MycoData

Cordyceps · 2023 · Journal Article · Biotechnology and applied biochemistry

Isolation and structural characterization of exopolysaccharide from the Cordyceps cicadae and the immunomodulatory activity on RAW264.7 cells.

A new exopolysaccharide component named as PC-EPS was isolated from Cordyceps cicadae, and its structure was determined. PC-EPS was identified to be constituted of mannose, glucose, and galactose (28.84:1:19.42), with an average molecular weight of 3.72 × 106 Da, according to the results of monosaccharide composition,….

Cordyceps · 2023 · Journal Article · BMC complementary medicine and therapies

Protective effect of Cordyceps sinensis against diabetic kidney disease through promoting proliferation and inhibiting apoptosis of renal proximal tubular cells.

BACKGROUND: Diabetic kidney disease (DKD) has mainly been considered as a glomerular disease. Our previous study showed that the progression of DKD was highly correlated with the dysfunction of renal proximal tubular cells..

OncologyMetabolic health

Cognition & nervesMetabolic health

Wood Ear · 2023 · Research Article · BioMed research international

The Polyherbal Functional Ingredient Containing Ginger, Chinese Date, and Wood Ear Mushroom Protects against Dementia following Metabolic Syndrome.

The anti-dementia effect following ischemic stroke with metabolic syndrome (MetS) of the polyherbal functional ingredient comprising ginger, Chinese date, and wood ear mushroom (GCJ) was hypothesized due to its neuroprotective effect against stroke..

Immune supportMetabolic healthRespiratory

Cordyceps · 2022 · Journal Article · Frontiers in pharmacology

Bailing capsule (Cordyceps sinensis) ameliorates renal triglyceride accumulation through the PPARα pathway in diabetic rats.

Diabetic nephropathy (DN) is a severe diabetic complication of the kidney and is the main cause of end-stage kidney disease worldwide. Cordyceps sinensis (C.

Energy & fatigueMetabolic health

Reishi · 2022 · Journal Article · G3 (Bethesda, Md.)

Comparative transcriptome analysis of genes and metabolic pathways involved in sporulation in Ganoderma lingzhi.

Over the past decades, Ganoderma lingzhi spores have received considerable attention as a great potential pharmaceutical resource. However, the genetic regulation of sporulation is not well understood..

Oyster Mushroom · 2022 · Research Article · 3 Biotech

Conversion of golden oyster mushroom, Pleurotus citrinopileatus to sugar syrup using enzymatic hydrolysis as a substrate for novel bacterial cellulose (Nata) fermentation.

Enzymatic hydrolysis of the golden oyster mushroom (Pleurotus citrinopileatus) generated a new bacterial cellulose (BC). The sugar syrup obtained from the hydrolysis of mushroom powder by commercial enzymes gave maximum total soluble solids (TSS) content at 8.83 ± 0.29°Brix, while 8.82 ± 0.06 mg GAE/g substrate of….

Metabolic healthGut & microbiomeLiver support

Cordyceps · 2022 · Research Article · Frontiers in nutrition

Cordyceps guangdongensis lipid-lowering formula alleviates fat and lipid accumulation by modulating gut microbiota and short-chain fatty acids in high-fat diet mice.

Obesity has caused serious health and economic problems in the world. Cordyceps guangdongensis is a high-value macrofungus with broad application potential in the food and bio-medicine industry.

Energy & fatigueMetabolic healthSkin & hydration

Cordyceps · 2022 · Journal Article · RSC advances

Cordyceps sinensis-mediated biotransformation of notoginsenoside R1 into 25-OH-20(S/R)-R2 with elevated cardioprotective effect against DOX-induced cell injury.

Notoginsenoside R1 is a dammarane saponin in Panax notoginseng with promising cardioprotective effects. The bioactivity-structure relationship of such saponins suggested that the presence of a hydroxyl group at C25 could elevate its performance..

Energy & fatigueMetabolic health

Oyster Mushroom · 2022 · Research Article · Frontiers in nutrition

Evaluation of Volatile Profile and In Vitro Antioxidant Activity of Fermented Green Tea Infusion With Pleurotus sajor-caju (Oyster Mushroom).

