MycoData

Reishi · 2023 · Preprint · journal metadata

A Review of the Application of Ganoderma lucidum (Curtis) P. Karst. In Nanotechnology for the Treatment of Cancer

Ganoderma lucidum, commonly known as the "Lingzhi" or "Reishi" mushroom, has long been recognized for its potential health benefits, and medicinal properties in traditional Chinese medicine..

OncologyImmune supportEnergy & fatigueMetabolic health

Oyster Mushroom · 2023 · Preprint · journal metadata

Active compound test: ethanolic extract of White Oyster Mushroom (Pleurotus ostreatus) Using HPLC and LC-MS

Background: The use of herbs as traditional medicine in Indonesia is increasing, with more than 40% of Indonesia's population utilizing them. White oyster mushroom ( Pleurotus Ostreatus ) is a fungus that has various therapeutic effects including antioxidant, anti-inflammatory, anti-bacterial, anti-cholesterol, and….

OncologyCognition & nerves

King Oyster · 2023 · Preprint · journal metadata

Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from Pleurotus eryngii Fruiting Bodies

Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the Sarcin-Ricin Loop (SRL) of the large rRNA. The cleaved SRL interacts differently with some ribosomal proteins (P-stalk)..

OncologyImmune supportEnergy & fatigueMetabolic health

Chaga · 2023 · Preprint · journal metadata

Inonotus obliquus upregulates muscle regeneration and augments function through muscle oxidative metabolism

Abstract Background Skeletal muscle wasting related to aging or pathological conditions is critically associated with the increased incidence and prevalence of secondary diseases including cardiovascular diseases, metabolic syndromes, and chronic inflammations..

OncologyImmune supportCognition & nerves

King Oyster · 2023 · Preprint · journal metadata

The discovery of ergothioneine biosynthesis genes from Pleurotus eryngii and its combinatorial expression in yeast

Ergothioneine (EGT) is a natural amino acid derived from histidine, which has many active functions such as anti-oxidation, anti-inflammation, anti-cancer and prevention of neurodegenerative diseases. Pleurotus eryngii is a delicious edible fungus with high EGT content..

OncologyImmune supportRespiratory

Cordyceps · 2023 · Preprint · journal metadata

Therapeutic potential of Cordyceps militaris mushroom against SARS-CoV-2: Virtual screening against Mpro and in vitro validation

Pathogenic coronavirus, including COVID-19, threatens human health, and there are strong demands for efficient therapeutics. Cordyceps militaris is a medicinal mushroom that has long been used for immune enhancement, anticancer, and antiviral effects.

King Oyster · 2022 · Preprint · journal metadata

Enhancement of hyphae growth and medium optimization by Pleurotus eryngii-3 under submerged fermentation

Abstract There were a variety of amino acids and polysaccharides in Pleurotus eryngii contained that could improve human immunity and prevent cancer. In this paper, the medium was screened and carton and nitrogen sources were screened and optimized as 40 g/L corn flour and soybean meal by P.

Reishi · 2022 · Preprint · journal metadata

Ganoderma lucidum Methanolic Extraction as a Potent Phytoconstituent: Characterization, in-vitro Antimicrobial and Cytotoxic Activity

Background: Ganoderma lucidum has attracted tremendous attention due to its exceptional antimicrobial and anticancer properties that can be delicately tuned by controlling the initial extraction content and concentration..

OncologyEnergy & fatigue

Chaga · 2021 · Preprint · journal metadata

Characterization and Anticancer Effects of Folate Targeted Inotodiol Liposome From Inonotus Obliquus (Chaga Mushroom)

Abstract Inotodiol, one tetracyclic triterpenoid isolated from inonotus obliquus (Chaga mushroom) possess excellent anticancer, antioxidant and anti-inflammatory activities, however it has not been applied to medical use due to its low solubility and low bioavailability..

OncologyImmune supportEnergy & fatigue

Cordyceps · 2021 · Preprint · journal metadata

Cordyceps Militaris Carotenoids Protect ARPE-19 Cells From Oxidative Stress Damage Induced By Hydrogen Peroxide

A retinal disorder known as age-related macular degeneration (AMD) can be very damaging, which may result in vision loss. Cordyceps militaris has antioxidant, anti-inflammatory, anticancer activity and immunomodulatory functions..

