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OncologyImmune supportEnergy & fatigueLiver support

Reishi · 2026 · Journal Article · Journal of ethnopharmacology

Protective effects of Ganoderma lucidum polysaccharide peptides against cisplatin-induced toxicity.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) has been used in traditional Chinese medicine for centuries to enhance vitality and support organ function.

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Structural characterization, lipid-lowering activity, and emulsifying properties of polysaccharides derived from wheat pericarp via Ganoderma lucidum solid-state fermentation.

The biotransformation of agricultural by-products through fungal solid-state fermentation (SSF) represents a sustainable and efficient strategy for enhancing the functional properties of plant polysaccharides..

Energy & fatigueMetabolic healthLiver support

Shiitake · 2026 · Research Article · Microbiology spectrum

The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid govern thermotolerance in Lentinula edodes mycelia subjected to heat stress.

Heat stress poses a significant constraint on the annual production of Lentinula edodes (L. edodes), a challenge that has been intensified by global warming.

Reishi · 2026 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Therapeutic potential of the medicinal mushroom Ganoderma lucidum in metabolic syndrome: Antioxidant, hypoglycemic, and hepatoprotective activities.

The objective of this study was to investigate the impact of Ganoderma lucidum mycelium on biochemical parameters altered in rats with fructose-induced metabolic syndrome..

Immune supportLiver supportRespiratory

Reishi · 2026 · Journal Article · Carbohydrate polymers

Virus-inspired Ganoderma lucidum polysaccharide-functionalized adjuvant with pseudo-zwitterionic interface for potentiated nasal immunization.

Intranasal vaccination is promising against respiratory infections but hindered by the mucus barrier. To overcome the adhesion-penetration dilemma, we developed a virus-inspired hybrid nanoparticle (GHNP) by functionalizing a cationic polymer/lipid core (HNP) with Ganoderma lucidum polysaccharide (GLP)..

Reishi · 2025 · Research Article · Frontiers in chemistry

A new lanostane-type triterpene with lipid-lowering activity from Ganoderma lucidum and an additional analogue.

Non-alcoholic fatty liver disease (NAFLD) represents a chronic liver disorder with widespread global prevalence, primarily attributed to hepatic lipid accumulation, oxidative stress, and inflammatory responses..

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Plant Foods Hum Nutr

Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice

The hepatoprotective effect of the alcoholic extracts of Ganoderma lucidum fermentation products (GFE) was investigated. C57BL/6 mice were pretreated with GFE for 7 days and then subjected to the chronic-binge ethanol feeding model..

OncologyImmune supportCognition & nervesLiver support

Zhu Ling · 2025 · Research Article · Computational and structural biotechnology journal

Anticancer effects and mechanisms of Pulsatilla chinensis, Bupleurum chinense and Polyporus umbellatus on human lung carcinoma and hepatoma cells.

Herbs are extensively utilized in Traditional Chinese Medicine (TCM) for lung and liver cancer treatment, but the mechanisms behind these herbs remain largely unknown. Here, high-throughput transcriptomic analysis technology was used to uncover molecular mechanisms of herbal treatment..

Immune supportEnergy & fatigueGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Association of α-Klotho with anti-aging effects of Ganoderma lucidum in animal models.

ETHNOPHARMACOLOGICAL RELEVANCE: Aging is a complex, universal process characterized by structural and functional decline across multiple organs. Ganoderma lucidum (G.

Metabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · Journal of ethnopharmacology

Betulinic acid from Inonotus obliquus ameliorates T2DM by modulating short-chain fatty acids producing bacteria and amino acids metabolism in db/db mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus has also been used as a traditional folk medicine in Europe and Northeastern China to treat metabolic diseases. Betulinic acid (BA) is a major ingredient with anti-diabetic property derived from I.

Immune supportEnergy & fatigueGut & microbiomeLiver support

Snow Fungus · 2025 · Journal Article · International journal of biological macromolecules

Biomacromolecular composite microspheres based on sodium alginate and tremella fuciformis polysaccharide for enhanced protection and delivery of camellia oil: A comprehensive study in simulated digestion.

This study presents the development of a novel polysaccharide biomolecule composite microsphere system based on sodium alginate (SA) and tremella fuciformis polysaccharide (TFP) for the encapsulation and controlled release of camellia oil (CO)..

