MycoData

Chitin-glucan complex (CGC) is an emerging novel prebiotic with numerous physiological activities in amelioration of clinical manifestations. In the present work, natural deep eutectic solvent (NADES), ultrasonication, and submerged fermentation using probiotic microorganisms were deployed for the extraction of CGC….

Immune supportGut & microbiome

High relevance

Cordyceps · 2024 · Journal Article · Industrial crops and products

Extraction, structural identification and anti-tumor activity of two Cordyceps militaris polysaccharides evaluated by S180 tumor-bearing mice

In this study, we extracted and isolated two polysaccharides with molecular weights of 2.28 × 10⁴ Da and 2.71 × 10³ Da from Cordyceps militaris, named CMP-90 and CMP-E, respectively..

OncologyImmune support

High relevance

Snow Fungus · 2024 · Research Article · Molecules (Basel, Switzerland)

Functionalities of Tremella fuciformis Polysaccharides Modified with Gallic Acid.

This research aimed to modify polysaccharides extracted from the edible mushroom Tremella fuciformis with gallic acid (GA) and to complex them with zinc ions. The functionalities of the modified Tremella fuciformis polysaccharides (TFPs) were investigated..

Immune support

High relevance

Reishi · 2024 · Randomized Controlled Trial · The British journal of nutrition

Ganoderma lucidum dry extract supplementation modulates T lymphocyte function in older women.

Ganoderma lucidum (a mushroom used in traditional Chinese medicine) compounds may attenuate ageing-related physiological changes and restore normal immunity. However, studies on the physiological effects of Ganoderma lucidum dry extract food supplements are few..

Immune support

High relevance

Reishi · 2024 · Journal Article · Journal of ethnopharmacology

Ganoderma lucidum ethanol extracts ameliorate hepatic fibrosis and promote the communication between metabolites and gut microbiota g_Ruminococcus through the NF-κB and TGF-β1/Smads pathways.

ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum, a traditional edible medicinal mushroom, has been widely reported to improve liver diseases as a dietary intervention for people..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2024 · Preprint · journal metadata

Ganoderma lucidum Extract Modulates Gene Expression Profiles Associated with Antioxidant Defense, Cytoprotection, and Senescence in Human Dermal Fibroblasts: A Transcriptomic Analysis

Cellular senescence plays a crucial role in skin aging, with senescent dermal fibroblasts contributing to reduced skin elasticity and increased inflammation. This study investigated the potential of Ganoderma lucidum (Reishi) extract to modulate the senescent phenotype of human dermal fibroblasts..

Immune supportSkin & hydration

High relevance

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Ganoderma lucidum polysaccharide promotes broiler health by regulating lipid metabolism, antioxidants, and intestinal microflora.

Ganoderma lucidum polysaccharides (GLP) are the primary bioactive macromolecular compounds of Ganoderma lucidum, possessing antioxidant and immunomodulatory effects. Hot water extract of Juncao-substrate Ganoderma Lucidum residue (HWE-JGLR) is abundant in GLP..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Research Article · Heliyon

Ganoderma lucidum polysaccharides reduce the severity of acute liver injury by improving the diversity and function of the gut microbiota.

Acute liver injury (ALI) is an abnormal liver function caused by oxidative stress, inflammation and other mechanisms.The interaction between intestine and liver plays an important role in ALI, and natural polysaccharides can participate in the regulation of ALI by regulating the composition of intestinal flora..

Immune supportGut & microbiomeLiver support

High relevance

Reishi · 2024 · Research Article · Frontiers in pharmacology

Ganoderma lucidum spore extract improves sleep disturbances in a rat model of sporadic Alzheimer's disease.

Introduction: Ganoderma lucidum (G. lucidum, Lingzhi) has long been listed as a premium tonic that can be used to improve restlessness, insomnia, and forgetfulness..

Immune supportCognition & nerves

High relevance

Almond Mushroom · 2024 · Journal Article · Journal of ethnopharmacology

GC/MS and 2D NMR-based approach to evaluate the chemical profile of hydroalcoholic extract from Agaricus blazei Murill and its anti-inflammatory effect on human neutrophils.

ETHNOPHARMACOLOGICAL RELEVANCE: Agaricus blazei Murill (AbM) is one of the main mushrooms used for medicinal purposes. The use of AbM in the preparation of teas is widespread mainly in Asian countries, while in Brazil it is used as a functional food to combat inflammatory diseases and cancer..

