MycoData

Sporoderm-Broken Ganoderma lucidum spore polysaccharides (BGLSPs) have demonstrated therapeutic potential in inflammatory bowel disease (IBD), however, their mechanisms of action in colitis remain unclear..

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Structural characterisation and cholesterol and bile salts adsorption properties of Ganoderma lucidum dietary fiber

This study prepared Ganoderma lucidum insoluble dietary fiber (GIDF) and soluble dietary fiber (GSDF) via enzymatic methods. The structural and physicochemical properties of GIDF and GSDF were systematically characterized using scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, X-ray….

Energy & fatigueMetabolic healthGut & microbiomeSkin & hydration

High relevance

Lion's Mane · 2025 · Journal Article · Journal of agricultural and food chemistry

Structural Characterization and Gastrointestinal Fate of a High-Molecular-Weight Hericium erinaceus Polysaccharide during Digestion and Fermentation.

This study systematically isolated a high-molecular-weight polysaccharide (HHEP; 9.14 × 103 kDa) from Hericium erinaceus, consisting predominantly of glucose (59.16% ± 0.09%), galactose (26.29% ± 0.59%), and mannose (5.69% ± 0.58%)..

Immune supportMetabolic healthGut & microbiome

High relevance

Enoki · 2025 · Research Article · Foods (Basel, Switzerland)

Structural Characterization of Polysaccharide from Flammulina velutipes and Its Impact on Hyperlipidemia Through Modulation of Hepatic Cholesterol Metabolism and Gut Microbiota.

FVPB1, a novel heteropolysaccharide, was extracted from the Flammulina velutipes fruiting body, and its structure was determined by methylation analysis, nuclear magnetic resonance (NMR) spectroscopy..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Lion's Mane · 2025 · Journal Article · Food chemistry

Structural characterization of β-glucan in Hericium erinaceus pretreated by steam explosion and its effects on human gut microbiota in vitro.

To investigate the impact of steam explosion on the structure of β-glucan and its regulation human gut microbiota (GM), two polysaccharides were prepared from Hericium erinaceus fruit bodies treated by steam explosion and conventional crushing, respectively..

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Journal Article · International Journal of Biological Macromolecules

Structural-functional relationship of soluble dietary Fiber from Ganoderma lucidum-fermented sweet potato residue and its regulatory effects on gut microbiota

Sweet potato residue (SPR), a by-product of sweet potato processing, is rich in dietary fiber and other is rich in dietary fiber and other essential nutrients; however, its industrial utilization remains limited..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Structural-functional relationship of soluble dietary Fiber from Ganoderma lucidum-fermented sweet potato residue and its regulatory effects on gut microbiota.

Immune supportMetabolic healthGut & microbiome

High relevance

Maitake · 2025 · Research Article · NPJ science of food

Structure characterization of Grifola frondosa polysaccharide and its effect on insulin resistance in HFD-fed mice.

Polysaccharide extracted from Grifola frondosa (GFP) was selected in this study. After preliminary separation, four factions were collected, named GFP-F1, GFP-F2, GFP-F3 and GFP-F4.

Immune supportMetabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2025 · Journal Article · Food Chemistry

Structure characterization, simulated digestion, and microbial modulation of Pleurotus ostreatus polysaccharides

Edible mushrooms polysaccharides are widely recognized for their biological activities, yet the prebiotic potential of Pleurotus ostreatus polysaccharides (POP) remains underexplored. In this study, POP was isolated, structurally characterized, and evaluated for digestibility and impact on gut microbiota..

Immune supportGut & microbiome

High relevance

Oyster Mushroom · 2025 · Journal Article · Food chemistry

Structure characterization, simulated digestion, and microbial modulation of Pleurotus ostreatus polysaccharides.

Immune supportGut & microbiome

High relevance

Reishi · 2025 · Research Article · Scientific reports

Study on the anti-tumor effect of Wall-broken ganoderma lucidum spore powder on papillary thyroid cancer.

Wall-broken Ganoderma lucidum spore powder (BGLSP), a traditional Chinese medicinal substance, contains bioactive triterpenoids with anti-tumor potential. However, its efficacy and mechanisms against papillary thyroid cancer (PTC) remain unclear..

