MycoData

OncologyImmune supportSkin & hydrationRespiratory

Chaga · 2010 · Review · Applied microbiology and biotechnology

Chemical diversity of biologically active metabolites in the sclerotia of Inonotus obliquus and submerged culture strategies for up-regulating their production.

Inonotus obliquus (Fr.) Pilat is a white rot fungus belonging to the family Hymenochaetaceae in the Basidiomycota. In nature, this fungus rarely forms a fruiting body but usually an irregular shape of sclerotial conk called 'Chaga'.

OncologyImmune supportLiver support

Almond Mushroom · 2008 · Review · Scandinavian journal of immunology

Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer.

Agaricus blazei Murill (AbM) is an edible, medicinal mushroom of Brazilian origin. It is used traditionally against a range of diseases, including cancer and chronic hepatitis, and has been cultivated commercially for the health food market..

OncologyImmune supportMetabolic healthLiver support

Almond Mushroom · 2008 · Review Article · Evidence-based complementary and alternative medicine: eCAM

The Medicinal Mushroom Agaricus blazei Murrill: Review of Literature and Pharmaco-Toxicological Problems.

Agaricus blazei Murrill (ABM) popularly known as 'Cogumelo do Sol' in Brazil, or 'Himematsutake' in Japan, is a mushroom native to Brazil, and widely cultivated in Japan for its medicinal uses, so it is now considered as one of the most important edible and culinary-medicinal biotechnological species..

OncologyImmune supportMetabolic health

Shiitake · 2026 · Research Support, Non U.S. Gov'T · Journal of translational medicine

A novel combination for in vivo breast cancer treatment: TAK1 inhibition combined with metformin and Lentinula edodes compounds synergistically reinvigorates CD8+ T Cells.

BACKGROUND: Breast cancer (BC) is the most prevalent cancer among women, and retrieving the anti-tumor function of the immune system seems a promising treatment approach for its crucial role in combating cancer cells..

Immune supportGut & microbiomeSkin & hydration

Shiitake · 2026 · Evaluation Study · Food chemistry

Intense pulsed light-assisted water extraction of polysaccharides from Lentinula edodes: In vitro structural characterization and verification of antioxidant activities.

Polysaccharides from Lentinula edodes (L. edodes) exhibit antioxidant and immunomodulatory activities, but conventional extraction is limited by low efficiency and potential loss of bioactivity..

OncologyImmune supportCognition & nervesMetabolic health

Shiitake · 2026 · Research Support, Non U.S. Gov'T · The breast journal

Lentinula edodes Cultured Extract Intake at Puberty Mitigates Inflammatory Signals at the Mammary Glands by the Involvement of Epigenetic Mechanisms in BALB/c Mice.

Exposure to immune stress or lipopolysaccharide (LPS) during critical developmental stages like puberty may lead to gut microbiome dysbiosis and epigenetic dysregulation in mammary glands, affecting gene expression and potentially elevating breast cancer susceptibility in adulthood..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2026 · Research Support, Non U.S. Gov'T · Biomolecules

Study on the Mechanism of Ganoderma lucidum Polysaccharides for Ameliorating Dyslipidemia via Regulating Gut Microbiota and Fecal Metabolites.

In today's world, unhealthy living habits have contributed to the rise in metabolic disorders like hyperlipidemia. Recognized as a popular edible and medicinal mushroom in China and various eastern nations, Ganoderma lucidum is a promising high-value functional and medicinal food with multiple biological activities..

Immune supportEnergy & fatigueMetabolic health

Lion's Mane · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Anti-radiation metabolomics of Hericium erinaceus polysaccharides based on gas chromatography-mass spectrometry].

A serum metabolomics analysis method based on gas chromatography-mass spectrometry(GC-MS) was used to investigate the metabolic regulation mechanism of Hericium erinaceus(H. erinaceus) polysaccharides on radiation injury.

OncologyImmune supportEnergy & fatigueGut & microbiome

Reishi · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Efficacy of Ganoderma lucidum spores in invigorating spleen via spleen meridian].

Based on the model of spleen deficiency, this study investigated the medicinal properties of spleen meridian tropism of Ganoderma lucidum spores and their efficacy of strengthening the spleen..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Ganoderma lucidum spore polysaccharides regulate JAK2/STAT3 pathway to alleviate cancer-related fatigue in mouse model of spleen deficiency syndrome].

Ganoderma lucidum spore polysaccharides(GLSP) are the main active ingredients of G. lucidum spores and have pharmacological effects of regulating immunity and inhibiting tumor growth.