OncologyImmune support

High relevance

Cordyceps · 2024 · Journal Article · Journal of ethnopharmacology

Genotoxicity, acute and sub-acute toxicity profiles of methanolic Cordyceps militaris (L.) Fr. extract in Swiss Albino Mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Cordyceps militaris, a traditional medicinal fungus, parasitizes the intestines of lepidopteron pupae or larvae, predominantly during the winter, and undergoes fruiting in the summer or autumn. Compounds extracted from C..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2024 · Journal Article · International journal of medicinal mushrooms

Hot Water Extract of the Caterpillar Medicinal Mushroom Cordyceps militaris (Ascomycetes) Fruiting Body Activates Myeloid Dendritic Cells through A Dectin-1-Mediated Pathway.

The traditional use of Cordyceps militaris, an entomopathogenic fungus, in East Asian medicine has been well documented. Our previous study revealed that the fruiting body powder of C..

OncologyImmune supportGut & microbiome

High relevance

Cordyceps · 2024 · Research Article · Insects

Immunomodulation and Protective Effects of Cordyceps militaris Extract Against Candida albicans Infection in Galleria mellonella Larvae.

Cordyceps militaris-derived formulations are currently used for multiple purposes because of their medical properties, especially immune system modulation. This study analyzes the inhibitory effects of C..

Immune support

High relevance

Cordyceps · 2024 · Research Article · Molecules (Basel, Switzerland)

Immunomodulatory Effect of Cordyceps militaris Polysaccharide on RAW 264.7 Macrophages by Regulating MAPK Signaling Pathways.

Polysaccharide is one of the principal bioactive components found in medicinal mushrooms and has been proven to enhance host immunity. However, the possible mechanism of immunomodulatory activity of Cordyceps militaris polysaccharide is not fully understood..

Immune supportMetabolic health

High relevance

Cordyceps · 2024 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Improvement of extracellular polysaccharides production from Cordyceps militaris immobilized alginate beads in repeated-batch fermentation

Cordyceps militaris (C. militaris) is a unique medicinal fungus of the genus Cordyceps.

Immune supportMetabolic health

High relevance

Yellow Morel · 2024 · Research Article · Food chemistry: X

In vitro digestion and fecal fermentation behaviors of exopolysaccharide from Morchella esculenta and its impacts on hypoglycemic activity via PI3K/Akt signaling and gut microbiota modulation.

This study aimed to evaluate the effects of gastrointestinal digestion on the physicochemical properties and hypoglycemic activity of extracellular polysaccharides from Morchella esculenta (MEPS)..

Immune supportMetabolic healthGut & microbiome

High relevance

King Oyster · 2024 · Journal Article · Food & function

In vitro gastrointestinal digestion and fecal fermentation of Pleurotus eryngii proteins extracted using different methods: insights for the utilization of edible mushroom-based proteins as novel nutritional and functional components.

Pleurotus eryngii (P. eryngii) protein is considered a high-quality protein because it is rich in essential amino acids and displays multiple significant functional characterizations that vary with its fabrication processes.

Immune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2024 · Preprint · journal metadata

In vitro simulation of oral gastric intestinal digestion and fecal fermentation of Cordyceps militaris polysaccharides reveal its digestion profile and effect on the modulation of the gut microbiota

Abstract Background: Polysaccharides isolated from Cordyceps militaris mycelia (IPS) are natural polymer compounds composed of monosaccharides, structurally diverse and exhibit various metabolic and biological activities..

Immune supportMetabolic healthGut & microbiome

High relevance

Turkey Tail · 2024 · Journal Article · Journal of AOAC International

Influence of Organic and Inorganic Compounds of Various Metals on the Synthesis of Polysaccharides by the Medicinal Mushroom Trametes versicolor.

BACKGROUND: To date, basidiomycetes are considered to be promising objects of biotechnology, due to a number of biologically active compounds, such as polysaccharides and triterpenes. These compounds have a high therapeutic potential and demonstrate immunomodulatory, antiviral, and antifungal activities..

Immune supportMetabolic healthRespiratory

High relevance

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

Inhibition mechanism of cordycepin and ergosterol from Cordyceps militaris Link. against xanthine oxidase and cyclooxygenase-2.

Cordyceps militaris Link. (C.

Immune supportEnergy & fatigue

High relevance

Chaga · 2024 · Journal Article · Toxicology mechanisms and methods

Inonotus obliquus aqueous extract inhibits intestinal inflammation and insulin metabolism defects in Drosophila.

In biomedical research, the fruit fly (Drosophila melanogaster) is among the most effective and flexible model organisms. Through the use of the Drosophila model, molecular mechanisms of human diseases can be investigated and candidate pharmaceuticals can be screened..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

King Oyster · 2024 · Journal Article · Food & function

Interactions between intestinal microbial fermentation products of Pleurotus eryngii polysaccharide with gut mucus.

