MycoData

Maitake · 2021 · Review · Molecules (Basel, Switzerland)

Mycomedicine: A Unique Class of Natural Products with Potent Anti-tumour Bioactivities.

Mycomedicine is a unique class of natural medicine that has been widely used in Asian countries for thousands of years. Modern mycomedicine consists of fruiting bodies, spores, or other tissues of medicinal fungi, as well as bioactive components extracted from them, including polysaccharides and, triterpenoids, etc..

Maitake · 2021 · Review · Molecules (Basel, Switzerland)

Proteomic Research on the Antitumor Properties of Medicinal Mushrooms.

Medicinal mushrooms are increasingly being recognized as an important therapeutic modality in complementary oncology. Until now, more than 800 mushroom species have been known to possess significant pharmacological properties, of which antitumor and immunomodulatory properties have been the most researched..

OncologyImmune supportCognition & nerves

Lion's Mane · 2021 · Review · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Therapeutic applications of mushrooms and their biomolecules along with a glimpse of in silico approach in neurodegenerative diseases.

Neurodegenerative diseases (NDs) represent a common neurological pathology that determines a progressive deterioration of the brain or the nervous system. For treating NDs, comprehensive and alternative medicines have attracted scientific researchers' attention recently..

OncologyEnergy & fatigueMetabolic healthGut & microbiome

Chaga · 2020 · Journal Article · Journal of food science

Antioxidant, α-amylase and α-glucosidase activity of various solvent fractions of I. obliquus and the preventive role of active fraction against H2 O2 induced damage in hepatic L02 cells as fungisome.

Inonotus obliquus is a traditional mushroom well known for its therapeutic value. In this study, various solvent fractions of I.

OncologyImmune supportGut & microbiome

Mesima · 2020 · Journal Article · Journal of medicinal food

Dietary Mixed Cereal Grains Ameliorate the Azoxymethane and Dextran Sodium Sulfate-Induced Colonic Carcinogenesis in C57BL/6J Mice.

The chemopreventive effects of various mixed cereal grain (MCG) samples on azoxymethane (AOM, 10 mg/kg) and dextran sulfate sodium (DSS, 0.02 g/mL)-induced colorectal cancer (CRC) in C57BL/6J mice were studied..

Turkey Tail · 2019 · Research Article · Molecules (Basel, Switzerland)

Microbial Asymmetric Functionalization of β-Cyclocitral-Derived Tetramethyl-Substituted γ-Lactone.

Searching for the new anticancer compounds we prepared three new β-cyclocitral-derived hydroxyl-γ-lactones by microbial hydroxylation of tetramethyl-substituted bicyclic γ-lactone. The substrate was transformed by the enzymatic system of filamentous fungi..

Shiitake · 2016 · Journal Article · Oncology letters

In vitro antitumor activity of Latcripin-15 regulator of chromosome condensation 1 domain protein.

Cancer is one of the most significant health problems worldwide and thus the development of novel therapeutic agents with fewer side effects is required. The present study investigated the in vitro anticancer effects of a newly isolated fungal protein..

OncologyRespiratory

Chaga · 2014 · Case Reports · Clinical nephrology

Chaga mushroom-induced oxalate nephropathy.

Chaga mushrooms have been used in folk and botanical medicine as a remedy for cancer, gastritis, ulcers, and tuberculosis of the bones. A 72-year-old Japanese female had been diagnosed with liver cancer 1 year prior to presenting at our department.

OncologyLiver support

Niu-Chang-Chih · 2014 · Randomized Controlled Trial · Nutrition research (New York, N.Y.)

Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer.

Natural products, such as fermented soybeans, have been used to treat various physical conditions, including cancer. MB-6 is a botanical preparation composed of fermented soybean extract, green tea extract, Antrodia camphorata mycelia, spirulina, grape seed extract, and curcumin extract..

OncologyGut & microbiome

Maitake · 2013 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Genes related to suppression of malignant phenotype induced by Maitake D-Fraction in breast cancer cells.

It is already known that the Maitake (D-Fraction) mushroom is involved in stimulating the immune system and activating certain cells that attack cancer, including macrophages, T-cells, and natural killer cells. According to the U.S..

OncologyImmune supportEnergy & fatigue

Maitake · 2011 · Research Support, Non U.S. Gov'T · Journal of medicinal food

Maitake (D fraction) mushroom extract induces apoptosis in breast cancer cells by BAK-1 gene activation.

