MycoData

Cancer is a leading cause of death around the world. Apoptosis, one of the pathways of programmed cell death, is a promising target for cancer therapy.

Oncology

Medium relevance

Niu-Chang-Chih · 2019 · Review · Journal of food biochemistry

Antrodia cinnamomea-An updated minireview of its bioactive components and biological activity.

Antrodia cinnamomea or Antrodia camphorata is a distinctive mushroom of Taiwan, which is being used as a traditional medicine to treat various health-related conditions. More than 78 compounds have been identified in A.

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Shiitake · 2019 · Review · Journal of ethnopharmacology

Do recent research studies validate the medicinal plants used in British Columbia, Canada for pet diseases and wild animals taken into temporary care?

ETHNOPHARMACOLOGICAL RELEVANCE: There are insufficient safe and effective treatments for chronic pain in pets. In cases such as osteoarthritis there is no commercially available cure and veterinarians use NSAIDs to manage pain..

OncologyImmune supportCognition & nervesRespiratory

Medium relevance

Snow Fungus · 2019 · Review · Progress in molecular biology and translational science

Tremella polysaccharide: The molecular mechanisms of its drug action.

Tremella fuciformis is an edible medicinal mushroom well known as "Yiner" or "Baimuer" in China and has been used as a Chinese herb for many years. T.

OncologyImmune supportCognition & nervesMetabolic health

Medium relevance

Turkey Tail · 2016 · Review · International journal of medicinal mushrooms

Recent Advances and Challenges in Studies of Control of Cancer Stem Cells and the Gut Microbiome by the Trametes-Derived Polysaccharopeptide PSP (Review).

The medicinal mushroom Trametes versicolor has been well recognized for its activity in maintaining the general health of the population and in managing and treating human diseases in various cultures. Its use has been recently gaining acceptance and popularity in Western countries.

OncologyImmune supportGut & microbiome

Medium relevance

Chaga · 2004 · Review · Journal of natural products

Biologically active compounds from Aphyllophorales (polypore) fungi.

This review describes biologically active natural products isolated from Aphyllophorales, many of which are known as polypores. Polypores are a large group of terrestrial fungi of the phylum Basdiomycota (basidiomycetes), and they along with certain Ascomycota are a major source of pharmacologically active substances..

OncologyImmune supportMetabolic healthRespiratory

Medium relevance

Maitake · 2004 · Review · Mini reviews in medicinal chemistry

Cellular and physiological effects of Ganoderma lucidum (Reishi).

In Asia, a variety of dietary products have been used for centuries as popular remedies to prevent or treat different diseases. A large number of herbs and extracts from medicinal mushrooms are used for the treatment of diseases..

OncologyImmune supportMetabolic health

Medium relevance

Almond Mushroom · 2023 · Preprint · journal metadata

Colorectal cancer as a model for biological evolution

Complexity in cancer research has led to the creation of powerful analytical tools for helping experimental in vivo and in vitro methods. These tools range from systems of differential equations resolved in computer simulations, to lattice models and agent-based models (ABMs)..

OncologyGut & microbiome

Medium relevance

Almond Mushroom · 2020 · Journal Article · Aquatic toxicology (Amsterdam, Netherlands)

Abamectin at environmentally-realistic concentrations cause oxidative stress and genotoxic damage in juvenile fish (Schizothorax prenanti).

Abamectin (ABM) has been extensively used in Chinese aquaculture systems for parasite control, but no information is available regarding its effects on the important freshwater commercial fish species Schizothorax prenanti. We performed an acute toxicity test to determine the effects of ABM on S..

OncologyEnergy & fatigueLiver support

Medium relevance

Agarikon · 2020 · Research Article · Molecules (Basel, Switzerland)

Antitumor, Immunomodulatory and Antiangiogenic Efficacy of Medicinal Mushroom Extract Mixtures in Advanced Colorectal Cancer Animal Model.

Due to frequent drug resistance and/or unwanted side-effects during conventional and targeted cancer treatments, development of multi-target therapies is an important research field..

OncologyImmune support

Medium relevance

Almond Mushroom · 2020 · Journal Article · Frontiers in oncology

Comparison of Hematologic Toxicity and Bone Marrow Compensatory Response in Head and Neck vs. Cervical Cancer Patients Undergoing Chemoradiotherapy.

Background: Hematologic toxicity is a critical problem limiting treatment delivery in cancer patients undergoing concurrent chemoradiotherapy. However, the extent to which anatomic variations in radiation dose limit chemotherapy delivery is poorly understood..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Shiitake · 2020 · Journal Article · International journal of medicinal mushrooms

Quantification of Mushroom-Derived Soluble β-1,6-Glucan Using the Function-Modified Recombinant β-1,6-Glucanase.

