MycoData

Insect-associated fungi are prolific producers of peptidic natural products with potent biological activities. Paraisaria is a genus of insect-pathogenic fungi (Family Ophiocordycipitaceae) in the Order Hypocreales, which also includes other Cordyceps-like fungi..

Oncology

Medium relevance

Cordyceps · 2026 · Research Article · Discover oncology

Sex determining region Y box protein 2 (SOX2) expression, alteration, regulation and its diagnostics, prognostics and therapeutics in lung cancer.

Lung cancer is the leading cause of cancer death in China and worldwide. Sex determining region Y box protein 2 (SOX2) is involved in pluripotency regulation in embryonic stem cells, morphogenesis, and homeostasis of tracheobronchial epithelia, as well as cancer..

OncologyRespiratory

Medium relevance

Cordyceps · 2025 · Research Article · Molecules (Basel, Switzerland)

8-OXO-Cordycepin Is Not a Suitable Substrate for Adenosine Deaminase-Preliminary Experimental and Theoretical Studies.

Adenosine deaminase (ADA) is one of the most important enzymes in nucleoside metabolism, regulating the levels of adenosine and deoxyadenosine triphosphate (ADT/dATP) on either side of the cell membrane..

Oncology

Medium relevance

Almond Mushroom · 2025 · Research Article · Bulletin of mathematical biology

Astrocyte Reprogramming Drives Tumor Progression and Chemotherapy Resistance in Agent-Based Models of Breast Cancer Brain Metastases.

Breast cancer brain metastases (BCBM) affect nearly 90,000 patients annually in the United States and carry a significant risk of mortality. As metastatic lesions develop, the unique milieu of the brain microenvironment shapes disease progression and therapeutic response..

OncologyCognition & nerves

Medium relevance

Almond Mushroom · 2025 · Research Article · Bioengineering (Basel, Switzerland)

Bidirectional Endothelial Feedback Drives Turing-Vascular Patterning and Drug-Resistance Niches: A Hybrid PDE-Agent-Based Study.

We present a hybrid partial differential equation-agent-based model (PDE-ABM). In our framework, tumor cells secrete tumor angiogenic factor (TAF), while endothelial cells chemotactically migrate and branch in response..

OncologyEnergy & fatigue

Medium relevance

Cordyceps · 2025 · Journal Article · International immunopharmacology

Cordycepin alleviates renal ischemia-reperfusion injury by suppressing the p38/JNK signaling pathway.

Renal ischemia-reperfusion injury (IRI) makes a significant contribution to delayed graft function (DGF) and reduced allograft survival time post-transplantation, thereby complicating the prognosis of renal transplant recipients..

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Cordyceps · 2025 · Research Article · Chemical science

Cordycepin: a dual-function molecular element for aptamer engineering with enhanced anticancer activity.

Cordycepin (3'-deoxyadenosine, 3'-dA), derived from the fungus Cordyceps sinensis, has shown significant bioactivity as an inhibitor of enzymes related to 2'-deoxyadenosine (dA). However, its therapeutic efficacy is insufficient for clinical use, which may be addressed through targeted delivery systems..

OncologyGut & microbiomeLiver support

Medium relevance

Almond Mushroom · 2025 · Journal Article · Molecular imaging and biology

Enhancing the Half-Life of ODAP-Urea Based Radioligands by Incorporating Albumin-Binding Moieties.

PURPOSE: Prostate-specific membrane antigen-targeted radioligand therapy (PSMA-RLT) is a promising approach to treating metastatic castration-resistant prostate cancer (mCRPC)..

Oncology

Medium relevance

Cordyceps · 2025 · Journal Article · Phytomedicine

Ginsenoside F2-modified liposomes delivering FTY720 enhance glioblastoma targeting and antitumor activity via ferroptosis

Glioblastoma (GBM) is the most malignant primary intracranial tumor. Owing to its unfavorable prognosis and frequent recurrence, patient outcomes are poor even with standard treatment..

OncologyCognition & nervesEnergy & fatigueLiver support

Medium relevance

Cordyceps · 2025 · Journal Article · Phytomedicine: international journal of phytotherapy and phytopharmacology

Ginsenoside F2-modified liposomes delivering FTY720 enhance glioblastoma targeting and antitumor activity via ferroptosis.

BACKGROUND: Glioblastoma (GBM) is the most malignant primary intracranial tumor. Owing to its unfavorable prognosis and frequent recurrence, patient outcomes are poor even with standard treatment..

