MycoData

OncologyImmune supportLiver support

Maitake · 1996 · Journal Article · Biological & pharmaceutical bulletin

Effect of β-Glucans on the Nitric Oxide Synthesis by Peritoneal Macrophage in Mice

Nitric oxide (NO) is an important effector molecule on antimicrobial and antitumor effects of macrophages. (1 -> 3)-beta-D-Glucan (beta-glucan) is well known to show various immunopharmacological effects such as antimicrobial effect and antitumor effect by activating various points of host defense mechanisms..

Maitake · 1995 · Journal Article · Biological & pharmaceutical bulletin

Enhancement of LPS Triggered TNF-α (Tumor Necrosis Factor-α) Production by (1→3)-β-D-Glucans in Mice

Effects of (1-->3)-beta-D-glucans on tumor necrosis factor-alpha (TNF-alpha) production in mice in vivo were investigated with or without triggering stimulation of lipopolysaccharide (LPS)..

OncologyImmune supportCognition & nerves

Maitake · 1995 · Journal Article · Biological & pharmaceutical bulletin

Structure-Activity Relationship of (1→3)-β-D-Glucans in the Induction of Cytokine Production from Macrophages, in Vitro

In a previous study, we reported that one of the gel-forming (1-->3)-beta-D-glucans, grifolan (from Grifola frondosa, GRN), stimulated cytokine production from macrophages in vitro..

OncologyImmune supportMetabolic healthRespiratory

Enoki · 1990 · Journal Article · Journal of food protection

Nutritional and Medicinal Value of Specialty Mushrooms.

Although the button mushroom ( Agaricus bisporus ) accounts for slightly over half of total world mushroom production, specialty mushrooms, e.g., shiitake ( Lentinula edodes ), straw ( Volvariella volvacea ), oyster ( Pleurotus spp.), and enokitake ( Flammulina velutipes ), are increasing in popularity..

Maitake · 1987 · Journal Article · Journal of pharmacobio-dynamics

Antitumor effect of polysaccharide grifolan NMF-5N on syngeneic tumor in mice.

Antitumor activity of grifolan NMF-5N, a beta-1,3-glucan obtained from mycelia of Grifola frondosa, was examined. Grifolan NMF-5N showed antitumor activities in allogeneic and syngeneic murine tumor systems..

Enoki · 1985 · Journal Article · Japanese journal of cancer research: Gann

Proflamin, a new antitumor agent: preparation, physicochemical properties and antitumor activity.

Proflamin is a new biological response-modifying antitumor agent. It was isolated from the culture mycelium of Flammulina velutipes (Curt.

OncologyImmune supportEnergy & fatigue

Chaga · 2020 · Research Support, Non U.S. Gov'T · Cells

3,4-Dihydroxybenzalacetone (DBL) Prevents Aging-Induced Myocardial Changes in Senescence-Accelerated Mouse-Prone 8 (SAMP8) Mice.

Aging is a predominant risk factor for the development and progression of cardiovascular complications. Physiologically and anatomically, the heart undergoes numerous changes that result in poor cardiac function in the elderly population..

OncologyImmune supportSkin & hydration

Shiitake · 2019 · Case Reports · The American Journal of dermatopathology

Histological Features of Flagellate Erythema.

Flagellate erythema is a distinctive eruption characterized by "whip-like" linear or curvilinear streaks and plaques, occurring mainly on the trunk. It has classically been described in 2 disparate clinical settings: chemotherapy with bleomycin and ingestion of mushrooms (most commonly Shiitake mushrooms)..

Shiitake · 2017 · Case Reports · Dermatology online journal

A gastronomic delight?

Flagellate dermatitis (FD) exhibits a striking clinical appearance similar to whiplash marks. General dermatologists are likely to encounter this clinical appearance as a more localized presentation of phytophotodermatosis.

Shiitake · 2017 · Case Reports · Pediatric dermatology

Flagellate Dermatitis in a Child Most Likely Secondary to Doxorubicin.

Flagellate dermatitis, a cutaneous eruption in which the patient appears to have been whipped, has been described with antineoplastic agents and shiitake mushroom ingestion..