For many years mushrooms have been used empirically in traditional medicine to treat several diseases. Study of the maitake mushroom, with its immunomodulatory and antitumoral properties, has led to the isolation of several bioactive compounds.

Maitake · 2009 · Patent · journal metadata

LOW-MOLECULAR-WEIGHT SUBSTANCE DERIVED FROM MAITAKE MUSHROOM AND HAVING IMMUNOSTIMULATING ACTIVITY AND ANTI-TUMOR ACTIVITY

Disclosed is a substance derived from a Maitake mushroom, which has a lower molecular weight compared with those of conventional saccharide-protein complexes and a different structure from those of the conventional saccharide-protein complexes, and also has a high immunostimulating activity and a high anti-tumor….

OncologyCognition & nervesEnergy & fatigue

Almond Mushroom · 2026 · English Abstract · Nan fang yi ke da xue xue bao = Journal of Southern Medical University

[Diffusion cycle-consistent generative adversarial networks for pelvic active bone marrow segmentation].

OBJECTIVES: To establish a pelvic active bone marrow (ABM) segmentation method based on diffusion cycle-consistent generative adversarial networks for improving individualized precision of conventional anatomical atlas-based methods..

Almond Mushroom · 2025 · English Abstract · Gan to kagaku ryoho. Cancer & chemotherapy

[The Efficacy of CDK4/6 Inhibitors as Late Therapy in Patients Treated with Palbociclib and Abemaciclib Two Sequentially].

The combination of endocrine therapy and cyclin-dependent kinase 4/6 inhibitor(CDK4/6 inhibitor)is recommended as primary treatment for hormone receptor-positive HER2-negative metastatic or recurrent breast cancer..

OncologyImmune supportEnergy & fatigue

Almond Mushroom · 2025 · Research Support, Non U.S. Gov'T · Acta biomaterialia

Dual-targeting Aggregation-induced emission polymer micelles mediate immunogenic sonodynamic therapy for Tumor cell growth inhibition and macrophage reprogramming.

Sonodynamic therapy (SDT) is a promising cancer treatment known for its deep tumor penetration and high efficacy. However, developing highly efficient sonosensitizers remains a significant challenge..

Almond Mushroom · 2025 · Research Support, Non U.S. Gov'T · Bioconjugate chemistry

Preclinical Evaluation of an Integrin αvβ6-Targeted Photodynamic Therapy.

Photodynamic therapy (PDT) is a minimally invasive treatment in which an external light source activates an injected photosensitizer (PS) to generate reactive oxygen species, causing localized cell death..

Almond Mushroom · 2024 · Research Support, Non U.S. Gov'T · The international journal of biochemistry & cell biology

Abemaciclib-induced epithelial-mesenchymal transition mediated by cyclin-dependent kinase 4/6 independent of cell cycle arrest pathway.

Abemaciclib (ABM), a cyclin-dependent kinase 4/6 inhibitor, shows pharmacological effects in cell cycle arrest. Epithelial-mesenchymal transition is an important cellular event associated with pathophysiological states such as organ fibrosis and cancer progression..

Almond Mushroom · 2024 · Research Support, Non U.S. Gov'T · Technology in cancer research & treatment

Dose-Volume Parameters of Spared Magnetic Resonance Imaging-Defined Active Bone Marrow Predict Hematologic Toxicity in Pelvic Malignancies Patients Undergoing Radiotherapy: A Cohort Study.

Background: The objective of this investigation is to evaluate the superiority of dose-volume parameters relying on magnetic resonance imaging (MRI)-defined active bone marrow (ABM) over those based on total bone marrow (TBM) contoured via CT in the prediction of hematologic toxicity (HT) occurrence among patients….

Almond Mushroom · 2023 · Journal Article · The international journal of biostatistics

Agent based modeling in health care economics: examples in the field of thyroid cancer.

Although they remain little used in the field of Health Care Economics, Agent Based Models (ABM) are potentially powerful decision-making tools that open up great prospects. The reasons for this lack of popularity are essentially to be found in a methodology that should be further clarified..

Almond Mushroom · 2023 · Research Article · Bulletin of mathematical biology

Connecting Agent-Based Models with High-Dimensional Parameter Spaces to Multidimensional Data Using SMoRe ParS: A Surrogate Modeling Approach.

Across a broad range of disciplines, agent-based models (ABMs) are increasingly utilized for replicating, predicting, and understanding complex systems and their emergent behavior..