OncologyImmune supportGut & microbiomeSkin & hydration

High relevance

Reishi · 2025 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Surface-modifying Ganoderma lucidum spores as improved microcarriers in protein delivery

Bioactive proteins and peptides hold significant potential in the food industry, particularly for the development of functional foods and nutraceuticals. However, their effectiveness is often limited by poor oral bioavailability..

Energy & fatigueGut & microbiomeLiver support

High relevance

Maitake · 2025 · Research Article · Foods (Basel, Switzerland)

The Effects of Iterative Freeze-Thaw Cycles on the Structure, Functionality, and Digestibility of Grifola frondosa Protein.

To improve the processing performance and application potential of Grifola frondosa protein (GFP), this study employed multiple freeze-thaw (F-T) cycles to modify GFP and systematically evaluated the changes in its structure, functional properties, and digestive behavior..

Energy & fatigueGut & microbiome

High relevance

Oyster Mushroom · 2025 · Journal Article · Food Research International

Understanding the impact of different post-digestion enzymatic inhibition methods and storage conditions on standardized gastrointestinal model (INFOGEST): A case study of Pleurotus ostreatus mushroom biomass

INFOGEST became the standard digestion protocol to address inconsistencies in gastrointestinal tract (GIT) digestion protocols. However, sample collection, enzymatic inactivation methods, and storage conditions can significantly impact the accurate assessment of food compounds..

Metabolic healthGut & microbiome

High relevance

Oyster Mushroom · 2025 · Journal Article · Food research international (Ottawa, Ont.)

Understanding the impact of different post-digestion enzymatic inhibition methods and storage conditions on standardized gastrointestinal model (INFOGEST): A case study of Pleurotus ostreatus mushroom biomass.

Metabolic healthGut & microbiome

High relevance

Reishi · 2025 · Journal Article · Journal of pharmaceutical and biomedical analysis

UPLC-Q-TOF/MS-based study on chemical composition, in vivo metabolites, and tissue distribution of ethanol extract of Ganoderma lucidum.

Ganoderma lucidum (G. lucidum), a medicinal fungus, exhibits diverse pharmacological effects against many diseases.

OncologyEnergy & fatigueGut & microbiomeLiver support

High relevance

Yellow Morel · 2025 · Journal Article · International journal of medicinal mushrooms

Valorization of Morchella esculenta (Ascomycota) Using a Healthy Extraction Method: Investigation of Bioavailability, Anti-Acetylcholinesterase, and Antioxidant Potentials.

Edible fungi are unexploited natural sources of high added value biomolecules, such as phenolic compounds. This study used an innovative and green extraction method based on the quick, easy, new, cheap, reproducible (QUENCHER) process of Morchella esculenta..

Cognition & nervesGut & microbiome

High relevance

Enoki · 2024 · Journal Article · Food & function

A novel neuroprotective peptide YVYAETY identified and screened from Flammulina velutipes protein hydrolysates attenuates scopolamine-induced cognitive impairment in mice.

Flammulina velutipes protein hydrolysates are known for their abundant amino acids and excellent developmental values. This study aimed to identify and screen neuroprotective peptides from F..

OncologyCognition & nervesEnergy & fatigueGut & microbiome

High relevance

Maitake · 2024 · Journal Article · Molecular nutrition & food research

A Water Polysaccharide-Protein Complex from Grifola frondosa Inhibit the Growth of Subcutaneous but Not Peritoneal Colon Tumor under Fasting Condition.

SCOPE: Grifola frondosa has been shown to induce immune modulatory, modulate autophagy, and apoptosis in cancer cells. However, little is known about its potential for managing tumor progression as an adjunct to nutrient restriction.

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Plant foods for human nutrition (Dordrecht, Netherlands)

Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice.

The hepatoprotective effect of the alcoholic extracts of Ganoderma lucidum fermentation products (GFE) was investigated. C57BL/6 mice were pretreated with GFE for 7 days and then subjected to the chronic-binge ethanol feeding model..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Mesima · 2024 · Journal Article · International journal of biological macromolecules

Ameliorative effect of an acidic polysaccharide from Phellinus linteus on ulcerative colitis in a DSS-induced mouse model.

Phellinus linteus, a rare medicinal fungus, displays strong antitumor and anti-inflammatory activities because of its active metabolites, particularly polysaccharides. We investigated effects of P..

OncologyImmune supportGut & microbiome

High relevance

Yellow Morel · 2024 · Journal Article · International journal of medicinal mushrooms

Antimicrobial Activity of Three Italian Strains of Morchella esculenta (Ascomycota).

