MycoData

Mesima · 2006 · Comparative Study · British journal of cancer

Phellinus linteus sensitises apoptosis induced by doxorubicin in prostate cancer.

It has been demonstrated that the Phellinus linteus (PL) mushroom, which mainly consists of polysaccharides, possesses antitumour activity. The mechanisms of PL against malignant growth remain unknown.

Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Effect and mechanism of Ganoderma leucocontextum extract on cadmium-toxic nephropathy.

ETHNOPHARMACOLOGICAL RELEVANCE: Cadmium (Cd) can first damage the kidney, leading to renal tubular dysfunction and irreversible renal damage. Ganoderma lucidum is a traditional Chinese herb that can enhances kidney qi and is extensively used in the management of renal diseases..

OncologyImmune supportCognition & nervesEnergy & fatigue

Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Lucidenic acid A drives PI3K/AKT/BDNF signaling to improve memory impairment in mice and alleviate cellular nerve damage.

ETHNOPHARMACOLOGICAL RELEVANCE: Enhancing memory and alleviating amnesia are among the conditions that Ganoderma lucidum has historically been used to treat. However, there are relatively few studies on the potential therapeutic effects of active ingredients derived from Ganoderma lucidum in the treatment of memory….

OncologyImmune supportCognition & nervesGut & microbiome

Lion's Mane · 2026 · Journal Article · Computational biology and chemistry

Modulation of ABCB1 by Erinacerin S: Binding dynamics and transmembrane helix remodeling.

Erinacerins are a group of bioactive heterocyclic organic compounds known as Isoindolin-1-one metabolites with the molecular formula C8H9N, derived from the mycelia or fruiting bodies of the mushroom Hericium erinaceus. They are known for their neuroprotective, anti-inflammatory, and anticancer properties..

Maitake · 2022 · Brief Report · BMC research notes

CD3Ɛ immune restorative ability induced by Maitake Pro4x in immunosupressed BALBc mice.

OBJECTIVES: The aim of this research was to determine if the rich beta glucan compound called Maitake Pro4X can recover the T cell/NK population depleted by Dexamethasone treatment in lymph nodes from cancer-free BALBc female mice..

Almond Mushroom · 2022 · Clinical Trial · American journal of clinical oncology

Hematologic Toxicity Comparison of Intensity Modulated Proton Therapy and Intensity Modulated Radiation Therapy in Anal Cancer Patients.

PURPOSE: We hypothesize that hematologic toxicity will be lower in anal cancer patients treated definitively with intensity modulated proton therapy (IMPT) compared with patients treated with intensity modulated radiation therapy (IMRT)..

Shiitake · 2021 · Other · Nutrients

Combining the Anticancer and Immunomodulatory Effects of Astragalus and Shiitake as an Integrated Therapeutic Approach.

Astragalus root (Huang Qi) and Shiitake mushrooms (Lentinus edodes) are both considered medicinal foods and are frequently used in traditional Chinese medicine due to their anticancer and immunomodulating properties..

Wood Ear · 2017 · Journal Article · Roczniki Panstwowego Zakladu Higieny

Quantitative evaluation of 1,3,1,6 β-D-glucan contents in wild-growing species of edible Polish mushrooms.

BACKGROUND: Macrofungal β-glucans are mainly represented by compounds with β-1,3- and β-1,6 glycosidic bonds. They have been shown to have immunomodulatory, anticancer, and antioxidant properties..

OncologyImmune supportMetabolic healthSkin & hydration

Turkey Tail · 2010 · Patent · journal metadata

Strain Of Turkey Tail Mushroom, Extract From The Same, And Use Of The Same

The present invention provides a new strain of turkey tail mushroom (Trametes versicolor (L.: Fr.) Pilat) having excellent biological activities (Accession number: FERM BP-10633)..

OncologyImmune supportMetabolic healthSkin & hydration

Turkey Tail · 2008 · Patent · journal metadata

STRAIN OF TURKEY TAIL MUSHROOM, EXTRACT FROM THE SAME, AND USE OF THE SAME

The present invention provides a new strain of turkey tail mushroom (Trametes versicolor (L.:Fr.)Pilat) having excellent biological activities (Accession number: FERM BP-10633)..