OncologyCognition & nervesEnergy & fatigueLiver support

Medium relevance

Cordyceps · 2025 · Journal Article · Immunological investigations

Hirsutella sinensis Fungus Promotes CD8+ T Cell-Mediated Anti-Tumor Immunity by Affecting Tumor-Associated Macrophages-Derived CCRL2.

INTRODUCTION: Hirsutella sinensis fungus (HSF)is an artificial substitute for Cordyceps sinensis and has shown promising therapeutic effects in various diseases including cancer. Previous studies have demonstrated that HSF can affect macrophage polarization and activate systemic immune response..

OncologyImmune supportRespiratory

Medium relevance

Chaga · 2025 · Research Article · Allergy, asthma & immunology research

Inotodiol Attenuates Mucosal Inflammation in a Mouse Model of Eosinophilic Chronic Rhinosinusitis.

PURPOSE: Inotodiol (22-hydroxy lanosterol), a unique component of chaga mushrooms, is believed to be a medicinal component with reported antitumor, antiviral, and anti-inflammatory properties..

OncologyImmune supportRespiratory

Medium relevance

Almond Mushroom · 2025 · Research Article · Bulletin of mathematical biology

Modelling the Impact of HIF on Metabolism and the Extracellular Matrix: Consequences for Tumour Growth and Invasion.

The extracellular matrix (ECM) is a complex structure involved in many biological processes with collagen being the most abundant protein. Density of collagen fibers in the matrix is a factor influencing cell motility and migration speed..

OncologyEnergy & fatigueMetabolic healthSkin & hydration

Medium relevance

Almond Mushroom · 2025 · Journal Article · Biotechnology and applied biochemistry

Preliminary Assessment of Cytotoxic Effects of Murraya koenigii Toluene Extracts on PA1 Cells via LC-MS, In Vitro, and In Silico Approaches.

Murraya koenigii (MK) is a medicinal plant known for its diverse phytochemical constituents and therapeutic properties. This study presents the first comprehensive analysis of MK leaf and stem whole extracts obtained using toluene, a non-polar solvent that enabled selective extraction of lipophilic phytochemicals..

OncologyImmune supportMetabolic health

Medium relevance

Cordyceps · 2025 · Research Article · Scientific reports

The impact of Nrf2/HO-1, PD-L1/Bax/Bcl-2 and TNF-α/Il-6 signaling pathways in the ameliorative role of cordycepin against acrylamide-induced cardiac toxicity in rats.

Acrylamide (ACR) is a hazardous and possibly carcinogenic chemical compound that humans are constantly exposed to in their daily life. ACR passively affect many organ systems, including the cardiovascular system..

OncologyImmune supportEnergy & fatigue

Medium relevance

Almond Mushroom · 2024 · Research Article · eLife

Agent-based model demonstrates the impact of nonlinear, complex interactions between cytokinces on muscle regeneration.

Muscle regeneration is a complex process due to dynamic and multiscale biochemical and cellular interactions, making it difficult to identify microenvironmental conditions that are beneficial to muscle recovery from injury using experimental approaches alone..

OncologyImmune supportEnergy & fatigueLiver support

Medium relevance

Almond Mushroom · 2024 · Research Article · Bulletin of mathematical biology

AMBER: A Modular Model for Tumor Growth, Vasculature and Radiation Response.

Computational models of tumor growth are valuable for simulating the dynamics of cancer progression and treatment responses. In particular, agent-based models (ABMs) tracking individual agents and their interactions are useful for their flexibility and ability to model complex behaviors..

OncologyEnergy & fatigue

Medium relevance

Almond Mushroom · 2024 · Journal Article · Computer methods and programs in biomedicine

An agent-based method to estimate 3D cell migration trajectories from 2D measurements: Quantifying and comparing T vs CAR-T 3D cell migration.

BACKGROUND AND OBJECTIVE: Immune cell migration is one of the key features that enable immune cells to find invading pathogens, control tissue damage, and eliminate primary developing tumors. Chimeric antigen receptor (CAR) T-cell therapy is a novel strategy in the battle against various cancers..

OncologyImmune supportSkin & hydration

Medium relevance

Cordyceps · 2024 · Journal Article · Journal of ethnopharmacology

Bioinformatics analyses of infiltrating immune cell participation on pancreatic ductal adenocarcinoma progression and in vivo experiment of the therapeutic effect of Shuangshen granules.