Mesima · 2025 · Journal Article · Journal of photochemistry and photobiology. B, Biology

Biophysical effects of Phellinus Linteus on hepatocellular carcinoma cells studied by atomic force microscopy.

Precisely quantifying cancer cell morphology and physical properties is crucial for advancing cancer therapeutics, drug screening, and pharmacological assessment..

Immune supportEnergy & fatigueLiver support

Turkey Tail · 2025 · Research Article · International journal of molecular sciences

Biopolymers of Polycaprolactone Loaded with Caffeic Acid and Trametes versicolor Extract Induced Proliferation in Human Coronary Artery Endothelial Cells and Inhibited Platelet Activity.

In atherosclerosis, the proliferation and migration of endothelial and smooth muscle cells (SMCs) and platelet activation alter endothelial function. Naturally occurring substances, such as caffeic acid (CA) and Trametes versicolor extract (TvE), have medicinal properties and are traditionally used for their….

Energy & fatigueMetabolic healthLiver support

Reishi · 2025 · Research Article · International journal of food science

Characterisation and Hypolipidaemic Effects of Tlayudas, Widely Consumed Tortillas, Containing Ganoderma lucidum Extracts on an In Vivo Model of Hypercholesterolaemia.

Tlayudas, a variant of tortillas, are a highly consumed and low-cost traditional Mexican food, typical of the Oaxaca region. We developed new functional food products from tlayudas (T) containing standardised hydroalcoholic extracts (T + Gl-1 and T + Gl-2) of the medicinal mushroom Ganoderma lucidum (Gl) from Mexico..

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · Food Hydrocolloids

Co-microencapsulation of Lactobacillus paracasei and Inonotus obliquus polysaccharide in alginate system: Physicochemical and functional properties

In this study, sodium alginate (SA) was used as shell material, and Lactobacillus paracasei JY062/Inonotus obliquus polysaccharide (IOP) were used as core material (JY062-IOP/SA). The microcapsules were prepared by polymer gel technology and analyzed by SEM, FTIR, TGA and XRD..

Shiitake · 2025 · Journal Article · Biological & pharmaceutical bulletin

Continuous Ingestion of a Standardized Extract of Cultured Lentinula edodes Mycelia Suppresses Spontaneous Carcinogenesis in a Murine Model

AHCC®, a standardized extract of cultured Lentinula edodes mycelia, suppresses the proliferation of both cancer cell line-derived and patient-derived xenografts transplanted into mice. However, the mechanism of action underlying the suppressive effect of AHCC on spontaneous carcinogenesis remains unclear..

Chaga · 2025 · Research Article · Polymers

Design and Evaluation of a Inonotus obliquus-AgNP-Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential.

Inonotus obliquus, a medicinal mushroom valued for its bioactive compounds, has not been previously characterized from Romanian sources. This study presents the first comprehensive chemical and biological screening of I..

Shiitake · 2025 · Research Article · Frontiers in nutrition

Effect of soluble dietary fiber extracted from Lentinula edodes (Berk.) Pegler on lipid metabolism and liver protection in mice on high-fat diet.

With the increasing annual production of Lentinula edodes, the residues of Lentinus edodes are mass produced and wasted every year. In order to further explore the added value and effective utilization of Lentinus edodes, we studied the lipid-lowering efficacy and liver protective effect of Lentinus edodes soluble….

Yellow Morel · 2025 · Journal Article · International Journal of Biological Macromolecules

Exploring the mechanism of Morchella esculenta polysaccharides ameliorating liver lipid metabolism in high-fat diet mice by transcriptomics

This study isolated a high-molecular-weight Morchella esculenta polysaccharide (MEP-1), mainly composed of glucose with a triple-helix structure. MEP-1 alleviated high-fat diet (HFD)-induced hepatic lipid metabolic disorders and inflammation by significantly reducing the levels of TC, TG, LDL-C, TNF-α, IL-6, and….

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Exploring the mechanism of Morchella esculenta polysaccharides ameliorating liver lipid metabolism in high-fat diet mice by transcriptomics.

Enoki · 2025 · Research Article · Frontiers in nutrition

Flammulina velutipes mycorrhizae dietary fiber attenuates the development of obesity via regulating lipid metabolism in high-fat diet-induced obese mice.