OncologyImmune supportCognition & nervesEnergy & fatigue

Cordyceps · 2026 · Review · Die Naturwissenschaften

Research advances on Cordyceps sinensis and its components in relation to omics biomarkers for the neurological disorders.

Cordyceps is a traditional medicinal fungus belonging to the species Ophiocordyceps sinensis. It grows in the alpine ecological zone of the Tibetan Plateau and exhibits dual characteristics of both insects and fungi.

Oyster Mushroom · 2025 · Review · Heliyon

A comprehensive review on multifunctional bioactive properties of elm oyster mushroom Hypsizygus ulmarius (Bull.) Redhead (Agaricomycetes): Current research, challenges and future trends.

Mushrooms have evolved as a nutritional powerhouse, harnessing a diverse spectrum of bioactive molecules to fortify human health. Hypsizygus ulmarius represents a pioneering species within the oyster mushrooms distinguished by its unique characteristics and potential abilities..

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2025 · Systematic Review · Carbohydrate research

Structural basis of immunomodulation by edible fungal polysaccharides: From molecular characteristics to action mechanisms.

Edible Fungal polysaccharides as Immunomodulators: A Systematic Review at the Crossroads of Immunology, Natural Products Chemistry, and Microbiology. The chemical structure-specifically molecular weight, branching degree, and functional group modifications-directly dictates immunological activity..

Cordyceps · 2024 · Review · Frontiers in pharmacology

Use of bailing capsules (cordyceps sinensis) in the treatment of chronic kidney disease: a meta-analysis and network pharmacology.

The Bailing Capsule is a commonly used traditional Chinese medicine for the treatment of chronic kidney disease (CKD). However, its therapeutic effects and pharmacological mechanisms have not been fully explored..

OncologyImmune supportGut & microbiome

King Oyster · 2022 · Journal Article · International journal of biological macromolecules

A fungal cellulose nanocrystals-based approach to improve the stability of triterpenes loaded Pickering emulsion.

Depolysaccharide residues of edible fungus Pleurotus eryngii (dePSR-Pe), a mushroom industry waste, have abundant cellulose. In this study, the cellulose nanocrystals of P.

King Oyster · 2022 · Journal Article · Natural product research

Cell death induction by mycelium extracts from Pleurotus spp. on cervical cancer cell lines.

Mushrooms have health benefits, including anti-tumoral properties. We evaluated the cytotoxic and cell death induction effects of water-soluble extracts of Pleurotus ostreatus and Pleurotus eryngii mycelium in the cervical cancer cell lines HeLa (HVP18+) and SiHa (HVP16+) as well as the non-tumoral cell line HaCaT..

Cordyceps · 2021 · Research Article · Molecules (Basel, Switzerland)

Cordycepin Sensitizes Cholangiocarcinoma Cells to Be Killed by Natural Killer-92 (NK-92) Cells.

Immunotherapy harnessing immune functions is a promising strategy for cancer treatment. Tumor sensitization is one approach to enhance tumor cell susceptibility to immune cell cytotoxicity that can be used in combination with immunotherapy to achieve therapeutic efficiency..

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2020 · Journal Article · Biological and Pharmaceutical Bulletin

Amelioration of the Lipogenesis, Oxidative Stress and Apoptosis of Hepatocytes by a Novel Proteoglycan from Ganoderma lucidum

The steatosis and resultant oxidative stress and apoptosis play the important roles in the progression of nonalcoholic fatty liver disease (NAFLD), therefore, searching for the effective drugs against NAFLD has been a hot topic..