ETHNOPHARMACOLOGICAL RELEVANCE: Shuangshen granules (SSG), a nationally patented Chinese medicinal formula, including Panax quinquefolium L., Panax notoginseng (Burkill) F. H..

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Cordyceps · 2024 · Journal Article · Cancer genomics & proteomics

Cordycepin Activates Autophagy to Suppress FGF9-induced TM3 Mouse Leydig Progenitor Cell Proliferation.

BACKGROUND/AIM: Fibroblast growth factor 9 (FGF9) is a member of the human FGF family known for its pivotal roles in various biological processes, such as cell proliferation, tissue repair, and male sex determination including testis formation..

OncologyImmune supportGut & microbiome

Medium relevance

Cordyceps · 2024 · Research Article · Heliyon

Cordycepin enhances anti-tumor immunity in breast cancer by enhanceing ALB expression.

OBJECTIVE: The treatment of breast cancer still faces great challenges, and it is necessary to continuously explore effective drugs and targets to promote immune precision medicine. This study aims to investigate the immune-related regulatory mechanism of cordycepin in breast cancer..

OncologyImmune support

Medium relevance

Cordyceps · 2024 · Journal Article · European journal of pharmacology

Cordycepin enhances the Anticancer efficacy of PD-L1 blockade by modulating the tumor microenvironment of colon cancer.

BACKGROUND: PD-L1 blockade has been found to be effective in treating multiple malignancies. Combined therapy is proposed to provide better therapeutic effects.

OncologyImmune supportGut & microbiome

Medium relevance

Cordyceps · 2024 · Journal Article · Viruses

Cordycepin Inhibits Enterovirus A71 Replication and Protects Host Cell from Virus-Induced Cytotoxicity through Adenosine Action Pathway.

Enterovirus A71 (EV-A71) infection typically causes mild illnesses, such as hand-foot-and-mouth disease (HFMD), but occasionally leads to severe or fatal neurological complications in infants and young children. Currently, there is no specific antiviral treatment available for EV-A71 infection..

OncologyCognition & nervesGut & microbiomeRespiratory

Medium relevance

Maitake · 2024 · Journal Article · Molecules (Basel, Switzerland)

Effects of a β-Glucan-Rich Blend of Medicinal Mushrooms and Botanicals on Innate Immune Cell Activation and Function Are Enhanced by a Very Low Dose of Bovine Colostrum Peptides.

Nutraceutical immune support offers potential for designing blends with complementary mechanisms of action for robust support of innate immune alertness. We documented enhanced immune activation when bovine colostrum peptides (BC-Pep) were added to an immune blend (IB) containing β-glucans from yeast, shiitake,….

OncologyImmune supportRespiratory

Medium relevance

Reishi · 2024 · Journal Article · International journal of molecular sciences

Exploring Senolytic and Senomorphic Properties of Medicinal Plants for Anti-Aging Therapies.

Senolytic and senomorphic therapies have gained more and more attention in the last decade. This kind of therapy is based on the killing of cellular senescent cells without harming the "normal" cells.

OncologyImmune supportSkin & hydration

Medium relevance

Almond Mushroom · 2024 · Research Article · Entropy (Basel, Switzerland)

Exploring the Role of Genetic and Environmental Features in Colorectal Cancer Development: An Agent-Based Approach.

The complexity of issues in cancer research has led to the introduction of powerful computational tools to help experimental in vivo and in vitro methods. These tools, which typically focus on studying cell behavior and dynamic cell populations, range from systems of differential equations that are solved numerically….

OncologyGut & microbiome

Medium relevance

Reishi · 2024 · Journal Article · Scientific reports

Ganoderma tsuage promotes pain sensitivity in aging mice.

Advances in modern medicine have extended human life expectancy, leading to a world with a gradually aging society. Aging refers to a natural decline in the physiological functions of a species over time, such as reduced pain sensitivity and reaction speed..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Cordyceps · 2024 · Journal Article · Journal of the Chinese Medical Association: JCMA

Hirsutella sinensis intensifies testicular function and spermatogenesis in male mice with high-fat diet-induced obesity.

BACKGROUND: Hirsutella sinensis (HS) is a mycelium isolated from the fruiting body of the medicinal mushroom Cordyceps sinensis. This study explored whether HS treatment affects reproductive dysfunction in a high-fat diet (HFD)-induced mouse model and regulates various mechanisms, focusing on oxidative stress,….

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Shiitake · 2024 · Journal Article · Cell biochemistry and biophysics

Lentinan mitigates pemetrexed chemoresistance by the PI3K/Akt pathway in non-small cell lung cancer.