INTRODUCTION: Mounting evidence has shown that Flammulina velutipes mycorrhizae dietary fiber (Fv-DF) has the potential to significantly improve health outcomes by addressing lipid metabolic disorders..

OncologyImmune supportEnergy & fatigueLiver support

Reishi · 2025 · Research Article · Molecules (Basel, Switzerland)

Ganoderma lucidum Glycoprotein Microemulsion: Improved Transdermal Delivery and Protective Efficacy in UV-Induced Cell and Animal Models.

BACKGROUND: Photoaging, induced by chronic ultraviolet (UV) exposure, is a multifactorial skin disorder characterized by oxidative stress, inflammation, and extracellular matrix degradation..

Immune supportEnergy & fatigueLiver supportSkin & hydration

Reishi · 2025 · Journal Article · Biomacromolecules

Ganoderma lucidum Polysaccharide/carboxymethyl Chitosan Hydrogels Modulate Macrophage Polarization for Wound Healing.

Wound healing remains a global challenge for clinical and experimental research. Hydrogels prepared from natural polysaccharides show great potential in the wound healing process..

Reishi · 2025 · Journal Article · Food Research International

Green tea fermented by Ganoderma lucidum presented anti-obesity properties via enhanced thermogenesis in vitro and on C57BL/6J mice

High-fat diets contribute to obesity and metabolic disorders. Ganoderma lucidum is renowned for its abundant bioactive compounds and diverse pharmacological effects.

Reishi · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Green tea fermented by Ganoderma lucidum presented anti-obesity properties via enhanced thermogenesis in vitro and on C57BL/6J mice.

High-fat diets contribute to obesity and metabolic disorders. Ganoderma lucidum is renowned for its abundant bioactive compounds and diverse pharmacological effects.

Yellow Morel · 2025 · Journal Article · International journal of biological macromolecules

Hepatoprotective effects of polysaccharide from Morchella esculenta are associated with activation of the AMPK/Sirt1 signaling pathway in mice with NAFLD.

The functional food application of edible fungus polysaccharides has been widely studied based on their variety of potential pharmacological activities. However, the hepatoprotective effects and mechanisms of Morchella esculenta polysaccharide against nonalcoholic fatty liver disease (NAFLD) remain unknown..

Metabolic healthGut & microbiomeLiver support

Lion's Mane · 2025 · Research Article · Foods (Basel, Switzerland)

Hericium erinaceus Protein Alleviates High-Fat Diet-Induced Hepatic Lipid Accumulation and Oxidative Stress In Vivo.

Dietary interventions with food-derived natural products have emerged as a promising strategy to alleviate obesity. This study aims to investigate the anti-obesity effect of Hericium erinaceus protein (HEP) and its underlying mechanism..

Immune supportGut & microbiomeLiver support

Reishi · 2025 · Journal Article · International journal of biological macromolecules

High molecular weight polysaccharides from Ganoderma lucidum attenuates inflammatory responses, gut microbiota, and liver metabolomic in lipopolysaccharide-induced liver injury mice.

High molecular weight polysaccharides (GLPH, ≥300 kDa) are the major compounds of Ganoderma lucidum with improving liver function. However, the effect of GLPH on improving acute liver injury (ALI) wasn't revealed..

Oyster Mushroom · 2025 · Research Article · Metabolites

In Vivo Effectiveness of Pleurotus ostreatus in Degradation of Toxic Metabolites of Filamentous Fungi Such as Aflatoxin B1 and Zearalenone.

BACKGROUND/OBJECTIVES: Mycotoxins, secondary metabolites synthesized by filamentous fungi, have been classified as dangerous substances and proven to be carcinogenic, as well as to have genotoxic, nephrotoxic, hepatotoxic, teratogenic, and mutagenic properties..

Liver support

OncologyImmune supportLiver support

Reishi · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of Ganoderma lucidum.

Ganoderma lucidum is a traditional Chinese medicinal fungus, and ganoderma triterpenoids (GTs) are one of the main bioactive compounds. These compounds have various pharmacological functions, including anti-tumor, antioxidant, anti-inflammatory, liver-protective, and immune-regulating effects..

Immune supportCognition & nervesLiver support

Reishi · 2025 · Research Article · Frontiers in pharmacology

Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer's disease.