OncologyImmune supportEnergy & fatigueMetabolic health

Oyster Mushroom · 2021 · Preprint · journal metadata

In-silico Study Of Oyster Mushroom (Pleurotus Ostreatus ) Targeting PARP Protein (4UND)

Oyster mushroom( Pleurotus ostreatus) is belong to the group of healthy foods, as they contain high levels of proteins, vitamins and different classes of compounds, it is discovered that oyster mushrooms could play a key role in maintaining good health..

OncologyImmune supportRespiratory

Almond Mushroom · 2021 · Preprint · journal metadata

Subcritical Water Extracts from Agaricus blazei Murrill's Mycelium Inhibits the Expression of Immune Checkpoint Molecules and Axl receptor

Agaricus blazei Murrill or Himematsutake is an edible and medicinal mushroom. Agaricus blazei Murrill's fruiting body extracts have anticancer properties, although the mechanism is unknown..

OncologyEnergy & fatigueMetabolic health

Cordyceps · 2021 · Preprint · journal metadata

Transcriptome Analysis of Ophiocordyceps Sinensis Under Low-Temperature Treatment

Abstract This study aims to investigate the effect of low temperature on the gene expression in Ophiocordyceps Sinensis. To set up the experiments, two groups of Ophiocordyceps Sinensis were grown at 4°C and 18°C, respectively, for 60 days..

OncologyEnergy & fatigueRespiratory

Cordyceps · 2026 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Cordycepin-Enriched Cordyceps militaris Extract ARA815 Induces Ferroptosis in Lung Cancer Cells In Vivo and In Vitro.

Cordyceps militaris, a traditional medicinal fungus and a promising food supplement, has demonstrated anticancer potential, yet its underlying mechanisms and in vivo efficacy remain poorly defined. Previously, we developed an optimized extraction and preparation protocol to enrich the bioactive content of C..

Chaga · 2024 · English Abstract · Wei sheng yan jiu = Journal of hygiene research

[Anti-tumor effect of Inonotus obliquus extract on 4T1 tumor-bearing mice].

OBJECTIVE: To explore the antitumor effect of Inonotus obliquus extract on 4T1 tumor-bearing mice in vivo and its possible mechanism. METHODS: 4T1 tumor-bearing mice model was established..

Shiitake · 2024 · Research Support, Non U.S. Gov'T · Toxins

Edodin: A New Type of Toxin from Shiitake Mushroom (Lentinula edodes) That Inactivates Mammalian Ribosomes.

Ribosome-inactivating proteins (RIPs) are a group of proteins with rRNA N-glycosylase activity that irreversibly inhibit protein synthesis and consequently cause cell death..

Maitake · 2024 · Research Support, Non U.S. Gov'T · International journal of biological sciences

Polysaccharide isolated from Grifola frondosa eliminates myeloid-derived suppressor cells and inhibits tumor growth by enhancing T cells responses.

Myeloid derived suppressor cells (MDSCs) are known to accumulate in cancer patients and tumor-bearing mice, playing a significant role in promoting tumor growth. Depleting MDSCs has emerged as a potential therapeutic strategy for cancer..

OncologyImmune supportMetabolic healthGut & microbiome

Shiitake · 2024 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Simulated human digestion and fermentation of a high-molecular weight polysaccharide from Lentinula edodes mushroom and protective effects on intestinal barrier.

Lentinula edodes (Shiitake) is an important edible mushroom and polysaccharides are its major constituents with proven health benefits. The study was to investigate the gut bacterial fermentation and subsequent effects on gut barrier function of a glucan-rich polysaccharide, LePS40 precipitated from the mushroom water….

OncologyImmune supportMetabolic healthGut & microbiome

Almond Mushroom · 2023 · Research Article · Nutrients

Agaricus blazei Polysaccharide Alleviates DSS-Induced Colitis in Mice by Modulating Intestinal Barrier and Remodeling Metabolism.

Ulcerative colitis (UC) is a chronic noninfectious intestinal disease that severely affects patients' quality of life. Agaricus blazei Murrill polysaccharide (ABP) is an effective active ingredient extracted from Agaricus blazei Murrill (ABM)..

Chaga · 2023 · Research Article · Frontiers in pharmacology

Anti-cancer activity of Chaga mushroom (Inonotus obliquus) against dog bladder cancer organoids.

Despite its disadvantages, chemotherapy is still commonly used for the treatment of bladder cancer (BC). Developing natural supplements that can target cancer stem cells (CSCs) which cause drug resistance and distant metastasis is necessary..

