MycoData

Chaga · 2025 · Research Article · International journal of molecular sciences

Molecular Mechanisms of Phytochemicals from Chaga Mushroom (Inonotus obliquus) Against Colorectal Cancer: Insights from Network Pharmacology, Molecular Docking, and Bioinformatics.

This study aimed to explore the molecular mechanisms of phytochemicals from Chaga mushroom (Inonotus obliquus) against colorectal cancer (CRC) using a combination of network pharmacology, molecular docking, and bioinformatics. Active components and targets of Chaga mushroom and CRC were collected from databases..

OncologyImmune support

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2025 · Review · Brazilian journal of biology = Revista brasleira de biologia

Morphology, anticancer and neurological activities of Hericium erinaceus.

Hericium erinaceus, commonly known as Lion's Mane, is a species of medicinal mushroom that possesses remarkable therapeutic properties and has been extensively employed in the practice of traditional Chinese medicine. H..

Chaga · 2025 · Review · Current issues in molecular biology

Natural Products and Health Care Functions of Inonotus obliquus.

With the increasing attention of modern medicine to natural medicinal agents, Inonotus obliquus (chaga), a macrofungus with remarkable medicinal value, has gradually garnered widespread academic interest. This paper reviews the primary bioactive components of I..

OncologyImmune support

Immune supportMetabolic healthLiver support

Maitake · 2025 · Research Article · Nutrients

Network Pharmacology-Based Elucidation of the Hypoglycemic Mechanism of Grifola frondosa GF5000 Polysaccharides via GCK modulation in Diabetic Rats.

BACKGROUND/OBJECTIVES: Our lab has previously reported that Grifola frondosa (maitake mushroom) GF5000 has antidiabetic potential owing to its ability to improve insulin resistance..

Immune supportCognition & nervesEnergy & fatigue

Enoki · 2025 · Research Article · Nutrients

Neuroprotective and Neurotrophic Potential of Flammulina velutipes Extracts in Primary Hippocampal Neuronal Culture.

Flammulina velutipes (enoki mushroom) is a functional edible mushroom rich in antioxidants, polysaccharides, mycosterols, fiber, and minerals. Accumulating evidence highlights its therapeutic potential across diverse pathological contexts, including boosting cognitive function..

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

New insights of rotenone targeting cordycepin synthetase 1-cordycepin synthetase 2-glyceraldehyde-3-phosphate dehydrogenase (Cns1-Cns2-GAPDH) triple complex to enhance cordycepin synthesis in Cordyceps militaris.

Cordycepin isolated from Cordyceps militaris is an adenosine analogue with various biological activities, and its synthesis is dependent on cordycepin synthetase 1 (Cns1) and cordycepin synthetase 2 (Cns2)..

Immune supportSkin & hydration

Snow Fungus · 2025 · Research Article · Foods (Basel, Switzerland)

Non-Animal Hyaluronic Acid from Tremella fuciformis: A New Source with a Structure and Chemical Profile Comparable to Hyaluronic Acid.

Tremella fuciformis is high in polysaccharides, which have a structure made up of a straight chain of (1→3) α-D-mannan and side chains of glucuronic acid, xylose, and fucose..

Immune supportCognition & nervesEnergy & fatigue

Reishi · 2025 · Research Article · Frontiers in chemistry

Non-destructive analysis of Ganoderma lucidum composition using hyperspectral imaging and machine learning.

BACKGROUND: Ganoderma lucidum is a widely used medicinal fungus whose quality is influenced by various factors, making traditional chemical detection methods complex and economically challenging..

Immune supportMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Carbohydrate polymers

Novel galactose-rich polysaccharide from Ganoderma lucidum: structural characterization and immunomodulatory activities

Galactose-rich polysaccharides from Ganoderma lucidum have emerged as promising immunomodulatory agents, yet their structural characteristics and mechanisms of action remain poorly understood. Here, we isolated and characterized a novel galactose-rich polysaccharide (GLP-1b, 16.79 kDa) from Ganoderma lucidum..

Immune supportMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Carbohydrate polymers

Novel galactose-rich polysaccharide from Ganoderma lucidum: structural characterization and immunomodulatory activities.