OncologyImmune supportLiver supportRespiratory

Reishi · 2025 · English Abstract · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Regulation of apoptosis and autophagy in hepatoblastoma cells by Ganoderma lucidum polysaccharides through Akt/mTOR pathway].

This research investigated the impact of Ganoderma lucidum polysaccharides(GLP) on hepatoblastoma HepG2 and Huh6 cell models, as well as KM mouse model with in situ transplanted tumors, so as to provide a theoretical basis for the clinical application of GLP..

Immune supportEnergy & fatigueMetabolic healthLiver support

Snow Fungus · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

A Novel Polysaccharide From Tremella fuciformis Alleviated High-Fat Diet-Induced Obesity by Promoting AMPK/PINK1/PRKN-Mediated Mitophagy in Mice.

SCOPE: Polysaccharides from Tremella fuciformis have gained significant interest due to their diverse biological activities. This study focuses on characterizing a purified polysaccharide, TPSP2, extracted from T.

OncologyImmune supportGut & microbiome

Zhu Ling · 2025 · Comparative Study · International journal of biological macromolecules

Comparative study of physicochemical properties, antioxidant activity, antitumor activity and in vitro fermentation prebiotic properties of Polyporus umbellatus (Pers.) Fries polysaccharides at different solvent extractions.

Polyporus umbellatus (Pers.) Fries (PU), a medicinal fungus, contains polysaccharides (PUPs) as its primary bioactive components. In this paper, physicochemical properties, biological activities and in vitro fermentation prebiotic properties of PUPs, extracted by 90 °C hot water (PUP-W), 0.9 % NaCl (PUP-N), citric….

Immune supportCognition & nerves

Cordyceps · 2025 · Evaluation Study · Food chemistry

Food traceability analysis and quality marker monitoring in Ophiocordyceps sinensis with multimodal ensemble learning.

Ophiocordyceps sinensis (OS) faces serious risks of food fraud, including quality misrepresentation, adulteration and illegal additives. To preserve the economic interests of consumers and the transparent management of food trade, so this study proposed a rapid and non-destructive detection tool to identify….

Immune supportCognition & nervesEnergy & fatigue

Snow Fungus · 2025 · Evaluation Study · Food chemistry

Monitoring Tremella fuciformis submerged fermentation using ATR-MIR combined with chemometrics.

This study employed mid-infrared attenuated total reflection (ATR-MIR) spectroscopy and chemometrics to monitor the submerged fermentation process of Tremella fuciformis (T. fuciformis)..

Mesima · 2025 · Research Support, Non U.S. Gov'T · Integrative cancer therapies

Perioperative Clinical Usage of Phellinus Linteus as a Nutraceutical for Non-FOLFIRINOX-Based Postoperative Adjuvant Chemotherapy for Resected Pancreatic Cancer: A Retrospective Cohort Study.

INTRODUCTION: Most patients with pancreatic cancer experience systemic recurrence within 1 to 2 years after radical pancreatectomy. Phellinus linteus (PL) has demonstrated anti-inflammatory, antioxidant, and anti-cancer properties, suggesting potential as an adjunct to cancer therapy..

OncologyImmune support

Immune supportSkin & hydration

Chaga · 2025 · Research Support, Non U.S. Gov'T · Bioengineered

Photoregulation of the biosynthetic activity of fungus Inonotus obliquus using colloidal solutions of biogenic metal nanoparticles and low-intensity laser radiation.

This article presents new data on the integrated use of colloidal solutions of nanoparticles and low-intensity laser radiation on the biosynthetic activity of the medicinal mushroom Inonotus obliquus in vitro..

Oyster Mushroom · 2025 · Research Support, Non U.S. Gov'T · Fungal genetics and biology: FG & B

Physiological function of hydrophobin Hydph16 in cell wall formation in agaricomycete Pleurotus ostreatus.

Hydrophobins are small-secreted proteins with both hydrophobic and hydrophilic regions, enabling the mycelium to break through the air-medium interface by reducing the medium surface tension. Over 20 putative hydrophobin-encoding genes have been predicted in the agaricomycete Pleurotus ostreatus..

OncologyImmune supportGut & microbiome

Almond Mushroom · 2025 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

The Age-Dependent Anticancer Efficacy of Agaricus blazei Murill Polysaccharide in Colon Cancer.

Agaricus blazei Murill polysaccharide (ABMP) has been found to exhibit significant immune regulatory effects, making them a promising candidate for complementary to the pharmacological treatment of colorectal cancer immune-related diseases..

Reishi · 2025 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

The GCN4-Swi6B module mediates low nitrogen-induced cell wall remodeling in Ganoderma lucidum.