Three genetically identified and morphologically characterized strains (MesAQ2-C, MesAQ6-2 and MesFI2-3) of the culinary-medicinal ascomycete mushroom Morchella esculenta (L.) Pers. collected in central-north Italy have been studied for their antifungal and antibacterial activities..

Gut & microbiome

High relevance

Wood Ear · 2024 · Research Article · Foods (Basel, Switzerland)

Auricularia auricula-judae Attenuates the Progression of Metabolic Syndrome in High-Fat Diet-Induced Obese Rats: Enzymatic Pre-Digestion Technology Is Superior to Superfine Grinding Method.

Auricularia auricula-judae (AAJ) has been cultivated for food in China for centuries, and is also used as a folk medicine for the regulation of glucose and lipid metabolism. However, there are few studies on the effects of different processing technologies on the therapeutic efficacy of AAJ to date..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2024 · Journal Article · Heliyon

Bioactivities and industrial standardization status of Ganoderma lucidum: A comprehensive review

Ganoderma lucidum (GL) is a potent source of bioactive compounds with diverse nutritional and pharmacological benefits. Its popularity as a dietary supplement, herbal remedy, and wellness product is steadily on the rise..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Enoki · 2024 · Journal Article · International journal of biological macromolecules

Chitosan from the base of Flammulina velutipes stipe alleviates oral Candida albicans infection via modulating Th-17 cell differentiation and Streptococcus mutans.

The base of Flammulina velutipes (F. velutipes) stipe are agricultural wastes generated during the cultivation of edible fungus F.

Immune supportGut & microbiome

High relevance

Shiitake · 2024 · Journal Article · International journal of biological macromolecules

Dietary fiber-rich Lentinula edodes stems influence the structure and in vitro digestibility of low-moisture extruded maize starches.

Low-moisture extrusion (LME) can be used to improve the utilization of dietary fiber-rich Lentinula edodes stems (LES). The incorporation of dietary fiber can affect heat-induced interactions of starch molecules, which are critical for modifying starch characteristics via LME..

Gut & microbiome

High relevance

Reishi · 2024 · Journal Article · Anticancer research

Effect of Ganoderma lucidum on Cisplatin-induced Nephrotoxicity and Gastrointestinal Toxicity.

BACKGROUND/AIM: Cancer remains a major global health challenge, with an estimated 10 million cancer-related deaths in 2020, hindering efforts to extend life expectancy. Cisplatin, an effective platinum-based chemotherapeutic agent used against various malignancies, has numerous side effects..

OncologyGut & microbiome

High relevance

Yellow Morel · 2024 · Research Article · Frontiers in veterinary science

Effect of Morchella esculenta polysaccharides on the rectal microbiota of mice challenged with lipopolysaccharides.

INTRODUCTION: Intestinal dysfunction poses a severe problem by preventing the digestion and absorption of nutrients. The gut, being the most vital organ for these processes, plays a crucial role in ensuring our body receives the nutrients it needs..

OncologyImmune supportGut & microbiomeRespiratory

High relevance

Snow Fungus · 2024 · Journal Article · International journal of biological macromolecules

Effect of steam explosion modified soluble dietary fiber from Tremella fuciformis stem on the quality and digestibility of biscuits.

Steam explosion (SE) technology is an effective modification method for improving resource utilization of edible fungi processing by-products. In this study, the effect of SE-modified Tremella fuciformis (T.

Metabolic healthGut & microbiome

High relevance

Snow Fungus · 2024 · Journal Article · Lebensmittel-Wissenschaft + [i.e. und] Technologie. Food science + technology. Science + technologie alimentaire

Effect of Tremella fuciformis on dough structure and rheology, noodle flavor, and quality characteristics

To improve the quality characteristics and enrich their nutrition and flavor, Tremella fuciformis (TF) powder was incorporated into noodles. This study explored the effects of TF on noodle quality and flavor characteristics..

Gut & microbiome

High relevance

Almond Mushroom · 2024 · Research Article · Animal bioscience

Effects of dietary supplementation of polysaccharide from Agaricus blazei Murr on productive performance, egg quality, blood metabolites, intestinal morphology and microbiota of Korean quail.