OncologyEnergy & fatigue

OncologyImmune supportSkin & hydrationRespiratory

Cordyceps · 2023 · Research Article · PloS one

Antimicrobial, antioxidant, anti-inflammatory, and cytotoxic activities of Cordyceps militaris spent substrate.

Cordyceps militaris is a medicinal mushroom and has been extensively used as a traditional medicine in East Asia. After the chrysalis seeds are matured and harvested, the spent substrate of C.

OncologyImmune supportCognition & nervesMetabolic health

Lion's Mane · 2023 · Research Article · Molecules (Basel, Switzerland)

Antioxidative Activities of Micronized Solid-State Cultivated Hericium erinaceus Rich in Erinacine A against MPTP-Induced Damages.

The Lion's mane mushroom (Hericium erinaceus, HE) is a traditional medical mushroom with high nutritional and economic value. HE possesses anticancer, antimicrobial, antioxidant, immunomodulating, neurotrophic, and neuroprotective activities..

Niu-Chang-Chih · 2023 · Journal Article · Environmental toxicology

Antrodia camphorata and coenzyme Q0, a novel quinone derivative of Antrodia camphorata, impede HIF-1α and epithelial-mesenchymal transition/metastasis in human glioblastoma cells.

Antrodia camphorata (AC) and Coenzyme Q0 (CoQ0 ), a novel quinone derivative of AC, exhibits antitumor activities. The present study evaluated EMT/metastasis inhibition and autophagy induction aspects of AC and CoQ0 in human glioblastoma (GBM8401) cells..

OncologyMetabolic healthLiver supportSkin & hydration

Cordyceps · 2023 · Research Article · Pharmaceutics

CD44-Targeted Lipid Polymer Hybrid Nanoparticles Enhance Anti-Breast Cancer Effect of Cordyceps militaris Extracts.

This study aimed to improve the anticancer effect of Cordyceps militaris herbal extract (CME) on breast cancer cells with hyaluronic acid (HYA) surface-decorated lipid polymer hybrid nanoparticles (LPNPs) and evaluate the applicability of a synthesized poly(glycerol adipate) (PGA) polymer for LPNP preparation..

Reishi · 2023 · Research Article · Evidence-based complementary and alternative medicine: eCAM

CD8+ T Cell-Mediated Therapeutic Antitumor Effect of an Herbal Mixture Containing Ganoderma lucidum.

Although Kampo-a traditional Japanese herbal medicine-contributes in the control of tumor growth in vivo in experimental animals, most of the antitumor effects are prophylactic and not therapeutic..

OncologyImmune supportSkin & hydration

Chaga · 2023 · Journal Article · International journal of medicinal mushrooms

Chaga Medicinal Mushroom, Inonotus obliquus (Agaricomycetes), Polysaccharides Alleviate Photoaging by Regulating Nrf2 Pathway and Autophagy.

Inonotus obliquus is a medicinal mushroom that contains the valuable I. obliquus polysaccharides (IOP), which is known for its bioactive properties.

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2023 · Research Article · Chinese medicine

Cordycepin from Cordyceps militaris ameliorates diabetic nephropathy via the miR-193b-5p/MCL-1 axis.

BACKGROUND: Diabetic nephropathy (DN) is a chronic kidney disease that develops in patients with diabetes mellitus. Cordycepin (CRD), a secondary metabolite produced by Cordyceps militaris, has a variety of bioactive properties..

OncologyImmune supportRespiratory

Turkey Tail · 2023 · Journal Article · International journal of medicinal mushrooms

Detection of Mitogenic and Genotoxic Effects of the Turkey Tail Medicinal Mushroom (Trametes versicolor, Agaricomycetes) Extracts from Mexico on Human Lymphocyte Cultures.

Diseases caused by a compromised immune system, characterized by decreased production and diversification of T lymphocytes, such as immunodeficiencies or chronic infections, are becoming increasingly prominent..

OncologyEnergy & fatigueGut & microbiome

Cordyceps · 2023 · Journal Article · Heliyon

Development of an efficient method for separation and purification of cordycepin from liquid fermentation of Cordyceps militaris and analysis of cordycepin antitumor activity

Cordycepin (3 ′-deoxyadenosine) is the main active component of Cordyceps militaris, which is a chemical marker for quality detection of Cordyceps militaris and has important medicinal development value. Existing methods for obtaining cordycepin are complex and costly..

OncologyEnergy & fatigueGut & microbiome

Cordyceps · 2023 · Research Article · Heliyon

Development of an efficient method for separation and purification of cordycepin from liquid fermentation of Cordyceps militaris and analysis of cordycepin antitumor activity.