Mushroom is one of the major sources of β-glucan used in medical applications and traditional therapies. Thus, structure analysis and quantification of β-glucan content is crucial to evaluate medicinal mushrooms.

OncologyImmune support

Medium relevance

Almond Mushroom · 2020 · Journal Article · The Journal of international medical research

Survival analysis of afatinib versus erlotinib for individuals with advanced del19 lung adenocarcinoma with asymptomatic brain metastasis after pemetrexed-cisplatin chemotherapy: a retrospective study.

OBJECTIVE: To evaluate survival following afatinib (AF) and erlotinib (ER) treatment in advanced del19 lung adenocarcinoma (AD19LA) with asymptomatic brain metastasis (ABM) after pemetrexed-cisplatin chemotherapy (PCC)..

OncologyCognition & nervesRespiratory

Medium relevance

Almond Mushroom · 2020 · Journal Article · Molecular imaging and biology

The Effects of an Albumin Binding Moiety on the Targeting and Pharmacokinetics of an Integrin αvβ6-Selective Peptide Labeled with Aluminum [18F]Fluoride.

PURPOSE: The αvβ6-BP peptide selectively targets the integrin αvβ6, a cell surface receptor recognized as a prognostic indicator for several challenging malignancies..

Oncology

Medium relevance

Shiitake · 2019 · Journal Article · Food & function

Lentinan administration relieves gut barrier dysfunction induced by rotavirus in a weaned piglet model.

Rotavirus (RV) is a pathogen that induces severe diarrhea in infants and young animals. Shiitake mushroom is a traditional food, which can improve physiological function, including gut health.

OncologyGut & microbiomeRespiratory

Medium relevance

King Oyster · 2019 · Research Article · Nutrients

The Effect of Mushroom Extracts on Human Platelet and Blood Coagulation: In vitro Screening of Eight Edible Species.

Cardiovascular diseases remain the leading global cause of mortality indicating the need to identify all possible factors reducing primary and secondary risk. This study screened the in vitro antiplatelet and anticoagulant activities of hot water extracts of eight edible mushroom species (Agaricus bisporus,….

OncologyImmune support

Medium relevance

Shiitake · 2015 · Clinical Trial · Nutrition and cancer

Antioxidant and Anticoagulant Status Were Improved by Personalized Dietary Intervention Based on Biochemical and Clinical Parameters in Cancer Patients.

We investigated whether personalized dietary intervention could improve clinical measurements such as immune cell-mediated cytotoxicity, serum albumin, derivatives of reactive oxygen metabolites (D-ROMS), D-dimer, and fibrinogen..

OncologyImmune supportEnergy & fatigueMetabolic health

Medium relevance

Lion's Mane · 2015 · Research Support, Non U.S. Gov'T · Food chemistry

Isolation and identification of aromatic compounds in Lion's Mane Mushroom and their anticancer activities.

Lion's Mane Mushroom (Hericium erinaceum) is a traditional edible mushroom widely used in culinary applications and as an herbal medicine in East Asian countries..

OncologyCognition & nerves

Medium relevance

King Oyster · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Structure characterization and antitumor activity of a polysaccharide from the alkaline extract of king oyster mushroom.

A water-soluble polysaccharide, designated as KOMAP, was isolated and purified from the alkaline extract of king oyster mushroom, which was composed of glucose (Glc), mannose (Man) and arabinose (Ara) in a molar ratio of 6.2:2.1:2.0. It had an average molecular weight of 2.1×10(4)Da..

OncologyImmune supportMetabolic health

Medium relevance

Nameko · 2014 · Research Support, Non U.S. Gov'T · Biochimie

Purification and characterization of a novel antitumor protein with antioxidant and deoxyribonuclease activity from edible mushroom Pholiota nameko.

A novel antitumor protein from the edible mushroom Pholiota nameko (PNAP) was purified through a two-step chromatographic procedure including SP cation exchange chromatogram and Superdex gel filtration..

OncologyEnergy & fatigue

Medium relevance

Maitake · 2010 · Research Support, Non U.S. Gov'T · BJU international

Synergistic potentiation of interferon activity with maitake mushroom d-fraction on bladder cancer cells.

OBJECTIVE: To examine whether the combination of interferon (IFN)-alpha and maitake mushroom D-fraction (PDF), a bioactive mushroom extract, might potentiate the anticancer activity of IFN-alpha in bladder cancer T24 cells in vitro..