Almond Mushroom · 2023 · Journal Article · International journal for numerical methods in biomedical engineering

Development and application of an agent-based model for the simulation of the extravasation process of circulating tumor cells.

The primary cause for cancer-related death is metastasis, and although this phenomenon is the hallmark of cancer, it remains poorly understood. Since studies on the underlying mechanisms are still demanding by experimental means prognostic tools based on computer models can be of great value, not only for elucidating….

Almond Mushroom · 2023 · Research Article · Therapeutics and clinical risk management

Economic Evaluation for Palbociclib Plus Fulvestrant vs Ribociclib Plus Fulvestrant and Abemaciclib Plus Fulvestrant in Endocrine-Resistant Advanced or Metastatic Breast Cancer in Italy.

BACKGROUND: To date, no study evaluated the cost-effectiveness of palbociclib (PAL) plus fulvestrant (FUL) vs ribociclib (RIB) plus FUL and abemaciclib (ABM) plus FUL in Italy..

OncologyCognition & nervesRespiratory

Almond Mushroom · 2023 · Research Article · Journal of neuro-oncology

Generation of patient-derived pediatric pilocytic astrocytoma in-vitro models using SV40 large T: evaluation of a modeling workflow.

PURPOSE: Although pediatric low-grade gliomas (pLGG) are the most common pediatric brain tumors, patient-derived cell lines reflecting pLGG biology in culture are scarce. This also applies to the most common pLGG subtype pilocytic astrocytoma (PA)..

OncologyImmune supportGut & microbiome

Maitake · 2023 · Research Article · Pharmaceuticals (Basel, Switzerland)

Influences of Yogurt with Functional Ingredients from Various Sources That Help Treat Leaky Gut on Intestinal Barrier Dysfunction in Caco-2 Cells.

The impact of yogurts made with starter culture bacteria (L. bulgaricus and S.

Almond Mushroom · 2023 · Research Article · Acta orthopaedica

Major surgery for metastatic bone disease is not a risk for 30-day mortality: a population-based study from Denmark.

BACKGROUND AND PURPOSE: Surgery for bone metastases in the appendicular skeleton (aBM) is a trade-off between limb function and survival. A previous study from a highly specialized center found that extended surgery is not a risk for 30-day mortality and hypothesized that wide resection and reconstruction might reduce….

OncologyImmune supportEnergy & fatigueSkin & hydration

Reishi · 2023 · Journal Article · The Gulf journal of oncology

Oral Intake of Combined Natural Immunostimulants Suppresses the 7,12-DMBA/ Croton Oil Induced Two-step Skin Carcinogenesis in Swiss Albino Mice.

BACKGROUND: The immune system is critical in fighting cancer, so is it possible that the natural stimulation of this system can slow down or stop the evolution of cancer?.

Almond Mushroom · 2023 · Journal Article · Environmental toxicology and pharmacology

Synergetic effects of polyethylene microplastic and abamectin pesticides on the eyes of zebrafish larvae and adults through activation of apoptosis signaling pathways.

Although the toxicity of microplastics (MPs) and pesticides has recently been described, the possible effects of combining these pollutants are poorly understood. Thus, we evaluated the potential impact of exposure to polyethylene MP (PE-MP) and abamectin (ABM) (alone and combined) in zebrafish..

OncologyImmune supportCognition & nervesMetabolic health

Almond Mushroom · 2023 · Research Article · Environmental science and pollution research international

The potential effect of Moringa oleifera ethanolic leaf extract against oxidative stress, immune response disruption induced by abamectin exposure in Oreochromis niloticus.

Abamectin (ABM), a naturally fermented product of Streptomyces avermitilis, is applied to pest control in livestock and agriculture fields. The aim of the current study is to evaluate the protective effects of Moringa oleifera leaf ethanolic extract (MOE) on biochemical changes including oxidative stress indices,….

Almond Mushroom · 2022 · Research Article · Pharmaceutics

A Comparison of Evans Blue and 4-(p-Iodophenyl)butyryl Albumin Binding Moieties on an Integrin αvβ6 Binding Peptide.

Serum albumin binding moieties (ABMs) such as the Evans blue (EB) dye fragment and the 4-(p-iodophenyl)butyryl (IP) have been used to improve the pharmacokinetic profile of many radiopharmaceuticals..