UNLABELLED: In natural habitats, microorganisms encounter various unfavorable environmental stresses, including nitrogen deficiency. As the outermost barrier, the cell wall plays a crucial role in the interaction between the cell and the external environment..

Immune supportMetabolic healthGut & microbiome

Yellow Morel · 2024 · Comparative Study · International journal of biological macromolecules

Comparative study on physicochemical properties and hypoglycemic activities of intracellular and extracellular polysaccharides from submerged fermentation of Morchella esculenta.

The structural characteristic, physicochemical properties and structure-hypoglycemic activity relationship of intracellular (IPS) and extracellular (EPS) from submerged fermentation of Morchella esculenta were systematically compared and assessed..

Immune supportMetabolic healthGut & microbiome

Maitake · 2024 · Published Erratum · Food & function

Correction: Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats.

Correction for 'Grifola frondosa polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats' by Lu Li et al., Food Funct., 2019, 10, 2560-2572, https://doi.org/10.1039/C9FO00075E..

Immune supportLiver support

Oyster Mushroom · 2024 · Research Support, Non U.S. Gov'T · Journal of the American Nutrition Association

Effect of Pleurotus ostreatus Water Extract Consumption on Blood Parameters and Cytokine Values in Healthy Volunteers.

OBJECTIVE: Our aim in this study is, does 29-day regular consumption of Pleurotus ostreatus water extract by volunteer individuals who meet the study criteria have an effect on blood and cytokine values?.

OncologyImmune supportCognition & nerves

Chaga · 2024 · Research Support, Non U.S. Gov'T · Communications biology

Fungal polysaccharides from Inonotus obliquus are agonists for Toll-like receptors and induce macrophage anti-cancer activity.

Fungal polysaccharides can exert immunomodulating activity by triggering pattern recognition receptors (PRRs) on innate immune cells such as macrophages. Here, we evaluate six polysaccharides isolated from the medicinal fungus Inonotus obliquus for their ability to activate mouse and human macrophages..

OncologyImmune supportMetabolic healthRespiratory

Reishi · 2024 · Research Support, Non U.S. Gov'T · Journal of the Chinese Medical Association: JCMA

Ganoderma lucidum spore oil synergistically enhances the function of cyclophosphamide in the prevention of breast cancer metastasis.

BACKGROUND: Ganoderma lucidum ( G. lucidum ) is a traditional Chinese herbal medicine that has shown potential as an alternative adjuvant therapy for cancer patients.

Reishi · 2024 · Research Support, Non U.S. Gov'T · Communications biology

GlPRMT5 inhibits GlPP2C1 via symmetric dimethylation and regulates the biosynthesis of secondary metabolites in Ganoderma lucidum.

PRMT5, a type II arginine methyltransferase, is involved in transcriptional regulation, RNA processing and other biological processes and signal transduction. Secondary metabolites are vital pharmacological compounds in Ganoderma lucidum, and their content is an important indicator for evaluating the quality of G..

Maitake · 2024 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Grifola frondosa polysaccharide's therapeutic potential in oxazolone-induced ulcerative colitis.

Grifola frondosa polysaccharide (GFP) is a consumable fungus recognized for its potential health advantages. The present study aimed to investigate the development and potential etiologies of ulcerative colitis (UC) utilizing oxazolone (OXZ) as an inducer in mice, along with assessing the therapeutic effects of GFP at….

OncologyImmune supportCognition & nerves

Reishi · 2024 · Research Support, Non U.S. Gov'T · Bioscience reports

Screening of active components of Ganoderma lucidum and decipher its molecular mechanism to improve learning and memory disorders.

Learning and memory impairment (LMI), a common degenerative central nervous system disease. Recently, more and more studies have shown that Ganoderma lucidum (GL) can improve the symptoms of LMI..

OncologyImmune supportLiver supportRespiratory

Reishi · 2024 · Research Support, Non U.S. Gov'T · Journal of cellular and molecular medicine

Sporoderm-broken spores of Ganoderma lucidum modulate hepatoblastoma malignancy by regulating RACK1-mediated autophagy and tumour immunity.

Hepatoblastoma (HB), a primary liver tumour, is notorious for its high metastatic potential and poor prognosis. Ganoderma lucidum, an edible mushroom species utilized in traditional Chinese medicine for addressing various tumour types, presents an intriguing avenue for HB treatment.

OncologyImmune supportSkin & hydration

Niu-Chang-Chih · 2024 · Research Support, Non U.S. Gov'T · Cell communication and signaling: CCS

The in vitro and in vivo depigmentation activity of coenzyme Q0, a major quinone derivative from Antrodia camphorata, through autophagy induction in human melanocytes and keratinocytes.