Oncology

Medium relevance

Almond Mushroom · 2024 · Research Support, Non U.S. Gov'T · Theranostics

Albumin-seeking dyes with adjustable assemblies in situ enable programmable imaging windows and targeting tumor imaging.

Cyanine dyes are widely used organic probes for in vivo imaging due to their tunable fluorescence. They can form complexes with endogenous albumin, resulting in enhanced brightness and photostability..

Oncology

Medium relevance

Almond Mushroom · 2024 · Research Support, Non U.S. Gov'T · Chaos (Woodbury, N.Y.)

Chaotic dynamics and optimal therapeutic strategies for Caputo fractional tumor immune model in combination therapy.

In this paper, a Caputo fractional tumor immune model of combination therapy is established. First, the stability and biological significance of each equilibrium point are analyzed, and it is demonstrated that chaos may arise under specific conditions..

OncologyImmune support

Medium relevance

Cordyceps · 2023 · Journal Article · Advances in biochemical engineering/biotechnology

Bioactive Compounds from Medicinal Mushrooms.

Research progress of active compounds and biological activities of medicinal mushroom-Ganoderma spp., Hericium spp., Phellinus spp., and Cordyceps spp. were summarized systematically..

OncologyImmune supportMetabolic healthLiver support

Medium relevance

Cordyceps · 2023 · Journal Article · Biological & pharmaceutical bulletin

Cordycepin Enhances the Cytotoxicity of Human Natural Killer Cells against Cancerous Cells.

Cancer treatment with natural killer (NK) cell immunotherapy is promising. NK cells can recognize and kill cancer cells without sensitization, making them a potential cancer treatment alternative.

OncologyImmune support

Medium relevance

Cordyceps · 2023 · Journal Article · Journal of food and drug analysis

Cordycepin inhibits ERK pathway to suppress FGF9-induced tumorigenesis with MA-10 mouse Leydig tumor cells.

Fibroblast growth factor 9 (FGF9) is a member of FGF family, and abnormal expression of FGF9 can promote tumorigenesis. Cordycepin, a major bioactive component in fungus Cordyceps sinensis, could suppress various tumors..

OncologyGut & microbiome

Medium relevance

Oyster Mushroom · 2023 · Journal Article · Die Pharmazie

Delivery of free amino acids into and through the stratum corneum of the skin using micro emulsions and microemulsion-based hydrogels: Formulation, characterization, and ex-vivo permeation studies.

Free amino acids constitute the largest portion (40%) of the natural moisturizing factor. Their level might decline and cause dry skin condition.

OncologyLiver supportSkin & hydration

Medium relevance

Almond Mushroom · 2023 · Journal Article · European journal of epidemiology

Lympho-hematopoietic malignancies risk after exposure to low dose ionizing radiation during cardiac catheterization in childhood.

Pediatric patients with congenital heart disease (CHD) often undergo low dose ionizing radiation (LDIR) from cardiac catheterization (CC) for the diagnosis and/or treatment of their disease. Although radiation doses from a single CC are usually low, less is known about the long-term radiation associated cancer risks..

Oncology

Medium relevance

Lion's Mane · 2023 · Journal Article · European journal of medicinal chemistry

Nature-inspired new isoindole-based Passerini adducts as efficient tumor-selective apoptotic inducers via caspase-3/7 activation.

The development of novel therapeutics promoting selective tumor elimination is the mainstay of clinical oncology. Emerging insights into tumor targeting reveal caspases activation, especially caspase-3, as a personalized anticancer strategy..

OncologyRespiratory

Medium relevance

Almond Mushroom · 2023 · Journal Article · Cancers

Quantifying Intratumoral Heterogeneity and Immunoarchitecture Generated In-Silico by a Spatial Quantitative Systems Pharmacology Model.

Spatial heterogeneity is a hallmark of cancer. Tumor heterogeneity can vary with time and location.

OncologyImmune support

Medium relevance

Shiitake · 2023 · Journal Article · Euroasian journal of hepato-gastroenterology

Role of Biobran (Arabinoxylan Rice Bran) on Patients with Advanced Stage Hepatocellular Carcinoma.

BACKGROUND AND OBJECTIVES: Carcinoma of liver - renowned, has taken third position in world ranking, comparing to other causes for cancer-related death, however, curative treatment of hepatocellular carcinoma (HCC) is largely absent and even proper management of HCC patients is extremely difficult..

OncologyImmune supportLiver support

Medium relevance

Cordyceps · 2023 · Journal Article · Journal of separation science

Simultaneous determination of cordycepin and its metabolite 3'-deoxyinosine in rat whole blood by ultra-high-performance liquid chromatography coupled with Q Exactive hybrid quadrupole orbitrap high-resolution accurate mass spectrometry and its application to accurate pharmacokinetic studies.