OncologyCognition & nerves

Lion's Mane · 2016 · Case Reports · Journal of neurosurgery

Endoscope-assisted endonasal versus supraorbital keyhole resection of olfactory groove meningiomas: comparison and combination of 2 minimally invasive approaches.

OBJECTIVE: Although the endonasal endoscopic approach has been applied to remove olfactory groove meningiomas, controversy exists regarding the efficacy and safety of this approach compared with more traditional transcranial approaches..

OncologyImmune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2015 · Journal Article · Pharmacology, biochemistry, and behavior

Effects of amycenone on serum levels of tumor necrosis factor-α, interleukin-10, and depression-like behavior in mice after lipopolysaccharide administration.

Accumulating evidence suggests that inflammation plays a role in the pathophysiology of depression and that anti-inflammatory substances have antidepressant effects. Amycenone is obtained from extracts of the Yamabushitake (Hericium erinaceum)..

Maitake · 2013 · Journal Article · Integrative cancer therapies

Induction of cell death in renal cell carcinoma with combination of D-fraction and vitamin C.

HYPOTHESIS: Although several conventional therapeutic options for advanced renal cell carcinoma (RCC) are currently available, the unsatisfactory outcomes demand establishing more effective interventions..

Turkey Tail · 2011 · Journal Article · Journal of ethnopharmacology

Acute and subchronic oral toxicity of Coriolus versicolor standardized water extract in Sprague-Dawley rats.

ETHNOPHARMACOLOGICAL RELEVANCE: Coriolus versicolor, which is known as Yun Zhi, is one of the commonly used Chinese medicinal herbs. Recent studies have demonstrated its antitumor activities on cancer cells which led to its widespread use in cancer patient..

OncologyMetabolic health

Turkey Tail · 2011 · Journal Article · PloS one

Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population.

Recent evidence suggested that prostate cancer stem/progenitor cells (CSC) are responsible for cancer initiation as well as disease progression. Unfortunately, conventional therapies are only effective in targeting the more differentiated cancer cells and spare the CSCs..

Nameko · 2003 · Research Support, Non U.S. Gov'T · Nutrition and cancer

Cruciferous vegetables, mushrooms, and gastrointestinal cancer risks in a multicenter, hospital-based case-control study in Japan.

We assessed the possible association of gastrointestinal cancers with cruciferous vegetables and mushrooms in a multicenter, hospital-based case-control study in an agricultural area of Japan..

OncologyGut & microbiome

OncologyImmune supportMetabolic health

Niu-Chang-Chih · 2015 · Comparative Study · Toxicology and applied pharmacology

4-Acetylantroquinonol B inhibits colorectal cancer tumorigenesis and suppresses cancer stem-like phenotype.

4-Acetylantroquinonol B (4-AAQB), closely related to the better known antroquinonol, is a bioactive isolate of the mycelia of Antrodia camphorata, a Taiwanese mushroom with documented anti-inflammatory, hypoglycemic, vasorelaxative, and recently demonstrated, antiproliferative activity..

Zhu Ling · 2015 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Efficacy of Zhuling polyporus polysaccharide with BCG to inhibit bladder carcinoma.

There is growing interest in reducing Bacille Calmette-Guerin (BCG) side effects while keeping intact its therapeutic efficacy. In the present study, we evaluated the efficacy of Sclerotia of Polyporus umbellatus FRIES (Zhuling) and its main ingredient Polyporus Polysaccharide (PPS) to attenuate side effects of BCG….

OncologyCognition & nerves

Maitake · 2015 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Lysophosphatidylethanolamine increases intracellular Ca(2+) through LPA(1) in PC-12 neuronal cells.

G protein-coupled receptors (GPCRs) have been implicated in lysophosphatidylethanolamine (LPE)-induced increases in intracellular Ca(2+) ([Ca(2+)]i), but in different cell types, this response may be dependent or independent of lysophosphatidic acid (LPA) GPCR..

Lion's Mane · 2014 · Research Support, Non U.S. Gov'T · International journal of medicinal mushrooms

Anti-inflammatory activity of mycelial extracts from medicinal mushrooms.