Shiitake · 2020 · Journal Article · Japanese Journal of Complementary and Alternative Medicine

Combination Treatment with in Situ Tumor Vaccination Therapy and Nutritional Intervention Utilizing Lentinula Edodes Mycelia Extract for Patient with Lingual Cancer: A Case Report

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Japanese Journal of Complementary and Alternative Medicine in 2020. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Turkey Tail · 2020 · Journal Article · Food Science and Technology Research

Fermentation Production, Purification and Characterization of a Fungal α-galactosidase from Trametes versicolor and Its Synergistic Degradation of Guar Gum with Mannanase

Metadata-grounded summary: This journal article indexes research on Trametes versicolor in Food Science and Technology Research in 2020. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

Maitake · 2020 · Journal Article · International journal of biological macromolecules

The structural characteristics of an acid-soluble polysaccharide from Grifola frondosa and its antitumor effects on H22-bearing mice.

The edible mushroom G. frondosa has been used as a kind of functional food for the prevention and therapy of various diseases in Asian countries.

Maitake · 2019 · Journal Article · International journal of biological macromolecules

Effect of Grifola frondosa polysaccharide on anti-tumor activity in combination with 5-Fu in Heps-bearing mice.

GP11 had been reported to have effectively anti-tumor activity by improving the immune function in our previous study. To avoid drawbacks of the 5-Fu, GP11 in combination with 5-Fu was investigated in this study.

OncologyImmune supportEnergy & fatigue

Shiitake · 2019 · Journal Article · Carbohydrate polymers

Selenium-containing polysaccharides from Lentinula edodes-Biological activity.

We hypothesized that selenium(Se)-enriched polysaccharides would possess superior biological activity when compared to those non-enriched. To verify this hypothesis, we obtained by biotechnological methods a Se-enriched analog of Japanese anticancer drug lentinan and, as a reference, the non-Se-enriched fraction..

Enoki · 2018 · Journal Article · International journal of biological macromolecules

Effects of polysaccharides from the base of Flammulina Velutipes stipe on growth of murine RAW264.7, B16F10 and L929 cells.

A polysaccharide (FVSP) was isolated from the base of Flammuliana Velutipes stipe, and FVSP was further purified by DEAE-cellulose-52 chromatography and Sephadex G-100 size-exclusion chromatography to obtain three fractions named FVSP-1, FVSP-2 and FVSP-3..

Turkey Tail · 2018 · Journal Article · The Japanese Forest Society Congress

Litter quality control of decomposition of leaves, twigs, and sapwood by the white-rot fungus Trametes versicolor

Metadata-grounded summary: This journal article indexes research on Trametes versicolor in The Japanese Forest Society Congress in 2018. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

Turkey Tail · 2018 · Journal Article · Journal of Water and Environment Technology

Membrane Type Wastewater Decolorization Using Culture Supernatant of Trametes versicolor

Metadata-grounded summary: This journal article indexes research on Trametes versicolor in Journal of Water and Environment Technology in 2018. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

OncologyImmune supportLiver support

Maitake · 2018 · Journal Article · International journal of biological macromolecules

The synergism and attenuation effect of Selenium (Se)-enriched Grifola frondosa (Se)-polysaccharide on 5-Fluorouracil (5-Fu) in Heps-bearing mice.

Previous study revealed that Se-GP11 could exhibited its antitumor activity by improving the immune functions. 5-Fu, as a chemotherapeutic drugs, can kill many immune cells in addition to tumor cells.

Shiitake · 2017 · Journal Article · Gan to kagaku ryoho. Cancer & chemotherapy

[Survival Benefit by Combined Administration of Cyclophosphamide, Lentinula edodes Mycelia Extract(LEM), and Ganoderma lucidum Mycelia Extract(MAK)in S1018B10 Tumor-Bearing Mice].

Cyclophosphamide(CY)was intraperitoneally administered once a week to C57BL/10mice that had received Rous sarcoma virus(RSV)-induced S1018B10 syngeneic tumor transplantation and in whom tumor diameter exceeded 4.5 mm. Survival was prolonged in a group of mice that also received a mixture of LEM and MAK orally..

OncologyRespiratory

Shiitake · 2017 · Journal Article · Japanese Journal of Complementary and Alternative Medicine

Evaluation of Quality of Life among Patients with Various Types of Cancer Treated with Oral Lentinula Edodes Mycelia Extract

Metadata-grounded summary: This journal article indexes research on Lentinula edodes in Japanese Journal of Complementary and Alternative Medicine in 2017. MycoData maps the paper to oncology based on its title, species context, article metadata, and study classification..