Green tea has distinct astringency, bitter taste, and typical green flavor because of its post-harvest treatment without withering and enzymatic oxidation. Microbial fermentation has been identified as a promising strategy that could give green tea infusion a special taste flavor..

Cordyceps · 2022 · Journal Article · Journal of fungi (Basel, Switzerland)

Integration of Untargeted Metabolomics with Transcriptomics Provides Insights into Beauvericin Biosynthesis in Cordyceps chanhua under H2O2-Induced Oxidative Stress.

Cordyceps chanhua is an important cordycipitoid mushroom widely used in Asia and beyond. Beauvericin (BEA), one of the bioactive compounds of C.

Cordyceps · 2022 · Research Article · Molecules (Basel, Switzerland)

Lowering the Intraocular Pressure in Rats and Rabbits by Cordyceps cicadae Extract and Its Active Compounds.

Cordyceps cicadae (CC), an entomogenous fungus that has been reported to have therapeutic glaucoma, is a major cause of blindness worldwide and is characterized by progressive retinal ganglion cell (RGC) death, mostly due to elevated intraocular pressure (IOP). Here, an ethanolic extract of C..

OncologyMetabolic health

Immune supportCognition & nervesMetabolic health

Wood Ear · 2022 · Research Article · BioMed research international

Neuroprotective Effect of Polyherbal Recipe Containing Ginger, Chinese Date, and Wood Ear Mushroom against Ischemic Stroke with Metabolic Syndrome Condition via Epigenetic Modification of Inflammation and Oxidative Stress.

Currently, the prevalence of stroke with metabolic syndrome (MetS) is increasing and the current therapeutic efficiency is still limited. Therefore, the applications of herbal recipes have gained much attention..

Energy & fatigueMetabolic health

Cordyceps · 2022 · Research Article · Heliyon

Optimization of Cordyceps sinensis fermentation Marsdenia tenacissima process and the differences of metabolites before and after fermentation.

In this paper, we explored the interaction of factors which influenced the Cordyceps sinensis fermentation Marsdenia tenacissima (Roxb.) Wight et Arn, a Dai (a national minority of China) medicine, and the optimal fermentation conditions. The differences of C..

Cordyceps · 2022 · Research Article · Foods (Basel, Switzerland)

Polysaccharides from Spores of Cordyceps cicadae Protect against Cyclophosphamide-Induced Immunosuppression and Oxidative Stress in Mice.

This study investigated the purification, preliminary structure and in vivo immunomodulatory activities of polysaccharides from the spores of Cordyceps cicadae (CCSP)..

Chaga · 2022 · Research Article · Biochemistry (Moscow) Supplement. Series A, Membrane and cell biology

The Mechanisms of Lipid Vesicle Fusion Inhibition by Extracts of Chaga and Buckthorn Leaves.

The ability of extracts of grapefruit seeds (ESG), sea buckthorn leaves (ESBL), and chaga (EC) to inhibit membrane fusion was evaluated. It was found that ESBL and EC inhibited Ca2+-mediated fusion of phosphatidylglycerol-enriched lipid vesicles; the inhibition indexes were about 90 and 100%, respectively..

Immune supportMetabolic healthLiver support

Cordyceps · 2021 · Journal Article · Chemistry & biodiversity

Alleviation of Liver Dysfunction, Oxidative Stress, and Inflammation Underlines the Protective Effects of Polysaccharides from Cordyceps cicadae on High Sugar/High Fat Diet-Induced Metabolic Syndrome in Rats.

This study investigated the protective effects of two polysaccharides (CPA-1 and CPB-2) from Cordyceps cicadae against high fructose/high fat diet (HF/HFD) induced obesity and metabolic disorders in rats. Rats were either fed with normal diet or HF/HFD and treated with CPA-1 and CPB-2 (100 and 300 mg/kg) for 11 weeks..

OncologyImmune supportMetabolic healthRespiratory

Cordyceps · 2021 · Journal Article · Journal of biochemical and molecular toxicology

Cordyceps acid alleviates lung cancer in nude mice.

The aim of this study is to examine the effect of cordyceps acid (CA) on lung cancer in mice. A lung cancer animal model was established by inoculating lung cancer cells under the armpit of nude mice.