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · Journal Article · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Pharmacokinetic and tissue distribution analysis of sporoderm-removed Ganoderma lucidum spore powder in rats.

Ganoderma lucidum (Lingzhi), a medicinal mushroom, is recognized for its broad pharmacological activities, including potential health and longevity benefits. Notably, several triterpenoids derived from its spores and fruiting body have demonstrated anti-inflammatory, anti-tumor, and immunomodulatory effects..

Immune supportGut & microbiomeLiver support

King Oyster · 2025 · Research Article · Food science & nutrition

Pleurotus eryngii Culture Filtrate and Aqueous Extracts Alleviate Aflatoxin B1 Synthesis.

Mycotoxins in food and feed are a significant health risk, even more so than pesticides and synthetic waste. These toxic secondary metabolites are produced by various fungal species, particularly after fungal colonization of crops..

King Oyster · 2025 · Research Article · Nutrients

Pleurotus eryngii Mushrooms Fermented with Human Fecal Microbiota Protect Intestinal Barrier Integrity: Immune Modulation and Signalling Pathways Counter Deoxycholic Acid-Induced Disruption in Healthy Colonic Tissue.

Background: This study explores the potential of the Pleurotus eryngii mushroom fermentation supernatant (FS-PEWS) as an intervention for mitigating sodium deoxycholate (SDC)-induced intestinal barrier dysfunction and inflammation..

Immune supportMetabolic healthGut & microbiome

King Oyster · 2025 · Journal Article · Food & function

Positive effect of a novel protein from Pleurotus eryngii on improving colitis: exploring potential mechanisms from the perspective of intestinal metabolism.

Pleurotus eryngii (P. eryngii) protein has demonstrated potential anti-inflammatory effects, but the specific mechanism has not been reported.

OncologyImmune supportEnergy & fatigueSkin & hydration

Cordyceps · 2025 · Research Article · Journal of cosmetic dermatology

Potential Cosmetic Applications of the Combined Extract of Panax ginseng, Ganoderma lucidum, Cordyceps militaris, and Several Asian Plants.

OBJECTIVE: Although bioactive compounds from single herbs are extensively explored in cosmetics, the synergistic potential of herbal combinations remains understudied..

Immune supportGut & microbiomeSkin & hydration

Reishi · 2025 · Journal Article · Food Bioscience

Preparation of novel Ganoderma lucidum protein-derived bioactive peptides and their oxidation resistance, melanin synthesis inhibition and anti-inflammatory functions

As a key active component in Ganoderma lucidum, the preparation and biological activities of Ganoderma lucidum immunomodulatory protein (rFIP-glu) have been reported, but its deep utilization, such as the preparation of bioactive peptides, has not been explored..

Snow Fungus · 2025 · Review · Frontiers in nutrition

Recent advances in polysaccharides from Tremella fuciformis: isolation, structures, bioactivities and application.

Tremella fuciformis, commonly known as snow fungus, is a traditional edible and medicinal fungus widely used in Asian countries for centuries. Its main bioactive constituents, Tremella fuciformis polysaccharides (TFPs), have attracted considerable attention in both food and pharmaceutical industries due to their….

OncologyImmune supportSkin & hydrationRespiratory

Reishi · 2025 · Review · Pharmaceutics

Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer.

Lung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is the major subtype, accounting for more than 85% of all lung cancer cases..

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2025 · Review · Natural product research

Reishi Mushroom (Ganoderma lucidum): pharmacology of a potent healer in traditional Chinese medicine.

Reishi mushroom, also known as Lingzhi or Ganoderma lucidum, is a widely studied macrofungus in Traditional Chinese Medicine, revered for over two millennia in Asia..

Immune supportMetabolic healthLiver support

King Oyster · 2025 · Research Article · Bioresources and bioprocessing

Revitalizing Pleurotus eryngii polysaccharides: gamma irradiation boosts antidiabetic and antioxidant potential.

Polysaccharides derived from Pleurotus eryngii possess various bioactive properties, including antioxidant, antidiabetic, anti-inflammatory, and immunomodulatory effects. In this study, polysaccharides were extracted from P..