Medicinal mushrooms have been essential components of traditional Chinese herbal medicines for thousands of years, and they protect against diverse health-related conditions. The components responsible for their anti-inflammatory activity have yet to be fully studied..

OncologyEnergy & fatigueGut & microbiome

Mesima · 2014 · Research Support, Non U.S. Gov'T · Anticancer research

Anticancer activity of hispidin via reactive oxygen species-mediated apoptosis in colon cancer cells.

Few studies have been performed on the anticancer activity of hispidin, a phenolic compound produced from the medicinal mushroom Phellinus linteus. Herein, we studied hispidin-induced apoptosis, which is associated with the generation of reactive oxygen species (ROS) in colon cancer cells..

OncologyImmune supportSkin & hydration

Mesima · 2014 · Research Support, Non U.S. Gov'T · International journal of molecular sciences

Hispolon decreases melanin production and induces apoptosis in melanoma cells through the downregulation of tyrosinase and microphthalmia-associated transcription factor (MITF) expressions and the activation of caspase-3, -8 and -9.

Hispolon is one of the most important functional compounds that forms Phellinus linteus (Berkeley & Curtis) Teng. Hispolon has antioxidant, anti-inflammatory, antiproliferative and anticancer effects.

OncologyImmune supportEnergy & fatigueRespiratory

Mesima · 2014 · Research Support, Non U.S. Gov'T · Journal of ethnopharmacology

Hispolon inhibition of inflammatory apoptosis through reduction of iNOS/NO production via HO-1 induction in macrophages.

ETHNOPHARMACOLOGICAL RELEVANCE: Phellinus linteus (Berkeley & Curtis), a well-known medical fungus, has long been used as a traditional medicine in Oriental countries to treat various diseases, and hispolon (HIS) is one of its bioactive components..

Agarikon · 2014 · Research Support, Non U.S. Gov'T · Molecules (Basel, Switzerland)

In vivo and in vitro anti-tumor effects of fungal extracts.

Fungal extracts are extensively used as nutritional supplements in Far-Eastern Asia. In this study, we aimed to evaluate the anti-cancer activities of some different fungal species against different cancer cell lines.

Turkey Tail · 2014 · Dissertation · journal metadata

Investigating the role of laccase and laccase mediator systems to improve the saccharification of biomass for bioethanol production

Metadata-grounded summary: This dissertation indexes research on Trametes versicolor in 2014. MycoData maps the paper to oncology, immune support based on its title, species context, article metadata, and study classification..

Maitake · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Protective effect of polysaccharides on simulated microgravity-induced functional inhibition of human NK cells.

Polysaccharides are believed to be strong immunostimulants that can promote the proliferation and activity of T cells, B cells, macrophages and natural killer (NK) cells. This study aimed to investigate the effects of five polysaccharides (Grifola frondosa polysaccharide (GFP), lentinan (LNT), G..

OncologyImmune supportSkin & hydration

Snow Fungus · 2014 · Evaluation Study · International journal of medicinal mushrooms

The optimum submerged culture condition of the culinary-medicinal white jelly mushroom (Tremellomycetes) and its antioxidant properties.

Tremella fuciformis is a natural edible and medicinal mushroom commercially available in Taiwan. In this study, the effects of initial pH, incubation time, and various media to optimize exopolysaccharide (EPS) production by T.

OncologyCognition & nervesEnergy & fatigueMetabolic health

Mesima · 2014 · Research Support, Non U.S. Gov'T · Experimental cell research

The protective effect of hispidin against hydrogen peroxide-induced apoptosis in H9c2 cardiomyoblast cells through Akt/GSK-3β and ERK1/2 signaling pathway.

Hispidin, a phenolic compound from Phellinus linteus (a medicinal mushroom), has been shown to possess strong anti-oxidant, anti-cancer, anti-diabetic, and anti-dementia properties. However, the cardioprotective efficacy of hispidin has not yet been investigated..

Niu-Chang-Chih · 2014 · Research Support, Non U.S. Gov'T · The Journal of organic chemistry

Total synthesis of (±)-antroquinonol d.

