MycoData

Metabolic healthGut & microbiome

Oyster Mushroom · 2026 · Journal Article · Food chemistry

Physicochemical and digestive properties of low-sodium bread enriched with Agaricus bisporus and Pleurotus ostreatus co-products.

The work explored the use of Agaricus bisporus (ABSF) and Pleurotus ostreatus (POSF) co-products as functional ingredients to partially or fully replace NaCl in bread (eight formulations, 0.5-6%; 50-100% replacement). Chemical, physicochemical, sensory, and in vitro digestion analyses were performed..

Reishi · 2026 · Journal Article · Carbohydrate polymers

Polysaccharide from Ganoderma lucidum-fermented wheat pericarp: Purification, structural features, and lipid-lowering mechanisms

This study purified and characterized a polysaccharide derived from wheat pericarp via solid-state fermentation (SSF) with Ganoderma lucidum, and evaluated its lipid-lowering effects using an oleic acid (OA)-induced HepG2 cell model..

Reishi · 2026 · Journal Article · Carbohydrate polymers

Polysaccharide from Ganoderma lucidum-fermented wheat pericarp: Purification, structural features, and lipid-lowering mechanisms.

Immune supportEnergy & fatigueMetabolic health

Reishi · 2026 · Research Article · Journal of nanobiotechnology

ROS-responsive Ganoderma lucidum polysaccharide nanocomposite targeting prosenescent oxidative stress niche for structural and functional diabetic tendon regeneration.

Diabetic patients exhibit higher tendon injury incidence, with elevated risks of healing failure and re-rupture than healthy individuals, posing major clinical challenges. Tendon stem/progenitor cells (TSPCs) are crucial for tendon homeostasis maintenance, and their senescence underlies regenerative impairment..

Reishi · 2026 · Research Article · Foods (Basel, Switzerland)

Solid-State Fermentation of Jatropha curcas Cake by Pleurotus ostreatus or Ganoderma lucidum Mycelium to Determine Multi-Bioactivities.

Non-toxic Jatropha curcas cake is a by-product rich in protein that can be used in the food industry. Proteolytic kinetics were used to identify and quantify its antioxidant, antidiabetic, angiotensin-converting enzyme inhibitory, and hypocholesterolemic capacities.

Immune supportMetabolic healthLiver support

Reishi · 2026 · Journal Article · Food research international (Ottawa, Ont.)

Structural characterization, lipid-lowering activity, and emulsifying properties of polysaccharides derived from wheat pericarp via Ganoderma lucidum solid-state fermentation.

The biotransformation of agricultural by-products through fungal solid-state fermentation (SSF) represents a sustainable and efficient strategy for enhancing the functional properties of plant polysaccharides..

Energy & fatigueMetabolic healthLiver support

Shiitake · 2026 · Research Article · Microbiology spectrum

The alterations of the synthetic pathway and metabolic flux of auxin indole-3-acetic acid govern thermotolerance in Lentinula edodes mycelia subjected to heat stress.

Heat stress poses a significant constraint on the annual production of Lentinula edodes (L. edodes), a challenge that has been intensified by global warming.

OncologyImmune supportMetabolic healthGut & microbiome

Enoki · 2026 · Research Article · International journal of molecular sciences

The Brown Strain of Flammulina velutipes Singer Attenuates 5-Fluorouracil-Induced Intestinal Injury by Suppressing Inflammation, Oxidative Stress, and Barrier Disruption via Modulation of Epithelial-Mesenchymal Transition and Tight Junction Integrity.

5-Fluorouracil (5-FU) remains a cornerstone chemotherapeutic for colorectal cancer, exerting its antitumor effects primarily through disruption of DNA and RNA synthesis and subsequent induction of apoptosis. Nonetheless, its clinical efficacy is often compromised by prominent adverse effects, particularly mucositis..

Cognition & nervesMetabolic health

Lion's Mane · 2026 · Journal Article · Biological trace element research

The Chronic Metabolic Fingerprint of Canine Anxiety: Hair Trace Element Dyshomeostasis and the Dissociation of Behavioral Recovery via Hericium erinaceus.

Canine anxiety is a complex welfare issue involving neuro-endocrine dysregulation. While acute stress biomarkers are widely used, the chronic metabolic consequences of anxiety remain under-investigated.

Metabolic healthLiver support

Reishi · 2026 · Journal Article · Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Therapeutic potential of the medicinal mushroom Ganoderma lucidum in metabolic syndrome: Antioxidant, hypoglycemic, and hepatoprotective activities.

