MycoData

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Enhanced production and anti-inflammatory activity of exopolysaccharides through the overexpression of β-1,3-glucanosyltransferase gene in Ganoderma lingzhi.

This study aimed to enhance the production and anti-inflammatory activity of exopolysaccharides (EPS) in Ganoderma lingzhi through genetic engineering. The β-1,3-glucanosyltransferase gene of the glycosyl-hydrolase 72 family was cloned and overexpressed in G.

Immune supportSkin & hydration

Shiitake · 2026 · Research Article · Diagnostics (Basel, Switzerland)

Flagellate Dermatitis Induced by Shiitake Mushrooms-Clinical Features of a Rare but Characteristic Entity.

We present the case of a 25-year-old male who attended a dermatological online consultation due to a whiplash-shaped, pruritic rash. The lesions in the form of well-demarcated linear erythematous papules, located mainly on the trunk and arms, had first appeared four days prior to the consultation..

OncologyImmune supportLiver support

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Ganoderma lingzhi Triterpenoids Ameliorate CCl4-Induced Acute Liver Injury in Mice.

The liver is a critical organ in drug metabolism and detoxification. Ganoderma lingzhi triterpenoids, a major class of bioactive compounds in G.

Chaga · 2026 · Research Article · Journal of Korean medical science

Kidney Injury Induced by High-Dose Chaga Mushroom Consumption: Experimental Evidence in a Rat Model.

BACKGROUND: Kidney damage can result not only from the overproduction of endogenous oxalate but also from excessive dietary intake. This study investigated whether oxalate-rich Chaga mushroom induces kidney injury..

Immune supportMetabolic healthGut & microbiome

King Oyster · 2026 · Journal Article · Food Hydrocolloids

Novel insights into selenium-biofortified P. eryngii polysaccharides: Unveiling selenium release patterns and gut microbiota modulation through in vitro models

Selenium biofortification of P. eryngii was achieved through exogenous selenium supplementation during cultivation, significantly increasing its selenium content.

Cordyceps · 2026 · Journal Article · Applied biochemistry and biotechnology

Quantitative Proteomics Analysis Insights into the Cordyceps Polysaccharides Biosynthesis.

Cordyceps polysaccharides, as bioactive macromolecules derived from Cordyceps sinensis, exhibit pharmacological activities such as immune modulation and anti-tumor properties. However, the understanding of their biosynthetic mechanisms remains limited..

Cordyceps · 2026 · Journal Article · Carbohydrate polymers

Structure characterization and in vitro immunomodulatory effects of a novel galactoglucomannan in cultivated Chinese cordyceps (Cordyceps sinensis).

Chinese cordyceps (Cordyceps sinensis) is a rare medicinal fungus with significant therapeutic value, and its cultivated variants have garnered increasing attention in recent years. However, detailed structural and functional insights into cultivated Chinese cordyceps (CCC) polysaccharides remain limited..

Immune supportMetabolic health

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Clerodendranthus spicatus-Cordyceps cicadae regulates mitophagy and protects renal tubular epithelial cells from hyperuricemic nephropathy.

ETHNOPHARMACOLOGICAL RELEVANCE: Clerodendranthus spicatus (CS) and Cordyceps cicadae (CC) are both medicine and food. They have long been used to treat kidney disease, but their mechanisms for treating hyperuricemic nephropathy (HN) are not yet clear..

Cordyceps · 2025 · Journal Article · Food Chemistry

Comprehensive identification and discovery of novel sterol compounds in Cordyceps sinensis and related species

Sterol compounds, including free sterols, steryl esters, and steryl glycosides, were comprehensively identified for the first time in Cordyceps sinensis, which is a common food and medicinal source in China, and its related species..

Cordyceps · 2025 · Journal Article · Food chemistry

Comprehensive identification and discovery of novel sterol compounds in Cordyceps sinensis and related species.

Enoki · 2025 · Journal Article · Food Research International

Contamination pathways of Listeria monocytogenes in Enoki mushrooms and their production environment at a commercial farm in South Korea

Listeria monocytogenes is a significant foodborne pathogen associated with high morbidity and mortality, particularly in immunocompromised populations. Contamination of Listeria monocytogenes in enoki mushrooms has led to multiple international outbreaks in recent years, yet the precise pathways of contamination….

