MycoData

BACKGROUND: The African continent is home to five biodiversity hotspots, boasting an immense wealth of medicinal flora, fungi and marine life. Diterpenes extracted from such natural products have compelling cytotoxic activities that warrant further exploration for the drug market, particularly in cancer therapy, where….

OncologyCognition & nerves

Medium relevance

Almond Mushroom · 2024 · Preprint · journal metadata

Bone Health in Newly Diagnosed Female Breast Cancer Patients in China: A Cross-sectional Study

Abstract Background and Purpose Bone health problem is one of the important concomitant diseases of breast cancer (BC). This study aimed to investigate the status of bone health of newly diagnosed female BC patients in China..

Oncology

Medium relevance

Reishi · 2024 · Review · International journal of medicinal mushrooms

Ganoderic Acid A: A Potential Natural Neuroprotective Agent for Neurological Disorders: A Review.

Ganoderic acid A (GAA) is one of the major triterpenoids in Ganoderma lucidum (GL). Accumulating evidence has indicated that GAA demonstrates multiple pharmacological effects and exhibits treatment potential for various neurological disorders..

OncologyImmune supportCognition & nerves

Medium relevance

Mesima · 2024 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Initial report on the multiple biological and pharmacological properties of hispolon: Exploring stochastic mechanisms.

The development of natural substances derived from nature poses a significant challenge as technologies for the extraction and characterization of active principles advance. Hispolon has received a lot of attention in recent years, ascribable to its wide range of biological activities..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Almond Mushroom · 2024 · Preprint · journal metadata

Integrating mechanism-based T cell phenotypes into a model of tumor-immune cell interactions

ABSTRACT Interactions between cancer cells and immune cells in the tumor microenvironment influence tumor growth and can contribute to the response to cancer immunotherapies. It is difficult to gain mechanistic insights into the effects of cell-cell interactions in tumors using a purely experimental approach..

OncologyImmune support

Medium relevance

Cordyceps · 2024 · Review · Current issues in molecular biology

Medicinal Mushrooms in Metastatic Breast Cancer: What Is Their Therapeutic Potential as Adjuvant in Clinical Settings?

Breast cancer (BC) is the most commonly diagnosed tumor, remaining one of the leading causes of morbidity and mortality in females worldwide, with the highest rates in Western countries..

OncologyImmune supportCognition & nervesLiver support

Medium relevance

Almond Mushroom · 2024 · Preprint · journal metadata

On the equivalence between agent-based and continuum models for cell population modeling. Application to glioblastoma evolution in microfluidic devices

A bstract Mathematical models are invaluable tools for understanding the mechanisms and interactions that control the behavior of complex systems. Modeling a problem as cancer evolution includes many coupled phenomena being therefore impossible to obtain sufficient experimental results to fully evaluate all possible….

OncologyImmune support

Medium relevance

Lion's Mane · 2024 · Review · Antioxidants (Basel, Switzerland)

Oxidative Stress in Spinocerebellar Ataxia Type 3 and Its Attenuation by Herbal Remedies in Traditional Chinese Medicine: A Systematic Review.

Spinocerebellar ataxia type 3 (SCA3) is an autosomal dominant neurodegenerative disorder that gives rise to motor incoordination and progressive functional disabilities. Although pharmacological interventions have revealed promising prospects in the management of SCA3, adverse effects may become unbearable..

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Oyster Mushroom · 2024 · Preprint · journal metadata

Pleurotus sajor-caju (Fr.) Singer β-1,3- Glucanoligosaccharide (Ps-GOS) suppresses RANKLInduced Osteoclast Differentiation and Function in Pre-Osteoclastic RAW 264.7 Cells by Inhibiting the RANK/NFκB/cFOS/NFATc1 Signalling Pathway

Edible grey oyster mushroom, Pleurotus sajor-caju, β (1,3), (1,6) glucan possesses a wide range of biological activities, including anti-inflammation, anti- microorganisms, and antioxidant. However, its biological activity is limited by their low water solubility resulting from the high molecular weight..

OncologyImmune supportMetabolic health

Medium relevance

Reishi · 2024 · Review · Chinese journal of natural medicines

Polysaccharides from Chinese herbal medicine: a review on the hepatoprotective and molecular mechanism.

Polysaccharides, predominantly extracted from traditional Chinese medicinal herbs such as Lycium barbarum, Angelica sinensis, Astragalus membranaceus, Dendrobium officinale, Ganoderma lucidum, and Poria cocos, represent principal bioactive constituents extensively utilized in Chinese medicine..