The objective of this study was to investigate the impact of Ganoderma lucidum mycelium on biochemical parameters altered in rats with fructose-induced metabolic syndrome..

Shiitake · 2026 · Journal Article · Fungal biology

Transcriptomic analysis of the dynamic changes in polysaccharide biosynthesis metabolism in Lentinula edodes throughout liquid fermentation.

Lentinula edodes, a mushroom valued both nutritionally and medicinally, produces polysaccharides as its principal bioactive compounds, known for their significant pharmacological effects. However, low yields have limited their large-scale industrial application..

Immune supportCognition & nervesMetabolic health

Cordyceps · 2026 · Research Article · BMC microbiology

Transcriptomic and metabolomic insights into the long-term survival strategies of Ophiocordyceps sinensis following host immune perturbation.

BACKGROUND: Ophiocordyceps sinensis is a premier medicinal fungus with a unique slow-killing parasitic strategy, yet the molecular basis of its long-term persistence in host hemocoel remains elusive..

Shiitake · 2026 · Research Article · Journal of fungi (Basel, Switzerland)

Transcriptomic and Physiological Profiling Reveals Metabolic Determinants and Key Regulatory Hubs of Fruiting Body Degeneration in Lentinula edodes.

Frequent strain degeneration during subcultivation, characterized by impaired sporulation and fruiting body formation, represents a major constraint in fungal agricultural production..

Lion's Mane · 2026 · Research Article · Molecules (Basel, Switzerland)

Ultrasound-Assisted Extraction of Polyphenols from Hericium erinaceus: Optimization, Bioactivities and LC-MS-Based Chemical Profiling.

In this study, the Box-Behnken Design (BBD) was adopted to optimize the ultrasound-assisted extraction (UAE) conditions of polyphenols from Hericium erinaceus (H. erinaceus) on the basis of single-factor experiments, with extraction time, solid-liquid ratio and ethanol concentration as the key investigation factors..

Reishi · 2026 · Journal Article · International journal of biological macromolecules

Unique synergistic and compensatory interaction between β-1,3-glucosyltransferase isoenzyme in Ganoderma lucidum polysaccharide biosynthesis.

Two β-1,3-glucosyltransferase isoenzymes, designated GL20535 and GL24465, are present in Ganoderma lucidum polysaccharide (GLPS) biosynthesis. Previous studies have demonstrated that the expression level of gl20535 significantly influences the yield of GLPS, and silencing gl20535 results in upregulation of gl24465..

Turkey Tail · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

A Chromosome-Scale Genome of Trametes versicolor and Transcriptome-Based Screening for Light-Induced Genes That Promote Triterpene Biosynthesis.

Trametes versicolor is an important fungus with medicinal properties and a significant role in lignocellulose degradation. In this study, we constructed a high-quality chromosome-level genome of T.

OncologyImmune supportMetabolic health

Reishi · 2025 · Journal Article · International journal of biological macromolecules

A glucomannan from defatted Ganoderma lucidum spores: structural characterization and immunomodulatory activity via activating TLR4/MyD88/NF-κB signaling pathway.

Ganoderma lucidum spores are tiny mature germ cells ejected from the abaxial side of the pileus and were responsible for multiple pharmacological properties. The defatted G.

Immune supportMetabolic healthLiver support

Reishi · 2025 · Research Article · Frontiers in chemistry

A new lanostane-type triterpene with lipid-lowering activity from Ganoderma lucidum and an additional analogue.

Non-alcoholic fatty liver disease (NAFLD) represents a chronic liver disorder with widespread global prevalence, primarily attributed to hepatic lipid accumulation, oxidative stress, and inflammatory responses..

Reishi · 2025 · Journal Article · Carbohydrate polymers

A novel galactoglucan from Ganoderma lucidum ameliorates ethanol-induced gastric ulcers by modulating FAK-MAPK signaling pathway

Gastric ulcer (GU) is a prevalent gastrointestinal disorder that significantly impacts patients' quality of life. Current treatments, including proton pump inhibitors and H₂ receptor antagonists, often present limitations such as adverse side effects and incomplete healing, highlighting the urgent need for new….

Reishi · 2025 · Journal Article · Carbohydrate polymers

A novel galactoglucan from Ganoderma lucidum ameliorates ethanol-induced gastric ulcers by modulating FAK-MAPK signaling pathway.

Gastric ulcer (GU) is a prevalent gastrointestinal disorder that significantly impacts patients' quality of life. Current treatments, including proton pump inhibitors and H2 receptor antagonists, often present limitations such as adverse side effects and incomplete healing, highlighting the urgent need for new….

