MycoData

Viruses are responsible for numerous serious outbreaks and pandemics worldwide. In this context, lectins, which are carbohydrate-binding proteins, have garnered attention due to their antiviral properties against RNA and DNA viruses..

Respiratory

High relevance

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Evidence to support cultivated fruiting body of Ophiocordyceps sinensis (Ascomycota)'s role in relaxing airway smooth muscle.

ETHNOPHARMACOLOGICAL RELEVANCE: Ophiocordyceps sinensis (O. sinensis) is a genus of Ascomycete fungus that is endemic to the alpine meadows of the Tibetan Plateau and adjoining Himalayas..

Immune supportEnergy & fatigueMetabolic healthRespiratory

High relevance

Agarikon · 2025 · Research Article · Frontiers in pharmacology

Exploration of the role of Fomitopsis officinalis Ames in the treatment of gastric cancer using network pharmacology, molecular docking, and in vitro experiments.

BACKGROUND: Gastric cancer (GC) is one of the most common malignant tumors worldwide, with approximately one million people diagnosed with gastric cancer each year..

OncologyImmune supportCognition & nervesRespiratory

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Functional characterization of Ganoderma lucidum polysaccharide and the mechanism of inducing tomato resistance to Tomato yellow leaf curl virus.

Using functional polysaccharides as elicitors to induce plant disease resistance has emerged as an effective plant protection strategy. In this study, we found that crude polysaccharides derived from by-products of Ganoderma lucidum can effectively prevent and control the Tomato Yellow Leaf Curl Virus (TYLCV)..

Immune supportEnergy & fatigueMetabolic healthRespiratory

High relevance

Reishi · 2025 · Research Article · Frontiers in pharmacology

Integrated metabolomic, transcriptomic and network analysis elucidates therapeutic mechanisms of Ganoderma lucidum spore oil against granulomatous pulmonary nodules.

Granulomatous pulmonary nodules represent a substantial health threat, with no available targeted therapies. Interventions based on medicinal plants approaches are pivotal for prevention and treatment.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Maitake · 2025 · Research Article · Food science & nutrition

Mesenchymal Stem Cell-Conditioned Media-Derived Exosomes Loaded With Grifola frondosa Extract Inhibit Lung Cancer via NF-κB and MAPK Pathway Modulation.

The increasing prevalence of drug resistance diminishes the efficacy of chemotherapy and other therapeutic modalities for individuals diagnosed with lung cancer. Therefore, it is imperative to develop novel treatment approaches..

OncologyEnergy & fatigueGut & microbiomeRespiratory

High relevance

Lion's Mane · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Mitochondrial energy homeostasis-mediated respiration suppression: A novel mechanism for combating wilting of Hericium erinaceus via electron beam generated X-ray irradiation

This study explored the mechanism of Hericium erinaceus wilting delayed by 1.0 kGy electron-beam generated X-ray (EBGX) irradiation from modulating respiratory pathways and energy homeostasis perspectives..

Energy & fatigueMetabolic healthRespiratory

High relevance

Wood Ear · 2025 · Journal Article · International journal of biological macromolecules

Oral pharmacokinetics and tissue distribution of a homogeneous polysaccharide from Auricularia auricula-judae: dual-method validation of absorption and distribution.

Polysaccharides encounter significant challenges in vivo pharmacokinetic studies because of their complex structures and the limitations of current detection methods, thereby impeding their development and biomedical applications..

Immune supportLiver supportRespiratory

High relevance

Mesima · 2025 · Research Article · Foods (Basel, Switzerland)

Phellinus linteus Mycelia Extracts Show Potent Antiviral and Immunomodulatory Effects in H1N1 Influenza Virus-Infected Mice.

Phellinus linteus, a medicinal mushroom with an ancient history in traditional medicine, serves as a valuable raw material for functional foods. While previous studies have shown promising antiviral effects, the present work is the most comprehensive investigation of P..

Immune supportRespiratory

High relevance

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Restoring Mitochondrial Function and Remodeling Gut Microbiota by Low-Molecular-Weight β-Glucan of Hericium erinaceus in Alcohol-Induced Gastrointestinal Injury.

Excessive alcohol consumption poses significant risks for gastrointestinal injury; β-glucans from Hericium erinaceus are known for gastroprotective properties; however, the efficacy of its high-molecular-weight β-glucan is often limited by poor solubility and bioavailability, leaving its protective mechanisms against….

Immune supportEnergy & fatigueGut & microbiomeRespiratory

High relevance

Reishi · 2025 · Research Article · Journal of advanced veterinary and animal research

The protective effects of Ganoderma lucidum polysaccharides on blood physiology, immune function, and organ architecture in growing stressed rabbits.