Immune supportEnergy & fatigueMetabolic healthSkin & hydration

Cordyceps · 2021 · Journal Article · Frontiers in pharmacology

Cordyceps cicadae Ameliorates Renal Hypertensive Injury and Fibrosis Through the Regulation of SIRT1-Mediated Autophagy.

Hypertensive renal injury is a complication of hypertension. Cordyceps cicadae (C.

Cordyceps · 2021 · Journal Article · Phytotherapy research: PTR

Cordyceps sinensis aqueous extract regulates the adaptive immunity of mice subjected to 60 Co γ irradiation.

Cordyceps sinensis (CS) is a traditional Chinese medicine that is known for treating various diseases, and particularly for exerting therapeutic effects in immune disorders. The adaptive immunoregulatory effects of CS aqueous extract (CSAE) on γ-irradiated mice have not been reported previously..

Cordyceps · 2021 · Journal Article · International journal of medical sciences

Intraocular pressure-lowering effect of Cordyceps cicadae mycelia extract in a glaucoma rat model.

Glaucoma is a leading cause of irreversible blindness worldwide. This study evaluates the reduction of intraocular pressure (IOP) induced by C.

Immune supportEnergy & fatigueMetabolic health

Cordyceps · 2021 · Journal Article · Frontiers in pharmacology

Supercritical Carbon Dioxide Extracts of Cordyceps sinensis: Chromatography-based Metabolite Profiling and Protective Efficacy Against Hypobaric Hypoxia.

The toxicity and disposal concerns of organic solvents used in conventional extraction purposes has entailed the need for greener alternatives. Among such techniques, supercritical fluid extraction (SFE) has gained popularity by yielding extracts of high purity in a much faster manner..

Immune supportEnergy & fatigueMetabolic healthLiver support

Oyster Mushroom · 2021 · Journal Article · Journal of proteomics

Tandem mass tag-based proteomics for studying the effects of a biotechnologically produced oyster mushroom against hepatic steatosis in obese Zucker rats.

Hepatic steatosis is a very common response to liver injury and often attributed to metabolic disorders. Prior studies have demonstrated the efficacy of a biotechnologically produced oyster mushroom (Pleurotus sajor-caju, PSC) in alleviating hepatic steatosis in obese Zucker rats..

Metabolic healthLiver support

Oyster Mushroom · 2021 · Journal Article · International journal of medicinal mushrooms

The Pink Oyster Mushroom, Pleurotus djamor (Agaricomycetes): A Potent Antioxidant and Hypoglycemic Agent.

The present investigation aimed to study the physicochemical properties, nutritional indices, antioxidant properties, and hypoglycemic effects of dried pink oyster mushroom (Pleurotus djamor) powder..

OncologyMetabolic healthGut & microbiome

Almond Mushroom · 2020 · Randomized Controlled Trial · International journal of radiation oncology, biology, physics

A Multi-atlas Approach for Active Bone Marrow Sparing Radiation Therapy: Implementation in the NRG-GY006 Trial.

PURPOSE: Sparing active bone marrow (ABM) can reduce acute hematologic toxicity in patients undergoing chemoradiotherapy for cervical cancer, but ABM segmentation based on positron emission tomography/computed tomography (PET/CT) is costly..

OncologyImmune supportCognition & nervesMetabolic health

Enoki · 2016 · Review · Frontiers in pharmacology

Golden Needle Mushroom: A Culinary Medicine with Evidenced-Based Biological Activities and Health Promoting Properties.

Flammulina velutipes (enoki, velvet shank, golden needle mushroom or winter mushroom), one of the main edible mushrooms on the market, has long been recognized for its nutritional value and delicious taste..

OncologyImmune supportMetabolic healthGut & microbiome

Maitake · 2009 · Journal Article · International immunopharmacology

Maitake beta-glucan enhances therapeutic effect and reduces myelosupression and nephrotoxicity of cisplatin in mice.

Cisplatin is broadly used clinically as an anticancer drug. Despite its significant anticancer activity, cisplatin-induced nephrotoxicity and myelosuppression limit its use..

Immune supportEnergy & fatigueMetabolic healthLiver support

King Oyster · 2026 · Journal Article · International journal of biological macromolecules

Antidiabetic effects of Agaricus bisporus polysaccharide in HFD/STZ-induced mice.