Enoki · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Contamination pathways of Listeria monocytogenes in Enoki mushrooms and their production environment at a commercial farm in South Korea.

OncologyImmune supportEnergy & fatigueRespiratory

Cordyceps · 2025 · Research Article · Immunity, inflammation and disease

Cordyceps sinensis (CS) Alleviates Chronic Obstructive Pulmonary Disease Symptoms (COPD) by Targeting Inflammation, Apoptosis, and Oxidative Stress Through Ingredient-Gene-Disease Interaction.

OBJECTIVE: Cordyceps sinensis (CS) is a fungus that parasitizes the larvae and corpses of Batmadaceae insects. CS is used as a traditional Chinese medicine and has shown promising clinical efficacy in the treatment of chronic obstructive pulmonary disease (COPD)..

Cordyceps · 2025 · Research Article · Journal of inflammation research

Cordyceps Sinensis Reduces Inflammation and Protects BEAS-2B Cells From LPS-Induced THP-1 Cell Injury.

INTRODUCTION: Cordyceps sinensis, an entomogenous fungus with unique biological properties, has demonstrated significant anti-inflammatory potential. However, its effects on inflammation regulation need to be further investigated in detail..

Immune supportMetabolic health

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Decoding the difference of four species of Cordyceps based on polysaccharides and immunomodulation activity.

Nucleosides and polysaccharides are the main bioactive ingredients of Cordyceps genus. Nucleosides shows significant differences in different Cordyceps species.

Reishi · 2025 · Research Article · Microbial cell factories

Effect of different colloidal gold nanomaterials on Ganoderma lingzhi fermentation for production of ganoderma polysaccharide and triterpenoid through macroscopic and microscopic investigation.

Ganoderma lingzhi (G. lingzhi) is a Basidiomycete macrofungus valued for its secondary metabolites with pharmacological activity.

Immune supportRespiratory

Cordyceps · 2025 · Journal Article · Journal of ethnopharmacology

Fermented Cordyceps Powder alleviates silica-induced inflammation and fibrosis by inhibiting M1 macrophage polarization via the HMGB1-TLR4-NF-κB pathway.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps sinensis is a valuable Chinese medicine that has the effects of tonifying the lungs and kidneys, regulating the immune system, etc..

Nameko · 2025 · Research Article · Foods (Basel, Switzerland)

Impacts of Six Methods of Extraction on Physicochemical Properties, Structural Characteristics and Bioactivities of Polysaccharides from Pholiota nameko Residue.

By integrating waste valorization with green extraction, in the current study, the impacts of distinct extraction methods on the extraction yield, structural characterization, in vitro antioxidant abilities and in vitro immunomodulatory activity of polysaccharides from Pholiota nameko residue (PNRP) were determined,….

Immune supportMetabolic health

Reishi · 2025 · Journal Article · Journal of agricultural and food chemistry

Improved Production and Rheological Properties of Exopolysaccharides by Co-Overexpression of β-1,3-Glucan Synthase and UDP-Glucose Pyrophosphorylase Genes in Ganoderma lingzhi.

The β-1,3-glucan synthase gene 2 (gls2) from the biosynthetic pathway of polysaccharides was cloned and overexpressed in G. lingzhi.

Immune supportGut & microbiome

Cordyceps · 2025 · Journal Article · Life sciences in space research

Moxifloxacin plus Cordyceps polysaccharide ameliorate intestinal barrier damage due to abdominal infection via anti-inflammation and immune regulation under simulated microgravity.

BACKGROUND: Currently, there is limited research on the impact of abdominal infection on intestinal damage under microgravity conditions. Cordyceps polysaccharide (CPS), the main active ingredient of Cordyceps, has demonstrated various pharmacological effects, including anti-inflammatory, antioxidant, and….

Reishi · 2025 · Research Article · Integrative cancer therapies

Patients' Expectations and Barriers Toward Reishi Mushroom Use in Cancer Care: A Cross-Sectional Survey.

BACKGROUND: Reishi mushroom is one of the most commonly used supplements among cancer patients. However, limited data exists on why patients choose Reishi.