Cordycepin (3 '-deoxyadenosine) is the main active component of Cordyceps militaris, which is a chemical marker for quality detection of Cordyceps militaris and has important medicinal development value. Existing methods for obtaining cordycepin are complex and costly..

Reishi · 2023 · Research Article · Foods (Basel, Switzerland)

Evaluation of Immune Modulation by β-1,3; 1,6 D-Glucan Derived from Ganoderma lucidum in Healthy Adult Volunteers, A Randomized Controlled Trial.

Fungi-derived β-glucan, a type of glucopolysaccharide, has been shown to possess immune-modulatory properties in clinical settings. Studies have indicated that β-glucan derived from Ganoderma lucidum (commonly known as Reishi) holds particular promise in this regard, both in laboratory and in vivo settings..

Oyster Mushroom · 2023 · Journal Article · Molecular biology reports

Expression profiling of laccase and β-glucan synthase genes in Pleurotus ostreatus during different developmental stages.

BACKGROUND: Pleurotus ostreatus, commonly known as the oyster mushroom, is a saprophytic fungus with many applications in biotechnology and medicine. This mushroom is a rich source of proteins, polysaccharides, and bioactive compounds that have been shown to possess anticancer, antioxidant, and immunomodulatory….

OncologyImmune supportSkin & hydration

Maitake · 2023 · Research Article · Nutrition research and practice

Extracts of Grifola frondosa inhibit the MAPK signaling pathways involved in keratinocyte inflammation and ameliorate atopic dermatitis.

BACKGROUND/OBJECTIVES: Grifola frondosa, commonly referred to as the maitake mushroom, has been studied extensively to explore its potential health benefits. However, its anti-inflammatory effects in skin disorders have not been sufficiently elucidated..

OncologyImmune supportEnergy & fatigueMetabolic health

Enoki · 2023 · Journal Article · The Science of the total environment

Flammulina velutipes polysaccharide counteracts cadmium-induced gut injury in mice via modulating gut inflammation, gut microbiota and intestinal barrier.

Cadmium (Cd), as Group I carcinogen, can induce damage to various organs including the gut. It is of great importance to meet the rising demand for effective therapies against Cd-induced damage and investigate the mechanism..

Reishi · 2023 · Research Article · Materials (Basel, Switzerland)

Ganoderma lucidum-Mediated Green Synthesis of Silver Nanoparticles with Antimicrobial Activity.

"Green chemistry" is a simple and easily reproductible method that provides nanoparticles characterized by better stability and good dispersion in an aqueous solution. Nanoparticles can be synthesized by algae, bacteria, fungi, and plant extracts..

OncologyImmune supportEnergy & fatigue

Reishi · 2023 · Journal Article · South African journal of botany

GC–MS, molecular identification, proximate and mineral content composition of two wild mushrooms (Ganoderma lucidum, Pleurotus ostreatus) from Gilgit Baltistan Northern area of Pakistan

For a very long time, diverse civilizations all over the world have recognised that mushrooms, which are the fruiting bodies of fungi, have medicinal characteristics and used to treat different kinds of human diseases..

King Oyster · 2023 · Journal Article · International journal of biological macromolecules

Heterogalactan WPEP-N-b from Pleurotus eryngii enhances immunity in immunocompromised mice.

This study reports on in vivo immunomodulatory activities mediated by WPEP-N-b, a heterogalactan from Pleurotus eryngii. Using cyclophosphamide (CTX)-induced immunosuppressed mice, we demonstrate here that WPEP-N-b enhances immunity as determined by the immune organ index, peripheral blood immune cell content,….

OncologyEnergy & fatigueGut & microbiomeLiver support

King Oyster · 2023 · Journal Article · Journal of the science of food and agriculture

Identification and preparation of selenium-containing peptides from selenium-enriched Pleurotus eryngii and their protective effect on lead-induced oxidative damage in NCTC1469 hepatocytes.

BACKGROUND: Lead (Pb) is a highly toxic and persistent substance that easily accumulates in living organisms, eliciting cellular toxicity and oxidative stress. Some selenium-containing proteins and peptides prepared from plant extracts are beneficial for protecting the body's health and resisting external….