Fungal polysaccharides have garnered attention for their antidiabetic potential. Here, we evaluated five edible fungal polysaccharides-Agaricus bisporus (ABP), Pleurotus eryngii (PEP), Boletus spp.

Metabolic healthGut & microbiome

Cordyceps · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Cordycepin-mediated protection against bisphenol A-induced male reproductive toxicity via PI3K/mTOR/HIF-1α signaling.

Environmental endocrine disruptors, such as bisphenol A (BPA), pose significant threats to male reproductive health. Cordycepin, a bioactive nucleoside derived from Cordyceps militaris, has demonstrated antioxidant and bioregulatory effects; however, its protective role against BPA-induced reproductive toxicity….

Cordyceps · 2026 · Journal Article · Bioresource technology

Efficient production of cordycepin in engineered Saccharomyces cerevisiae.

Cordycepin (COR) is an important bioactive nucleoside with antitumor and immunomodulatory activities, but its conventional production via Cordyceps militaris fermentation is limited by long cultivation periods and low titers. Therefore, microbial heterologous synthesis represents an attractive alternative..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Cordyceps · 2026 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Elucidation of mechanisms underlying the therapeutic effects of cordycepin on pulmonary hypertension, with a focus on cell senescence and gut microbiota.

INTRODUCTION: Pulmonary hypertension (PH) is a progressive cardiopulmonary disorder characterized by excessive pulmonary vascular remodeling and aberrant proliferation of pulmonary artery smooth muscle cells (PASMCs). Emerging evidence suggests that gut microbiota dysbiosis contributes to PH development..

Cordyceps · 2025 · Research Article · Bioresources and bioprocessing

Comparative evaluation of free radical scavenging activity and total metabolite profiles among 30 macrofungi species.

The high antioxidant content of mushrooms such as polyphenols, polysaccharides, carotenoids, ergothioneine, glutathione, vitamins, and other compounds, has sparked interest in their potential use in preventive and therapeutic medicine..

Immune supportMetabolic healthSkin & hydration

Cordyceps · 2025 · Journal Article · Molecular immunology

Cordycepin ameliorates high glucose-induced proliferation, inflammation, and extracellular matrix deposition in glomerular mesangial cells through Smad7-dependent manner.

Diabetic nephropathy (DN) is one of the most common causes of end-stage renal disease. The extracellular matrix deposition is potent pathogenic factors of renal fibrosis and injury.

Cordyceps · 2025 · Journal Article · Journal of agricultural and food chemistry

Enhancing Cordycepin Biosynthesis in Yarrowia lipolytica via Lipid Droplets Compartmentalization Engineering and Optimized Fermentation Strategies.

Cordycepin, a physiologically active nucleoside compound with broad applications in healthcare, is biosynthesized in Cordyceps militaris through a protein complex formed by CmCns1 and CmCns2..

Cordyceps · 2025 · Journal Article · Current biology: CB

Fungal pathogen promotes caterpillar feeding and weight gain using a host-like trehalase.

Parasite-mediated extended phenotypes in hosts are of particular interest in biology. However, few parasite genes have been characterized for their selfish role in altering host behaviors to benefit parasite transmission or reproduction..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Food Research International

Study on the intervention mechanism of Ganodermalucidum polysaccharides in mice with atopic dermatitis

Taishan Red Reishi Mushroom, also known as Taishan Ganoderma lucidum, is a medicinal and edible mushroom. Polysaccharides from Taishan Ganodermalucidum (GLP) represent its most significant bioactive component..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Study on the intervention mechanism of Ganodermalucidum polysaccharides in mice with atopic dermatitis.

Immune supportEnergy & fatigueMetabolic health

Shiitake · 2024 · Journal Article · Aquaculture

Dietary lentinan improves growth, haemato-biochemical indices, resistance to Streptococcus agalactiae infection and expression of immune genes in Asian seabass, Lates calcarifer

Disease outbreak is the single major factor that causes high mortality and substantial economic losses in the farming of Asian seabass, Lates calcarifer. Strategies to improve the health of fishes using prophylactics is considered effective and safe over the use of chemicals and antibiotics..

Reishi · 2023 · Review · Integrative medicine (Encinitas, Calif.)