BACKGROUND: Coenzyme Q0 (CoQ0), a novel quinone derivative of Antrodia camphorata, has been utilized as a therapeutic agent (including antioxidant, anti-inflammatory, antiangiogenic, antiatherosclerotic, and anticancer agents); however, its depigmenting efficiency has yet to be studied..

OncologyImmune supportRespiratory

Snow Fungus · 2024 · Research Support, Non U.S. Gov'T · Aging

Tremella fuciformis polysaccharides induce ferroptosis in Epstein-Barr virus-associated gastric cancer by inactivating NRF2/HO-1 signaling.

Approximately 10% of gastric cancers are associated with Epstein-Barr virus (EBV). Tremella fuciformis polysaccharides (TFPs) are characterized by antioxidative and anti-inflammatory effects in different diseases.

OncologyImmune supportMetabolic healthLiver support

Snow Fungus · 2024 · Research Support, Non U.S. Gov'T · Mycologia

Triple quadrupole liquid chromatography-mass spectrometry-mediated evaluation of vitamin D2 accumulation potential, antioxidant capacities, and total polyphenol content of white jelly mushroom (Tremella fuciformis Berk.).

Tremella fuciformis Berk. (TF), or the white jelly mushroom, is well known for its myriad of pharmacological properties, such as immunomodulatory, anti-inflammatory, antidiabetic, antitumor, and antioxidant activities, and hypocholesterolemic and hepatoprotective effects that boost human health..

Snow Fungus · 2023 · Journal Article · International journal of biological macromolecules

A chromosome-scale genome and proteome draft of Tremella fuciformis.

In this study, we first reported a high-quality chromosome-scale genome of Tremella fuciformis using Pacbio HiFi sequencing combining Hi-C technology. According to 21.6 Gb PacBio HiFi reads and 18.1 Gb Hi-C valid reads, we drafted a T..

OncologyImmune supportGut & microbiomeLiver support

Maitake · 2023 · Journal Article · International journal of biological macromolecules

A cold-water extracted polysaccharide-protein complex from Grifola frondosa exhibited anti-tumor activity via TLR4-NF-κB signaling activation and gut microbiota modification in H22 tumor-bearing mice.

Grifola frondosa polysaccharide-protein complex (G. frondosa PPC) is a polymer which consists of polysaccharides and proteins/peptides linked by covalent bonds.

Shiitake · 2023 · Preprint · journal metadata

A novel method for detecting conformation-dependent β-glucans - Single, double, and triple-helical from Shiitake mushroom

This pioneering study explores the structural intricacies of therapeutic β-glucan in Shiitake ( Lentinula edodes ), i.e. Lentinan (LNT).

Immune supportRespiratory

Reishi · 2023 · Research Article · Journal of biomedical science

A novel mucosal bivalent vaccine of EV-A71/EV-D68 adjuvanted with polysaccharides from Ganoderma lucidum protects mice against EV-A71 and EV-D68 lethal challenge.

BACKGROUND: Human enteroviruses A71 (EV-A71) and D68 (EV-D68) are the suspected causative agents of hand-foot-and-mouth disease, aseptic meningitis, encephalitis, acute flaccid myelitis, and acute flaccid paralysis in children. Until now, no cure nor mucosal vaccine existed for EV-A71 and EV-D68..

Maitake · 2023 · Journal Article · International journal of biological macromolecules

A Se-enriched Grifola frondosa polysaccharide induces macrophage activation by TLR4-mediated MAPK signaling pathway.

Se-polysaccharide (Se-GFP-22) from Se-enriched Grifola frondosa has double and cooperative activities of polysaccharide and Se. To delineate the underlying mechanism and signaling cascade involved in immune-stimulatory property of Se-GFP-22, the production of cellular mediators and key proteins in signaling pathway….

OncologyImmune support

OncologyImmune supportEnergy & fatigue

Shiitake · 2023 · Journal Article · Anticancer research

A Standardized Extract of Cultured Lentinula edodes mycelia Up-regulates COX-2 in Inflammation-related Malignant Progressive Fibrosarcoma Cell Clone QRsP-11.

BACKGROUND/AIM: Cyclooxygenase is an enzyme that transforms arachidonic acid to prostaglandins. Cyclooxygenase-2 (COX-2) is an isoform of cyclooxygenase.

