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Immune supportMetabolic healthLiver supportSkin & hydration

Shiitake · 2024 · Journal Article · International journal of biological macromolecules

Lentinan-loaded GelMA hydrogel accelerates diabetic wound healing through enhanced angiogenesis and immune microenvironment modulation.

Diabetic wound healing is a substantial clinical challenge, characterized by delayed angiogenesis and unresolved inflammation. Lentinan, a polysaccharide extracted from shiitake mushrooms, has the potential to regulate both macrophage polarization and angiogenesis, though this aspect remains inadequately explored..

Immune supportRespiratory

Cordyceps · 2024 · Journal Article · RSC advances

Naphthoquinone derivatives as potential immunomodulators: prospective for COVID-19 treatment.

Inflammation plays a crucial role in COVID-19, and when it becomes dysregulated, it can lead to severe outcomes, including death. Naphthoquinones, a class of cyclic organic compounds widely distributed in nature, have attracted significant interest due to their potential biological benefits..

Chaga · 2024 · Research Article · Open forum infectious diseases

Risk Factors for Spotted Fever Group Rickettsioses in Kilimanjaro Region, Tanzania.

BACKGROUND: Knowledge gaps exist on risk factors for spotted fever group rickettsioses (SFGR) in sub-Saharan Africa. We sought to identify SFGR risk factors in Kilimanjaro Region, Tanzania.

Immune supportRespiratory

Almond Mushroom · 2024 · Journal Article · The Lancet regional health. Southeast Asia

Routine immunization against Streptococcus pneumoniae and Haemophilus influenzae type B and antibiotic consumption in India: a dynamic modeling analysis.

BACKGROUND: Childhood vaccinations can reduce disease burden and associated antibiotic use, in turn reducing the risk of antimicrobial resistance (AMR). We retrospectively estimated the population-level reductions in antibiotic use in India following the introduction of vaccines against Streptococcus pneumoniae and….

Oyster Mushroom · 2024 · Journal Article · International journal of medicinal mushrooms

Size Matters: Influence of Particle Size on Antioxidant, β-Glucan, and Anti-Inflammatory Potential in Pleurotus floridanus (Agaricomycetes).

Cellular damage resulting from elevated levels of free radicals can lead to persistent health issues. Pleurotus floridanus, an edible white oyster mushroom, is rich in β-glucans with potent antioxidant and anti-inflammatory properties..

OncologyImmune supportGut & microbiomeSkin & hydration

Reishi · 2024 · Journal Article · International journal of biological macromolecules

Structural clarification of mannoglucan GSBP-2 from Ganoderma sinense and its effects on triple-negative breast cancer migration and invasion.

Ganoderma sinense, known as Lingzhi in China, is a medicinal fungus with anti-tumor properties. Herein, crude polysaccharides (GSB) extracted from G.

Turkey Tail · 2024 · Journal Article · Environmental research

Toxicological study on ibuprofen and selenium in freshwater mussel Lamellidens marginalis and exploring the microbial cytochrome through modelling and quantum mechanics approaches for its toxicity degradation in contaminated environment.

Toxicological stress in aquatic organisms is caused by the discharge of hundreds of toxic pollutants and contaminants among which the current study concentrates on the toxic effect of non-steroidal anti-inflammatory drug ibuprofen (IBF) and the trace element selenium (Se)..

OncologyImmune supportRespiratory

Chaga · 2024 · Journal Article · International immunopharmacology

β-glucan mitigates ovalbumin-induced airway inflammation by preventing oxidative stress and CD8+ T cell infiltration.

BACKGROUND: Bronchial asthma is a severe respiratory condition characterized by airway inflammation, remodeling, and oxidative stress. β-Glucan (BG) is a polysaccharide found in fungal cell walls with powerful immunomodulatory properties..

OncologyImmune supportCognition & nervesEnergy & fatigue

Chaga · 2023 · Preprint · journal metadata

Mixed Medicinal Mushroom Mycelia Attenuates Alzheimer's Disease Pathologies In Vitro and In Vivo

Alzheimer's disease (AD) is characterized by memory impairment and existence of amyloid-β (Aβ) plaques and neuroinflammation. Due to the pivotal role of oxidative damage in AD, natural antioxidative agents, such as polyphenol-rich fungi, have garnered scientific scrutiny..

Cordyceps · 2023 · Review · Biochemical and biophysical research communications

Pharmacological and therapeutic potentials of cordycepin in hematological malignancies.