Recently, Pleurotus eryngii (P. eryngii) polysaccharide (PEP) has received a lot of attention from many researchers as the primary active substance.

Immune supportGut & microbiome

High relevance

Oyster Mushroom · 2024 · Journal Article · Chemistry & biodiversity

Investigating the Anticancer Effects of Pleurotus ostreatus Polysaccharide on G0/G1 Cell Cycle Arrest and Apoptosis in Ehrlich Ascites Carcinoma Cells.

Cancer is one of the leading causes of mortality worldwide. Despite the advancement of cancer treatment by various means including surgery, chemotherapy etc, cancer is still a challenging disease to manage..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Journal Article · International journal of medicinal mushrooms

Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Nanogel in a Complete Freund's Adjuvant-Induced Rheumatoid Arthritis Rat Model: Anti-Arthritic, Anti-Inflammatory, and Antioxidative Activity.

Lingzhi or reishi mushroom, Ganoderma lucidum, is a medicinal mushroom quite widely developed as herbal medicine because it has acted as an anticancer, antitumor, antioxidant, and anti-inflammatory. The active mycochemical compounds of G..

OncologyImmune support

High relevance

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Low molecular weight polysaccharide of Tremella fuciformis exhibits stronger antioxidant and immunomodulatory activities than high molecular weight polysaccharide.

Low molecular weight polysaccharides had higher bio-activity and bioavailability compared to ultra-high molecular weight polysaccharides, this study aimed to obtain low molecular weight polysaccharides from Tremella fuciformis (TFLP) by using high-temperature and high-pressure assisted hydrochloric acid method to….

Immune supportGut & microbiome

High relevance

Turkey Tail · 2024 · Journal Article · South African journal of botany

Medicinal potential of Turkey tail mushroom (Trametes versicolor): A comprehensive review

Medicinal mushroom are known for their therapeutic capabilities and one such notable example is the Turkey tail mushroom (Trametes versicolor). This fascinating medicinal fungus, belonging to the genusTrametes that has been in used for centuries in traditional medicine systems, particularly in Asia..

OncologyImmune supportMetabolic healthLiver support

High relevance

Reishi · 2024 · Research Article · Food chemistry: X

Metabolite profiling, antioxidant and anti-glycemic activities of Tartary buckwheat processed by solid-state fermentation(SSF)with Ganoderma lucidum.

The aim of this study was to investigate the effect of Ganoderma lucidum fermentation on antioxidant and anti-glycemic activities of Tartary buckwheat. Xylanase, total cellulase (CMCase and FPase) and β-glucosidase in fermented Tartary buckwheat (FB) increased significantly to 242.06 U/g, 17.99 U/g and 8.67 U/g,….

Immune supportMetabolic health

High relevance

King Oyster · 2024 · Journal Article · Food chemistry

Metabolomics study of dietary Pleurotus eryngii β-type glycosidic polysaccharide on colitis induced by dextran sodium sulfate in mice - Exploration for the potential metabolic indicators in urine and serum.

Pleurotus eryngii, an edible mushroom recognized for its potent polysaccharides, demonstrates significant regulatory effects on metabolic processes. β-glucan (WPEP) derived from P..

Immune supportMetabolic healthGut & microbiome

High relevance

Shiitake · 2024 · Journal Article · International journal of biological macromolecules

Molecular identification of Shiitake (Lentinula edodes), analysis and production of beta-glucan using beech wood sawdust waste.

Lentinula edodes has the ability to grow and produce bioactive compounds on industrial by-products. This study aimed to produce B-glucan of cell wall Shiitake on Beechwood Sawdust (BWS) through a two-step procedure, which included fermentation and B-glucan extraction and purification..

Immune support

High relevance

Reishi · 2024 · Journal Article · International journal of medicinal mushrooms

Oral Administration of Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Extract Protects Gingival Tissues against Proinflammatory TNF-α and Oxidative Stress in Periodontitis Model Rats.

Ganoderma lucidum is a medicinal mushroom that has been used since ancient times. We studied whether chronic oral administration of G.

Immune support

High relevance

King Oyster · 2024 · Journal Article · International journal of biological macromolecules

Pleurotus eryngii polysaccharides alleviate aflatoxin B1-induced liver inflammation in ducks involving in remodeling gut microbiota and regulating SCFAs transport via the gut-liver axis.