Total synthesis of (±)-antroquinonol D, which is isolated from very expensive and rarely found Antrodia camphorata and which has potential anticancer properties, was achieved from 4-methoxyphenol. In addition, a Michael addition to dimethoxy cyclohexadienones was studied..

Maitake · 2013 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

A chemically sulfated polysaccharide from Grifola frondos induces HepG2 cell apoptosis by notch1-NF-κB pathway.

Sulfated polysaccharides have been known to inhibit proliferation in tumor cells. However, the molecular mechanisms involved in sulfated polysaccharides-induced apoptosis are still uncharacterized..

Zhu Ling · 2013 · Research Support, Non U.S. Gov'T · Applied spectroscopy

A sensitive spectrofluorometric method for determination of ergosta-4,6,8(14),22-tetraen-3-one in rat plasma, feces, and urine for application to pharmacokinetic studies using cerium(III) as a probe.

Ergosta-4,6,8(14),22-tetraen-3-one (ergone) isolated from Polyporus umbellatus possesses a variety of pharmacological activities in vivo and in vitro, including cytotoxic, diuretic, and immunosuppressive effect..

Turkey Tail · 2013 · Research Support, Non U.S. Gov'T · Human & experimental toxicology

Cytotoxic, genotoxic and antigenotoxic potencies of oligorutins.

Rutin has been enzymatically oligomerized by laccase from Trametes versicolor. Five fractions of oligomers were obtained from the monomers having high solubility in water, which can reach 351-times that of rutin.

Zhu Ling · 2013 · Research Support, Non U.S. Gov'T · Journal of cosmetic science

Inhibitory effects of Korean indigenous plants on tyrosinase and melanogenesis.

To search for new depigmenting cosmetic ingredients from Korean herbal extracts of traditional Korean medicines (TKMs), we screened about 17 TKM extracts collected in the Republic of Korea..

OncologyImmune supportCognition & nerves

Maitake · 2013 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine

Neurite outgrowth stimulatory effects of culinary-medicinal mushrooms and their toxicity assessment using differentiating Neuro-2a and embryonic fibroblast BALB/3T3.

BACKGROUND: Mushrooms are not only regarded as gourmet cuisine but also as therapeutic agent to promote cognition health. However, little toxicological information is available regarding their safety..

OncologyImmune supportCognition & nervesEnergy & fatigue

Maitake · 2013 · Research Support, Non U.S. Gov'T · BMC complementary and alternative medicine

Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells.

BACKGROUND: Senescence of the neurons is believed to be a focal factor in the development of age-related neurodegenerative diseases such as Alzheimer's disease. Diminutions in the levels of nerve growth factor (NGF) lead to major declines in brain cell performance..

OncologyImmune supportEnergy & fatigue

Niu-Chang-Chih · 2012 · Research Support, Non U.S. Gov'T · The Journal of nutritional biochemistry

Antroquinonol, a natural ubiquinone derivative, induces a cross talk between apoptosis, autophagy and senescence in human pancreatic carcinoma cells.

Pancreatic cancer is a malignant neoplasm of the pancreas. A mutation and constitutive activation of K-ras occurs in more than 90% of pancreatic adenocarcinomas.

OncologyMetabolic healthLiver supportRespiratory

Mesima · 2012 · Research Support, Non U.S. Gov'T · Oncology reports

BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer.

We have recently demonstrated that a natural dietary supplement BreastDefend (BD), which contains extracts from medicinal mushrooms (Coriolus versicolor, Ganoderma lucidum, Phellinus linteus), medicinal herbs (Scutellaria barbata, Astragalus membranaceus, Curcuma longa), and purified biologically active nutritional….

Mesima · 2011 · Research Support, Non U.S. Gov'T · Nutrition and cancer

A heat-stable extract from Mucuna stimulates the differentiation of bone marrow cells into dendritic cells and induces apoptosis in cancer cells.

Pine cone extract is known to induce differentiation of human mononuclear cells into dendritic cells (DCs) and also to induce apoptosis in human cancer cells. In the present study, we screened edible plants that contain components with biological activities similar to or more potent than those of pine cone extract..