Hematological malignancies(HMs) are highly heterogeneous diseases with globally rising incidence. Despite major improvements in the management of HMs, conventional therapies have limited efficacy, and relapses with high mortality rates are still frequent..

OncologyImmune supportLiver support

Turkey Tail · 2023 · Scoping Review · Cureus

Therapeutic Effects of Medicinal Mushrooms on Gastric, Breast, and Colorectal Cancer: A Scoping Review.

Cancer is the leading cause of mortality globally. With anticancer medications causing severe adverse effects, understanding the role of alternative and efficacious anticancer treatments with minimal or no side effects can be beneficial..

OncologyImmune supportMetabolic healthLiver support

Turkey Tail · 2023 · Preprint · journal metadata

Wild Mushrooms: A Hidden Treasure of Novel Bioactive Compounds

Mushrooms are unexploited treasures of secondary metabolites. Analysis of the chemical constituents of these mushrooms would be necessary for the assessment of their pharmacological and biological activities..

Yellow Morel · 2022 · Published Erratum · IMA fungus

Correction to: Heterothallism and potential hybridization events inferred for twenty-two yellow morel species.

Metadata-grounded summary: This published erratum indexes research on Morchella esculenta in IMA fungus in 2022. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Immune supportEnergy & fatigueRespiratory

Cordyceps · 2022 · Review · Explore (New York, N.Y.)

Integrative medicine considerations for convalescence from mild-to-moderate COVID-19 disease.

The majority of individuals infected with SARS-CoV-2 have mild-to-moderate COVID-19 disease. Convalescence from mild-to-moderate (MtoM) COVID-19 disease may be supported by integrative medicine strategies..

OncologyImmune supportEnergy & fatigueMetabolic health

Cordyceps · 2022 · Review · Frontiers in microbiology

Mushrooms as Potential Sources of Active Metabolites and Medicines.

BACKGROUND: Mushrooms exist as an integral and vital component of the ecosystem and are very precious fungi. Mushrooms have been traditionally used in herbal medicines for many centuries..

Almond Mushroom · 2021 · Editorial · Breastfeeding medicine: the official journal of the Academy of Breastfeeding Medicine

Breastfeeding Medicine Publication Policy and ABM's Statement Regarding Infant Feeding and Lactation-Related Language and Gender.

Metadata-grounded summary: This editorial indexes research on Agaricus blazei in Breastfeeding medicine: the official journal of the Academy of Breastfeeding Medicine in 2021. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Almond Mushroom · 2021 · Published Erratum · Breastfeeding medicine: the official journal of the Academy of Breastfeeding Medicine

Correction to: ABM Clinical Protocol #35: Supporting Breastfeeding During Maternal or Child Hospitalization, by Bartick et al. Breastfeed Med 2021;16(9):664-674. DOI: 10.1089/bfm.2021.29190.mba.

Metadata-grounded summary: This published erratum indexes research on Agaricus blazei in Breastfeeding medicine: the official journal of the Academy of Breastfeeding Medicine in 2021. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

OncologyImmune supportMetabolic health

Chaga · 2021 · Preprint · journal metadata

Effect of Anti-cancerous Compounds on Cancer Cells Extracted From Edible Mushrooms: A Review

Mushrooms have been an invaluable ingredient in terms of food and medicine to humanity since time immemorial. Mushrooms have been shown to be possessing properties such as anti-tumor, antiproliferative, antioxidant, immunomodulatory, anti-diabetic..

Immune supportGut & microbiome

Shiitake · 2021 · Letter · Cutis

Flagellate Shiitake Mushroom Reaction With Histologic Features of Acute Generalized Exanthematous Pustulosis.

Metadata-grounded summary: This letter indexes research on Lentinula edodes in Cutis in 2021. MycoData maps the paper to immune support, gut & microbiome based on its title, species context, article metadata, and study classification..

Almond Mushroom · 2021 · Review · Microbiology insights

Meningococcal Disease Burden in India: A Systematic Review and Meta-Analysis.

OBJECTIVE: To perform systematic review and meta-analysis of meningococcal disease burden in India. METHODS: We searched publications on meningococcal disease in India between 1996 and 2020 using PubMed and Google Scholar..

Shiitake · 2021 · Review · Journal of clinical and translational research

The effects of twenty-four nutrients and phytonutrients on immune system function and inflammation: A narrative review.