BACKGROUND/OBJECTIVES: Although Alzheimer's disease (AD) is the most prevalent dementia in late life, with amyloid beta (Aβ) deposition and neuroinflammation are recognized among its primary pathological features. Currently, there is currently still a lack of effective therapeutic drugs for AD.

Turkey Tail · 2025 · Journal Article · Applied biochemistry and biotechnology

Investigation on the Detoxification of Indoxyl Sulfate (IS) and Indole-3-Acetic Acid (IAA) Protein-Bound Uremic Toxins (PBUTs) Using Trametes versicolor Biocompatible Laccase: In Situ Synchrotron Imaging, Experimental and Computational Studies.

The removal of protein-bound uremic toxins (PBUTs), such as indoxyl sulfate (IS) and indole-3-acetic acid (IAA), from hemodialysis (HD) patients remains a significant challenge due to their strong binding to serum proteins, such as albumin..

Liver support

OncologyEnergy & fatigueGut & microbiomeLiver support

Lion's Mane · 2025 · Research Article · Frontiers in fungal biology

LED light spectra influence the stimulation of mycelial growth and anticancer activity in Hericium erinaceus mycelium.

INTRODUCTION: Hericium erinaceus is a medicinal mushroom known for producing diverse bioactive metabolites with therapeutic potential. However, cultivation strategies aimed at enhancing both fungal yield and metabolite bioactivity, particularly through light-mediated physiological modulation, remain insufficiently….

Immune supportGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Food & function

Modification of Ganoderma lucidum spore shells into probiotic carriers: selective loading and colonic delivery of Lacticaseibacillus rhamnosus and effective therapy of inflammatory bowel disease.

Inflammatory bowel disease (IBD) is a chronic inflammation with a high incidence rate. Many probiotics, including Lacticaseibacillus rhamnosus (L.

Cordyceps · 2025 · Journal Article · Environmental toxicology

Modulatory Effects of Ophiocordyceps sinensis Mycelia on Hepatosteatosis Development in a High-Fat Dietary Habit.

The global rise in obesity is closely associated with the increasing prevalence of nonalcoholic fatty liver disease (NAFLD) and metabolic syndromes, posing significant health challenges..

Turkey Tail · 2025 · Journal Article · International journal of biological macromolecules

Myco-macromolecular symbiosis: Chitosan-folate ZnO nanoplatforms from Trametes versicolor for dual-functional oncological and antibacterial therapy.

The increasing prevalence of antibiotic-resistant bacteria and cancer necessitates the development of novel, targeted therapeutic strategies. This study aimed to develop a multifunctional nanoplatform combining antibacterial and anticancer properties through green synthesis and strategic surface functionalization..

OncologyImmune supportLiver supportSkin & hydration

Niu-Chang-Chih · 2025 · Research Article · International journal of molecular sciences

Natural Polysaccharide-Based Nanoparticles Enhance Intracellular Delivery and Cytotoxicity of Antrodia camphorata in Breast Cancer Cells.

Antrodia camphorata (AC), a medicinal fungus native to Taiwan, contains bioactive compounds such as triterpenoids with anticancer properties. However, their high lipophilicity results in poor aqueous solubility and limited bioavailability, restricting their therapeutic application..

Immune supportLiver support

Oyster Mushroom · 2025 · Journal Article · Chemistry & biodiversity

Optimization and Hepatoprotective Potential of Sulfated Polysaccharide From Pleurotus ostreatus.

In this study, we explored an efficient method for synthesizing sulfated Pleurotus ostreatus polysaccharides (SPOP) with a higher degree of substitution. The structure conformation was characterized and confirmed by the Fourier transform infrared (FT-IR) spectroscopy analysis..

Immune supportLiver supportRespiratory

Wood Ear · 2025 · Journal Article · International journal of biological macromolecules

Oral pharmacokinetics and tissue distribution of a homogeneous polysaccharide from Auricularia auricula-judae: dual-method validation of absorption and distribution.

Polysaccharides encounter significant challenges in vivo pharmacokinetic studies because of their complex structures and the limitations of current detection methods, thereby impeding their development and biomedical applications..

Snow Fungus · 2025 · Journal Article · Chemistry & biodiversity

Polysaccharides from Tremella Fuciformis Enhance Glucose and Lipid Metabolism in HepG2 Cells Through Activating the AMPK Signaling Pathway.