Cordycepin from Cordyceps possesses excellent pharmacological properties, including anti-inflammation and anti-tumor effects, therefore representing a potential alternative medicine. However, doubts about the pharmacokinetic results of cordycepin had been raised in the previous study due to its rapid deamination..

OncologyImmune supportEnergy & fatigue

Medium relevance

Niu-Chang-Chih · 2022 · Research Article · International journal of molecular sciences

4-Acetylantroquinonol B Suppresses Prostate Cancer Growth and Angiogenesis via a VEGF/PI3K/ERK/mTOR-Dependent Signaling Pathway in Subcutaneous Xenograft and In Vivo Angiogenesis Models.

Prostate cancer is a major cause of cancer-related mortality in men in developed countries. The compound, 4-acetylantroquinonol B (4AAQB), is isolated from Antrodia cinnamomea (commonly known as Niu-Chang-Chih), which has been shown to inhibit cancer growth..

Oncology

Medium relevance

Almond Mushroom · 2022 · Journal Article · PLoS computational biology

A computational modeling approach for predicting multicell spheroid patterns based on signaling-induced differential adhesion.

Physiological and pathological processes including embryogenesis and tumorigenesis rely on the ability of individual cells to work collectively to form multicell patterns. In these heterogeneous multicell systems, cell-cell signaling induces differential adhesion between cells that leads to tissue-level patterning..

Oncology

Medium relevance

Cordyceps · 2022 · Journal Article · American journal of cancer research

Cordycepin enhances radiosensitivity to induce apoptosis through cell cycle arrest, caspase pathway and ER stress in MA-10 mouse Leydig tumor cells.

Radiotherapy is a localized treatment commonly used in various types of cancer. However, major limitation of radiotherapy is the development of resistance of tumor cells to radiosensitivity.

Oncology

Medium relevance

Cordyceps · 2022 · Journal Article · Evidence-based complementary and alternative medicine: eCAM

Cordycepin Induces Apoptosis through JNK-Mediated Caspase Activation in Human OEC-M1 Oral Cancer Cells.

Cordycepin, a bioactive compound extracted from Cordyceps sinensis, can induce apoptosis in human OEC-M1 oral cancer cells. However, the exact mechanism is still unclear.

OncologyImmune support

Medium relevance

Cordyceps · 2022 · Journal Article · Oncology letters

Cordycepin inhibits the proliferation and progression of NPC by targeting the MAPK/ERK and β-catenin pathways.

Cordycepin is an extract from the Cordyceps genus of ascomycete fungi. In the present study, the anticancer potential of cordycepin against nasopharyngeal carcinoma (NPC), and the potential underlying mechanisms, were investigated..

OncologyGut & microbiomeSkin & hydration

Medium relevance

Cordyceps · 2022 · Journal Article · Frontiers in oncology

Cordycepin Inhibits Triple-Negative Breast Cancer Cell Migration and Invasion by Regulating EMT-TFs SLUG, TWIST1, SNAIL1, and ZEB1.

Cancer metastasis is the most important cause of cancer-related death, and epithelial-to-mesenchymal transition (EMT) plays crucial roles in cancer metastasis. Cordycepin (CD) is highly enriched in the medicinally used Cordyceps mushroom..

Oncology

Medium relevance

Cordyceps · 2022 · Journal Article · Frontiers in aging neuroscience

Integration of network pharmacology and molecular docking to explore the molecular mechanism of Cordycepin in the treatment of Alzheimer's disease.

BACKGROUND: Cordycepin is a nucleoside adenosine analog and an active ingredient isolated from the liquid fermentation of Cordyceps. This study sought to explore the mechanism underlying the therapeutic effect of Cordycepin against Alzheimer's disease using network pharmacology and molecular docking technology..

OncologyCognition & nerves

Medium relevance

Almond Mushroom · 2022 · Journal Article · RSC medicinal chemistry

Metabolic labelling of cancer cells with glycodendrimers stimulate immune-mediated cytotoxicity.

The recruitment of antibody naturally present in human blood stream at the surface of cancer cells have been proved a promising immunotherapeutic strategy to fight cancer..

OncologyImmune supportMetabolic health

Medium relevance

Shiitake · 2022 · Journal Article · Alternative therapies in health and medicine

RBAC and Its Role with the Immune System.

CONTEXT: Rice Bran Arabinoxylan Compound (RBAC) is a trusted and proven immunomodulator made from a rice bran extract that has been enzymatically modified with an enzyme complex from the shiitake mushroom. OBJECTIVE: The study's primary objective was to identify the role of RBAC in supporting cancer therapies..