BACKGROUND AND AIM: Recently, optimal immune function has become a primary focus of worldwide attention not only in the prevention of chronic disease but also as one strategy to reduce the severity of acute illness..

Immune supportCognition & nervesEnergy & fatigue

Lion's Mane · 2021 · Review · Journal of clinical and translational research

The effects of twenty-one nutrients and phytonutrients on cognitive function: A narrative review.

BACKGROUND AND AIM: Brain health is becoming more important to the average person as the number of people with cognitive impairments, such as Alzheimer's disease (AD), is rising significantly..

OncologyImmune supportCognition & nervesSkin & hydration

Cordyceps · 2021 · Review · Molecules (Basel, Switzerland)

The Role of Autophagy in Anti-Cancer and Health Promoting Effects of Cordycepin.

Cordycepin is an adenosine derivative isolated from Cordyceps sinensis, which has been used as an herbal complementary and alternative medicine with various biological activities..

Immune supportMetabolic health

King Oyster · 2020 · Research Article · Animals: an open access journal from MDPI

Evaluation of Waste Mushroom Compost as a Feed Supplement and Its Effects on the Fat Metabolism and Antioxidant Capacity of Broilers.

Pennisetum purpureum Schum No. 2 waste mushroom compost (PWMC) is the main byproduct when cultivating Pleurotus eryngii.

OncologyImmune supportMetabolic healthGut & microbiome

King Oyster · 2020 · Research Article · Molecules (Basel, Switzerland)

Genoprotective Properties and Metabolites of β-Glucan-Rich Edible Mushrooms Following Their In Vitro Fermentation by Human Faecal Microbiota.

A variety of bioactive compounds, constituents of edible mushrooms, in particular β-glucans, i.e., a group of β-d-glucose polysaccharides abundant in the fungal cell walls, have been linked to immunomodulating, anticancer and prebiotic activities..

Cordyceps · 2020 · Research Article · Journal of fungi (Basel, Switzerland)

Interplay between Fungal Infection and Bacterial Associates in the Wax Moth Galleria mellonella under Different Temperature Conditions.

Various insect bacterial associates are involved in pathogeneses caused by entomopathogenic fungi. The outcome of infection (fungal growth or decomposition) may depend on environmental factors such as temperature..

Shiitake · 2020 · Research Article · Vaccines

Seaweed-Based Products and Mushroom β-Glucan as Tomato Plant Immunological Inducers.

The effects of the abiotic inducers β-glucan, extracted from Shiitake (Lentinula edodes), BFIICaB® (Kappaphycus alvarezii) and BKPSGII® (K. alvarezii X Sargassum sp.) on tomato plants infected with Fusarium oxysporum f.

Immune supportMetabolic health

King Oyster · 2019 · Journal Article · International journal of biological macromolecules

Analyses of active antioxidant polysaccharides from four edible mushrooms.

Four water-soluble polysaccharides were extracted from Pleurotus eryngii, Flammulina velutipes, Pleurotus ostreatus and white Hypsizygus marmoreus. Using anion exchange and gel permeation chromatography, a neutral and an acidic fraction were purified from each water-soluble polysaccharide..

Cordyceps · 2019 · Research Article · American journal of translational research

Cordycepin inhibits human ovarian cancer by inducing autophagy and apoptosis through Dickkopf-related protein 1/β-catenin signaling.

Cordycepin, the major active component from Cordyceps militaris, has been reported to significantly inhibit some types of cancer; however, its effects on ovarian cancer are still not well understood..

King Oyster · 2018 · Research Article · Biotechnology for biofuels

Mechanistic insight in the selective delignification of wheat straw by three white-rot fungal species through quantitative 13C-IS py-GC-MS and whole cell wall HSQC NMR.

BACKGROUND: The white-rot fungi Ceriporiopsis subvermispora (Cs), Pleurotus eryngii (Pe), and Lentinula edodes (Le) have been shown to be high-potential species for selective delignification of plant biomass..

Cordyceps · 2016 · Journal Article · International journal of medicinal mushrooms

Anti-Inflammation Properties of Fruiting Bodies and Submerged Cultured Mycelia of Culinary-Medicinal Higher Basidiomycetes Mushrooms.

This research shows the phenolic composition and anti-inflammation properties of fruiting bodies and mycelia of 15 strains of 12 species of higher Basidiomycetes medicinal mushrooms. In this research, 15 extracts were prepared and their effects on inflammation-related mediators in RAW 264.7 cells were evaluated..