Aflatoxin B1 (AFB1) is one of the most widespread contaminants in agricultural commodities. Pleurotus eryngii (PE) is widely used as a feed additive for its anti-inflammatory properties, and its major active substance is believed to be polysaccharides..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

King Oyster · 2024 · Journal Article · Fish & shellfish immunology

Pleurotus eryngii root waste and soybean meal co-fermented protein improved the growth, immunity, liver and intestinal health of largemouth bass (Micropterus salmoides).

The present study aimed to evaluate the effect of king oyster mushroom (Pleurotus eryngii) root waste and soybean meal co-fermented protein (CFP) on growth performance, feed utilization, immune status, hepatic and intestinal health of largemouth bass (Micropterus salmoides)..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Almond Mushroom · 2024 · Journal Article · Journal of agricultural and food chemistry

Polysaccharide Isolated from Agaricus blazei Murill Alleviates Intestinal Ischemia/Reperfusion Injury through Regulating Gut Microbiota and Mitigating Inflammation in Mice.

Intestinal ischemia-reperfusion (I/R) injury is a serious disease in medical settings, and gut dysbiosis is a major contributor to its development. Polysaccharides from Agaricus blazei Murill (ABM) showed a range of pharmacological activities, yet no studies assessed the potential of ABM polysaccharides for….

Immune supportGut & microbiome

High relevance

Cordyceps · 2024 · Research Article · Molecules (Basel, Switzerland)

Polysaccharides as Quality Marker to Rapid Profile for Ophiocordyceps sinensis by PXRD.

BACKGROUND: Ophiocordyceps sinensis has long been recognized as a mysterious and valuable traditional Chinese medicine but there has been little research on quality markers for O. sinensis..

Immune support

High relevance

Cordyceps · 2024 · Journal Article · Food Research International

Polysaccharides from Cordyceps militaris prevent obesity in association with modulating gut microbiota and metabolites in high-fat diet-fed mice

Improved gut microbes and nutritious metabolites have been considered as the mediators of health benefits from indigestible polysaccharides, but their role in the anti-obesity effect of polysaccharides from Cordyceps militaris (CMP) remains elusive..

Immune supportMetabolic healthGut & microbiome

High relevance

Chaga · 2024 · Journal Article · Industrial crops and products

Polysaccharides from Inonotus obliquus employing subcritical water extraction: Extraction optimization, physiochemical properties and bioactivities analysis

As one of the main components in Inonotus obliquus, polysaccharides was potentially to be developed for the special physiochemical properties and bioactivity. However, the low extraction efficiency of Inonotus obliquus polysaccharides (IOP) significantly hindered the in-depth research and development..

Immune supportGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Innovative Food Science and Emerging Technologies

Preparing Ganoderma lucidum slices by improved steam explosion enhances their apparent, functional and structural properties

Ganoderma lucidum slices exhibit antioxidant and enzyme inhibitory activity, enhancing vitality and longevity. However, untreated Ganoderma lucidum slices fail to meet specific physical and chemical requirements for consumption and processing because their bioactive compounds must be released before intake through….

Immune support

High relevance

Almond Mushroom · 2024 · Journal Article · International journal of biological macromolecules

Preventive intervention with Agaricus blazei murill polysaccharide exerts anti-tumor immune effect on intraperitoneal metastasis colorectal cancer.

Agaricus blazei murill (ABM) mainly exerts its antitumor effect via modulation of the immune system. However, the immunomodulatory role of the ABM polysaccharide (ABMP) in mice with subcutaneously and intraperitoneally implanted MC38 tumor remains to be explored..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2024 · Research Article · Frontiers in pharmacology

Protective effects of Cordyceps militaris against hepatocyte apoptosis and liver fibrosis induced by high palmitic acid diet.

BACKGROUND: Fatty Liver Disease (FLD) progresses from steatosis to steatohepatitis and, if left untreated, can lead to irreversible conditions such as cirrhosis and hepatocarcinoma. The etiology of FLD remains unclear, but factors such as overconsumption, poor diet, obesity, and diabetes contribute to its development..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Cordyceps · 2024 · Journal Article · Current microbiology

Proteomic Analysis Reveals Differentially Expressed Proteins in Cordyceps militaris Cultured with Different Media.

Cordyceps militaris is rich in high quality protein, which is an excellent protein supplement. In this study, proteins were extracted from C.

Immune supportMetabolic health

High relevance

Cordyceps · 2024 · Research Article · Journal of Ayurveda and integrative medicine

Quest for Anti-SARS-CoV-2 antiviral therapeutics: in-silico and in-vitro analysis of edible mushroom- Cordyceps militaris.