Pemetrexed is a folate analog metabolic inhibitor that is given for therapy of non-small cell lung cancer (NSCLC). Drug resistance affects the efficacy of pemetrexed in NSCLC.

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Almond Mushroom · 2024 · Journal Article · European journal of nuclear medicine and molecular imaging

Optimizing the pharmacokinetics of an 211At-labeled RGD peptide with an albumin-binding moiety via the administration of an albumin-binding inhibitor.

PURPOSE: A probe for targeted alpha therapy (TAT) using the RGD peptide (Ga-DOTA-K([211At]APBA)-c(RGDfK) ([211At]1)) with albumin-binding moiety (ABM) was recently developed. [211At]1 highly accumulated in tumors and significantly inhibited tumor growth in U-87 MG tumor-bearing mice..

Oncology

Medium relevance

Oyster Mushroom · 2024 · Journal Article · International journal of medicinal mushrooms

Size Matters: Influence of Particle Size on Antioxidant, β-Glucan, and Anti-Inflammatory Potential in Pleurotus floridanus (Agaricomycetes).

Cellular damage resulting from elevated levels of free radicals can lead to persistent health issues. Pleurotus floridanus, an edible white oyster mushroom, is rich in β-glucans with potent antioxidant and anti-inflammatory properties..

OncologyImmune support

Medium relevance

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Structural clarification of mannoglucan GSBP-2 from Ganoderma sinense and its effects on triple-negative breast cancer migration and invasion.

Ganoderma sinense, known as Lingzhi in China, is a medicinal fungus with anti-tumor properties. Herein, crude polysaccharides (GSB) extracted from G.

OncologyImmune supportGut & microbiomeSkin & hydration

Medium relevance

Chaga · 2024 · Journal Article · International immunopharmacology

β-glucan mitigates ovalbumin-induced airway inflammation by preventing oxidative stress and CD8+ T cell infiltration.

BACKGROUND: Bronchial asthma is a severe respiratory condition characterized by airway inflammation, remodeling, and oxidative stress. β-Glucan (BG) is a polysaccharide found in fungal cell walls with powerful immunomodulatory properties..

OncologyImmune supportRespiratory

Medium relevance

Cordyceps · 2023 · Review · Drug discovery today

Cordycepin and kinase inhibition in cancer.

Cordycepin, a nucleoside from Cordyceps mushrooms, has many beneficial properties for health, including anticancer activities. In cancer cells, cordycepin targets various signaling molecules.

Oncology

Medium relevance

Chaga · 2023 · Preprint · journal metadata

Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo

Alzheimer's disease (AD) is characterized by memory impairment and existence of amyloid-β (Aβ) plaques and neuroinflammation. Due to the pivotal role of oxidative damage in AD, natural antioxidative agents, such as polyphenol-rich fungi, have garnered scientific scrutiny..

OncologyImmune supportCognition & nervesEnergy & fatigue

Medium relevance

Cordyceps · 2023 · Review · Biochemical and biophysical research communications

Pharmacological and therapeutic potentials of cordycepin in hematological malignancies.

Hematological malignancies(HMs) are highly heterogeneous diseases with globally rising incidence. Despite major improvements in the management of HMs, conventional therapies have limited efficacy, and relapses with high mortality rates are still frequent..

OncologyImmune support

Medium relevance

Cordyceps · 2023 · Review · Frontiers in nephrology

Plant-derived compounds for treating autosomal dominant polycystic kidney disease.

Autosomal dominant polycystic kidney disease (ADPKD), the most common monogenic hereditary kidney disease, is the fourth leading cause of end-stage kidney disease worldwide..

Oncology

Medium relevance

Turkey Tail · 2023 · Scoping Review · Cureus

Therapeutic Effects of Medicinal Mushrooms on Gastric, Breast, and Colorectal Cancer: A Scoping Review.

Cancer is the leading cause of mortality globally. With anticancer medications causing severe adverse effects, understanding the role of alternative and efficacious anticancer treatments with minimal or no side effects can be beneficial..

OncologyImmune supportLiver support

Medium relevance

Turkey Tail · 2023 · Preprint · journal metadata

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Mushrooms are unexploited treasures of secondary metabolites. Analysis of the chemical constituents of these mushrooms would be necessary for the assessment of their pharmacological and biological activities..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Cordyceps · 2022 · Review · Frontiers in microbiology

Mushrooms as Potential Sources of Active Metabolites and Medicines.