OncologyEnergy & fatigueRespiratory

Niu-Chang-Chih · 2011 · Research Support, Non U.S. Gov'T · Mutation research

Antroquinonol inhibits NSCLC proliferation by altering PI3K/mTOR proteins and miRNA expression profiles.

Antroquinonol a derivative of Antrodia camphorata has been reported to have antitumor effects against various cancer cells. However, the effect of antroquinonol on cell signalling and survival pathways in non-small cell lung cancer (NSCLC) cells has not been fully demarcated..

Zhu Ling · 2011 · Research Support, Non U.S. Gov'T · Biochimica et biophysica acta

Ergosta-4,6,8(14),22-tetraen-3-one induces G2/M cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.

BACKGROUND: Mushrooms have been used in Asia as traditional foods and medicines for a long time. Ergosta-4,6,8(14),22-tetraen-3-one (ergone) is one of the well-known bioactive steroids, which exists widely in various medicinal fungi such as Polyporus umbellatus, Russula cyanoxantha, and Cordyceps sinensis..

OncologyLiver support

Mesima · 2011 · Research Support, Non U.S. Gov'T · International journal of oncology

Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid™: mechanism of activity.

Since the use of dietary supplements as alternative treatments or adjuvant therapies in cancer treatment is growing, a scientific verification of their biological activity and the detailed mechanisms of their action are necessary for the acceptance of dietary supplements in conventional cancer treatments..

OncologyImmune supportMetabolic healthLiver support

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Nutrition and cancer

Dietary effect of Antrodia Camphorate extracts on immune responses in WEHI-3 leukemia BALB/c mice.

Antrodia camphorata has been recognized to be a traditional Chinese medicine for abdominal pain, diarrhea, and to protect against hepatitis virus infection. Several ingredients derived from A.

Mesima · 2010 · Research Support, Non U.S. Gov'T · Journal of agricultural and food chemistry

Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways.

Cancer metastasis is a primary cause of cancer death. Hispolon is an active phenolic compound of Phellinus linteus, a mushroom that has recently been shown to have antioxidant and anticancer activities..

OncologyLiver support

OncologyImmune supportRespiratory

Mesima · 2010 · Research Support, Non U.S. Gov'T · Journal of medical virology

Induction of cross-protective immunity against influenza A virus H5N1 by an intranasal vaccine with extracts of mushroom mycelia.

The identification of a safe and effective adjuvant that is able to enhance mucosal immune responses is necessary for the development of an efficient inactivated intranasal influenza vaccine..

Niu-Chang-Chih · 2010 · Research Support, Non U.S. Gov'T · Bioorganic & medicinal chemistry letters

Methylantcinate A induces tumor specific growth inhibition in oral cancer cells via Bax-mediated mitochondrial apoptotic pathway.

An ergostane type triterpenoid methylantcinate A (MAA) isolated from the fruiting bodies of Antrodia camphorata inhibited the growth of oral cancer cell lines OEC-M1 and OC-2 in a dose-dependent manner, without cytotoxic to normal oral gingival fibroblast cells..

OncologyEnergy & fatigue

Maitake · 2010 · Research Support, Non U.S. Gov'T · International journal of oncology

Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells.

Mushrooms are an integral part of Traditional Chinese Medicine (TCM), and have been used for millennia to prevent or treat a variety of diseases. Currently mushrooms or their extracts are used globally in the form of dietary supplements..

OncologyImmune supportSkin & hydrationRespiratory

Lion's Mane · 2010 · Patent · journal metadata

Transdermal infusion paste preparation for enhancing immunity and preparation method thereof

The invention provides a transdermal infusion paste preparation for enhancing immunity and a preparation method thereof and relates to a preparation for enhancing the immunity and a preparation method thereof..

OncologyLiver supportSkin & hydrationRespiratory

Chaga · 2009 · English Abstract · Biomeditsinskaia khimiia

[Antitumor activity of the plant remedy peptide extract PE-PM in a new mouse T-lymphoma/eukemia model].

A new mouse ASF-LL model of adult T-lymphoma/leukemia (ATLL) in humans was characterized by cytological, histopathological, and flow cytometry analyses. Encouraging similarities of morphological, pathological, and clinical signs were found..