OBJECTIVE: This experiment explored the plausible effects of Ganoderma lucidum polysaccharides (GLP) to reduce the deterioration effects of heat stress (HS) in growing rabbits by studying blood physiology, growth, immunity, inflammation, and organ structure..

Immune supportLiver supportRespiratory

High relevance

Oyster Mushroom · 2024 · Journal Article · Food Hydrocolloids

Antiviral and technological properties of β-glucan-rich aqueous fractions from Pleurotus ostreatus waste biomass

In the present work, aqueous fractions were extracted from the discarded Pleurotus ostreatus biomass (AF) and from a waste product (RAF) generated from it in the industry (stipes) with the aim of valorizing these wastes into new food ingredients..

Respiratory

High relevance

Yellow Morel · 2024 · Research Article · Frontiers in veterinary science

Effect of Morchella esculenta polysaccharides on the rectal microbiota of mice challenged with lipopolysaccharides.

INTRODUCTION: Intestinal dysfunction poses a severe problem by preventing the digestion and absorption of nutrients. The gut, being the most vital organ for these processes, plays a crucial role in ensuring our body receives the nutrients it needs..

OncologyImmune supportGut & microbiomeRespiratory

High relevance

Lion's Mane · 2024 · Journal Article · Chemistry & biodiversity

Hericium erinaceus Extract Induces Apoptosis via PI3K/AKT and RAS/MAPK Signaling Pathways in Prostate Cancer Cells.

Prostate cancer (PCa) is increasing globally, surpassing lung cancer in incidence. Despite available treatment options, prostate cancer remains incurable.

OncologyRespiratory

High relevance

Reishi · 2024 · Research Article · Molecules (Basel, Switzerland)

Improvement of Echinacea purpurea and Ganoderma lucidum Extracts with Cell Model on Influenza A/B Infection.

Since 2019, COVID-19 has been raging around the world. Respiratory viral infectious diseases such as influenza and respiratory syncytial virus (RSV) infection are also prevalent, with influenza having the ability to cause seasonal pandemics..

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Snow Fungus · 2024 · Research Article · Foods (Basel, Switzerland)

Investigating the Respiratory and Energy Metabolism Mechanisms behind ε-Poly-L-lysine Chitosan Coating's Improved Preservation Effectiveness on Tremella fuciformis.

Freshly harvested Tremella fuciformis contains high water content with an unprotected outer surface and exhibits high respiration rates, which renders it prone to moisture and nutrient loss, leading to decay during storage..

Energy & fatigueMetabolic healthRespiratory

High relevance

Maitake · 2024 · Journal Article · Journal of the science of food and agriculture

Isolation and identification of active components from Grifola frondosa and its anti-EV71 virus effect.

BACKGROUND: It is reported that anti-enterovirus 71 (EV71) drugs have some side effects on human health. Notably, fungi plays a crucial role in promoting human health and anti-virus.

OncologyEnergy & fatigueRespiratory

High relevance

Maitake · 2024 · Journal Article · Journal of the science of food and agriculture

Isolation and identification of active components from Grifola frondosa and its anti‐EV71 virus effect

BACKGROUND: It is reported that anti‐enterovirus 71 (EV71) drugs have some side effects on human health. Notably, fungi plays a crucial role in promoting human health and anti‐virus.

OncologyEnergy & fatigueRespiratory

High relevance

Cordyceps · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

The Anti-Inflammatory Effects and Mechanism of the Submerged Culture of Ophiocordyceps sinensis and Its Possible Active Compounds.

The pharmacological effects of the fruiting body of Ophiocordyceps sinensis (O. sinensis) such as antioxidant, anti-virus, and immunomodulatory activities have already been described, whereas the anti-inflammatory effects and active components of the submerged culture of O..

Immune supportCognition & nervesRespiratory

High relevance

Reishi · 2023 · Review · Foods (Basel, Switzerland)

Exploring the Potential Medicinal Benefits of Ganoderma lucidum: From Metabolic Disorders to Coronavirus Infections.

Ganoderma lucidum is a medicinal mushroom that has been traditionally used in Chinese medicine for centuries. It has been found to have a wide range of medicinal properties, including antioxidant, anti-inflammatory, and immune-boosting effects.

Immune supportMetabolic healthRespiratory

High relevance

Reishi · 2023 · Review · Nutrients

Ganoderma lucidum: Novel Insight into Hepatoprotective Potential with Mechanisms of Action.