Enoki · 2025 · Research Article · Foods (Basel, Switzerland)

Activity Analysis and Inhibition Mechanism of Four Novel Angiotensin I-Converting Enzyme Inhibitory Peptides Prepared from Flammulina velutipes by Enzymatic Hydrolysis.

In order to innovatively develop high-activity ACE inhibitory peptides from edible fungi, the conditions for a double-enzymatic hydrolysis preparation of ACE inhibitory peptides from Flammulina velutipes were optimized by response surface methodology..

Immune supportMetabolic healthGut & microbiomeLiver support

Reishi · 2025 · Journal Article · Plant Foods Hum Nutr

Alcoholic Extracts from the Ganoderma Lucidum Fermentation Product Alleviated Ethanol-Induced Liver Injury, Gut Leakiness, and Gut Dysbiosis in Mice

The hepatoprotective effect of the alcoholic extracts of Ganoderma lucidum fermentation products (GFE) was investigated. C57BL/6 mice were pretreated with GFE for 7 days and then subjected to the chronic-binge ethanol feeding model..

Reishi · 2025 · Journal Article · International journal of biological macromolecules

Alternative splicing of Gllac7 regulate lignin degradation in Ganoderma lucidum.

Laccases are key enzymes involved in lignin degradation in the white-rot fungus Ganoderma lucidum. Gllac7, which exists as two alternative splice isoforms, Gllac7.1 and Gllac7.2, plays a significant role in the lignin degradation process in G.

Oyster Mushroom · 2025 · Journal Article · International journal of medicinal mushrooms

Antihyperlipidemic Effect of Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) Extract in Rats with Postnatal Sucrose Consumption Whose Mothers Also Consumed Sucrose.

Male offspring of rats whose mothers consumed sucrose (5% solution) during gestation and lactation were also given the sucrose solution instead of drinking water for 3 months, and subsequently, for 1 month, they were given an aqueous extract obtained from dehydrated fruiting bodies of Pleurotus ostreatus..

OncologyImmune supportMetabolic healthGut & microbiome

Reishi · 2025 · Journal Article · Journal of medicinal food

Antioxidant Properties of Mexican Ganoderma lucidum Extracts in Obese C57BL/6 Mice Fed with a High-Fat and Sugar Diet.

Oxidative stress is a key factor of comorbidities in obesity. A Mexican genotype of the medicinal mushroom Ganoderma lucidum (Gl) contains bioactive compounds showing antioxidant, hypocholesterolemic, anti-inflammatory, anticancer, and prebiotic properties..

Metabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · Journal of ethnopharmacology

Betulinic acid from Inonotus obliquus ameliorates T2DM by modulating short-chain fatty acids producing bacteria and amino acids metabolism in db/db mice.

ETHNOPHARMACOLOGICAL RELEVANCE: Inonotus obliquus has also been used as a traditional folk medicine in Europe and Northeastern China to treat metabolic diseases. Betulinic acid (BA) is a major ingredient with anti-diabetic property derived from I.

OncologyImmune supportMetabolic healthRespiratory

Oyster Mushroom · 2025 · Research Article · Current research in food science

Bioactive properties of selenium-enriched polysaccharides extracted from Pleurotus ostreatus using ultrasonic-assisted extraction.

Mushrooms are well recognized as functional foods owing to their rich nutritional and medicinal properties, particularly polysaccharides with notable therapeutic potential..

Energy & fatigueMetabolic healthLiver support

Reishi · 2025 · Research Article · International journal of food science

Characterisation and Hypolipidaemic Effects of Tlayudas, Widely Consumed Tortillas, Containing Ganoderma lucidum Extracts on an In Vivo Model of Hypercholesterolaemia.

Tlayudas, a variant of tortillas, are a highly consumed and low-cost traditional Mexican food, typical of the Oaxaca region. We developed new functional food products from tlayudas (T) containing standardised hydroalcoholic extracts (T + Gl-1 and T + Gl-2) of the medicinal mushroom Ganoderma lucidum (Gl) from Mexico..

Cordyceps · 2025 · Journal Article · Food chemistry

Characteristics of lipid accumulation induced by high-altitude environment improve the total antioxidant capacity of Ophiocordyceps sinensis.

Ophiocordyceps sinensis is a traditional Chinese herbal medicine and nutritional supplement, which is rich in functional components beneficial to health. The biosynthesis of these components is affected by environment factors, especially lipids..