OncologyImmune supportMetabolic health

Shiitake · 2025 · Research Article · Scientific reports

Safety assessment and in vitro cytotoxicity profiling of fruiting bodies from Lentinula edodes (shiitake) strains in HeLa and MCF-7 cell lines.

Medicinal mushrooms offer diverse therapeutic benefits, but proper administration is crucial to avoid long-term health issues linked to fungal toxicity. This study evaluated the safety and in vitro cytotoxic potential of Lentinula edodes (shiitake) mushrooms for broader use in food and health supplements..

Cordyceps · 2025 · Research Article · Food science & nutrition

Selenium-Enriched Cordyceps militaris Polysaccharides Alleviate Insulin Resistance in HepG2 Cells by Regulating the PI3K/AKT/GLUT4 Signaling Pathway.

Metal ion-rich Cordyceps militaris polysaccharides (CMP) are obtained by biotransformation and chemical synthesis. The physicochemical properties and bioactivity of selenium-enriched CMP (Se-CMP) obtained using biotransformation remain unclear.

Oyster Mushroom · 2025 · Journal Article · Journal of food science

Simultaneous extraction and purification of polysaccharides and proteins from Pleurotus ostreatus using an aqueous two-phase system.

Pleurotus ostreatus is a nutrient-dense edible fungus renowned for its delicate texture, appealing flavor, and numerous potential health benefits. Simultaneous extraction within the framework of food resource processing facilitates the concurrent isolation and analysis of multiple target compounds..

Cordyceps · 2025 · Research Article · Foods (Basel, Switzerland)

Soy Sauce Fermentation with Cordyceps militaris: Process Optimization and Functional Profiling.

This study presents the development and optimization of a functional soy sauce fermented with Cordyceps militaris (C. militaris), a medicinal fungus known for its high cordycepin and polysaccharide content.

Immune supportCognition & nerves

Reishi · 2025 · Research Article · Frontiers in pharmacology

Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation.

INTRODUCTION: Sporoderm-Removed Ganoderma lucidum Spore Powder (S-GLSP), derived from the spores of the medically valued fungus Ganoderma lucidum, exhibits diverse pharmacological activities and shows considerable potential in the treatment of Alzheimer's disease (AD)..

Cordyceps · 2025 · Review · Antonie van Leeuwenhoek

Strain improvement of Cordyceps militaris for optimized bioactive metabolite biosynthesis: current progress and prospective approaches.

Cordyceps militaris is a rare and highly valued medicinal fungus that has attracted considerable attention due to its production of diverse bioactive compounds, including nucleosides such as cordycepin, polysaccharides, lovastatin, carotenoids, etc., all of which exhibit significant nutritional and therapeutic….

Reishi · 2025 · Journal Article · Carbohydrate polymers

Structural and functional benefits of Ganoderma lucidum polysaccharides due to space mutagenesis

Ganoderma lucidum samples from space-mutated strains transported by China's “Shenzhou” recoverable satellites, along with traditionally cultivated counterparts, were selected for this study..

Reishi · 2025 · Journal Article · Carbohydrate polymers

Structural and functional benefits of Ganoderma lucidum polysaccharides due to space mutagenesis.

Ganoderma lucidum samples from space-mutated strains transported by China's "Shenzhou" recoverable satellites, along with traditionally cultivated counterparts, were selected for this study..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Structural characteristics of a heteropolysaccharide from Ganoderma lucidum and its protective effect against Alzheimer's disease via modulating the microbiota-gut-metabolomics.

Ganoderma lucidum is a traditional Chinese medicine used to treat Alzheimer's disease (AD), whose main active ingredient is polysaccharides. A heteropolysaccharide named GLPZ-1 was isolated from Ganoderma lucidum.

OncologyImmune supportMetabolic healthGut & microbiome

King Oyster · 2025 · Journal Article · International journal of biological macromolecules

Structural characteristics of Pleurotus eryngii polysaccharide and its protective mechanisms against mastitis in mice.

Mastitis, a common inflammatory condition in female mammals, increases the risk of breast cancer and causes substantial economic losses. Although antibiotics effectively treat mastitis, their overuse poses a threat to public health and safety..