Ganoderma lucidum (G. lucidum) has been widely used for its health benefits as an edible and traditional medicinal mushroom for thousands of years in Asian countries.

OncologyImmune supportLiver supportRespiratory

High relevance

Oyster Mushroom · 2023 · Review · Foods (Basel, Switzerland)

Modulation of the Gut Microbiota with Prebiotics and Antimicrobial Agents from Pleurotus ostreatus Mushroom.

Pleurotus ostreatus (Jacq. ex Fr.) P.

Immune supportGut & microbiomeRespiratory

High relevance

Reishi · 2022 · Review · Frontiers in pharmacology

Antioxidant, antibacterial, antitumor, antifungal, antiviral, anti-inflammatory, and nevro-protective activity of Ganoderma lucidum: An overview.

Ganoderma lucidum is a very medicinal mushroom that has been utilized in Oriental medicine for many years. It has a wide range of pharmacological and therapeutic properties, and has been used for many years as a health promoter..

OncologyImmune supportRespiratory

High relevance

Cordyceps · 2021 · Review Article · 3 Biotech

Novel formulation development from Ophiocordyceps sinensis (Berk.) for management of high-altitude maladies.

Ophiocordyceps sinensis (Berk.) is a fungus closely related to medicinal mushroom, which belongs to the family Ophiocordycipitaceae. It is a well-known and rich herbal source of bioactive active constituents.

OncologyImmune supportMetabolic healthRespiratory

High relevance

Turkey Tail · 2014 · Randomized Controlled Trial · International journal of medicinal mushrooms

Control of oral human papillomavirus (HPV) by medicinal mushrooms, Trametes versicolor and Ganoderma lucidum: a preliminary clinical trial.

This preliminary randomized study investigated the efficacy of medicinal mushrooms, Trametes versicolor (TV), Ganoderma lucidum (GL), and Laetiporus sulphureus (LS), on the clearance of oral human papillomavirus (HPV, serotypes 16 and 18)..

Respiratory

High relevance

Reishi · 2024 · Research Article · Journal of biomaterials and nanobiotechnology

Rapid Green Synthesis of Silver Nanoparticles by Reishi and Their Antibacterial Activity and Mechanisms.

Nanotechnology is a rapidly growing field in biomedical engineering with references to efficiency, safety, and cost-effective approaches. Herein, the objective of this study was to examine an innovative approach to rapidly synthesis silver nanoparticles from an aqueous extract of medicinal mushroom Ganoderma lucidum….

Respiratory

High relevance

Chaga · 2023 · English Abstract · Voprosy virusologii

[Antiviral activity of basidial fungus Inonotus obliquus aqueous extract against SARS-CоV-2 virus (Coronaviridae: Betacoronavirus: Sarbecovirus) in vivo in BALB/c mice model].

INTRODUCTION: The COVID-19 pandemic combined with seasonal epidemics of respiratory viral diseases requires targeted antiviral prophylaxis with restorative and immunostimulant drugs. The compounds of natural origin are low-toxic, but active against several viruses at the same time..

Immune supportRespiratory

High relevance

Chaga · 2023 · English Abstract · Voprosy virusologii

[Screening of antiviral activity of samples from chaga Inonotus obliquus and humic acid from brown coal on Vero cell culture against ectromelia virus (Poxviridae: Orthopoxvirus; ECTV)].

INTRODUCTION: The mouse-specific orthopoxvirus, ectromelia virus, is one of the best models that can be used to study key issues of pathogenesis, prevention, and treatment of smallpox, and to develop measures to increase virulence, transmissibility, or the ability to overcome vaccine immunity..

OncologyImmune supportRespiratory

High relevance

Shiitake · 2023 · Research Support, Non U.S. Gov'T · Virology

Prevalence and diversity of mycoviruses occurring in Chinese Lentinula edodes germplasm resource.

Incidence and banding patterns of virus-like dsRNA elements in 215 Chinese genetically diverse Lentinula edodes strains collected from wide geographic distribution (or producing areas) were first investigated, and 17 viruses were identified including eight novel viruses..

Respiratory

High relevance

Agarikon · 2022 · Research Support, Non U.S. Gov'T · Anti-cancer agents in medicinal chemistry

Anti-oxidant and Anticancerous Effect of Fomitopsis officinalis (Vill. ex Fr. Bond. et Sing) Mushroom on Hepatocellular Carcinoma Cells In Vitro through NF-kB Pathway.

BACKGROUND: Fomitopsis officinalis (Vill. ex Fr.