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Purification, structural characterization, and in vitro immunomodulatory activity of a low-molecular-weight polysaccharide from cultivated Chinese cordyceps.

Cultivated Chinese cordyceps, an optimal substitute for the endangered wild resource, has recently been produced on a large scale. This work sought to explore the structural features and immunomodulatory activity of a novel low-molecular-weight polysaccharide (CSP1a, 15.7 kDa) isolated from cultivated Chinese….

Immune supportCognition & nervesGut & microbiome

Shiitake · 2025 · Research Article · Nutrients

Shiitake Mushroom-Derived Vesicle-like Nanoparticles Improve Cognitive Function and Reshape Gut Microbiota and Fecal Metabolome in Aged Mice.

BACKGROUND/OBJECTIVES: Population aging and its associated chronic conditions have become an unprecedented challenge in the United States and worldwide. Many aged individuals experience certain forms of cognitive decline, which increases their risk of developing a pre-dementia condition called mild cognitive….

OncologyImmune supportEnergy & fatigue

Cordyceps · 2025 · Journal Article · International journal of biological macromolecules

Unleashing the power within: Enhancing hydrogel bio-mimetic polymer actuators (HBPA) through sodium alginate crosslinking with cordyceps polysaccharide (CO-PS).

Hydrogel crosslinking varies in properties and stability, with many physiochemical crosslinkers boosting hydrogel performance but raising issues about biotoxicity, sourcing, and compatibility..

Immune supportMetabolic healthLiver support

Cordyceps · 2025 · Journal Article · Journal of medicinal food

Wild Cordyceps Polysaccharides Alleviate Atherosclerosis by Attenuating Macrophage Cholesterol Accumulation Through the PPARγ-LXRα-ABCA1/ABCG1 Pathway.

Cordyceps has been clinically used to treat atherosclerosis (AS) since the 1980s. However, the active components responsible for its effects and the underlying mechanisms remain poorly understood.

Reishi · 2024 · Journal Article · Brazilian journal of biology = Revista brasleira de biologia

Adding-value to Ganoderma lingzhi by producing enzymes and antioxidant compounds under submerged fermentation using different culture media.

Ganoderma lingzhi is widely reported for its medicinal properties, presenting several bioactive substances with potential pharmaceutical and industrial application. This study aimed to evaluate the production of mycelial biomass, extracellular enzymes and antioxidant compounds by G..

Shiitake · 2024 · Research Article · Journal of fungi (Basel, Switzerland)

Chemical Composition, Antioxidant and Anti-Inflammatory Activity of Shiitake Mushrooms (Lentinus edodes).

Shiitake mushrooms (Lentinus edodes) are renowned as the "King of mountain treasures" in China due to their abundant nutritional and health-enhancing properties. Intensive chemical investigations of the fruiting bodies and mycelium of Shiitake mushrooms (Lentinus edodes) afforded five new compounds (1-5), named….

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2024 · Research Article · Journal of diabetes investigation

Cordyceps cicadae polysaccharides attenuate diabetic nephropathy via the miR-30a-3p/TRIM16 axis.

OBJECTIVE: The molecular mechanism of the protective effect of Cordyceps cicadae polysaccharides (CCPs) on renal tubulointerstitial fibrosis in diabetic nephropathy (DN) is still unclear. This study aims to further understand the molecular mechanisms behind the therapeutic benefits of CCP on diabetic nephropathy..

Immune supportMetabolic healthGut & microbiomeLiver support

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

Cordyceps polysaccharide improves polycystic ovary syndrome by inhibiting gut-derived LPS/TLR4 pathway to attenuates insulin resistance.

Polycystic ovary syndrome (PCOS) is an endocrine disorder marked by aberrant glucose metabolism and reproductive dysfunction. It is characterized by polycystic ovaries, ovulatory dysfunction, and hyperandrogenemia..

Maitake · 2024 · Journal Article · Basic & clinical pharmacology & toxicology

Ehrlich ascites carcinoma provokes renal toxicity and DNA injury in mice: Therapeutic impact of chitosan and maitake nanoparticles.

