MycoData

OncologyImmune supportLiver support

Mesima · 2022 · Randomized Controlled Trial · Medicine

Effects of Phellinus linteus extract on immunity improvement: A CONSORT-randomized, double-blinded, placebo-controlled trial.

BACKGROUND: Immunity protects the body from external threats and prevents the development of cancer. Biological response modifiers extracted from natural sources are being actively studied, and the immunostimulatory and anticancer effects of various types of fungi have been reported..

OncologyImmune supportLiver supportSkin & hydration

Reishi · 2022 · Review · Frontiers in pharmacology

Ganoderma lucidum: Current advancements of characteristic components and experimental progress in anti-liver fibrosis.

Ganoderma lucidum (G. lucidum, Lingzhi) is a well-known herbal medicine with a variety of pharmacological effects.

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2022 · Review · Frontiers in pharmacology

Ganoderma lucidum: Unutilized natural medicine and promising future solution to emerging diseases in Africa.

Ganoderma lucidum is a well-known medicinal mushroom that has been used for the prevention and treatment of different ailments to enhance longevity and health specifically in China, Japan, and Korea..

Shiitake · 2022 · Review · International journal of molecular sciences

Immunomodulatory Properties of Polysaccharides from Lentinula edodes.

Lentinula edodes (Berk.) Pegler, also known as shiitake mushroom, is a popular edible macrofungus and a source of numerous bioactive substances with multiple beneficial health effects. L..

Turkey Tail · 2022 · Review · Biomedicines

Polysaccharide-Peptide from Trametes versicolor: The Potential Medicine for Colorectal Cancer Treatment.

The incidence and mortality of colorectal cancer have shown an upward trend in the past decade. Therefore, the prevention, diagnosis, and treatment of colorectal cancer still need our continuous attention..

OncologyImmune supportLiver support

Shiitake · 2022 · Clinical Trial · Integrative cancer therapies

Preventing Recurrence of Hepatocellular Carcinoma After Curative Hepatectomy With Active Hexose-correlated Compound Derived From Lentinula edodes Mycelia.

PURPOSE: Active hexose-correlated compound (AHCC), a standardized extract of cultured Lentinula edodes mycelia, exerts antitumor effects through anti-inflammatory and immune-modulatory functions..

Cordyceps · 2022 · Review · Frontiers in nutrition

Structural Elucidation and Activities of Cordyceps militaris-Derived Polysaccharides: A Review.

Cordyceps militaris is a parasitic edible fungus and has been used as tonics for centuries. Polysaccharides are a major water-soluble component of C.

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2022 · Review · The American journal of Chinese medicine

The Pharmacological Rationales and Molecular Mechanisms of Ganoderma lucidum Polysaccharides for the Therapeutic Applications of Multiple Diseases.

As a versatile Chinese herb, Ganoderma lucidum (Leyss. ex Fr.) Karst (G.

Maitake · 2021 · Meta-Analysis · Journal of ethnopharmacology

Antitumor activities of Grifola frondosa (Maitake) polysaccharide: A meta-analysis based on preclinical evidence and quality assessment.

ETHNOPHARMACOLOGICAL RELEVANCE: The antitumor effects of Grifola frondosa/maitake polysaccharide (GFP) have been reported in many preclinical studies, especially in vivo experiments..

Maitake · 2021 · Review · Foods (Basel, Switzerland)

Bioactive Ingredients and Medicinal Values of Grifola frondosa (Maitake).

Grifola frondosa (G. frondosa), generally known as hen-of-the-woods or maitake in Japanese and hui-shu-hua in Chinese, is an edible mushroom with both nutritional and medicinal properties..

Mesima · 2021 · Clinical Trial Protocol · Trials

Clinical trial to analyze the effects of oral intake of Phellinus linteus (sanghuang) extract on immune function: a study protocol for a randomized, double-blind controlled trial.

BACKGROUND: As the population of Korea ages, interest in healthcare has increased. In particular, there is an increasing demand for immune-function improvement to prevent infectious diseases.

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2021 · Review · Phytotherapy research: PTR

Ganoderma lucidum (Reishi) an edible mushroom; a comprehensive and critical review of its nutritional, cosmeceutical, mycochemical, pharmacological, clinical, and toxicological properties.

Reishi owes an exceptional value in nutritional, cosmeceutical, and medical treatments; however, none of the studies has provided its future-driven critical assessment..

OncologyImmune supportMetabolic healthRespiratory

Cordyceps · 2021 · Review · Frontiers in bioengineering and biotechnology

New Insights Into the Biosynthesis of Typical Bioactive Components in the Traditional Chinese Medicinal Fungus Cordyceps militaris.

Cordyceps militaris, a traditional medicinal ingredient with a long history of application in China, is regarded as a high-value fungus due to its production of various bioactive ingredients with a wide range of pharmacological effects in clinical treatment..