Turkey Tail · 2025 · Journal Article · Journal of food composition and analysis

Chemical composition of Trametes versicolor, Hericium erinaceus, and Pleurotus ostreatus mushroom biomass: Deciphering their rich α-glucan composition and nutritional value

This study provides the first comprehensive characterization of the Trametes versicolor (TV), Hericium erinaceus (HE), and Pleurotus ostreatus (PO) biomasses, emphasizing their abundant α-glucan content and the presence of (1→4)-β-glucans..

Immune supportMetabolic healthGut & microbiomeLiver support

Chaga · 2025 · Journal Article · Food Hydrocolloids

Co-microencapsulation of Lactobacillus paracasei and Inonotus obliquus polysaccharide in alginate system: Physicochemical and functional properties

In this study, sodium alginate (SA) was used as shell material, and Lactobacillus paracasei JY062/Inonotus obliquus polysaccharide (IOP) were used as core material (JY062-IOP/SA). The microcapsules were prepared by polymer gel technology and analyzed by SEM, FTIR, TGA and XRD..

Reishi · 2025 · Research Article · Journal of fungi (Basel, Switzerland)

Combined Transcriptomic and Metabolomic Analyses of the Response of Ganoderma lucidum to Elevated CO2.

Carbon dioxide (CO2) is a key environmental factor that regulates the morphology of fruiting bodies in edible fungi. High CO2 concentrations often lead to the formation of antler-shaped abnormal fruiting bodies in Ganoderma lucidum.

Shiitake · 2025 · Research Article · BMC complementary medicine and therapies

Comparative study on the therapeutic potential of aqueous extracts from commercially cultivated Agaricus bisporus and Lentinula edodes in Sri Lanka: antioxidant, anticancer, antidiabetic, and antibacterial properties.

BACKGROUND: Mushrooms have long been recognized as rich sources of bioactive compounds. Among edible mushrooms, Agaricus bisporus and Lentinula edodes are highly valued for their nutritional and medicinal profiles..

OncologyMetabolic health

Reishi · 2025 · Research Article · Clinical diabetes: a publication of the American Diabetes Association

Comparing the Effects of Ganoderma lucidum and Kombucha Mushrooms on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Clinical Trial.

This randomized clinical trial compared the effects of Ganoderma lucidum and kombucha mushrooms on glycemic control in patients with type 2 diabetes. After the intervention, there were significant differences among the G..

Shiitake · 2025 · Research Article · Foods (Basel, Switzerland)

Comparison of the Conventional, Chemical, and Ultrasound Extraction of Crude Polysaccharides and Their Properties from Lentinula edodes (Berk.) Pegler.

This study aimed to compare the efficiency of four extraction methods, hot water (HW), hot alkaline (HA), ultrasound-assisted water (UW), and ultrasound-assisted alkaline (UA), for extracting crude β-glucan from Lentinula edodes, focusing on yield, functionality, and antidiabetic potential..

Reishi · 2025 · Journal Article · International journal of medicinal mushrooms

Consumption of Tlayudas (Tortillas) Containing Standardized Extracts from Mexican Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) Increases the Expression of Antioxidant Genes in C57BL/6 Mice Fed a High-Cholesterol Diet.

Maize is relevant part of Mexican food and culture. Tlayudas are a regional variant of tortillas from Oaxaca region.

Immune supportEnergy & fatigueMetabolic health

Shiitake · 2025 · Journal Article · Industrial crops and products

Cytology, transcriptomics, and proteomics analyses revealed selenium accumulation mechanisms and nutritional quality changes at sodium selenite in Lentinula edodes

Lentinula edodes is one of the most popular edible mushrooms worldwide, with remarkable potential for selenium (Se) biofortification. However, little is known about the mechanisms underlying Se stress in L.

Reishi · 2025 · Research Article · Food chemistry: X

Dynamic changes of nutrients, isoflavone composition and antioxidant activities during liquid-state fermentation of soybean embryo homogenate by Ganoderma lucidum.

This study aims to explore compositional changes of oligosaccharides, amino-type nitrogen, free amino acids volatile compounds, isoflavones, total phenol, total flavonoid, and antioxidant capacities during liquid-state fermentation (LSF) of soybean embryo homogenate (SEH) by Ganoderma lucidum to improve usability as….

Immune supportMetabolic healthGut & microbiomeSkin & hydration

Enoki · 2025 · Journal Article · Food chemistry

Effect of Flammulina velutipes polysaccharidees on the quality and digestibility of fresh wet rice noodles: A study perspective from physicochemical and postprandial glucose homeostasis in vivo.