OncologyImmune support

Medium relevance

Almond Mushroom · 2021 · Journal Article · Cancers

A Spatial Quantitative Systems Pharmacology Platform spQSP-IO for Simulations of Tumor-Immune Interactions and Effects of Checkpoint Inhibitor Immunotherapy.

Quantitative systems pharmacology (QSP) models have become increasingly common in fundamental mechanistic studies and drug discovery in both academic and industrial environments..

OncologyImmune supportRespiratory

Medium relevance

Almond Mushroom · 2021 · Journal Article · Radiotherapy and oncology: journal of the European Society for Therapeutic Radiology and Oncology

Correlations between bone marrow radiation dose and hematologic toxicity in locally advanced cervical cancer patients receiving chemoradiation with cisplatin: a systematic review.

Patients with locally advanced cervical cancer (LACC) treated with chemoradiation often experience hematologic toxicity (HT), as chemoradiation can induce bone marrow (BM) suppression..

Oncology

Medium relevance

Almond Mushroom · 2021 · Journal Article · Frontiers in chemistry

How Different Albumin-Binders Drive Probe Distribution of Fluorescent RGD Mimetics.

The biodistribution of medical imaging probes depends on the chemical nature of the probe and the preferred metabolization and excretion routes. Especially targeted probes, which have to reach a certain (sub)cellular destination, have to be guided to the tissue of interest..

Oncology

Medium relevance

Cordyceps · 2021 · Journal Article · ACS chemical biology

Identifying the Cellular Target of Cordyheptapeptide A and Synthetic Derivatives.

Cordyheptapeptide A is a lipophilic cyclic peptide from the prized Cordyceps fungal genus that shows potent cytotoxicity in multiple cancer cell lines. To better understand the bioactivity and physicochemical properties of cordyheptapeptide A with the ultimate goal of identifying its cellular target, we developed a….

Oncology

Medium relevance

Almond Mushroom · 2021 · Journal Article · Journal of agricultural and food chemistry

Monooxygenase LaPhzX is Involved in Self-Resistance Mechanisms during the Biosynthesis of N-Oxide Phenazine Myxin.

Self-resistance genes are deployed by many microbial producers of bioactive natural products to avoid self-toxicity. Myxin, a di-N-oxide phenazine produced by Lysobacter antibioticus OH13, is toxic to many microorganisms and tumor cells..

OncologyEnergy & fatigue

Medium relevance

Oyster Mushroom · 2021 · Journal Article · Analytical biochemistry

Purification and characterization of a synergistic bioactive lectin from Pleurotus flabellatus (PFL-L) with potent antibacterial and in-vitro radical scavenging activity.

Lectin is a carbohydrate-binding protein, which exhibits a plethora of biological properties such as antimicrobial, antifungal, and anticancer activities. In the present study, lectin, with an antibacterial and antioxidant potential, was purified from the oyster mushroom Pleurotus flabellatus.

Oncology

Medium relevance

Cordyceps · 2021 · Journal Article · Frontiers in pharmacology

The Novel Chinese Medicine JY5 Formula Alleviates Hepatic Fibrosis by Inhibiting the Notch Signaling Pathway.

Advanced liver fibrosis can lead to cirrhosis, resulting in an accelerated risk of hepatocellular carcinoma and liver failure. Fuzheng Huayu formula (FZHY) is a traditional Chinese medicine formula treated liver fibrosis in China approved by a Chinese State Food and Drug Administration (NO: Z20050546), composed of….

OncologyLiver supportSkin & hydration

Medium relevance

Cordyceps · 2020 · Brief Report · Cell chemical biology

Mechanism of Activation of AMPK by Cordycepin.

Cordycepin (3'-deoxyadenosine) is a major bioactive agent in Cordyceps militaris, a fungus used in traditional Chinese medicine. It has been proposed to have many beneficial metabolic effects by activating AMP-activated protein kinase (AMPK), but the mechanism of activation remained uncertain..

OncologyMetabolic health

Medium relevance

Cordyceps · 2019 · Research Support, Non U.S. Gov'T · Pharmacological research

Natural medicines for the treatment of fatigue: Bioactive components, pharmacology, and mechanisms.

It is a common phenomenon that people are in a sub-health condition and facing "unexplained fatigue", which seriously affects their health, work efficiency and quality of life. Meanwhile, fatigue is also a common symptom of many serious diseases such as HIV/AIDS, cancer, and schizophrenia..

OncologyEnergy & fatigue