OncologyImmune supportLiver support

Medium relevance

Reishi · 2024 · Review · Chinese medicine

Potential of natural products and gut microbiome in tumor immunotherapy.

Immunotherapy is a novel treatment approach for malignant tumors, which has opened a new journey of anti-tumor therapy. Although some patients will show a positive response to immunotherapy, unfortunately, most patients and cancer types do not achieve an ideal response to immunotherapy..

OncologyImmune supportGut & microbiomeLiver support

Medium relevance

Almond Mushroom · 2024 · Preprint · journal metadata

Simulations probe the role of space in the interplay between drug-sensitive and drug-resistant cancer cells

The interplay between drug-sensitive and drug-resistant cancer cells has been observed to impact cell-to-cell interactions in experimental settings. However, the role that space plays in these interactions remains unclear..

Oncology

Medium relevance

Almond Mushroom · 2024 · Preprint · bioRxiv: the preprint server for biology

SMoRe GloS: An efficient and flexible framework for inferring global sensitivity of agent-based model parameters.

Agent-based models (ABMs) have become essential tools for simulating complex biological, ecological, and social systems where emergent behaviors arise from the interactions among individual agents..

Oncology

Medium relevance

Almond Mushroom · 2024 · Preprint · journal metadata

Spatially Fractionated GRID radiation potentiates immune-mediated tumor control

Abstract Background Tumor-immune interactions shape a developing tumor and its tumor immune microenvironment (TIME) resulting in either well-infiltrated, immunologically inflamed ‘hot’ tumor beds, or ‘cold’ immune deserts with low levels of infiltration..

OncologyImmune support

Medium relevance

Cordyceps · 2024 · Review · Frontiers in pharmacology

Structural and pharmacological insights into cordycepin for neoplasms and metabolic disorders.

Cytotoxic adenosine analogues were among the earliest chemotherapeutic agents utilised in cancer treatment. Cordycepin, a natural derivative of adenosine discovered in the fungus Ophiocordyceps sinensis, directly inhibits tumours not only by impeding biosynthesis, inducing apoptosis or autophagy, regulating the cell….

OncologyImmune supportMetabolic health

Medium relevance

Reishi · 2024 · Review · Phytomedicine: international journal of phytotherapy and phytopharmacology

Targeting CD8+ T cells with natural products for tumor therapy: Revealing insights into the mechanisms.

BACKGROUND: Despite significant advances in cancer immunotherapy over the past decades, such as T cell-engaging chimeric antigen receptor (CAR)-T cell therapy and immune checkpoint blockade (ICB), therapeutic failure resulting from various factors remains prevalent..

OncologyImmune support

Medium relevance

Lion's Mane · 2019 · Review · International journal of medicinal mushrooms

Medicinal, Nutritional, and Cosmetic Values of Macrofungi Distributed in Mazandaran Province of Northern Iran (Review).

A total of 82 species and 2 variations of medicinal and edible macrofungi (Basidiomycota and Ascomy-cota) have been collected and identified in Mazandaran Province of Northern Iran..

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Niu-Chang-Chih · 2019 · Review · Chemico-biological interactions

Pharmacological activities of antroquinonol- Mini review.

Antrodia camphorata is an expensive mushroom that grows on the inner cavity of an endangered native tree of Taiwan namely Cinnamomum kanehirai Hayata. It is used as a traditional medicine in Taiwan and has several health benefits including free radical scavenging, anti-inflammatory, antimicrobial, hepatoprotective,….

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Almond Mushroom · 2019 · Clinical Trial · Cancer medicine

The volume of 99m Tc sulfur colloid SPET-defined active bone marrow can predict grade 3 or higher acute hematologic toxicity in locally advanced cervical cancer patients who receive chemoradiotherapy.

BACKGROUND: The purpose of the current study was to evaluate whether radiation dose-volume metrics to technetium-99m (99m Tc) sulfur colloid single-photon emission tomography (SPET)-defined active bone marrow (ABM) subregions can more accurately predict acute hematologic toxicity in locally advanced cervical cancer….

Oncology

Medium relevance

Nameko · 2016 · Research Support, Non U.S. Gov'T · Journal of the science of food and agriculture

Purification and characterization of a ∼43 kDa antioxidant protein with antitumor activity from Pholiota nameko.

BACKGROUND: Pholiota nameko water-soluble protein (PNWSP), isolated from the dried fruiting bodies of Pholiota nameko, was purified by a successive chromatographic process using Q anion exchange column, SP cation exchange column and Superdex 200 gel filtration column..

OncologyEnergy & fatigue

Medium relevance

Almond Mushroom · 2026 · Research Article · PloS one

A biologically constrained agent-based model of cancer stem cell dynamics with reinforcement learning-guided adaptive radiotherapy.