Immune supportMetabolic healthGut & microbiome

Shiitake · 2023 · Research Article · Veterinary sciences

A Supplement with Bromelain, Lentinula edodes, and Quercetin: Antioxidant Capacity and Effects on Morphofunctional and Fecal Parameters (Calprotectin, Cortisol, and Intestinal Fermentation Products) in Kennel Dogs.

Oxidative stress causes several pathological conditions in humans and animals, including gastrointestinal disorders. The aim of this study was to analyze the antioxidant capacity of three natural powdered raw materials containing quercetin, bromelain, and Lentinula edodes and develop a new feed supplement for dogs….

Immune supportMetabolic health

Shiitake · 2023 · Journal Article · International journal of biological macromolecules

Active polysaccharides from Lentinula edodes and Pleurotus ostreatus by addition of corn straw and xylosma sawdust through solid-state fermentation.

In this study, Lentinula edodes and Pleurotus ostreatus were selected as representatives to explore the effects of corn straw and xylosma sawdust on the production and activity of polysaccharides by edible fungi during solid-state fermentation..

Immune supportSkin & hydration

Almond Mushroom · 2023 · Journal Article · International journal of biological macromolecules

Agaricus blazei Murill polysaccharides/alginate/poly(vinyl alcohol) blend as dressings for wound healing.

Macromolecules with antioxidant properties such as polysaccharides from Agaricus blazei Murill mushroom (PAbs) are an excellent option for manufacturing wound dressings..

Reishi · 2023 · Journal Article · International journal of biological macromolecules

Anti-inflammatory and intestinal microbiota modulation properties of Ganoderma lucidum β-d-glucans with different molecular weight in an ulcerative colitis model.

This study systematically investigated the therapeutic effects and the corresponding mechanisms of β-D-glucans from Ganoderma lucidum (G. lucidum) with different molecular weights (Mws) on ulcerative colitis (UC).

Lion's Mane · 2023 · Research Article · Polymers

Antioxidant Activities and Prebiotic Activities of Water-Soluble, Alkali-Soluble Polysaccharides Extracted from the Fruiting Bodies of the Fungus Hericium erinaceus.

In this study, the digestion and fermentation properties of the bioactive water-soluble polysaccharide (HEP-W), and alkali-soluble polysaccharide (HEP-A) from Hericium erinaceus and the impact on the human colonic microbiota were determined using simulated saliva-gastrointestinal digestion and human fecal fermentation….

OncologyImmune supportMetabolic health

Maitake · 2023 · Research Article · International journal of food science

Antioxidant and Immunomodulatory Activities of Polysaccharides from Fermented Wheat Products of Grifola frondosa: In Vitro Methods.

Despite the well-known health benefits of Grifola frondosa, there is a lack of understanding regarding the potential antioxidant and immunomodulatory properties of different varieties when fermented with wheat grains. We aimed to explore the potential of G.

Immune supportGut & microbiomeLiver support

Yellow Morel · 2023 · Research Article · Foods (Basel, Switzerland)

Antioxidative and Protective Effect of Morchella esculenta against Dextran Sulfate Sodium-Induced Alterations in Liver.

Morchella esculenta is an edible mushroom with special flavor and high nutritional value for humans, primarily owing to its polysaccharide constituents. M.

Reishi · 2023 · Research Article · Veterinary world

Antiprotozoal activity of Boesenbergia rotunda (L.) Mansf and Ganoderma lucidum (Fr.) Kart extracts against Blastocystis hominis.

BACKGROUND AND AIM: Blastocystis hominis is an intestinal protozoan in humans and animals. The parasite causes mild-to-severe intestinal complications, such as diarrhea, in healthy humans and immunocompromised hosts..

Immune supportMetabolic healthGut & microbiomeLiver support

Wood Ear · 2023 · Journal Article · International journal of biological macromolecules

Auricularia auricula-judae (Bull.) polysaccharides improve obesity in mice by regulating gut microbiota and TLR4/JNK signaling pathway.

Obesity has emerged as a crucial factor impacting people's lives, and gut microbiota disorders contribute to its development and progression. Auricularia auricula-judae (Bull.) polysaccharides (AAPs), a traditional functional food in Asia, exhibit potential anti-obesity effects..

OncologyImmune supportRespiratory

Cordyceps · 2023 · Journal Article · Journal of ethnopharmacology

Bioinformatics analysis and in vivo validation study of Ophiocordyceps sinensis (Berk.)G.H.Sungetal against lung adenocarcinoma.

ETHNOPHARMACOLOGICAL RELEVANCE: Lung adenocarcinoma (LUAD) is one of the main types of lung cancer. Ophiocordyceps sinensis has many potentially useful pharmacologic features, such as lung protection, and both anti-inflammatory and antioxidant activities..