OBJECTIVE: This study aimed to investigate the effects of dietary supplementation with Agaricus blazei polysaccharide (ABP) at varying concentrations on the performance, egg quality, blood biochemistry, intestinal morphology, and microflora of quail..

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Journal of the science of food and agriculture

Effects of different wall-breaking methods on the nutrient release of Ganoderma lucidum spore powder during in vitro digestion.

BACKGROUND: The hard double-walled structure of Ganoderma lucidum spore powder (GLSP) is difficult for the human body to digest, so it is very important to break the wall of GLSP..

Immune supportGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Journal of the science of food and agriculture

Effects of different wall‐breaking methods on the nutrient release of Ganoderma lucidum spore powder during in vitro digestion

BACKGROUND: The hard double‐walled structure of Ganoderma lucidum spore powder (GLSP) is difficult for the human body to digest, so it is very important to break the wall of GLSP..

Immune supportGut & microbiome

High relevance

Enoki · 2024 · Research Article · Frontiers in microbiology

Effects of Flammulina velutipes mushroom residues on growth performance, apparent digestibility, serum biochemical indicators, rumen fermentation and microbial of Guizhou black goat.

INTRODUCTION: The primary objective of the current study was to evaluate the effects of Flammulina velutipes mushroom residue (FVMR) in a fermented total mixed ration (FTMR) diet on the fattening effect and rumen microorganisms in Guizhou black male goats..

Immune supportEnergy & fatigueGut & microbiome

High relevance

Lion's Mane · 2024 · Journal Article · Comparative biochemistry and physiology. Toxicology & pharmacology: CBP

Effects of Hericium erinaceus polysaccharide in porcine IPEC-J2 intestinal epithelial cells against apoptosis induced by oxidative stress.

This study was intended to investigate whether Hericium erinaceus polysaccharides (HEP) prevent oxidative stress and apoptosis of intestinal porcine epithelial cells from jejunum (IPEC-J2 cells) induced by hydrogen peroxide (H2O2). Crude HEP were extracted and purified by chromatography..

OncologyImmune supportEnergy & fatigueGut & microbiome

High relevance

Oyster Mushroom · 2024 · Journal Article · Environmental research

Effects of initial corncob particle size on the short-term composting for preparation of cultivation substrates for Pleurotus ostreatus.

The short-term composting based on corncob for preparing Pleurotus ostreatus cultivation medium originated from agricultural production practices and so lacked systematic investigation..

Energy & fatigueGut & microbiome

High relevance

Reishi · 2024 · Journal Article · Journal of food science

Enhancement of exercise-induced fatigue alleviation and liver selenium regulation through in situ nanoselenium synthesis by Lactobacillus rhamnosus cells, empowered by Ganoderma lucidum spore loading.

Given the increasing awareness of the negative effects of fatigue on daily activities, mental health, and quality of life, antifatigue supplements are becoming increasingly popular among consumers. Selenium has been found to have antifatigue potential in high dosage, but may cause toxicity effects to the body..

Energy & fatigueGut & microbiomeLiver support

High relevance

Reishi · 2024 · Journal Article · World J Microbiol Biotechnol

Enhancing high-efficiency breeding and microbial microdroplet cultivation techniques for Ganoderma lucidum

Ganoderma lucidum is known for its bioactive compounds, such as polysaccharides and triterpenoids, which are crucial in food and medicine. However, liquid fermentation encounters challenges in terms of strain differentiation and stability..

Immune supportGut & microbiome

High relevance

Reishi · 2024 · Journal Article · World journal of microbiology & biotechnology

Enhancing high-efficiency breeding and microbial microdroplet cultivation techniques for Ganoderma lucidum.

Immune supportGut & microbiome

High relevance

Oyster Mushroom · 2024 · Journal Article · Animal feed science and technology

Enhancing the nutritional value of canola meal through solid culture with Pleurotus ostreatus

Canola or rapeseed meal is a source of high-value protein, vitamins, and minerals. However, its feeding application for monogastric animals has been impeded due to the presence of antinutrients and undigestible fiber..

Gut & microbiome

High relevance

Reishi · 2024 · Journal Article · Fitoterapia

Explore the mechanisms of triterpenoids from Ganoderma lucidum in the protection against Alzheimer's disease via microbiota-gut-brain axis with the aid of network pharmacology.

Ganoderma lucidum (Curtis) P. Karst.(G.