Cancer stem cells (CSCs) represent a rare but critical subpopulation within tumors, driving recurrence, resistance to therapy, and aggressive growth. To better understand CSC behavior in solid tumors, we developed a biologically constrained agent-based model (ABM) that simulates tumor progression initiated from a….

OncologyCognition & nervesEnergy & fatigue

Medium relevance

Almond Mushroom · 2026 · Research Article · Pharmaceuticals (Basel, Switzerland)

A Mechanistic Digital Twin of uPAR-Driven Prostate Cancer Invasion Integrating ODE Signalling and Agent-Based Modelling.

Background: Aberrant signalling through the urokinase-type plasminogen activator receptor (uPAR) is a key driver of tumour invasion and progression in prostate cancer, yet linking molecular-level perturbations to emergent spatial invasion phenotypes remains challenging..

Oncology

Medium relevance

Almond Mushroom · 2026 · Research Article · Journal of applied clinical medical physics

Active bone marrow dose reconstruction in a large-scale cohort study of cancer patients treated with photon radiotherapy.

BACKGROUND: Previous studies have investigated the dose-response relationship between external beam radiotherapy (EBRT) and leukemia by reconstructing the mean active bone marrow (ABM) dose as part of the exposure assessment..

Oncology

Medium relevance

Cordyceps · 2026 · Journal Article · Frontiers in bioscience (Landmark edition)

Context-Dependent Modulation of Macrophage Plasticity by Cordycepin Drives Tumor Regression in Melanoma.

BACKGROUND AND AIM: Cordycepin (CDC), an adenosine (ADO) analog from Cordyceps mushrooms, exhibits potent anti-tumor and immunomodulatory activities. However, the precise mechanisms governing its effects on macrophage plasticity remain poorly understood..

OncologyImmune support

Medium relevance

Almond Mushroom · 2026 · Research Article · Pharmaceuticals (Basel, Switzerland)

Development and Application of an UPLC-MS/MS Method for Simultaneous Quantification of Abemaciclib and Tamoxifen with Their Active Metabolites in Rat Plasma: Application to a Pharmacokinetic Study.

Background: Abemaciclib (ABM) in combination with tamoxifen (TAM) is an extremely significant treatment regimen for hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) breast cancer. It is approved for patients to reduce the risk of cancer recurrence..

OncologyEnergy & fatigueSkin & hydration

Medium relevance

Almond Mushroom · 2026 · Journal Article · Journal of medicinal chemistry

Icosahedral Carborane: A Safe Albumin Binder for Augmenting Radiopharmaceuticals' Tumor Uptake and Retention.

Albumin-binding moieties (ABMs) improve radioligands' pharmacokinetics by leveraging their long circulatory half-life to enhance tumor uptake and accumulation. In this study, we demonstrated icosahedral carborane (hereafter referred to as BSH) as a newly applied ABM with moderate albumin-binding affinity and favorable….

Oncology

Medium relevance

Almond Mushroom · 2026 · Journal Article · Bulletin of mathematical biology

SSRCA: A Novel Machine Learning Pipeline to Perform Sensitivity Analysis for Agent-Based Models.

Agent-based models (ABMs) are widely used in biology to understand how individual actions scale into emergent population behavior. Modelers employ sensitivity analysis (SA) algorithms to quantify input parameters' impact on model outputs, however, it is hard to perform SA for ABMs due to their computational and….

OncologyCognition & nerves

Medium relevance

Cordyceps · 2026 · Journal Article · Carbohydrate polymers

Structural characteristics and bioactivities of an exopolysaccharide from mycelial fermentation of a medicinal fungus Cs-HK1.

Cs-HK1 fungus is originated from the Chinese caterpillar fungus, Cordyceps (=Ophiocordyceps) sinensis, a valuable in Chinese Tibetan medicine. The exopolysaccharides (EPS) produced by Cs-HK1 mycelial fermentation have shown multiple bioactivities that are dependent on their structural characteristics..

OncologyImmune supportMetabolic health

Medium relevance

Almond Mushroom · 2026 · Journal Article · Toxicon: official journal of the International Society on Toxinology

The impact of abamectin treatment on oxidative stress and the caspase-3/caspase-8/caspase-9/Bcl-2/Bax/Fas/p53 mediated apoptotic pathway: Role of baicalin and vitamin E.

Abamectin (ABM) is synthesised by Streptomyces avermitilis and is used for the treatment of Onchocerca volvulus in humans and also in the veterinary and agricultural areas. The study employed 48 male Wistar Albino rats, aged 2-3 months and weighed 150-200 g, 8 per group.