OncologyImmune supportMetabolic healthRespiratory

Chaga · 2021 · Review · Polymers

Recent Developments in Inonotus obliquus (Chaga mushroom) Polysaccharides: Isolation, Structural Characteristics, Biological Activities and Application.

Inonotus obliquus (Chaga mushroom) is a kind of medicine and health food widely used by folk in China, Russia, Korea, and some occidental countries. Among the extracts from Inonotus obliquus, Inonotus obliquus polysaccharide (IOPS) is supposed to be one of the major bioactive components in Inonotus obliquus, which….

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2019 · Clinical Trial · Oxidative medicine and cellular longevity

Cordyceps militaris Improves Chronic Kidney Disease by Affecting TLR4/NF-κB Redox Signaling Pathway.

Cordyceps militaris may show good promise in protecting against chronic kidney disease (CKD) but the molecular mechanism remains unclear. CKD risk is associated with the Toll-like receptor 4/nuclear factor-kappa B (TLR4/NF-κB) signaling pathway..

OncologyImmune supportGut & microbiome

Shiitake · 2015 · Randomized Controlled Trial · Journal of the American College of Nutrition

Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults.

BACKGROUND: Mushrooms are widely cited for their medicinal qualities, yet very few human intervention studies have been done using contemporary guidelines. OBJECTIVE: The aim of this study was to determine whether consumption of whole, dried Lentinula edodes (shiitake) mushrooms could improve human immune function..

Almond Mushroom · 2012 · Randomized Controlled Trial · Scandinavian journal of immunology

Agaricus blazei Murrill and inflammatory mediators in elderly women: a randomized clinical trial.

There is scientific evidence to suggest that the medicinal mushroom Agaricus blazei Murrill (AbM) has immunomodulatory effects on cytokine synthesis, both in vitro and in vivo. This study was the first randomized, double-blind, placebo-controlled trial designed to investigate these purported actions in elderly women..

OncologyImmune supportCognition & nerves

Maitake · 2009 · Randomized Controlled Trial · Journal of cancer research and clinical oncology

A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects.

BACKGROUND: Cancer patients commonly use dietary supplements to "boost immune function". A polysaccharide extract from Grifola frondosa (Maitake extract) showed immunomodulatory effects in preclinical studies and therefore the potential for clinical use..

Reishi · 2017 · Systematic Review · International journal of medicinal mushrooms

The Efficacy and Toxicity of Using the Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Agaricomycetes), and Its Products in Chemotherapy (Review).

Around the world, cancer patients often combine conventional anticancer treatment with complementary alternative medicines derived from natural sources such as fungi and mushrooms, including the popular lingzhi or reishi medicinal mushroom Ganoderma lucidum..

OncologyImmune supportRespiratory

Cordyceps · 2025 · Journal Article · Plant science

Overexpression of Cordyceps militaris Cmcns1/cns2 gene to produce cordycepin results in increased resistance to Ralstonia solawacearum, Alternaria alternate and TMV in tobacco(Nicotiana tabacum L.)

Cordycepin (COR), the first nucleoside antibiotic isolated from fungi, exhibits antibacterial, antitumor, antiviral, and anti-inflammatory activities. In this study, we constructed a Cmcns1/cns2 fusion gene vector and transformed tobacco using Agrobacterium tumefaciens-mediated genetic transformation..

OncologyImmune supportRespiratory

Cordyceps · 2025 · Journal Article · Plant science: an international journal of experimental plant biology

Overexpression of Cordyceps militaris Cmcns1/cns2 gene to produce cordycepin results in increased resistance to Ralstonia solawacearum, Alternaria alternate and TMV in tobacco(Nicotiana tabacum L.).

OncologyImmune supportMetabolic healthLiver support

Reishi · 2025 · Journal Article · JPMA. The Journal of the Pakistan Medical Association

Therapeutic potential of Ganoderma lucidum/ Reishi mushroom.

Metadata-grounded summary: This journal article indexes research on Ganoderma lucidum in JPMA. The Journal of the Pakistan Medical Association in 2025.

Cordyceps · 2023 · Systematic Review · Frontiers in pharmacology

Efficacy and safety of Ophiocordyceps sinensis in the treatment of Hashimoto's thyroiditis: a systematic review and meta-analysis.

Objective: To evaluate the efficacy and safety of Ophiocordyceps sinensis (OS) preparations for the treatment of Hashimoto's thyroiditis (HT). Methods: We searched eight databases to collect randomized controlled trials (RCTs) of OS combined with a low-iodine diet or levothyroxine for HT..

OncologyImmune supportMetabolic healthLiver support

Mesima · 2023 · Systematic Review · International journal of biological macromolecules

Polysaccharides from Phellinus linteus: A systematic review of their extractions, purifications, structures and functions.