Reishi · 2025 · Research Article · Scientific reports

Structural characteristics, sugar metabolizing enzyme activity and biological activity of Ganoderma lucidum polysaccharides at different growth stages.

The Ganoderma lucidum polysaccharides (GLPs) content, monosaccharide composition, molecular weight, sugar metabolism-related enzyme activities and in vitro antioxidant activities of Ganoderma lucidum fruiting body (GLFB) from cassava stalk cultivation at different growth stages (namely, differentiation stage, umbrella….

King Oyster · 2025 · Journal Article · International journal of biological macromolecules

Structure and strain specificity for polysaccharides from king oyster mushroom (Pleurotus eryngii) fruiting bodies.

King oyster mushroom Pleurotus eryngii is cultivated worldwide for culinary and to improve human health. However, the potential of some Mediterranean representatives of this species is still not evaluated.

Chaga · 2025 · Journal Article · Journal of Chromatography A

Supercritical fluid-based protocol for the identification and quantitation of triterpenoids in commercial Inonotus obliquus (chaga) samples

Inonotus obliquus is a fungal pathogen that parasitizes the trunks of broadleaved tree species. The sclerotia of this fungus, so-called chaga, show a broad range of traditional and medicinal uses..

Chaga · 2025 · Journal Article · Journal of chromatography. A

Supercritical fluid-based protocol for the identification and quantitation of triterpenoids in commercial Inonotus obliquus (chaga) samples.

Inonotus obliquus is a fungal pathogen that parasitizes the trunks of broadleaved tree species. The sclerotia of this fungus, so-called chaga, show a broad range of traditional and medicinal uses..

Enoki · 2025 · Journal Article · Food Research International

Superiority of ultrasound-extracted Flammulina velutipes polysaccharides over hot water-extracted ones in mitigating colonic cell pyroptosis: Discoveries into modulation of NLRP3 pathway

Flammulina velutipes is a major edible fungus with abundant yield and mature industrial production technology. Its main functional component, Flammulina velutipes polysaccharide, has huge development and utilization value..

Enoki · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Superiority of ultrasound-extracted Flammulina velutipes polysaccharides over hot water-extracted ones in mitigating colonic cell pyroptosis: Discoveries into modulation of NLRP3 pathway.

Chaga · 2025 · Journal Article · International journal of biological macromolecules

Sustainable valorization of Inonotus obliquus via temperature-gated natural deep eutectic solvents extraction: Polysaccharide-antioxidant partitioning.

Inonotus obliquus is a medicinal mushroom rich in bioactive metabolites, including polysaccharides and antioxidants, that provide notable nutritional and therapeutic benefits..

Immune supportEnergy & fatigue

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Synergistic anti-inflammatory effects of Ganoderma lucidum polysaccharide and ganoderic acid A on LPS-induced RAW264.7 cells by inhibition of TLR4/NF-κB activation.

Ganoderma lucidum, a food-grade medicinal mushroom, is rich in biologically active components that offer significant health benefits. This study investigated the synergistic anti-inflammatory effects of Ganoderma lucidum polysaccharide (GLP-1) and ganoderic acid A (GAA) in RAW264.7 cells..

King Oyster · 2025 · Journal Article · Journal of the science of food and agriculture

Systematic comparison of the effects of exogenous inorganic selenium and organic selenium on the quality and antioxidant capacity of Pleurotus eryngii

BACKGROUND: Pleurotus eryngii is an ideal food to improve the nutritional status of selenium (Se) in the human body. Besides Se accumulation and speciation, quality parameters and antioxidant capacity are key factors in determining the nutritional value of P.

Reishi · 2025 · Journal Article · Current pharmaceutical design

Systems Pharmacology-based Drug Discovery and Active Mechanism of Ganoderma lucidum Triterpenoids for Type 2 Diabetes Mellitus by Integrating Network Pharmacology and Molecular Docking.

BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a chronic metabolic disease primarily characterized by insufficient insulin secretion or reduced insulin sensitivity in the body's cells, leading to persistently high blood glucose levels..