OncologyMetabolic healthLiver support

Medium relevance

Almond Mushroom · 2025 · Research Article · CPT: pharmacometrics & systems pharmacology

A Multiple-Model-Informed Drug-Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab.

The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL-7 and murine IL-12 genes (hIL-7/mIL-12-VV) was demonstrated in CT26.WT-bearing mice..

OncologyRespiratory

Medium relevance

Almond Mushroom · 2025 · Journal Article · Comparative biochemistry and physiology. Toxicology & pharmacology: CBP

Abamectin at environmentally relevant concentrations impairs bone development in zebrafish larvae.

Abamectin (ABM) is a widely used pesticide in agriculture and veterinary medicine, which primarily acts by disrupting the neurological physiology of pests, leading to their paralysis and death. Its extensive application has resulted in contamination of many natural water bodies..

OncologyCognition & nerves

Medium relevance

Almond Mushroom · 2025 · Research Article · Research report (Health Effects Institute)

Accounting for Mobility in Air Pollution Exposure Estimates in Studies on Long-Term Health Effects.

INTRODUCTION: Large-scale epidemiological studies investigating long-term health effects of air pollution can typically only consider the residential locations of the participants, thereby ignoring the space-time-activity patterns that likely influence total exposure..

OncologyEnergy & fatigueMetabolic healthRespiratory

Medium relevance

Almond Mushroom · 2025 · Research Article · PloS one

Agent-based modeling for personalized prediction of an experimental immune response to immunotherapeutic antibodies.

Targeting immune checkpoint pathways to evoke an immune response against tumors has revolutionized clinical oncology over the last decade. Antibodies that block the PD-1/PD-L1 pathway have demonstrated effective antitumor activity in cancer patients and are approved for treatment of several different types of cancer..

OncologyImmune supportCognition & nerves

Medium relevance

Almond Mushroom · 2025 · Journal Article · Oral diseases

Ameloblastoma Diagnosis From Serum Metabolic Profiling.

INTRODUCTION: Ameloblastoma (ABM) is an aggressive, localized, infiltrating epithelial odontogenic neoplasm. The molecular pathogenesis of ABM is unknown, and studying its metabolic profile may allow the identification of biomarkers relevant to the diagnosis and prediction of pathology..

OncologyImmune supportMetabolic health

Medium relevance

Almond Mushroom · 2025 · Research Article · PLoS computational biology

An efficient and flexible framework for inferring global sensitivity of agent-based model parameters.

Agent-based models (ABMs) have become essential tools for simulating complex biological, ecological, and social systems where emergent behaviors arise from the interactions among individual agents..

Oncology

Medium relevance

Almond Mushroom · 2025 · Research Article · Scientific reports

Bone health in newly diagnosed female breast cancer patients in China: a cross-sectional study.

Bone health problem is one of the important concomitant diseases of breast cancer (BC). This study aimed to investigate the bone health status of newly diagnosed female BC patients in China..

Oncology

Medium relevance

Almond Mushroom · 2025 · Journal Article · Cancer treatment and research communications

Efficacy and safety of upfront radiotherapy with immune checkpoint inhibitors for brain metastasis in non-small cell lung cancer.

INTRODUCTION: The optimal timing of radiotherapy (RT) for asymptomatic brain metastasis (aBM) in patients with non-small cell lung cancer (NSCLC) without targetable oncogenic drivers treated with immune checkpoint inhibitors (ICIs) remains unclear..

OncologyImmune supportCognition & nervesRespiratory

Medium relevance

Almond Mushroom · 2025 · Research Article · Molecules (Basel, Switzerland)

Engineering a Radiohybrid PSMA Ligand with an Albumin-Binding Moiety and Pharmacokinetic Modulation via an Albumin-Binding Competitor for Radiotheranostics.

The prostate-specific membrane antigen (PSMA) is a well-established target for radiotheranostics in prostate cancer. We previously demonstrated that 4-(p-astatophenyl)butyric acid (APBA), an albumin-binding moiety (ABM) labeled with astatine-211 (211At), enables the modulation of pharmacokinetics and enhancement of….

Oncology

Medium relevance

Almond Mushroom · 2025 · Journal Article · Operative neurosurgery (Hagerstown, Md.)

Evaluation of Mental and Emotional Factors in Awake Brain Mapping for Low-Grade Glioma: A Study of 55 Cases.

BACKGROUND AND OBJECTIVES: Awake brain mapping (ABM) is widely used for low-grade gliomas in eloquent brain regions, where preservation of neurological function is essential. The aim of this study was to evaluate perioperative anxiety and quality of life (QoL) in patients undergoing ABM..