OncologyImmune supportGut & microbiome

Shiitake · 2016 · Journal Article · Oncology reports

Lentinan mitigates therarubicin-induced myelosuppression by activating bone marrow-derived macrophages in an MAPK/NF-κB-dependent manner.

Bone marrow (BM) suppression (also known as myelosuppression) is the most common and most severe side-effect of therarubicin (THP) and thereby limits the clinical application of this anticancer agent..

Immune supportGut & microbiomeLiver supportSkin & hydration

King Oyster · 2016 · Journal Article · ACS applied materials & interfaces

Prolonged Three-Dimensional Co-Delivery of Yamanaka Factors for Cell Reprogramming.

Reprogramming somatic cells into a pluripotent state has been widely investigated in two-dimensional (2D) systems but not described in the more biologically faithful three-dimensional (3D) scaffolds..

Maitake · 2014 · Research Support, Non U.S. Gov'T · Carbohydrate polymers

Extraction, preliminary characterization and antioxidant activity of Se-enriched Maitake polysaccharide.

A Se-enriched Grifola frondosa polysaccharide (Se-GP) was obtained from G. frondosa enriched with Se by spraying an Na2SeO3 solution during fruit body growth using a Box-Behnken design and compared to G.

Maitake · 2012 · Review · Anti-cancer agents in medicinal chemistry

The cancer preventive effects of edible mushrooms.

An increasing body of scientific literature suggests that dietary components may exert cancer preventive effects. Tea, soy, cruciferous vegetables and other foods have been investigated for their cancer preventive potential..

Enoki · 1995 · Journal Article · Hua zhong nong ye da xue xue bao = Journal Huazhong (Central China) Agricultural University

Distinguishing strains of Flammuline velutipes with RAPD

Metadata-grounded summary: This journal article indexes research on Flammulina velutipes in Hua zhong nong ye da xue xue bao = Journal Huazhong (Central China) Agricultural University in 1995. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Zhu Ling · 1994 · Journal Article · Zhonghua wei sheng wu xue he mian yi xue za zhi = Zhonghua weishengwuxue he mianyixue zazhi

The effects several extractives of traditional Chinese pharmaceuticals on human polymorphonuclear leukocytes phagocytic and killing function

Metadata-grounded summary: This journal article indexes research on Polyporus umbellatus in Zhonghua wei sheng wu xue he mian yi xue za zhi = Zhonghua weishengwuxue he mianyixue zazhi in 1994. MycoData maps the paper to immune support based on its title, species context, article metadata, and study classification..

Immune supportMetabolic healthGut & microbiomeLiver support

Shiitake · 2026 · Research Support, Non U.S. Gov'T · Molecular nutrition & food research

Active Hexose Correlated Compound Modulates Gut Microbiota and Improves Intestinal Barrier Function in a High-Fat Diet-Induced NAFLD in Rats.

Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading cause of chronic liver disease worldwide, correlating with increased obesity and metabolic disorders. Gut microbiota dysbiosis and impaired intestinal barrier integrity are key factors in NAFLD pathogenesis..

OncologyImmune supportGut & microbiome

Shiitake · 2026 · Evaluation Study · Food chemistry

Unlocking protein and bioactive peptide recovery in relation to mushroom species and pulsed electric field treatment: proteomic and peptidomic insights via LC-TOF-MS/MS and SDS-PAGE following in vitro digestion.

Edible mushrooms are increasingly recognized due to their high-quality protein content and bioactive potential. This study evaluated pulsed electric fields (PEF) (50 kJ/kg, 2.5 kV/cm, 6 h) to enhance the recovery of functional proteins and peptides from Agaricus bisporus, A..

Immune supportMetabolic healthRespiratory

Oyster Mushroom · 2025 · Brief Report · Current therapeutic research, clinical and experimental

Effect of a Pleuran-Based Supplement on Salivary IgA Secretion in Children With Recurrent Respiratory Infections.

BACKGROUND: ß-glucans isolated from natural sources have demonstrated pluripotent immunomodulatory potential, making them a promising supportive treatment for the management of recurrent respiratory infections (RRIs) in children..

Immune supportEnergy & fatigue

Snow Fungus · 2025 · Research Support, Non U.S. Gov'T · Genome biology and evolution

Massive Gene Loss in the Fungus Sporothrix epigloea Accompanied a Shift to Life in a Glucuronoxylomannan-based Gel Matrix.