This study investigated the effects of alkali-extracted Flammulina velutipes polysaccharides (AEFP) on the physicochemical properties, starch digestibility, and glycemic response of fresh wet rice noodles (WRN)..

Lion's Mane · 2025 · Journal Article · Cryo letters

Effect of Hericium erinaceus polysaccharides on the cryopreservation of bull semen.

BACKGROUND: The field of sperm cryopreservation requires the search for and development of new effective cryopreservatives with low toxicity. OBJECTIVE: The purpose of this study was to evaluate the characteristics of bull spermatozoa subjected to freezing and storage at -80 degree C for 28 days in a diluent with the….

Oyster Mushroom · 2025 · Journal Article · South African journal of botany

Effect of preservation techniques on the phytochemical profile, antioxidant activity, and glucose adsorption capacity of oyster mushrooms (Pleurotus ostreatus)

The growing demand for foods with enhanced shelf life and nutritional value has driven the rapid expansion of processed food products, often outpacing natural alternatives..

Metabolic healthLiver support

Shiitake · 2025 · Research Article · Frontiers in nutrition

Effect of soluble dietary fiber extracted from Lentinula edodes (Berk.) Pegler on lipid metabolism and liver protection in mice on high-fat diet.

With the increasing annual production of Lentinula edodes, the residues of Lentinus edodes are mass produced and wasted every year. In order to further explore the added value and effective utilization of Lentinus edodes, we studied the lipid-lowering efficacy and liver protective effect of Lentinus edodes soluble….

Immune supportEnergy & fatigueMetabolic healthGut & microbiome

Reishi · 2025 · Research Article · Animals: an open access journal from MDPI

Effects of Ganoderma lucidum Polysaccharides on Dexameth-Asone-Induced Immune Injury in Goslings.

This study aimed to investigate the role of ganoderma lucidum polysaccharides (GLP) in mitigating dexamethasone (DEX)-induced immune injury in goslings. Dexamethasone (DEX) is commonly used to establish an animal model of immune suppression, which mimics the immune injury caused by stress or certain pathological….

Maitake · 2025 · Journal Article · Journal of food science

Effects of Simulated Digestion on the Structure and Macrophages and Dendritic Cells Activation of Grifola frondosa Polysaccharides.

The present work was analyzed the effects of simulated digestion on the structure of a multibranched polysaccharide (PM) from Grifola frondosa. Additionally, the activation effect of PM on macrophages and dendritic cells was compared before and after simulated digestion..

Metabolic healthGut & microbiome

Wood Ear · 2025 · Research Article · Clinical nutrition research

Effects of the Intestinal Status and Clinical Factors of Korean Middle-Aged People Through the Consumption of Functional Foods Containing Auricularia auricula-judae Powder: Prospective, Randomized, Open-Label, and Control Comparative Trial.

This study aimed to evaluate the effects of functional foods containing Auricularia auricula-judae powder on gut health and clinical indicators in middle-aged and older adults..

Snow Fungus · 2025 · Research Article · International journal of molecular sciences

Effects of ε-Poly-L-Lysine/Chitosan Composite Coating on the Storage Quality, Reactive Oxygen Species Metabolism, and Membrane Lipid Metabolism of Tremella fuciformis.

This study aimed to investigate the efficacy of a composite coating composed of 150 mg/L ε-Poly-L-lysine (ε-PL) and 5 g/L chitosan (CTS) in extending the shelf life and maintaining the postharvest quality of fresh Tremella fuciformis. Freshly harvested T..

Maitake · 2025 · Journal Article · International journal of biological macromolecules

Efficient production, structural characterization and bioactivity of an extracellular polysaccharide from Grifola frondosa endophytic Burkholderia sp.

Endophytic bacteria Burkholderia sp. (GFB) was firstly identified and isolated from Grifola frondosa.

OncologyImmune supportEnergy & fatigueMetabolic health

Reishi · 2025 · Research Article · Antioxidants (Basel, Switzerland)

Evaluation of Anticancer Potential of Ganoderma lucidum on MCF-7 Breast Cancer Cells Through Genetic Transcription of Energy Metabolism.

Ganoderma lucidum has long been recognized for its medicinal properties, particularly due to its antioxidant, anti-inflammatory, and pro-apoptotic components such as polysaccharides and triterpenoids. This study aimed to evaluate the cytotoxic and molecular effects of ethanol and methanol extracts of G..