OncologyCognition & nerves

Medium relevance

Almond Mushroom · 2025 · Research Article · Scientific reports

Gene expression and agent-based modeling improve precision prognosis in breast cancer.

Breast cancer survival is hard to predict because of the complex ways genes and cells interact. This study offers a new method to improve these predictions by combining gene expression profiling (GEP) with agent-based modeling (ABM).

Oncology

Medium relevance

Almond Mushroom · 2025 · Research Article · Physics and imaging in radiation oncology

Hybrid deep learning enables multi-institutional delineation of active bone marrow for gynecologic radiotherapy.

BACKGROUND AND PURPOSE: Pelvic radiotherapy for gynecologic cancer inevitably irradiates sensitive areas like iliac bones, lumbar vertebrae, and sacrum. Using 18F-FDG PET/CT as a reference, we developed a deep learning method to detect hematopoietic active bone marrow (ABM) on CT in gynecologic cancer patients and….

OncologyCognition & nervesEnergy & fatigue

Medium relevance

Almond Mushroom · 2025 · Journal Article · Physical review. E

Modeling adhesion in stochastic and mean-field models of cell migration.

Adhesion between cells plays an important role in many biological processes such as tissue morphogenesis and homeostasis, wound healing, and cancer cell metastasis..

OncologySkin & hydration

Medium relevance

Almond Mushroom · 2025 · Research Article · Journal of virology

Modeling of hepatitis B virus infection spread in primary human hepatocytes.

Chronic hepatitis B virus (HBV) infection poses a significant global health threat, causing severe liver diseases including cirrhosis and hepatocellular carcinoma..

OncologyLiver supportRespiratory

Medium relevance

Almond Mushroom · 2025 · Research Article · Frontiers in oncology

Myth or reality: the oxygen effect in rectal cancer radiotherapy.

BACKGROUND: The oxygen microenvironment plays a crucial role in tumor radio-sensitivity, influencing the effectiveness of radiotherapy. The oxygen effect, which increases radiosensitivity in the presence of oxygen, has been extensively studied but not fully understood..

OncologyEnergy & fatigue

Medium relevance

Almond Mushroom · 2025 · Journal Article · Nature

Oncogenic fusions converge on shared mechanisms in initiating astroblastoma.

Chromosomal rearrangements and gene fusions are the initial events in the development of many cancers. Astroblastoma (ABM), a brain cancer of unknown cellular origin and challenging to treat, is associated with diverse in-frame gene fusions, including MN1-BEND2 and MN1-CXXC5 (refs.

OncologyCognition & nerves

Medium relevance

Almond Mushroom · 2025 · Journal Article · Journal of theoretical biology

Simulations probe the role of space in the interplay between drug-sensitive and drug-resistant cancer cells.

Oncology

Medium relevance

Shiitake · 2025 · Journal Article · Preparative biochemistry & biotechnology

Statistical optimization of fermentation conditions for metabolites production by Lentinus edodes and investigation of anticancer activity.

A statistical method was utilized in this study to enhance Lentinus edodes (shiitake) secondary metabolites, thereby improving its anticancer properties. The importance of employing the statistical method in this study stemmed from the initial statistical optimization of the substrate in submerged conditions, and the….

OncologyImmune support

Medium relevance

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Two Mycopolysaccharides from Hirsutella sinensis mycelia: Structural characterization and dual antioxidant-cardioprotective functions.

Cordyceps sinensis, a precious traditional Chinese herb, exhibits diverse polysaccharide structures and functions across strains. This study screened Hirsutella sinensis 02-3 and successfully extracted two mycopolysaccharides (fungal polysaccharides): ISP-AII (MW = 4.70 kDa) and ISP-BII (MW = 75.42 kDa)..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Almond Mushroom · 2024 · Research Article · Medical physics

A novel method for rapid estimation of active bone marrow dose for radiotherapy patients in epidemiological studies.

BACKGROUND: In a dedicated effort to improve the assessment of clonal hematopoiesis (CH) and study leukemia risk following radiotherapy, we are developing a large-scale cohort study among cancer patients who received radiation..

OncologyEnergy & fatigue

Medium relevance

Almond Mushroom · 2024 · Research Article · Cancers

Agent-Based Modeling of Virtual Tumors Reveals the Critical Influence of Microenvironmental Complexity on Immunotherapy Efficacy.

Since the introduction of the first immune checkpoint inhibitor (ICI), immunotherapy has changed the landscape of molecular therapeutics for cancers. However, ICIs do not work equally well on all cancers and for all patients..

OncologyImmune support