Polysaccharides have gained substantial attention for their diverse biological activities. The present study was conucted to elucidate the effects and molecular mechanisms of Tremella fuciformis-derived polysaccharides (PTP-3a) on glucose and lipid metabolism in palmitic acid (PA) - treated HepG2 cells..

Metabolic healthGut & microbiomeLiver support

Yellow Morel · 2025 · Journal Article · Food & function

Preparation of Morchella esculenta protein and its preventive effect on nonalcoholic fatty liver disease in mice.

Morchella esculenta is a valuable edible fungus with multidimensional bioactivities; however, research on M. esculenta protein and its beneficial effects on nonalcoholic fatty liver disease (NAFLD) have been limited.

Immune supportCognition & nervesGut & microbiomeLiver support

Lion's Mane · 2025 · Journal Article · International Journal of Biological Macromolecules

Recent insights into Hericium erinaceus polysaccharides: Gastrointestinal, gut microbiota, microbial metabolites, overall health and structure-function correlation

Hericium erinaceus polysaccharides (HEPs) have attracted significant interest due to their potential to support gastrointestinal health and modulate gut microbiota..

Immune supportGut & microbiomeLiver supportSkin & hydration

Snow Fungus · 2025 · Journal Article · Langmuir: the ACS journal of surfaces and colloids

Soy Protein Isolate/Tremella Fuciformis Polysaccharide Complex-Stabilized High Internal Phase Pickering Emulsions: Andrographolide Delivery, Digestive Behavior, and 3D Printability.

The development of advanced bioactive delivery systems is critical for enhancing nutraceutical stability, controlled release, and functional food design. This study presented the fabrication of high internal phase Pickering emulsions (HIPPEs) stabilized by soy protein isolate (SPI) and Tremella fuciformis….

Immune supportMetabolic healthGut & microbiomeLiver support

Enoki · 2025 · Research Article · Foods (Basel, Switzerland)

Structural Characterization of Polysaccharide from Flammulina velutipes and Its Impact on Hyperlipidemia Through Modulation of Hepatic Cholesterol Metabolism and Gut Microbiota.

FVPB1, a novel heteropolysaccharide, was extracted from the Flammulina velutipes fruiting body, and its structure was determined by methylation analysis, nuclear magnetic resonance (NMR) spectroscopy..

Energy & fatigueGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Surface-modifying Ganoderma lucidum spores as improved microcarriers in protein delivery

Bioactive proteins and peptides hold significant potential in the food industry, particularly for the development of functional foods and nutraceuticals. However, their effectiveness is often limited by poor oral bioavailability..

Immune supportEnergy & fatigueLiver support

Wood Ear · 2025 · Journal Article · International journal of medicinal mushrooms

The In Vitro and In Vivo Antioxidant Capacities of Auricularia auricula-judae (Agaricomycetes) Polysaccharides Prepared via Free Radical-Mediated Methods.

As a basidiomycete fungus, the cell wall of the Auricularia auricula-judae fruiting body is extremely tough and complex, making it difficult to extract the polysaccharides. In this study, A..

Immune supportLiver supportRespiratory

Reishi · 2025 · Research Article · Journal of advanced veterinary and animal research

The protective effects of Ganoderma lucidum polysaccharides on blood physiology, immune function, and organ architecture in growing stressed rabbits.

OBJECTIVE: This experiment explored the plausible effects of Ganoderma lucidum polysaccharides (GLP) to reduce the deterioration effects of heat stress (HS) in growing rabbits by studying blood physiology, growth, immunity, inflammation, and organ structure..

Oyster Mushroom · 2025 · Journal Article · International journal of radiation biology

The role of polysaccharide POM extracted from Pleurotus ostreatus in curbing and treating the harmful effects on liver and kidney resulting from radiation exposure.

PURPOSE: This research assesses the radioprotective and antioxidant activity of polysaccharide (POM) derived from Pleurotus ostreatus strain on rats suffering from metabolic problems due to irradiation..

Reishi · 2025 · Journal Article · Journal of ethnopharmacology

Triterpenes from Ganoderma lucidum inhibit hepatocellular carcinoma by regulating enhancer-associated lncRNA in vivo.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (G. lucidum) has been widely used as adjuvant of anti-tumor therapy for variety tumors.