In this study, the impact of chitosan (CS) and maitake (GF) nanoparticles towards the renal toxicity induced by Ehrlich ascites carcinoma (EAC) in vivo model was conducted. Besides benchmark negative control group, EAC model was constructed by intraperitoneal injection (i.p.) of 2.5 × 106 cells..

Immune supportCognition & nervesMetabolic healthGut & microbiome

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

Exploratory studies of the antidepressant effect of Cordyceps sinensis polysaccharide and its potential mechanism.

Cordyceps sinensis, a traditionally prized medicinal fungus, contains polysaccharides as one of its main bioactive constituents, known for their significant immunomodulatory properties..

Immune supportEnergy & fatigueRespiratory

Cordyceps · 2024 · Journal Article · Journal of biomolecular structure & dynamics

In silico screening of potential inhibitors from Cordyceps species against SARS-CoV-2 main protease.

Coronavirus disease 2019 (COVID-19) is a result of a retroviral infection of SARS-CoV-2. Due to its virulence and high infection rate, it is a matter of serious concern and a global health emergency..

Immune supportMetabolic healthGut & microbiome

Maitake · 2024 · Journal Article · International journal of biological macromolecules

Metabolomic differences between non-hydrothermal treated water-soluble (WSPs) and hydrothermally treated water-insoluble (WIPs) Maitake polysaccharides fermented by Lactobacillus acidophilus and L. plantarum.

Bacterial Metabolite through a fermentation process is a growing trend and a promising alternative for use as functional components. Non-hydrothermal water-soluble (WSPs) and hydrothermally treated water-insoluble (WIPs) Maitake polysaccharides were fermented with Lactobacillus acidophilus (LA) and Lactobacillus….

Immune supportGut & microbiome

Maitake · 2024 · Research Article · PloS one

Positive modulation of a new reconstructed human gut microbiota by Maitake extract helpfully boosts the intestinal environment in vitro.

The human gut is a complex environment where the microbiota and its metabolites play a crucial role in the maintenance of a healthy state. The aim of the present work is the reconstruction of a new in vitro minimal human gut microbiota resembling the microbe-microbe networking comprising the principal phyla….

Immune supportEnergy & fatigueMetabolic health

Shiitake · 2024 · Research Article · Frontiers in veterinary science

Shiitake mushroom powder supplementation increase antioxidative activity in dogs.

INTRODUCTION: The prevalence of age-related diseases, including obesity (a lipid metabolism disorder), increases with the increase in a dog's lifespan. Most of age-related diseases are associated with oxidative stress by excessive production of reactive oxygen species (ROS) from impaired mitochondrial functions..

Cordyceps · 2023 · Review · Current opinion in biotechnology

Functional genomics and systems biology of Cordyceps species for biotechnological applications.

The use of Cordyceps species for the manufacture of natural products has been established; however, the tremendous advances observed in recent years in genetic engineering and molecular biology have revolutionized the optimization of Cordyceps as cell factories and drastically expanded the biotechnological potential….

Immune supportCognition & nervesEnergy & fatigue

Cordyceps · 2023 · Review · Nutrients

Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents.

Cordyceps, also known as "zombie fungus", is a non-poisonous mushroom that parasitizes insects for growth and development by manipulating the host system in a way that makes the victim behave like a "zombie". These species produce promising bioactive metabolites, like adenosine, β-glucans, cordycepin, and ergosterol..

Cordyceps · 2022 · Review · Molecules (Basel, Switzerland)

Chinese Cordyceps: Bioactive Components, Antitumor Effects and Underlying Mechanism-A Review.

Chinese Cordyceps is a valuable source of natural products with various therapeutic effects. It is rich in various active components, of which adenosine, cordycepin and polysaccharides have been confirmed with significant immunomodulatory and antitumor functions..

OncologyImmune supportCognition & nervesMetabolic health

Cordyceps · 2022 · Review · Frontiers in pharmacology

Mechanism of Cordyceps sinensis and its Extracts in the Treatment of Diabetic Kidney Disease: A Review.

Diabetic kidney disease (DKD) is the major reason of chronic kidney disease (CKD)-caused end-stage renal failure (ESRF), and leads to high mortality worldwide. At present, the treatment of DKD is mainly focused on controlling the hyperglycemia, proteinuria, and hypertension, but is insufficient on the effective delay….