Fungi are well-known for their ability to both produce and catabolize complex carbohydrates to acquire carbon, often in the most extreme of environments. Glucuronoxylomannan (GXM)-based gel matrices are widely produced by fungi in nature and though they are of key interest in medicine and pharmaceuticals, their….

Reishi · 2024 · Research Support, Non U.S. Gov'T · Toxicology and applied pharmacology

Ganoderic acid T, a Ganoderma triterpenoid, modulates the tumor microenvironment and enhances the chemotherapy and immunotherapy efficacy through downregulating galectin-1 levels.

Ganoderic acid T (GAT), a triterpenoid molecule of Ganoderma lucidum, exhibits anti-cancer activity; however, the underlying mechanisms remain unclear. Therefore, in this study, we aimed to investigate the anti-cancer molecular mechanisms of GAT and explore its therapeutic applications for cancer treatment..

Immune supportCognition & nervesSkin & hydration

Lion's Mane · 2024 · Research Support, Non U.S. Gov'T · Biochemical and biophysical research communications

Hericenone C attenuates the second phase of formalin-induced nociceptive behavior by suppressing the accumulation of CD11c-positive cells in the paw epidermis via phosphorylated P65.

Hericenone C is one of the most abundant secondary metabolites derived from Hericium erinaceus, under investigation for medicinal properties. Here, we report that Hericenone C inhibits the second phase of formalin-induced nociceptive behavior in mice..

OncologyImmune supportGut & microbiomeLiver support

Reishi · 2023 · Journal Article · BMC cancer

AGA induces sub-G1 cell cycle arrest and apoptosis in human colon cancer cells through p53-independent/p53-dependent pathway.

BACKGROUND: Despite the advancement in chemotherapeutic drugs for colon cancer treatment, it is still a life-threatening disease worldwide due to drug resistance. Therefore, an urgently needed to develop novel drugs for colon cancer therapies..

OncologyImmune supportGut & microbiome

Mesima · 2023 · Research Article · Biomedicines

Blockade of the SRC/STAT3/BCL-2 Signaling Axis Sustains the Cytotoxicity in Human Colorectal Cancer Cell Lines Induced by Dehydroxyhispolon Methyl Ether.

Colorectal cancer (CRC) is the third most prevalent human cancer globally. 5-Fluorouracil (5-FU)-based systemic chemotherapy is the primary strategy for advanced CRC treatment, yet is limited by poor response rate..

Almond Mushroom · 2023 · Research Article · Daru: journal of Faculty of Pharmacy, Tehran University of Medical Sciences

Clove volatile oil-loaded nanoemulsion reduces the anxious-like behavior in adult zebrafish.

BACKGROUND: Clove volatile oil (CVO) and its major compound, eugenol (EUG), have anxiolytic effects, but their clinical use has been impaired due to their low bioavailability. Thus, their encapsulation in nanosystems can be an alternative to overcome these limitations..

OncologyImmune supportEnergy & fatigueMetabolic health

Niu-Chang-Chih · 2023 · Journal Article · Archives of toxicology

Coenzyme Q0 defeats NLRP3-mediated inflammation, EMT/metastasis, and Warburg effects by inhibiting HIF-1α expression in human triple-negative breast cancer cells.

Coenzyme Q0 (CoQ0) is a derivative quinone from Antrodia camphorata (AC) that exerts anticancer activities. This study examined the anticancer attributes of CoQ0 (0-4 µM) on inhibited anti-EMT/metastasis and NLRP3 inflammasome, and altered Warburg effects via HIF-1α inhibition in triple-negative breast cancer….

Oyster Mushroom · 2023 · Journal Article · International journal of biological macromolecules

Composition, structural properties and immunomodulatory activity of several aqueous Pleurotus β-glucan-rich extracts.

In this work, aqueous extracts from six different Pleurotus species were obtained and their yield, gross composition, β-glucan content, monosaccharide profile, thermal stability, molecular weight distribution, and FT-IR were analyzed before and after purification through ethanol precipitation of the carbohydrate-rich….

Maitake · 2023 · Journal Article · Food chemistry

Compositional differences of β-glucan-rich extracts from three relevant mushrooms obtained through a sequential extraction protocol.

In this work, a sequential fractionation protocol (cold and hot aqueous and alkaline extractions) and detailed compositional analysis (gross composition, monosaccharide analysis, FTIR, TGA) was applied to three relevant mushrooms in terms of global production (Grifola frondosa, Lentinula edodes and Pleurotus….