OncologyLiver support

OncologyImmune supportRespiratory

Almond Mushroom · 2022 · Journal Article · Iranian journal of allergy, asthma, and immunology

Agent-based Modeling of Tumor and Immune System Interactions in Combinational Therapy with Low-dose 5-fluorouracil and Dendritic Cell Vaccine in Melanoma B16F10.

This study is designed to present an agent-based model (ABM) to simulate the interactions between tumor cells and the immune system in the melanoma model. The Myeloid-derived Suppressor Cells (MDSCs) and dendritic cells (DCs) are considered in this model as immunosuppressive and antigen-presenting agents respectively..

OncologyImmune supportRespiratory

Almond Mushroom · 2022 · Research Article · International journal of molecular sciences

An Agent-Based Model of Radiation-Induced Lung Fibrosis.

Early- and late-phase radiation-induced lung injuries, namely pneumonitis and lung fibrosis (RILF), severely constrain the maximum dose and irradiated volume in thoracic radiotherapy..

OncologyCognition & nerves

Almond Mushroom · 2022 · Research Article · Journal of radiosurgery and SBRT

Discovery of increased number or interval growth of brain metastases on same-day GammaKnife™ planning MRI: Predicting factors and patient outcomes.

PURPOSE: To determine factors associated with increased risk of finding new and/or enlarged brain metastases (BM) on GammaKnife™ (GK) MRI and their impact on patient outcomes. RESULTS: 43.9% of patients showed BM growth, 32.9% had additional brain metastases (aBM), and 18.1 % had both..

Almond Mushroom · 2022 · Research Article · Radiation oncology (London, England)

Dosimetric evaluation of bone marrow sparing in proton radiotherapy for cervical cancer guided by MR functional imaging.

BACKGROUND: To segment the pelvic active bone marrow (PABM) using magnetic resonance (MR) functional imaging and investigate the feasibility and dosimetric characteristics of cervical cancer proton radiotherapy for active bone marrow (ABM) sparing..

OncologyLiver supportSkin & hydration

Almond Mushroom · 2022 · Research Article · Pest management science

Enhanced and sustained pesticidal activity of a graphene-based pesticide delivery system against the diamondback moth Plutella xylostella.

BACKGROUND: Traditional abamectin (Abm) formulations have several shortcomings, such as low water solubility, burst release behavior, poor photostability, and short persistence periods, which decrease their pesticidal activity and the risks they pose to the environment..

OncologyImmune supportCognition & nervesLiver support

Reishi · 2022 · Journal Article · PloS one

Ganoderma tsugae prevents cognitive impairment and attenuates oxidative damage in d-galactose-induced aging in the rat brain.

Lingzhi has long been regarded as having life-prolonging effects. Research in recent years has also reported that Lingzhi possesses anti-tumor, anti-inflammatory, immunomodulatory, hepatoprotective, and anti-lipogenic effects..

Almond Mushroom · 2022 · Journal Article · Environmental toxicology

Investigation of the effects of hesperidin administration on abamectin-induced testicular toxicity in rats through oxidative stress, endoplasmic reticulum stress, inflammation, apoptosis, autophagy, and JAK2/STAT3 pathways.

In this study, the potential effects of hesperidin (HES) on chronic toxicity caused by abamectin (ABM) in the testicular tissue were investigated through oxidative stress, inflammation, endoplasmic reticulum stress (ERS), apoptosis, and autophagy pathways. Male Sprague Dawley rats were used in the study..

Almond Mushroom · 2022 · Research Article · Cancers

Surgical Treatment of Metastatic Bone Disease in the Appendicular Skeleton: A Population-Based Study.

Background: Population-based studies of patients with bone metastases in the appendicular skeleton (aBM) requiring surgery for complete or impending fracture are rare..

Almond Mushroom · 2021 · Journal Article · Chaos (Woodbury, N.Y.)

Agent-based modeling: Population limits and large timescales.

Modeling, simulation, and analysis of interacting agent systems is a broad field of research, with existing approaches reaching from informal descriptions of interaction dynamics to more formal, mathematical models..

OncologyImmune supportCognition & nervesRespiratory

Almond Mushroom · 2021 · Journal Article · Cancers

An Agent-Based Model of Combination Oncolytic Viral Therapy and Anti-PD-1 Immunotherapy Reveals the Importance of Spatial Location When Treating Glioblastoma.

Oncolytic viral therapies and immunotherapies are of growing clinical interest due to their selectivity for tumor cells over healthy cells and their immunostimulatory properties..