Cordyceps · 2022 · Review · Microorganisms

Metabolites and Their Bioactivities from the Genus Cordyceps.

The Cordyceps genus is a group of ascomycete parasitic fungi, and all known species of this genus are endoparasites; they mainly feed on insects or arthropods and a few feed on other fungi..

OncologyImmune supportLiver support

Cordyceps · 2022 · Review · Frontiers in pharmacology

Potential Therapeutic Strategies for Renal Fibrosis: Cordyceps and Related Products.

At present, there is no effective drug for the treatment of renal fibrosis; in particular, a safe and effective treatment for renal fibrosis should be established..

Oyster Mushroom · 2021 · Review · International journal of biological macromolecules

Promising anticancer activity of polysaccharides and other macromolecules derived from oyster mushroom (Pleurotus sp.): An updated review.

Cancer dominates among many causes of mortality worldwide. Traditional chemotherapeutic agents are powerful anti-cancer agents employed for treatment of this deadly disease.

OncologyImmune supportCognition & nervesMetabolic health

Cordyceps · 2021 · Review · Medicinal chemistry (Shariqah (United Arab Emirates))

Prospects for Discovering the Secondary Metabolites of Cordyceps Sensu Lato by the Integrated Strategy.

BACKGROUND: Some species of Cordyceps sensu lato are famous Chinese herbs with significant biological activities, often used as edible food and traditional medicine in China..

Immune supportSkin & hydration

Shiitake · 2020 · Journal Article · European journal of plant pathology

Physiological and histological aspects of innate and shiitake-induced resistance against bacterial spot on tomatoes

This study aimed to evaluate the protective effects conferred by polysaccharides obtained from basidiocarps discarded from the commercial production of Lentinula edodes (shiitake mushroom) in tomato cultivars against bacterial spot disease and to study their mode of action..

OncologyImmune supportGut & microbiomeLiver support

Mesima · 2020 · Research Article · International journal of molecular sciences

The Biofunctional Effects of Mesima as a Radiosensitizer for Hepatocellular Carcinoma.

The tropical basidiomycete fungus Phellinus linteus (Mesima) exhibits anti-tumor, anti-angiogenic, and immunomodulatory properties in various cancers including prostate, colon, and lung cancer along with melanoma by, for example, inducing apoptosis or cell cycle arrest..

Immune supportGut & microbiome

Chaga · 2018 · Journal Article · International immunopharmacology

The mast cell stabilizing activity of Chaga mushroom critical for its therapeutic effect on food allergy is derived from inotodiol.

While an anti-allergic effect of Chaga mushroom (Inonotus obliquus) has been indicated, its therapeutic effect on allergy and immunoregulatory mechanisms and chemical constituents directly responsible for that are hardly known..

Immune supportEnergy & fatigue

Oyster Mushroom · 2018 · Research Article · AMB Express

The use of fermented buckwheat to produce L-carnitine enriched oyster mushroom.

L-Carnitine is an essential compound that shuttles long chain fatty acids into mitochondria. The objective of this study was to produce L-carnitine enriched oyster mushroom (Pleurotus ostreatus) using common buckwheat fermented by Rhizopus oligosporus..

OncologyImmune supportEnergy & fatigue

Cordyceps · 2017 · Research Article · PloS one

Isolation, Culture and Characterization of Hirsutella sinensis Mycelium from Caterpillar Fungus Fruiting Body.

The caterpillar fungus Ophiocordyceps sinensis (previously called Cordyceps sinensis) has been used for centuries in Asia as a tonic to improve health and longevity. Recent studies show that O..

Maitake · 2016 · Journal Article · International journal of medicinal mushrooms

Characterization of Cross-Flow Ultrafiltration Fractions from Maitake Medicinal Mushroom, Grifoia frondosa (Agaricomycetes), Reveals Distinct Cytotoxicity in Tumor Cells.

β-glucans from Basidiomycetes like Grifola frondosa (the maitake mushroom) are well known for their health benefits. Polysaccharide preparations from medicinal mushrooms such as G.