OncologyEnergy & fatigueGut & microbiomeLiver support

King Oyster · 2023 · Journal Article · Journal of the science of food and agriculture

Identification and preparation of selenium‐containing peptides from selenium‐enriched Pleurotus eryngii and their protective effect on lead‐induced oxidative damage in NCTC1469 hepatocytes

BACKGROUND: Lead (Pb) is a highly toxic and persistent substance that easily accumulates in living organisms, eliciting cellular toxicity and oxidative stress. Some selenium‐containing proteins and peptides prepared from plant extracts are beneficial for protecting the body's health and resisting external….

Reishi · 2023 · Research Article · BMC research notes

In vitro anti-Toxoplasma gondii activity of Ganoderma lucidum extracts.

OBJECTIVE: Ganoderma extracts have the potential to be used as anti-cancer, anti-inflammatory, immunomodulator, and antimicrobial agents, as evaluated in numerous studies..

OncologyImmune supportCognition & nervesMetabolic health

King Oyster · 2023 · Research Article · Journal of fungi (Basel, Switzerland)

In Vitro Fermentation of Pleurotus eryngii Mushrooms by Human Fecal Microbiota: Metataxonomic Analysis and Metabolomic Profiling of Fermentation Products.

Edible mushrooms contain biologically active compounds with antioxidant, antimicrobial, immunomodulatory and anticancer properties. The link between their anticancer and immunomodulatory properties with their possible prebiotic activity on gut micro-organisms has been the subject of intense research over the last….

OncologyImmune supportEnergy & fatigueRespiratory

King Oyster · 2023 · Journal Article · International journal of medicinal mushrooms

King Oyster Mushroom, Pleurotus eryngii (Agaricomycetes), Extract Can Attenuate Doxorubicin-Induced Lung Damage by Inhibiting Oxidative Stress in Rats.

Doxorubicin (DOX), a broad spectrum chemotherapeutic, has toxic effects on healthy tissues. Mitochondrial processes and oxidative stress act in the DOX-induced toxicity, therefore antioxidant therapies are widely used..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2023 · Journal Article · Food & function

Mapping the metabolic characteristics of probiotic-fermented Ganoderma lucidum and its protective mechanism against Cd-induced nephrotoxicity.

An animal model of Cd-induced kidney damage was designed to investigate the nephroprotective potential of the probiotic-fermented Ganoderma lucidum (FGL) via metabonomic analysis. The results showed that FGL enhanced sugar and amino acid metabolism..

OncologyImmune supportMetabolic healthGut & microbiome

Maitake · 2023 · Research Article · Frontiers in nutrition

Structural properties and anti-inflammatory activity of purified polysaccharides from Hen-of-the-woods mushrooms (Grifola frondosa).

Grifola frondosa is an edible medicinal mushroom that has been proven to have a variety of health benefits. The main active ingredients of this mushroom are polysaccharides.

Reishi · 2023 · Journal Article · Biotechnic & histochemistry: official publication of the Biological Stain Commission

Synergistic apoptotic effects of ethanolic extracts of ginger and Ganoderma lucidum in a colorectal cancer cell line.

Current conventional therapy for colorectal cancer includes surgery, radiation and chemotherapy, all of which produce side effects. Herbal medicine can control the side effects of conventional treatments..

Reishi · 2023 · Journal Article · Food & function

The anti-hepatocellular carcinoma effects of polysaccharides from Ganoderma lucidum by regulating macrophage polarization via the MAPK/NF-κB signaling pathway.

The response of macrophages to environmental signals demonstrates its heterogeneity and plasticity. After different forms of polarized activation, macrophages reach the M1 or M2 activation state according to their respective environment..

OncologyCognition & nerves

King Oyster · 2023 · Research Article · International journal of molecular sciences

The Biological Action and Structural Characterization of Eryngitin 3 and 4, Ribotoxin-like Proteins from Pleurotus eryngii Fruiting Bodies.

Ribotoxin-like proteins (RL-Ps) are specific ribonucleases found in mushrooms that are able to cleave a single phosphodiester bond located in the sarcin-ricin loop (SRL) of the large rRNA. The cleaved SRL interacts differently with some ribosomal proteins (P-stalk)..

OncologyImmune supportMetabolic healthRespiratory

Reishi · 2023 · Research Article · Frontiers in pharmacology

The medicinal mushroom Ganoderma lucidum prevents lung tumorigenesis induced by tobacco smoke carcinogens.

Ganoderma lucidum (GL), commonly known as "Lingzhi", is a well-known medicinal mushroom with antioxidant and anti-cancer activity. This study examined the effects of a commercial GL product (GLSF) containing the spore and fruiting body in a 30:8 ratio on tobacco smoke carcinogen-induced lung toxicity and….