Cognition & nervesGut & microbiome

High relevance

Reishi · 2024 · Research Article · Journal of animal science

Functional properties of Ganoderma lucidum supplementation in canine nutrition.

Ganoderma lucidum (GL) is a mushroom that has been widely used in Asia for its immunostimulatory and anti-inflammatory capacity, which has been hypothesized to be attributed mainly to the recognition of its cell-surface patterns by cells of the immune system present in the gastrointestinal tract, resulting in a….

Immune supportCognition & nervesGut & microbiomeLiver support

High relevance

Reishi · 2024 · Research Article · Food chemistry: X

Ganoderma lucidum driven fermentation of Rosa roxburghii pomace: Effects on noodle physicochemical properties, digestion, and gut microbiota.

Rosa roxburghii pomace (RRP) is a high dietary fiber byproduct that is underutilized. This study investigated the effects of Ganoderma lucidum fermented Rosa roxburghii pomace (FRRP) on noodle cooking characteristics, texture, structure, in vitro digestion, and fermentation..

Immune supportMetabolic healthGut & microbiome

High relevance

Reishi · 2024 · Research Article · Chinese medicine

Ganoderma lucidum polysaccharide ameliorates cholesterol gallstone formation by modulating cholesterol and bile acid metabolism in an FXR-dependent manner.

BACKGROUND: Cholesterol gallstone (CG) disease is a worldwide common disease characterized by cholesterol supersaturation in gallbladder bile. Ganoderma lucidum polysaccharide (GLP) has been shown to possess various beneficial effects against metabolic disorders..

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Reishi · 2024 · Journal Article · Journal of agricultural and food chemistry

Ganoderma lucidum Polysaccharide Supplementation Significantly Activates T-Cell-Mediated Antitumor Immunity and Enhances Anti-PD-1 Immunotherapy Efficacy in Colorectal Cancer.

Ganoderma lucidum polysaccharide (GLP) is a prebiotic with immunomodulatory effects. However, the therapeutic potential of GLP in tumor immunotherapy has not been fully explored, especially in T cell-mediated antitumor immunity..

OncologyImmune supportGut & microbiome

High relevance

Oyster Mushroom · 2024 · Research Article · Mycobiology

Growth and Yield Performance of Pleurotus ostreatus Cultivated on Agricultural Residues.

Food insecurity and malnutrition are among the major problems in most developing nations recently. Mushroom cultivation is one of the promising strategies to overcome these challenges.

Energy & fatigueGut & microbiome

High relevance

Yellow Morel · 2024 · Journal Article · International journal of biological macromolecules

Gut microbiota combined with serum metabolites to reveal the effect of Morchella esculenta polysaccharides on lipid metabolism disordered in high-fat diet mice.

The ameliorating effects and mechanisms of Morchella esculenta polysaccharides (MEP-1) on lipid metabolism were investigated in high-fat diet (HFD) mice. The results showed that MEP-1 intervention significantly reduced serum TC, TG, LDL-C, and inflammatory factors (TNF-α, IL-1β and IL-6) in HFD mice in a….

Immune supportMetabolic healthGut & microbiomeLiver support

High relevance

Lion's Mane · 2024 · Journal Article · International journal of biological macromolecules

Hericium erinaceus polysaccharides ameliorate nonalcoholic fatty liver disease via gut microbiota and tryptophan metabolism regulation in an aged laying hen model.

Polysaccharides extracted from Hericium erinaceus (HEP) exhibit hepatoprotective activity in the alleviation of non-alcoholic fatty liver disease (NAFLD); however, the mechanisms underlying whether and how HEP regulation of the gut microbiota to alleviate liver-associated metabolic disorders are not well understood..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2024 · Journal Article · Food Research International

In vitro digestion and fecal fermentation of Tremella fuciformis exopolysaccharides from basidiospore-derived submerged fermentation

Tremella fuciformis polysaccharides (TFPS) belong to natural bioactive macromolecule with both edible and medicinal value, possessing much bioactivities such as anti-tumor, antioxidant, antidiabetics, and immunomodulatory..

OncologyImmune supportMetabolic healthGut & microbiome

High relevance

Snow Fungus · 2024 · Journal Article · Food research international (Ottawa, Ont.)

In vitro digestion and fecal fermentation of Tremella fuciformis exopolysaccharides from basidiospore-derived submerged fermentation.

OncologyImmune supportMetabolic healthGut & microbiome