OncologyImmune supportLiver supportRespiratory

High relevance

Almond Mushroom · 2022 · Case Reports · Case reports in gastroenterology

Interstitial Lung Disease Associated with Agaricus blazei Murill in a Patient with Pancreatic Ductal Adenocarcinoma Receiving Gemcitabine-Based Therapy.

A male in his sixties with locally advanced pancreatic ductal adenocarcinoma (PDAC) was administered gemcitabine plus nab-paclitaxel therapy. Computed tomography (CT) scans after five courses revealed nonspecific interstitial pneumonitis in addition to PDAC aggravation..

OncologyImmune supportRespiratory

High relevance

Oyster Mushroom · 2021 · Case Reports · International journal of occupational medicine and environmental health

A case of anaphylactic reaction following oyster mushroom (Pleurotus ostreatus) inhalation.

Oyster mushroom (Pleurotus ostreatus) is one of the most widely consumed mushrooms in the world. Its spores are highly potent allergens, but their main allergen, Pleo, has so far been very rarely reported.

Skin & hydrationRespiratory

High relevance

Shiitake · 2021 · Research Support, Non U.S. Gov'T · Virology

Mycoviral diversity and characteristics of a negative-stranded RNA virus LeNSRV1 in the edible mushroom Lentinula edodes.

Bioinformatics and RT-PCR analysis of RNA from four Lentinula edodes samples identified 22 different virus-like contigs comprising 15 novel and 3 previously reported viruses..

Respiratory

High relevance

Yellow Morel · 2021 · Research Support, Non U.S. Gov'T · Virus research

The unique genome organization of two novel fusariviruses hosted by the true morel mushroom Morchella esculenta.

Two putative mycoviruses belonging to the proposed family "Fusariviridae" were identified in Morchella esculenta by sequencing of double-stranded RNAs extracted from the morel mushroom. These viruses were tentatively named "Morchella esculenta fusarivirus 1″ (MeFV1) and "Morchella esculenta fusarivirus 2″ (MeFV2)..

Respiratory

High relevance

Cordyceps · 2023 · English Abstract · Nan fang yi ke da xue xue bao = Journal of Southern Medical University

[Cordycepin, a metabolite of Cordyceps militaris, inhibits xenograft tumor growth of tongue squamous cell carcinoma in nude mice].

OBJECTIVE: To evaluate the inhibitory effect of cordycepin on oral cancer xenograft in nude mice and explore the underlying mechanisms. METHODS: Sixteen BALB/c mice bearing subcutaneous human tongue squamous cell carcinoma (TSCC) TCA-8113 cell xenografts were randomized into model group and cordycepin treatment group….

OncologyEnergy & fatigueLiver supportRespiratory

High relevance

Maitake · 2023 · Preprint · journal metadata

Anti-α-glucosidase, anti-proliferative and anti-enterovirus 71 activity of secondary metabolites identified from Grifola frondosa

Grifola frondosa, an edible and medicinal resource, is widely used as functional foods worldwide. To explore bioactive compounds against α-glucosidase, human tumor cells and enterovirus 71 (EV71), eight compounds were isolated from G.

OncologyMetabolic healthRespiratory

High relevance

Oyster Mushroom · 2023 · Preprint · journal metadata

Antioxidant effect of ethanolic extract of Pleurotus Ostreatus on 4-hydroxy-2-nonenal (HNE) and glutathione (GSH) level in lung rats exposed to cigarette smoke

Background: Cigarette smoke can trigger oxidative stress. An alternative to overcome the harmful effects of cigarette smoke is through antioxidants.

Respiratory

High relevance

Lion's Mane · 2022 · Preprint · journal metadata

In vitro assessment of multipotential therapeutic importance of Hericium erinaceus mushroom extracts using different solvents

Abstract Infectious disease is one of the major threats to humans and it is the second leading cause of death worldwide, especially at present in which the Covid-19 and its modified variants. Edible mushrooms have many nutritional and medicinal values to human health..

Immune supportRespiratory

High relevance

Cordyceps · 2020 · Research Article · Mycobiology

Beneficial Effect of Cordyceps militaris on Exercise Performance via Promoting Cellular Energy Production.

Cordyceps militaris has been reported to the diverse pharmaceutical effects including cancer, inflammatory diseases, and bacteria or virus infection. However, the effect of C.

OncologyImmune supportEnergy & fatigueRespiratory

High relevance

Cordyceps · 2020 · Research Article · Sensors (Basel, Switzerland)

Implementation and Performance Evaluation of Integrated Wireless MultiSensor Module for Aseptic Incubator of Cordyceps militaris.

This paper originally proposes a wireless multisensor module with illuminance, temperature, relative humidity (RH) and carbon dioxide (CO2) sensors in an aseptic jar incubator for a solid-state fermentation (SSF) of Cordyceps militaris culture..

