer, facilitating cancer progression..

OncologyImmune support

High relevance

Cordyceps · 2022 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Adenosine derivatives from Cordyceps exert antitumor effects against ovarian cancer cells through ENT1-mediated transport, induction of AMPK signaling, and consequent autophagic cell death.

Cordyceps militaris is rich in adenosine derivatives, including 3'-deoxyadenosine, also known as cordycepin. It has been reported for antitumor effects, but its underlying molecular mechanism has yet to be elucidated..

Oncology

High relevance

Reishi · 2020 · Review · Applied microbiology and biotechnology

Mushroom extracts and compounds with suppressive action on breast cancer: evidence from studies using cultured cancer cells, tumor-bearing animals, and clinical trials.

This article reviews mushrooms with anti-breast cancer activity. The mushrooms covered which are better known include the following: button mushroom Agaricus bisporus, Brazilian mushroom Agaricus blazei, Amauroderma rugosum, stout camphor fungus Antrodia camphorata, Jew's ear (black) fungus or black wood ear fungus….

Oncology

High relevance

Cordyceps · 2019 · Review Article · Molecules (Basel, Switzerland)

Therapeutic Potential and Biological Applications of Cordycepin and Metabolic Mechanisms in Cordycepin-Producing Fungi.

Cordycepin(3'-deoxyadenosine), a cytotoxic nucleoside analogue found in Cordyceps militaris, has attracted much attention due to its therapeutic potential and biological value. Cordycepin interacts with multiple medicinal targets associated with cancer, tumor, inflammation, oxidant, polyadenylation of mRNA, etc..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Daru: journal of Faculty of Pharmacy, Tehran University of Medical Sciences

Anti-cancer effect of Cordyceps militaris in human colorectal carcinoma RKO cells via cell cycle arrest and mitochondrial apoptosis.

BACKGROUND: Cordyceps militaris has been used as a traditional medicine in Asian countries for a long time. Different types of Cordyceps extract were reported to have various pharmacological activities including an anti-cancer effect..

OncologyEnergy & fatigue

High relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Anti-Gastric Ulcer Activity of Polysaccharide Fraction Isolated from Mycelium Culture of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Higher Basidiomycetes).

Hericium erinaceus is a culinary-medicinal mushroom that is used in traditional medicine, in folk medicine, and as medicinal cuisine in Asian countries such as China, Japan, and Korea. H..

OncologyImmune supportCognition & nerves

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Journal of microbiology (Seoul, Korea)

Anti-tumor effect of Cordyceps militaris in HCV-infected human hepatocarcinoma 7.5 cells.

Cordyceps extract has been reported to have various pharmacological activities including an anti-cancer effect. We investigated the inhibitory effect of Cordyceps militaris on hepatitis C virus-infected human hepatocarcinoma 7.5 cells (J6/JFH1-huh 7.5 cells)..

OncologyLiver supportRespiratory

High relevance

Cordyceps · 2015 · Research Support, Non U.S. Gov'T · Phytotherapy research: PTR

Apoptotic Effects of the Extracts of Cordyceps militaris via Erk Phosphorylation in a Renal Cell Carcinoma Cell Line.

Cordyceps militaris (CM) is gaining attention as a traditional medicinal food, but its molecular biological mechanisms for anti-cancer activity are not identified or clarified..

Oncology

High relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · International journal of biological macromolecules

Characterization of two water-soluble lignin metabolites with antiproliferative activities from Inonotus obliquus.

The chaga mushroom, Inonotus obliquus has long been recognized as a remedy for cancer, gastritis, ulcers, and tuberculosis of the bones since the 16th century. Herein we reported the identification of two homogenous biological macromolecules, designated as IOW-S-1 and IOW-S-2 with anti-tumor activities from the….

OncologyEnergy & fatigue

High relevance

Chaga · 2015 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Chemical characterization and biological activity of Chaga (Inonotus obliquus), a medicinal "mushroom".

ETHNOPHARMACOLOGICAL RELEVANCE: In Russian traditional medicine, an extract from the mushroom Inonotus obliquus (Fr.) Pil´at is used as an anti-tumor medicine and diuretic. It has been reported that Inonotus obliquus has therapeutic effects, such as anti-inflammatory, immuno-modulatory and hepatoprotective effects..

OncologyImmune supportLiver support