Lion's Mane · 2017 · Journal Article · Food Science and Technology Research

Optimization of Enzyme-assisted Extraction of Antitumor Polysaccharides from Hericium erinaceus mycelia

Metadata-grounded summary: This journal article indexes research on Hericium erinaceus in Food Science and Technology Research in 2017. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

OncologyGut & microbiomeSkin & hydrationRespiratory

Mesima · 2017 · Research Article · International journal of molecular sciences

Phellinus linteus Grown on Germinated Brown Rice Increases Cetuximab Sensitivity of KRAS-Mutated Colon Cancer.

Colon cancer is one of the most common types of cancer, and it has recently become a leading cause of death worldwide. Among colon cancers, the v-ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS)-mutated form is notorious for its non-druggable features..

OncologyImmune supportMetabolic healthLiver support

Reishi · 2016 · Journal Article · Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan

Gene mutations in Ganoderma lucidum during continuous subculturing

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in Abstracts of Papers Presented at the Meeting of the Mycological Society of Japan in 2016. MycoData maps the paper to oncology, immune support, metabolic health, liver support based on its title, species context, article metadata, and study classification..

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2016 · Research Article · Immunity & ageing: I & A

Redox modulation of cellular stress response and lipoxin A4 expression by Hericium Erinaceus in rat brain: relevance to Alzheimer's disease pathogenesis.

BACKGROUND: There has been a recent upsurge of interest in complementary medicine, especially dietary supplements and foods functional in delaying the onset of age-associated neurodegenerative diseases..

OncologyImmune supportEnergy & fatigueGut & microbiome

Turkey Tail · 2022 · Research Support, Non U.S. Gov'T · The Cochrane database of systematic reviews

Coriolus (Trametes) versicolor mushroom to reduce adverse effects from chemotherapy or radiotherapy in people with colorectal cancer.

BACKGROUND: Radiotherapy and chemotherapy are used to improve survival in colorectal cancer but adverse effects can be a problem. Severe adverse effects may result in dose reduction or cessation of treatment, which have an impact on survival..

OncologyImmune supportMetabolic healthSkin & hydration

Nameko · 2020 · Research Article · Antioxidants (Basel, Switzerland)

Pholiota nameko Polysaccharides Promotes Cell Proliferation and Migration and Reduces ROS Content in H2O2-Induced L929 Cells.

Pholiota nameko, a type of edible and medicinal fungus, is currently grown extensively for food and traditional medicine in China and Japan. It possesses various biological activities, such as anti-inflammatory, anti-hyperlipidemia and antitumor activities.

Shiitake · 2018 · Journal Article · International journal of medicinal mushrooms

Antimicrobial, Cytotoxic, Anti-Inflammatory, and Antioxidant Activity of Culinary Processed Shiitake Medicinal Mushroom (Lentinus edodes, Agaricomycetes) and Its Major Sulfur Sensory-Active Compound-Lenthionine.

The antimicrobial, cytotoxic, anti-inflammatory, and antioxidant properties of aqueous extracts of raw and culinary processed shiitake mushrooms were evaluated and compared with those of lenthionine (1,2,3,5,6-penta-thiepane), the principal aroma-bearing substance of the shiitake medicinal mushroom (Lentinus edodes)..

OncologyImmune supportRespiratory

Shiitake · 2018 · Journal Article · International journal of medicinal mushrooms

Cross-Flow Ultrafiltration Fractions of a Cold Aqueous Extract of the Shiitake Culinary-Medicinal Mushroom, Lentinus edodes (Agaricomycetes), Exhibit Apoptosis in Tumor Cells.

Lentinus edodes (shiitake) ranks among the most well-known medicinal mushrooms worldwide. Immune-modulating effects of shiitake extracts have been widely demonstrated in animals and humans.

Shiitake · 2017 · Journal Article · Yonago acta medica

Shiitake Dermatitis-like Eruption Due to Tegafur/Gimeracil/Oteracil Combination Usage.