BACKGROUND: The emergence and evolution of SARS-CoV-2 resulted a severe threat to public health globally. Due to the lack of an effective vaccine with durable immunity, the disease transited into the endemic phase, necessitating potent antiviral therapy including a scientific basis for current traditional herbal….

Immune supportRespiratory

High relevance

Reishi · 2024 · Review · Heliyon

Research progress of Ganoderma lucidum polysaccharide in prevention and treatment of Atherosclerosis.

Atherosclerosis (AS) is a chronic inflammatory disease resulting from dysregulated lipid metabolism, constituting the pathophysiological foundation of cardiovascular and cerebrovascular diseases. AS has a high incidence rate and mortality rate worldwide..

Immune supportMetabolic healthGut & microbiome

High relevance

Lion's Mane · 2024 · Preprint · journal metadata

Role of Hericium Erinaceus as a Probiotic Stimulant

Abstract Lion's Mane mushroom ( Hericium erinaceus ) is gaining scientific interest for its potential health benefits, particularly its bioactive compounds and probiotic-stimulatory properties..

Immune supportGut & microbiome

High relevance

Cordyceps · 2024 · Research Article · Antioxidants (Basel, Switzerland)

Sea Cucumber Viscera Processed by Protease Hydrolysis Combined with Cordyceps militaris Fermentation Protect Caco-2 Cells against Oxidative Damage via Enhancing Antioxidant Capacity, Activating Nrf2/HO-1 Pathway and Improving Cell Metabolism.

Excessive reactive oxygen species (ROS) may lead to oxidative damage and metabolic disorder. The pathogenesis of human bowel inflammation is closely related to oxidative damage of intestinal epithelial cells caused by ROS..

OncologyImmune supportEnergy & fatigueMetabolic health

High relevance

Shiitake · 2024 · Journal Article · Carbohydrate polymers

Simulated human digestion and fermentation of a high-molecular weight polysaccharide from Lentinula edodes mushroom and protective effects on intestinal barrier

Lentinula edodes (Shiitake) is an important edible mushroom and polysaccharides are its major constituents with proven health benefits. The study was to investigate the gut bacterial fermentation and subsequent effects on gut barrier function of a glucan-rich polysaccharide, LePS40 precipitated from the mushroom water….

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Cordyceps · 2024 · Preprint · journal metadata

Solid-state fermentation product of Cordyceps militaris enhances the antioxidation and modulates immune response in grower pigs

Abstract Background: Pathogenic infections can significantly impact the health of livestock. Traditionally, antibiotic growth promoters (AGPs) have been used in feed to enhance growth performance and disease control..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Reishi · 2024 · Research Article · Frontiers in pharmacology

Sporoderm-removed Ganoderma lucidum spores ameliorated early depression-like behavior in a rat model of sporadic Alzheimer's disease.

Introduction: Ganoderma lucidum: (G. lucidum, Lingzhi) is a medicinal and edible homologous traditional Chinese medicine that is used to treat various diseases, including Alzheimer's disease and mood disorders.

Immune supportCognition & nerves

High relevance

King Oyster · 2024 · Research Article · Foods (Basel, Switzerland)

Steam Explosion-Assisted Extraction of Polysaccharides from Pleurotus eryngii and Its Influence on Structural Characteristics and Antioxidant Activity.

Pleurotus eryngii (PE) has been sought after for its various health benefits and high content of phenolic compounds. This study explored the feasibility of steam explosion (SE)-assisted extraction of polysaccharides with high antioxidant capacities from PE..

Immune supportMetabolic health

High relevance

Cordyceps · 2024 · Journal Article · International journal of biological macromolecules

Structural characteristics and anti-tumor activity of alcohol-precipitated polysaccharides from Cordyceps militaris under different ethanol concentrations.

Six Cordyceps militaris polysaccharides (named CMP-1, CMP-2, CMP-3, CMP-4, CMP-9, and CMP-A) were obtained by fractional alcohol precipitation. The experimental results showed that the six Cordyceps militaris polysaccharides had similar chemical composition and spectral features, and different molecular weights,….

OncologyImmune supportMetabolic health

High relevance

Maitake · 2024 · Journal Article · Carbohydrate research

Structural characterization and immunomodulatory effect of a starch-like Grifola frondosa polysaccharides on cyclophosphamide-induced immunosuppression in mice.

In this study, a pure Grifola frondosa polysaccharide (GFP-1) was extracted and purified from Grifola frondosa. By HPLC, GC-MS, FT-IR, and NMR analysis, GFP-1 was determined to be a starch-like polysaccharide with an average molecular weight of 3370 kDa..

Immune supportMetabolic healthGut & microbiome