Phellinus linteus (P. linteus) is a famous Chinese medicine and has a long history in China.

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2023 · Systematic Review · Food & function

Therapeutic potential and nutritional significance of Ganoderma lucidum - a comprehensive review from 2010 to 2022.

With a long history in traditional Asian medicine, Ganoderma lucidum (G. lucidum) is a mushroom species suggested to improve health and extend life.

OncologyImmune supportLiver support

Reishi · 2026 · Review · Pharmaceuticals (Basel, Switzerland)

Anti-Inflammatory Potential of Ganoderma lucidum Triterpenes: A Systematic Review and Meta-Analysis of Preclinical Evidence.

Background: Ganoderma lucidum triterpenes are bioactive compounds with recognized anti-inflammatory, antitumor, and immunomodulatory properties. This systematic review synthesizes evidence regarding the anti-inflammatory activity of these triterpenes based on studies from the last two decades..

OncologyImmune supportGut & microbiome

Enoki · 2026 · Review · Journal of the science of food and agriculture

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review.

Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti-inflammatory, antitumor, immunomodulatory, and gut microbiota-regulating effects..

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2026 · Scoping Review · Chemistry & biodiversity

Hericenones From Hericium erinaceus (Bull.) Pers.: A Scoping Review of Structural Diversity and Health Benefits.

Hericium erinaceus (Bull.) Pers., an edible and medicinal mushroom, has garnered significant scientific interest due to its rich array of bioactive compounds. Extensive research has highlighted the pharmacological properties of its constituents, including neuroprotective, neurotrophic, immunomodulatory, and anticancer….

OncologyImmune supportLiver supportSkin & hydration

Reishi · 2026 · Review · Phytotherapy research: PTR

Unlocking the Therapeutic Potential of Ganoderma lucidum: From Bioactive Compounds to Clinical Translation.

Ganoderma lucidum, a revered medicinal mushroom with a rich history in traditional East Asian medicine, has garnered significant scientific attention for its diverse pharmacological properties..

OncologyImmune supportEnergy & fatigue

Reishi · 2025 · Review · Food science & nutrition

A Review of Bioactive Components and Pharmacological Effects of Ganoderma lucidum.

Ganoderma lucidum, a distinguished traditional medicinal herb, has long been recognized for its purported benefits in promoting physical well-being, enhancing stamina, and boosting vitality. However, the mechanistic underpinnings of its antitumor activities and other therapeutic effects remain incompletely understood..

Reishi · 2025 · Review · International journal of biological macromolecules

A review of polysaccharides from Ganoderma lucidum: Preparation methods, structural characteristics, bioactivities, structure-activity relationships and potential applications.

Ganoderma lucidum (G. lucidum), commonly known as "fairy grass", is a saprophyte fungus belonging to the Polyporaceae family with a lengthy history of use as a food ingredient and traditional medicine in China.

OncologyImmune supportMetabolic healthGut & microbiome

Lion's Mane · 2025 · Review · Frontiers in nutrition

Advances in the extraction, purification, structural characterization, and elucidation of the biological functions of polysaccharides from Hericium erinaceus.

Hericium erinaceus has a high food and ornamental value and considerable benefits upon consumption and in research. The high polysaccharide content in H.

OncologyImmune supportCognition & nervesGut & microbiome

Lion's Mane · 2025 · Review · International journal of biological macromolecules

Extraction, purification, structural characteristics, biological activities, modifications, and applications from Hericium erinaceus polysaccharides: A review.

Hericium erinaceus (Bull.) Pers. is a respected medicinal and edible fungus known for its outstanding nutritional profile.

OncologyImmune supportGut & microbiome

Shiitake · 2025 · Review · International journal of molecular sciences

Lentinula edodes as a Source of Bioactive Compounds with Therapeutical Potential in Intestinal Inflammation and Colorectal Cancer.

Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a rising global health issue. Chronic intestinal inflammation is an important risk factor for colorectal cancer (CRC)..

Reishi · 2025 · Review · Food science & nutrition

Potential Active Compounds of Ganoderma lucidum and Their Anticancer Effects: A Comprehensive Review.

The incidence and mortality rates of cancer patients continue to rise. Although many physical and chemical therapies, such as targeted tumor treatments, are effective against cancer, they are often associated with varying degrees of side effects..

OncologyImmune supportCognition & nervesMetabolic health

Snow Fungus · 2025 · Review · Journal of food science

Structure, Function and Application of Tremella Fuciformis Polysaccharide: A Review.

Tremella fuciformis (TF) is a valuable edible fungus rich in various nutrients, with TF polysaccharide (TFP) as its primary bioactive component. Extensive studies have demonstrated that TFP exhibits significant bioactivities, including antioxidant, antitumor, immunomodulatory, memory-enhancing, anti-inflammatory,….