Energy & fatigueRespiratory

High relevance

Cordyceps · 2020 · Journal Article · Chinese journal of natural medicines

Overexpression of ribonucleotide reductase small subunit, RNRM, increases cordycepin biosynthesis in transformed Cordyceps militaris.

Cordycepin was the first adenosine analogue used as an anticancer and antiviral agent, which is extracted from Cordyceps militaris and hasn't been biosynthesized until now..

OncologyRespiratory

High relevance

Reishi · 2020 · Journal Article · Journal of biomolecular structure & dynamics

The identification of active compounds in Ganoderma lucidum var. antler extract inhibiting dengue virus serine protease and its computational studies.

The number of global dengue incidences is alarmingly high in recent years. The global distribution of four dengue serotypes has also added economic burden in the dengue-endemic countries..

Respiratory

High relevance

Almond Mushroom · 2019 · Research Article · Nutrients

Agaricus blazei-Based Mushroom Extract Supplementation to Birch Allergic Blood Donors: A Randomized Clinical Trial.

Since Agaricus blazei Murill (AbM) extract reduced specific IgE and ameliorated a skewed Th1/Th2 balance in a mouse allergy model, it was tested in blood donors with self-reported, IgE-positive, birch pollen allergy and/or asthma..

Respiratory

High relevance

Maitake · 2019 · Journal Article · Mycoscience

Isolation and characterization of a novel mycovirus infecting an edible mushroom, Grifola frondosa

Grifola frondosa (Maitake mushroom) is an important cultivated mushroom due to its medicinal and nutrient values. In this study, we isolated and characterized a novel partitivirus (named Grifola frondosa partitivirus 1, GfPV1) infecting a standard G.

Gut & microbiomeRespiratory

High relevance

Cordyceps · 2019 · Research Article · OncoTargets and therapy

Se-Enriched Cordyceps militaris Inhibits Cell Proliferation, Induces Cell Apoptosis, And Causes G2/M Phase Arrest In Human Non-Small Cell Lung Cancer Cells.

BACKGROUND: The anticancer effects of cordyceps on various tumors have been reported. However, little is known about the role of selenium (Se)-enriched Cordyceps militaris in non-small cell lung cancer (NSCLC)..

OncologyGut & microbiomeRespiratory

High relevance

Cordyceps · 2019 · Journal Article · Journal of medicinal food

The Extract of Cordyceps Militaris Inhibited the Proliferation of Cisplatin-Resistant A549 Lung Cancer Cells by Downregulation of H-Ras.

We investigated the antitumor effect of Cordyceps militaris extract (CME) on A549 cisplatin-resistant (CR) lung cancer cells. The proliferation of A549/CR cells was suppressed by CME.

OncologyRespiratory

High relevance

Turkey Tail · 2019 · Research Article · BMC complementary and alternative medicine

The mycelium of the Trametes versicolor (Turkey tail) mushroom and its fermented substrate each show potent and complementary immune activating properties in vitro.

BACKGROUND: The medicinal mushroom Trametes versicolor (Tv, Turkey Tail) is often prepared for consumption as a powder from the fungal mycelium and the fermented substrate on which it grew..

Immune supportMetabolic healthGut & microbiomeRespiratory

High relevance

Reishi · 2018 · Journal Article · International journal of medicinal mushrooms

Antiproliferative Effects of a Triterpene-Enriched Extract from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), on Human Lung Cancer Cells.

Ganoderma lucidum, a mushroom that has been used to treat disease in East Asia for centuries, has been shown to be effective against many types of tumors, but the exact cellular mechanism of action is unknown..

OncologyImmune supportRespiratory

High relevance

Chaga · 2018 · Journal Article · Journal of ethnopharmacology

Bioactivity-based analysis and chemical characterization of cytotoxic constituents from Chaga mushroom (Inonotus obliquus) that induce apoptosis in human lung adenocarcinoma cells.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus, also known as Chaga mushroom, is one of the most widely appreciated wild edible mushrooms in Russia and northern European countries and is renowned for its use in cancer treatment..

OncologyImmune supportRespiratory

High relevance

Cordyceps · 2018 · Journal Article · Enzyme and microbial technology

Cloning and protein expression of the sn-1(3) regioselective lipase from Cordyceps militaris.

In this study, the gene of a novel lipase with sn-1(3) regioselectivity (i.e., sn-1 or sn-3 specific) from Cordyceps militaris was successfully expressed by a heterologous expression system. Total RNA was extracted from C.

Respiratory