BACKGROUND: Mushrooms exist as an integral and vital component of the ecosystem and are very precious fungi. Mushrooms have been traditionally used in herbal medicines for many centuries..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Cordyceps · 2021 · Review · Frontiers in pharmacology

Applications of Herbal Medicine to Treat Autosomal Dominant Polycystic Kidney Disease.

Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary kidney disease, which is featured by progressively enlarged bilateral fluid-filled cysts. Enlarging cysts destroy the structure of nephrons, ultimately resulting in the loss of renal function..

OncologyMetabolic health

Medium relevance

Chaga · 2021 · Preprint · journal metadata

Effect of Anti-cancerous Compounds on Cancer Cells Extracted From Edible Mushrooms: A Review

Mushrooms have been an invaluable ingredient in terms of food and medicine to humanity since time immemorial. Mushrooms have been shown to be possessing properties such as anti-tumor, antiproliferative, antioxidant, immunomodulatory, anti-diabetic..

OncologyImmune supportMetabolic health

Medium relevance

Cordyceps · 2021 · Review · Molecules (Basel, Switzerland)

Secondary Metabolites of Purpureocilliumlilacinum.

Fungi can synthesize a wealth of secondary metabolites, which are widely used in the exploration of lead compounds of pharmaceutical or agricultural importance. Beauveria, Metarhizium, and Cordyceps are the most extensively studied fungi in which a large number of biologically active metabolites have been identified..

Oncology

Medium relevance

Shiitake · 2021 · Review · Journal of clinical and translational research

The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review.

BACKGROUND AND AIM: Recently, optimal immune function has become a primary focus of worldwide attention not only in the prevention of chronic disease but also as one strategy to reduce the severity of acute illness..

OncologyImmune support

Medium relevance

Cordyceps · 2021 · Review · Molecules (Basel, Switzerland)

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin.

Cordycepin is an adenosine derivative isolated from Cordyceps sinensis, which has been used as an herbal complementary and alternative medicine with various biological activities..

OncologyImmune supportCognition & nervesSkin & hydration

Medium relevance

Cordyceps · 2020 · Journal Article · Chinese journal of natural medicines

Cordycepin inhibits pancreatic cancer cell growth in vitro and in vivo via targeting FGFR2 and blocking ERK signaling.

Cordycepin (3'-deoxyadenosine) from Cordyceps militaris has been reported to have anti-tumor effects. However, the molecular target and mechanism underlying cordycepin impeding pancreatic cancer cell growth in vitro and in vivo remain vague..

Oncology

Medium relevance

Cordyceps · 2020 · Research Article · Nanotechnology, science and applications

Cordycepin Nanoencapsulated in Poly(Lactic-Co-Glycolic Acid) Exhibits Better Cytotoxicity and Lower Hemotoxicity Than Free Drug.

PURPOSE: Cordycepin, a natural product isolated from the fungus Cordyceps militaris, is a potential candidate for breast cancer therapy. However, due to its structural similarity with adenosine, cordycepin is rapidly metabolized into an inactive form in the body, hindering its development as a therapeutic agent..

OncologyLiver support

Medium relevance

King Oyster · 2020 · Research Article · Molecules (Basel, Switzerland)

Genoprotective Properties and Metabolites of β-Glucan-Rich Edible Mushrooms Following Their In Vitro Fermentation by Human Faecal Microbiota.

A variety of bioactive compounds, constituents of edible mushrooms, in particular β-glucans, i.e., a group of β-d-glucose polysaccharides abundant in the fungal cell walls, have been linked to immunomodulating, anticancer and prebiotic activities..

OncologyImmune supportMetabolic healthGut & microbiome

Medium relevance

Cordyceps · 2020 · Research Article · Journal of fungi (Basel, Switzerland)

Interplay between Fungal Infection and Bacterial Associates in the Wax Moth Galleria mellonella under Different Temperature Conditions.

Various insect bacterial associates are involved in pathogeneses caused by entomopathogenic fungi. The outcome of infection (fungal growth or decomposition) may depend on environmental factors such as temperature..

OncologyImmune support

Medium relevance

Maitake · 2019 · Journal Article · Journal of bioscience and bioengineering

Anti-osteoporotic effects of syringic acid and vanilic acid in the extracts of waste beds after mushroom cultivation.

In recent years, the number of patients with osteoporosis has increased as population grows older. Therefore, the chemoprevention of osteoporosis by better nutrition is important.

OncologyEnergy & fatigue