S-1 is a combination drug of tegafur, gimeracil and oteracil potassium that is designed on the basis of 5- fluorouracil. We report here for the first time that S-1 is a causative agent of drug eruption mimicking shiitake dermatitis..

OncologySkin & hydration

Shiitake · 2016 · Journal Article · Carbohydrate polymers

Antimicrobial and antitumor activities of chitosan from shiitake stipes, compared to commercial chitosan from crab shells.

Chitosan was prepared by alkaline N-deacetylation of chitin obtained from shiitake stipes and crab shells and its antimicrobial and antitumor activities were studied..

Nameko · 2016 · Journal Article · Journal of the science of food and agriculture

Purification and characterization of a ∼43 kDa antioxidant protein with antitumor activity from Pholiota nameko

BACKGROUND: Pholiota nameko water‐soluble protein (PNWSP), isolated from the dried fruiting bodies of Pholiota nameko, was purified by a successive chromatographic process using Q anion exchange column, SP cation exchange column and Superdex 200 gel filtration column..

OncologyEnergy & fatigue

Niu-Chang-Chih · 2005 · Patent · journal metadata

A method for producing biological active material with antrodia camphorata and composition thereof

The invention relates to producing biologically active material by cultivating Antrodia camphorata with liquid fermentation culture. This material can enhance immune activity, anti-tumor and anti-parasite.

OncologyImmune supportEnergy & fatigue

Niu-Chang-Chih · 2005 · Research Support, Non U.S. Gov'T · International immunopharmacology

Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway.

Antrodia camphorata (A. camphorata), well known in Taiwan as a traditional Chinese medicine, has been shown to exhibit antioxidant and anticancer effects.

OncologyImmune supportCognition & nervesLiver support

Niu-Chang-Chih · 2005 · Research Support, Non U.S. Gov'T · FEMS microbiology letters

Antrodia camphorata prevents rat pheochromocytoma cells from serum deprivation-induced apoptosis.

Antrodia camphorata (A. camphorata) is a rare medicinal fungus with antioxidative, vasorelaxtative, anti-inflammatory and anti-hepatitive effects.

OncologyImmune supportEnergy & fatigueLiver support

Niu-Chang-Chih · 2005 · Research Support, Non U.S. Gov'T · Cancer letters

Apoptotic effects of extract from Antrodia camphorata fruiting bodies in human hepatocellular carcinoma cell lines.

The fruiting body of Antrodia camphorata is well known in Taiwan as a traditional medicine for treating cancer and inflammation. The purpose of this study was to evaluate the apoptotic effects of ethylacetate extract from A.

OncologyImmune supportMetabolic health

Niu-Chang-Chih · 2005 · Comparative Study · Journal of agricultural and food chemistry

Characterization and functional study of Antrodia camphorata lipopolysaccharide.

Lipopolysaccharide (LPS) is a highly proinflammatory molecule isolated from bacteria. This study demonstrated the existence of LPS in a medicinal fungus, Antrodia camphorata.

Chaga · 2005 · Research Support, Non U.S. Gov'T · Life sciences

Immuno-stimulating effect of the endo-polysaccharide produced by submerged culture of Inonotus obliquus.

Inonotus obliquus BELYU1102 was selected from 12 different strains of Inonotus as a producer of immuno-stimulating polysaccharide. After a batch fermentation of I.

Niu-Chang-Chih · 2005 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Induction of apoptosis in human hepatoma cells by mycelia of Antrodia camphorata in submerged culture.

The effect of methanolic extracts of mycelia (MEM) from Antrodia camphorata (Polyporaceac, Aphyllophorales) of submerged culture (ACSC) on the inhibition of cell viability and the mechanism of MEM-induced cytotoxic in hepatoma cells were investigated..

OncologyLiver support

Niu-Chang-Chih · 2005 · Patent · journal metadata

Protein ACA1 of antrodia camphorata

A new protein, named ACA1, has been isolated and purified from the medical fungi Antrodia camphorata using the technique of anion-exchange chromatography. ACA1, a glycoprotein with a molecular mass of 29 kDa, has a pI value of pH 5.3 and contains 118 amino acids in its peptide moiety..