OncologyImmune supportCognition & nerves

Reishi · 2025 · Review · Chinese herbal medicines

Unraveling bioactive potential and production in Ganoderma lucidum through omics and machine learning modeling.

Ganoderma lucidum, a medicinal mushroom renowned for its production of a diverse array of compounds, accounts for the pharmacological effects including anti-inflammatory, antioxidant, immunomodulatory, and anticancer characteristics..

OncologyImmune supportMetabolic healthGut & microbiome

Almond Mushroom · 2024 · Review · Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

[Research progress on structures, activities, and biosynthesis of blazeispirol compounds from Agaricus blazei].

Agaricus blazei is a rare medicinal and edible fungus with a crispy taste and delicious flavor. Both fruiting body and mycelium are rich in polysaccharides, sterols, terpenoids, peptides, lipids, polyphenols, and other active ingredients, which have strong pharmacological activities such as anti-tumor, lipid-lowering,….

OncologyImmune supportMetabolic healthRespiratory

Chaga · 2024 · Review · Fungal biology and biotechnology

A review on the cultivation, bioactive compounds, health-promoting factors and clinical trials of medicinal mushrooms Taiwanofungus camphoratus, Inonotus obliquus and Tropicoporus linteus.

Medicinal mushrooms, such as Taiwanofungus camphoratus, Inonotus obliquus, and Tropicoporus linteus, have been used in traditional medicine for therapeutic purposes and promotion of overall health in China and many East Asian countries for centuries..

OncologyImmune supportCognition & nervesMetabolic health

Reishi · 2024 · Review · Chinese herbal medicines

Bioactive components, pharmacological properties and underlying mechanism of Ganoderma lucidum spore oil: A review.

Ganoderma lucidum is a Chinese medicinal fungus with a long history of use in healthcare and disease treatment. G.

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2024 · Review · Heliyon

Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review.

Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. Its popularity as a dietary supplement, herbal remedy, and wellness product is steadily on the rise..

Turkey Tail · 2024 · Review · Steroids

Ergostanes from the mushroom Trametes versicolor and their cancer cell inhibition: In vitro and in silico evaluation.

In this study, five steroid compounds were isolated from the fruiting bodies mushroom Trametes versicolor. The compounds, 9,19-cyclolanostane-3,29-diol (3), ergosta-7,22-dien-3-acetate (4), and ergosta-8(14),22-dien-3β,5α,6β,7α-tetrol (5), were identified from T.

Oncology

Reishi · 2024 · Review · The Journal of pharmacy and pharmacology

Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection.

OBJECTIVES: Ganoderma lucidum (GL) is a white rot fungus widely used for its pharmacological properties and health benefits. GL consists of several biological components, including polysaccharides, sterols, and triterpenoids..

Reishi · 2024 · Review · Heliyon

Ganoderma lucidum: Insight into antimicrobial and antioxidant properties with development of secondary metabolites.

Ganoderma lucidum is a versatile mushroom. Polysaccharides and triterpenoids are the major bioactive compounds and have been used as traditional medicinal mushrooms since ancient times.

OncologyImmune supportMetabolic healthGut & microbiome

Mesima · 2024 · Review · International journal of biological macromolecules

Phellinus linteus polysaccharides: A review on their preparation, structure-activity relationships, and drug delivery systems.

Phellinus linteus polysaccharides exhibit antitumor, immunomodulatory, anti-inflammatory, and antioxidant properties, mitigate insulin resistance, and enhance the diversity and abundance of gut microbiota. However, the bioactivities of P..

OncologyImmune supportCognition & nervesLiver support

Reishi · 2024 · Review · Life (Basel, Switzerland)

Research Progress on the Biological Activity of Ganoderic Acids in Ganoderma lucidum over the Last Five Years.

Ganoderma lucidum (G. lucidum) is a traditional edible and medicinal mushroom in China.

OncologyImmune supportCognition & nervesSkin & hydration

Reishi · 2024 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Therapeutic potential of the medicinal mushroom Ganoderma lucidum against Alzheimer's disease.

Alzheimer's disease (AD) is a high-incidence neurodegenerative disorder, characterized by cognitive impairment, memory loss, and psychiatric abnormalities. Ganoderma lucidum is a famous medicinal fungus with a long history of dietary intake, containing various bioactive components, and have been documented to exhibit….

Cordyceps · 2024 · Review · Journal of integrative medicine

Cordyceps as potential therapeutic agents for atherosclerosis.

Atherosclerosis is a leading cause of mortality and morbidity worldwide. Despite the challenges in managing atherosclerosis, researchers continue to investigate new treatments and complementary therapies..