A Comprehensive Review of Herbal Supplements Used for Persistent Symptoms Attributed to Lyme Disease.

CONTEXT: Lyme disease is the most common, tick-borne disease in the USA. While most patients successfully recover with antibiotics, some patients experience persistent symptoms for months to years.

Cordyceps · 2023 · Review · Molecules (Basel, Switzerland)

Medicinal Mushrooms: Their Bioactive Components, Nutritional Value and Application in Functional Food Production-A Review.

Medicinal mushrooms, e.g., Lion's Mane (Hericium erinaceus (Bull.) Pers.), Reishi (Ganoderma lucidum (Curtis) P. Karst.), Chaga (Inonotus obliquus (Ach.

Cognition & nervesMetabolic health

Lion's Mane · 2021 · Review · Bioscience, biotechnology, and biochemistry

Chemical studies on bioactive compounds related to higher fungi.

Hericium erinaceus (Yamabushitake in Japan) is a well-known edible and medicinal mushroom. We discovered antidementia compounds, hericenones C to H, from the fruiting bodies and erinacine A to I from the cultured mycelia of the fungus..

Energy & fatigueMetabolic healthGut & microbiome

Turkey Tail · 2025 · Research Support, Non U.S. Gov'T · Applied and environmental microbiology

Fungus-mediated bacterial survival and migration enhance wood lignin degradation.

UNLABELLED: Bacterial-fungal interactions are increasingly recognized as a key factor in wood decomposition; however, the specific mechanisms underlying these interactions remain unclear..

Almond Mushroom · 2024 · Systematic Review · Cell and tissue banking

Efficacy of mesenchymal stromal cells in the treatment of type 1 diabetes: a systematic review.

To investigate the efficacy of mesenchymal stromal cells in the treatment of type 1 diabetes. Articles about the effects of mesenchymal stromal cells for T1D were retrieved in PubMed, Web of Science, Embase, and the Cochrane Library databases up to July 2023..

Reishi · 2023 · Journal Article · Theranostics

GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis.

Background and Purpose: Atherosclerosis is the main pathophysiological foundation of cardiovascular disease, which was caused by inflammation and lipid metabolism disorder, along with vascular calcification..

Turkey Tail · 2023 · Research Article · Microorganisms

Optimization of Fermentation Conditions and Product Identification of a Saponin-Producing Endophytic Fungus.

BACKGROUND: Some fungal endophytes isolated from P. ginseng may present a new method of obtaining saponins.

Turkey Tail · 2022 · Research Article · Polymers

Effect of Tannin Furanic Polymer in Comparison to Its Mimosa Tannin Extract on the Growth of Bacteria and White-Rot Fungi.

Tannins are well-known to protect plants from bacteria and fungi, but nothing is known about its effects on microorganisms once they are copolymerized. Therefore, a study was conducted to evaluate the effect of a tannin−furanic polymer in comparison with industrial mimosa tannin extract on the in vitro growth of two….

Reishi · 2022 · Research Article · Food science and biotechnology

Inhibitory effect of plant essential oils on α-glucosidase.

Diabetes mellitus, associated with α-glucosidase, has been considered as a chronic metabolic disorder, seriously affecting human health. Thus, searching natural α-glucosidase inhibitors and investigating their inhibition mechanism are urgently important..

Immune supportMetabolic healthGut & microbiome

Cordyceps · 2026 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Cordyceps cicadae polysaccharides ameliorate ulcerative colitis by modulating the gut microbiota and regulating the bile acid/FXR/NF-κB signaling pathway.

BACKGROUND: Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease, closely linked to dysbiosis of the intestinal microbiota and abnormal bile acid homeostasis. Polysaccharides derived from Paecilomyces cicadae (CCP) exhibit immunomodulatory and anti-inflammatory effects..

Immune supportMetabolic healthGut & microbiome

Cordyceps · 2024 · Journal Article · Food & function

Soluble dietary fibers from solid-state fermentation of wheat bran by the fungus Cordyceps cicadae and their effects on colitis mice.

Ulcerative colitis is a chronic inflammatory disease with a complex pathogenesis for which there is no definitive therapeutic agent. Fermentation, as a green and efficient bioprocessing technique, has been shown to enhance the biological activity of food ingredients..