OncologyImmune supportEnergy & fatigue

Cordyceps · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Telomere-to-Telomere Assembly of the Cordyceps militaris CH1 Genome and Integrated Transcriptomic and Metabolomic Analyses Provide New Insights into Cordycepin Biosynthesis Under Light Stress.

Cordyceps militaris, a model species in the genus Cordyceps, is widely distributed globally and is known for its significant medicinal value. It has been traditionally used in Chinese medicine to enhance immunity, alleviate fatigue, and treat tumors, among other therapeutic purposes..

OncologyImmune supportLiver support

Chaga · 2025 · Journal Article · Bioscience, biotechnology, and biochemistry

The aqueous extracts of Inonotus obliquus (Chaga) augment host defense against Listeria monocytogenes infection.

Listeria monocytogenes, which grows in host cells intracellularly, is important as an opportunistic pathogen. Extracts of Chaga mushroom, Inonotus obliquus, have been shown to possess various biological activities.

Cordyceps · 2025 · Journal Article · Animal feed science and technology

The effects of dietary Cordyceps militaris substrate on growth, immunity, gonadal quality, and gut microbiota of the sea urchin Strongylocentrotus intermedius

Sea urchin Strongylocentrotus intermedius is a commercially valuable marine species in China. Cordyceps militaris culture (CMC), containing cordycepin, polysaccharides, cordycepic acid, amino acids, trace elements, and vitamins, was tested in varying concentrations (0.5 %, 1.0 %, and 1.5 %) in sea urchin feed to….

Immune supportGut & microbiomeLiver support

Cordyceps · 2025 · Journal Article · Journal of food science

The fermentation of Cordyceps militaris polysaccharide influenced gut bacterial LPS structure formation and changed its antigenicity.

Gut bacterial lipopolysaccharide (LPS) could be released into the circulatory system via the gut-liver axis and cause inflammatory immune response, while Cordyceps militaris polysaccharide (CMP40) has been reported to be effective in alleviating this inflammatory response..

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2025 · Research Article · Journal of microbiology and biotechnology

The Inhibitory Effects of Cordyceps militaris ARA301 Extract on Lipopolysaccharide-Induced Lung Injury in vivo.

Lung injury is a critical health concern associated with severe inflammatory responses and tissue damage that can weaken respiratory function and potentially become life-threatening in severe cases..

Immune supportMetabolic healthLiver support

Reishi · 2025 · Review · Food science & nutrition

The Nutritional Significance of Ganoderma lucidum on Human Health: A GRADE-Assessed Systematic Review and Meta-Analysis of Clinical Trials.

This study aimed to assess the impact of Ganoderma lucidum supplementation (200-11,200 mg/day, 1-24 weeks) on health-related indices in populations including healthy, at-risk, and chronic disease individuals..

OncologyImmune supportCognition & nerves

Reishi · 2025 · Research Article · Scientific reports

The protecting role of Ganoderma lucidum polysaccharides on the retinal neurovascular units in rats with retinal ischemia-reperfusion injury.

This study investigates the protective mechanisms of Ganoderma lucidum polysaccharides (GLP) on retinal neurovascular units (NVUs) in a rat model of retinal ischemia-reperfusion injury (RIR), focusing on oxidative stress, glial activation, vascular dysfunction, and functional recovery..

OncologyImmune supportMetabolic healthRespiratory

King Oyster · 2025 · Research Article · Pharmaceuticals (Basel, Switzerland)

Therapeutic Potential of Bioactive Compounds in Edible Mushroom-Derived Extracellular Vesicles: Isolation and Characterization of EVs from Pleurotus eryngii.

Background/Objectives: Over the past twenty years, there has been a rapid increase in studies aimed at comprehending how cells communicate with each other via Extracellular Vesicles (EVs), accompanied by a heightened interest in plant-derived extracellular vesicles due to their potential relevance in dietary….

Shiitake · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Transcriptomic analysis reveals cell wall polysaccharide metabolism associated with post-harvest softening in shiitake mushrooms (Lentinula edodes)

Shiitake mushrooms (Lentinula edodes) undergo rapid softening during postharvest storage, which reduces their texture, quality, and shelf life. To elucidate the underlying mechanisms, we examined cell wall polysaccharide metabolism during storage at 10 ± 0.5 °C..