OncologyEnergy & fatigueSkin & hydration

Almond Mushroom · 2021 · Journal Article · Frontiers in bioengineering and biotechnology

An in-silico Investigation Into the Role of Strain and Structure on Vascular Smooth Muscle Cell Growth.

The orientation of vascular cells can greatly influence the in vivo mechanical properties and functionality of soft vascular tissues. How cell orientation mediates the growth response of cells is of critical importance in understanding the response of soft tissues to mechanical stimuli or injury..

OncologyEnergy & fatigueLiver supportRespiratory

Oyster Mushroom · 2021 · Journal Article · Journal of fungi (Basel, Switzerland)

Antiviral, Cytotoxic, and Antioxidant Activities of Three Edible Agaricomycetes Mushrooms: Pleurotus columbinus, Pleurotus sajor-caju, and Agaricus bisporus.

In this study, we investigated aqueous extracts of three edible mushrooms: Agaricus bisporus (white button mushroom), Pleurotus columbinus (oyster mushroom), and Pleurotus sajor-caju (grey oyster mushroom)..

Almond Mushroom · 2021 · Research Article · BMC musculoskeletal disorders

Comparison of three treatment methods for simple bone cyst in children.

BACKGROUND: The unicameral bone cyst (UBC) is a kind of benign tumor whose clinical treatments and efficacy are controversial. The purpose of this study was to evaluate the efficacy of the elastic stable intramedullary nail (ESIN), the injection of autologous bone marrow (ABM), and the combination of ESIN and ABM in….

OncologyImmune supportEnergy & fatigue

Cordyceps · 2021 · Journal Article · The American journal of Chinese medicine

Cordycepin Attenuates Palmitic Acid-Induced Inflammation and Apoptosis of Vascular Endothelial Cells through Mediating PI3K/Akt/eNOS Signaling Pathway.

A well-known medicinal mushroom in the field of traditional Chinese medicine, Cordyceps sinensis, is a rare natural-occurring entomopathogenic fungus, and it typically grows at high altitudes on the plateau of the Himalayan..

Almond Mushroom · 2021 · Journal Article · Molecular pharmaceutics

Evaluation of Copper-64-Labeled αvβ6-Targeting Peptides: Addition of an Albumin Binding Moiety to Improve Pharmacokinetics.

The incorporation of non-covalent albumin binding moieties (ABMs) into radiotracers results in increased circulation time, leading to a higher uptake in the target tissues such as the tumor, and, in some cases, reduced kidney retention..

OncologyMetabolic healthLiver support

Almond Mushroom · 2021 · Research Article · Journal of medical radiation sciences

Feasibility of bone marrow sparing volumetric modulated arc therapy to spare active bone marrow in cervical and vaginal cancer patients: a retrospective dosimetric analysis.

INTRODUCTION: Chemoradiotherapy (CRT) is the standard treatment for locally advanced cervical and vaginal cancer. It is associated with high haematological toxicity (HT) that can lead to treatment interruptions and cancelled chemotherapy cycles, reducing the potential effectiveness of this regimen..

Cordyceps · 2021 · Journal Article · Biological & pharmaceutical bulletin

Identification of Ophiocordyceps gracilioides by Its Anti-tumor Effects through Targeting the NFκB-STAT3-IL-6 Inflammatory Pathway

Although more than 400 species of Cordyceps s.l. have been identified, most have not been well explored regarding their potential for medicinal use.

Almond Mushroom · 2021 · Research Article · Frontiers in physiology

Multiscale Modeling of Vascular Remodeling Induced by Wall Shear Stress.

OBJECTIVE: Hemodynamics-induced low wall shear stress (WSS) is one of the critical reasons leading to vascular remodeling. However, the coupling effects of WSS and cellular kinetics have not been clearly modeled..

OncologyImmune supportRespiratory

Almond Mushroom · 2021 · Journal Article · International journal of radiation oncology, biology, physics

Outcomes of Patients Living With HIV and Anal Cancer Treated With Definitive Intensity-Modulated Radiation Therapy and 5-Fluorouracil- or Capecitabine-Based Chemotherapy.

Purpose/objective(s) To assess outcomes after definitive chemo-irradiation in HIV patients with anal cancer, and evaluate hemato-immunologic (HI) toxicity by dynamics of CD4+ cell counts and lymphocytes and their association with the dose received by active bone marrow (ABM)..